Fat3 (FAT atypical cadherin 3) - Rat Genome Database

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Pathways
Gene: Fat3 (FAT atypical cadherin 3) Rattus norvegicus
Analyze
Symbol: Fat3
Name: FAT atypical cadherin 3
RGD ID: 620657
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion mediated by cadherin. Predicted to act upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Predicted to be located in dendrite. Predicted to be active in adherens junction and plasma membrane. Orthologous to human FAT3 (FAT atypical cadherin 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FAT tumor suppressor homolog 3; FAT tumor suppressor homolog 3 (Drosophila); Fta3 protein; protocadherin Fat 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,972,840 - 21,555,679 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl820,972,840 - 21,555,240 (-)EnsemblGRCr8
mRatBN7.2812,691,470 - 13,274,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl812,694,019 - 13,273,135 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx816,682,525 - 17,258,197 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,980,283 - 15,555,971 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,959,478 - 13,530,483 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0814,417,039 - 15,011,596 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl814,417,584 - 14,880,644 (-)Ensemblrn6Rnor6.0
Rnor_5.0814,504,017 - 15,096,304 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4812,701,734 - 13,283,589 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera814,159,097 - 14,735,217 (-)NCBICelera
RGSC_v3.1812,701,733 - 13,283,589 (-)NCBI
Cytogenetic Map8q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloroethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
graphite  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
PCB138  (ISO)
permethrin  (EXP)
Ptaquiloside  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. Mitsui K, etal., Biochem Biophys Res Commun 2002 Feb 1;290(4):1260-6.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21903076   PMID:30361391  


Genomics

Comparative Map Data
Fat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,972,840 - 21,555,679 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl820,972,840 - 21,555,240 (-)EnsemblGRCr8
mRatBN7.2812,691,470 - 13,274,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl812,694,019 - 13,273,135 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx816,682,525 - 17,258,197 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,980,283 - 15,555,971 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,959,478 - 13,530,483 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0814,417,039 - 15,011,596 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl814,417,584 - 14,880,644 (-)Ensemblrn6Rnor6.0
Rnor_5.0814,504,017 - 15,096,304 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4812,701,734 - 13,283,589 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera814,159,097 - 14,735,217 (-)NCBICelera
RGSC_v3.1812,701,733 - 13,283,589 (-)NCBI
Cytogenetic Map8q12NCBI
FAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,224,818 - 92,896,473 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,224,818 - 92,896,473 (+)Ensemblhg38GRCh38
GRCh371191,957,984 - 92,629,639 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,724,910 - 92,269,284 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1189,389,818 - 89,934,254 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1188,175,033 - 88,720,594 (+)NCBIHuRef
CHM1_11191,968,261 - 92,512,715 (+)NCBICHM1_1
T2T-CHM13v2.01192,147,480 - 92,825,282 (+)NCBIT2T-CHM13v2.0
Fat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39915,821,485 - 16,413,981 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl915,821,485 - 16,412,581 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38915,910,189 - 16,502,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,910,189 - 16,501,285 (-)Ensemblmm10GRCm38
MGSCv37915,714,637 - 16,182,675 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36915,660,586 - 16,128,624 (-)NCBIMGSCv36mm8
Celera913,190,165 - 13,658,604 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map95.16NCBI
Fat3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554141,472,067 - 1,962,265 (-)Ensembl
ChiLan1.0NW_0049554141,467,087 - 2,083,914 (-)NCBIChiLan1.0ChiLan1.0
FAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2993,086,949 - 93,766,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11194,174,805 - 94,856,216 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,242,937 - 87,921,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11190,737,036 - 91,417,091 (+)NCBIPanPan1.1PanPan1.1panPan2
FAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,711,304 - 8,355,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,711,995 - 8,213,266 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha217,726,049 - 8,305,922 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0217,887,082 - 8,530,931 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl217,887,107 - 8,388,711 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1217,673,213 - 8,316,021 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,741,688 - 8,385,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0217,786,294 - 8,429,295 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494777,516,471 - 78,120,541 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366741,775,744 - 2,374,883 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366741,770,884 - 2,104,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1924,772,394 - 25,476,424 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2928,097,757 - 28,730,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1183,471,266 - 84,159,858 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl183,609,116 - 84,158,537 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604341,615,074 - 42,308,057 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fat3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473537,094,858 - 37,622,688 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473536,951,642 - 37,627,652 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fat3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1811,640,317 - 12,096,895 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fat3
2709 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:76
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000015977
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
D8Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8821,241,834 - 21,242,024 (+)Marker Load Pipeline
mRatBN7.2812,960,479 - 12,960,669 (+)MAPPERmRatBN7.2
Rnor_6.0814,683,954 - 14,684,143NCBIRnor6.0
Rnor_5.0814,770,616 - 14,770,805UniSTSRnor5.0
RGSC_v3.4812,964,628 - 12,964,817UniSTSRGSC3.4
RGSC_v3.4812,964,627 - 12,964,817RGDRGSC3.4
Celera814,423,435 - 14,423,624UniSTS
RGSC_v3.1812,964,557 - 12,964,834RGD
FHH x ACI Map84.9UniSTS
FHH x ACI Map84.9RGD
Cytogenetic Map8q12UniSTS
D8Got12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2813,162,460 - 13,162,668 (+)MAPPERmRatBN7.2
Rnor_6.0814,885,520 - 14,885,727NCBIRnor6.0
Rnor_5.0814,971,603 - 14,971,810UniSTSRnor5.0
RGSC_v3.4813,171,130 - 13,171,337UniSTSRGSC3.4
RGSC_v3.4813,171,129 - 13,171,337RGDRGSC3.4
RGSC_v3.1813,171,130 - 13,171,337RGD
RH 3.4 Map8131.4UniSTS
RH 3.4 Map8131.4RGD
Cytogenetic Map8q12UniSTS
D8Got13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2813,180,211 - 13,180,494 (+)MAPPERmRatBN7.2
Rnor_6.0814,903,278 - 14,903,558NCBIRnor6.0
Rnor_5.0814,989,314 - 14,989,594UniSTSRnor5.0
RGSC_v3.4813,188,751 - 13,189,069RGDRGSC3.4
RGSC_v3.4813,188,751 - 13,189,031UniSTSRGSC3.4
Celera814,642,271 - 14,642,551UniSTS
RGSC_v3.1813,188,751 - 13,189,031RGD
RH 3.4 Map8139.5UniSTS
RH 3.4 Map8139.5RGD
Cytogenetic Map8q12UniSTS
D8Uia6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2812,712,294 - 12,712,417 (+)MAPPERmRatBN7.2
Rnor_6.0814,434,426 - 14,434,548NCBIRnor6.0
Rnor_5.0814,521,088 - 14,521,210UniSTSRnor5.0
RGSC_v3.4812,715,554 - 12,715,676UniSTSRGSC3.4
Celera814,175,617 - 14,175,739UniSTS
Cytogenetic Map8q12UniSTS
AU047810  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8820,980,456 - 20,980,639 (+)Marker Load Pipeline
mRatBN7.2812,699,086 - 12,699,269 (+)MAPPERmRatBN7.2
Rnor_6.0814,420,382 - 14,420,564NCBIRnor6.0
Rnor_5.0814,507,360 - 14,507,542UniSTSRnor5.0
RGSC_v3.4812,705,074 - 12,705,256UniSTSRGSC3.4
Celera814,162,437 - 14,162,619UniSTS
Cytogenetic Map8q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 10 67 163 62 61 30 32 30 6 255 130 11 142 79 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015977   ⟹   ENSRNOP00000015976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,977,117 - 21,554,472 (-)Ensembl
mRatBN7.2 Ensembl812,695,747 - 13,273,135 (-)Ensembl
Rnor_6.0 Ensembl814,417,584 - 14,880,644 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109404   ⟹   ENSRNOP00000096648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,972,840 - 21,555,240 (-)Ensembl
