Fat2 (FAT atypical cadherin 2) - Rat Genome Database

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Pathways
Gene: Fat2 (FAT atypical cadherin 2) Rattus norvegicus
Analyze
Symbol: Fat2
Name: FAT atypical cadherin 2
RGD ID: 620656
Description: Predicted to enable calcium ion binding activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in Golgi apparatus; anchoring junction; and membrane. Predicted to be active in adherens junction and plasma membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FAT tumor suppressor homolog 2; FAT tumor suppressor homolog 2 (Drosophila); Fath2; Megf1; multiple EGF-like domains protein 1; multiple epidermal growth factor-like domains 1; multiple epidermal growth factor-like domains protein 1; protocadherin Fat 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,864,765 - 39,957,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,864,766 - 39,956,902 (-)EnsemblGRCr8
mRatBN7.21039,364,072 - 39,456,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,364,073 - 39,456,216 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1044,051,017 - 44,140,369 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,541,102 - 43,630,456 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,044,810 - 39,134,160 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,583,025 - 40,682,598 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,584,403 - 40,657,861 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,421,638 - 40,513,778 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,648,951 - 40,749,409 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,701,431 - 38,790,574 (-)NCBICelera
RGSC_v3.11040,662,573 - 40,763,032 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
adherens junction  (IBA,IEA,ISO,ISS)
anchoring junction  (IEA)
Golgi apparatus  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34.
4. MEGF1/fat2 proteins containing extraordinarily large extracellular domains are localized to thin parallel fibers of cerebellar granule cells. Nakayama M, etal., Mol Cell Neurosci. 2002 Aug;20(4):563-78.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17110338   PMID:17900869   PMID:19199708   PMID:29053796  