mRatBN7.2 Ensembl812,694,019 - 13,273,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118830   ⟹   ENSRNOP00000089392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,976,657 - 21,555,240 (-)Ensembl
mRatBN7.2 Ensembl812,694,019 - 13,273,135 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173498   ⟹   ENSRNOP00000112789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,972,840 - 21,555,240 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173686   ⟹   ENSRNOP00000112730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,972,840 - 21,555,240 (-)Ensembl
RefSeq Acc Id: NM_001413472   ⟹   NP_001400401
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,555,240 (-)NCBI
mRatBN7.2812,691,470 - 13,273,903 (-)NCBI
RefSeq Acc Id: NM_138544   ⟹   NP_612553
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,977,117 - 21,554,472 (-)NCBI
mRatBN7.2812,695,747 - 13,273,135 (-)NCBI
Rnor_6.0814,417,043 - 15,011,596 (-)NCBI
Rnor_5.0814,504,017 - 15,096,304 (-)NCBI
RGSC_v3.4812,701,734 - 13,283,589 (-)RGD
Celera814,159,097 - 14,735,217 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080778   ⟹   XP_038936706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,555,679 (-)NCBI
mRatBN7.2812,691,470 - 13,274,336 (-)NCBI
RefSeq Acc Id: XM_039080780   ⟹   XP_038936708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,555,678 (-)NCBI
mRatBN7.2812,691,470 - 13,274,336 (-)NCBI
RefSeq Acc Id: XM_039080781   ⟹   XP_038936709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,555,678 (-)NCBI
mRatBN7.2812,691,470 - 13,274,335 (-)NCBI
RefSeq Acc Id: XM_039080782   ⟹   XP_038936710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,438,953 (-)NCBI
mRatBN7.2812,691,470 - 13,157,608 (-)NCBI
RefSeq Acc Id: XM_039080783   ⟹   XP_038936711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,972,840 - 21,314,163 (-)NCBI
mRatBN7.2812,691,470 - 13,032,786 (-)NCBI
RefSeq Acc Id: NP_612553   ⟸   NM_138544
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8R508 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015976   ⟸   ENSRNOT00000015977
RefSeq Acc Id: XP_038936708   ⟸   XM_039080780
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936706   ⟸   XM_039080778
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936709   ⟸   XM_039080781
- Peptide Label: isoform X3
- UniProtKB: F1LMF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936710   ⟸   XM_039080782
- Peptide Label: isoform X3
- UniProtKB: F1LMF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936711   ⟸   XM_039080783
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000096648   ⟸   ENSRNOT00000109404
Ensembl Acc Id: ENSRNOP00000089392   ⟸   ENSRNOT00000118830
RefSeq Acc Id: NP_001400401   ⟸   NM_001413472
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A8I6ABM1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112730   ⟸   ENSRNOT00000173686
Ensembl Acc Id: ENSRNOP00000112789   ⟸   ENSRNOT00000173498
Protein Domains
Cadherin   EGF-like   Laminin G   Laminin G-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620657 AgrOrtholog
BioCyc Gene G2FUF-31624 BioCyc
Ensembl Genes ENSRNOG00000011585 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015977 ENTREZGENE
  ENSRNOT00000109404 ENTREZGENE
  ENSRNOT00000118830 ENTREZGENE
  ENSRNOT00000173686 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
NCBI Gene 191571 ENTREZGENE
PANTHER FAT ATYPICAL CADHERIN-RELATED UniProtKB/Swiss-Prot
  PROTOCADHERIN-23 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Fat3 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011585 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF49313 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniProt A0A8I6ABM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LP38_RAT UniProtKB/TrEMBL
  A0ABK0M117_RAT UniProtKB/TrEMBL
  A6JND8_RAT UniProtKB/TrEMBL
  F1LMF4 ENTREZGENE, UniProtKB/TrEMBL
  FAT3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Fat3  FAT atypical cadherin 3  Fat3  FAT tumor suppressor homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fat3  FAT tumor suppressor homolog 3 (Drosophila)    Fta3 protein  Name updated 1299863 APPROVED
2002-08-07 Fat3  Fta3 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 34 cadherin domains, 4 epidermal growth factor (EGF)-like motifs, a laminin A-G motif and a cytoplasmic domain 625453
gene_expression expressed in fetal brain and spinal cord with peak expression at day E15 625453
gene_process may play a role in axon fasciculation 625453
gene_product 4555 amino acids, 500 kDa protein 625453