Genomics

Comparative Map Data
Fat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,864,765 - 39,957,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,864,766 - 39,956,902 (-)EnsemblGRCr8
mRatBN7.21039,364,072 - 39,456,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,364,073 - 39,456,216 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1044,051,017 - 44,140,369 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,541,102 - 43,630,456 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,044,810 - 39,134,160 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,583,025 - 40,682,598 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,584,403 - 40,657,861 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,421,638 - 40,513,778 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,648,951 - 40,749,409 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,701,431 - 38,790,574 (-)NCBICelera
RGSC_v3.11040,662,573 - 40,763,032 (-)NCBI
Cytogenetic Map10q22NCBI
FAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,504,092 - 151,594,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,504,092 - 151,591,331 (-)Ensemblhg38GRCh38
GRCh375150,883,653 - 150,970,892 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,863,847 - 150,928,698 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345150,863,846 - 150,928,698NCBI
Celera5146,965,062 - 147,029,916 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,029,050 - 146,093,922 (-)NCBIHuRef
CHM1_15150,316,083 - 150,380,950 (-)NCBICHM1_1
T2T-CHM13v2.05152,043,070 - 152,133,808 (-)NCBIT2T-CHM13v2.0
Fat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,141,435 - 55,228,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,141,435 - 55,227,390 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381155,250,609 - 55,337,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,250,609 - 55,336,564 (-)Ensemblmm10GRCm38
MGSCv371155,064,112 - 55,125,759 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361155,094,032 - 55,155,669 (-)NCBIMGSCv36mm8
Celera1159,839,223 - 59,900,066 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.5NCBI
Fat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,941,800 - 6,033,878 (-)Ensembl
ChiLan1.0NW_0049554085,944,236 - 6,033,776 (-)NCBIChiLan1.0ChiLan1.0
FAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,732,401 - 146,819,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,871,945 - 144,959,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,927,558 - 147,014,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,930,937 - 153,018,231 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,932,400 - 152,995,784 (-)EnsemblpanPan2panpan1.1
FAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,743,007 - 57,823,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,742,651 - 57,823,740 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha457,562,217 - 57,642,911 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0458,186,256 - 58,264,746 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,185,984 - 58,263,273 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,001,758 - 58,082,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,099,856 - 58,180,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,604,015 - 58,684,660 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,682,713 - 112,751,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651511,132,059 - 11,199,153 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651511,132,059 - 11,200,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,469,847 - 71,530,501 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11671,448,491 - 71,531,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,676,229 - 77,761,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,064,687 - 54,152,696 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,064,393 - 54,152,416 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603423,577,450 - 23,643,131 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,433,349 - 37,520,756 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473337,427,330 - 37,520,756 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fat2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1937,668,238 - 37,734,001 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fat2
634 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:238
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000058665
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Got61  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,404,991 - 39,405,197 (+)MAPPERmRatBN7.2
Rnor_6.01040,623,681 - 40,623,886NCBIRnor6.0
Rnor_5.01040,461,388 - 40,461,593UniSTSRnor5.0
RGSC_v3.41040,689,311 - 40,689,517RGDRGSC3.4
RGSC_v3.41040,689,312 - 40,689,517UniSTSRGSC3.4
Celera1038,741,234 - 38,741,433UniSTS
RGSC_v3.11040,702,935 - 40,703,140RGD
RH 3.4 Map10409.5UniSTS
RH 3.4 Map10409.5RGD
RH 2.0 Map10442.8RGD
Cytogenetic Map10q22UniSTS
AI409913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,364,116 - 39,364,268 (+)MAPPERmRatBN7.2
Rnor_6.01040,583,069 - 40,583,220NCBIRnor6.0
Rnor_5.01040,421,682 - 40,421,833UniSTSRnor5.0
RGSC_v3.41040,648,995 - 40,649,146UniSTSRGSC3.4
Celera1038,701,475 - 38,701,626UniSTS
RH 3.4 Map10411.4UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 7 20 102 45 50 20 46 20 6 204 82 9 81 81 90 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000058665   ⟹   ENSRNOP00000055459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,864,766 - 39,956,902 (-)Ensembl
mRatBN7.2 Ensembl1039,364,073 - 39,456,216 (-)Ensembl
Rnor_6.0 Ensembl1040,584,403 - 40,657,861 (-)Ensembl
RefSeq Acc Id: NM_022954   ⟹   NP_075243
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,864,766 - 39,956,902 (-)NCBI
mRatBN7.21039,364,073 - 39,456,216 (-)NCBI
Rnor_6.01040,583,025 - 40,682,598 (-)NCBI
Rnor_5.01040,421,638 - 40,513,778 (-)NCBI
RGSC_v3.41040,648,951 - 40,749,409 (-)RGD
Celera1038,701,431 - 38,790,574 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086801   ⟹   XP_038942729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,864,765 - 39,957,027 (-)NCBI
mRatBN7.21039,364,072 - 39,456,324 (-)NCBI
RefSeq Acc Id: XM_039086802   ⟹   XP_038942730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,864,765 - 39,957,027 (-)NCBI
mRatBN7.21039,364,072 - 39,456,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_075243 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942729 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA32458 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055459
GenBank Protein O88277 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075243   ⟸   NM_022954
- Peptide Label: precursor
- UniProtKB: O88277 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055459   ⟸   ENSRNOT00000058665
RefSeq Acc Id: XP_038942729   ⟸   XM_039086801
- Peptide Label: isoform X1
- UniProtKB: F1LPM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942730   ⟸   XM_039086802
- Peptide Label: isoform X1
- UniProtKB: F1LPM1 (UniProtKB/TrEMBL)
Protein Domains
Cadherin   EGF-like   Laminin G   Laminin G-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620656 AgrOrtholog
BioCyc Gene G2FUF-25084 BioCyc
Ensembl Genes ENSRNOG00000012575 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000058665 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Cadherin UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
KEGG Report rno:65048 UniProtKB/Swiss-Prot
NCBI Gene 65048 ENTREZGENE
PANTHER CADHERIN-23 UniProtKB/Swiss-Prot
  PROTOCADHERIN-16 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Fat2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012575 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF49313 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniProt F1LPM1 ENTREZGENE, UniProtKB/TrEMBL
  FAT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Fat2  FAT atypical cadherin 2  Fat2  FAT tumor suppressor homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Fat2  FAT tumor suppressor homolog 2 (Drosophila)  Fath2  fat tumor suppressor homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fath2  fat tumor suppressor homolog 2 (Drosophila)  Fat2  MEGF1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Fat2  MEGF1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains multiple cadherin and EGF-like motifs 68762
gene_expression expressed in the cerebellum of the rat brain 68762
gene_process Drosophila homolog controls the cell proliferation and morphogenesis in the larval imaginal discs 68762
gene_process involved in the development of the cerebellum 68762