Cyb5a (cytochrome b5 type A) - Rat Genome Database

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Gene: Cyb5a (cytochrome b5 type A) Rattus norvegicus
Analyze
Symbol: Cyb5a
Name: cytochrome b5 type A
RGD ID: 620558
Description: Predicted to enable enzyme binding activity and heme binding activity. Involved in response to cadmium ion. Located in endoplasmic reticulum membrane. Biomarker of pyelonephritis. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A); INTERACTS WITH (+)-schisandrin B; 1,2,4-trichlorobenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyb5; cytochrome b-5; cytochrome b5; cytochrome b5 type A (microsomal); MGC108694
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,487,923 - 80,520,544 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1814,453,966 - 14,455,094 (+)EnsemblGRCr8
GRCr8 Ensembl1880,477,388 - 80,535,826 (+)EnsemblGRCr8
mRatBN7.21878,213,067 - 78,245,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1814,179,160 - 14,180,288 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1878,202,342 - 78,258,535 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1880,316,171 - 80,348,668 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01880,988,228 - 81,020,725 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,823,908 - 78,856,406 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,694,818 - 81,726,821 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,694,808 - 81,726,821 (+)Ensemblrn6Rnor6.0
Rnor_5.01880,739,215 - 80,770,883 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41881,415,972 - 81,452,606 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1876,829,153 - 76,861,638 (+)NCBICelera
RGSC_v3.11881,489,421 - 81,526,056 (+)NCBI
Cytogenetic Map18q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichlorobenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-nitroquinoline N-oxide  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alfentanil  (ISO)
Allylamine  (EXP)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
anthracen-2-amine  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cetrorelix  (ISO)
chlorzoxazone  (ISO)
cisplatin  (EXP,ISO)
citral  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ferroheme b  (ISO)
fipronil  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
galangin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (EXP)
glycidyl methacrylate  (ISO)
halothane  (ISO)
heme b  (ISO)
hesperetin  (EXP)
hydrogen peroxide  (ISO)
hydroxylamine  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
limonene  (EXP)
lycopene  (ISO)
m-xylene  (EXP)
Malotilate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silibinin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium perchlorate  (EXP)
Sudan I  (EXP,ISO)
sunitinib  (ISO)
tangeretin  (EXP)
taurine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Chemical shift-based constraints for solution structure determination of paramagnetic low-spin heme proteins with bis-His and His-CN axial ligands: the cases of oxidized cytochrome b(5) and Met80Ala cyano-cytochrome c. Banci L, etal., J Biol Inorg Chem 2002 Apr;7(4-5):416-26.
2. Phenobarbital influence on neuromuscular block produced by rocuronium in rats. Braga Ade F, etal., Acta Cir Bras. 2008 Jul-Aug;23(4):343-7.
3. Membrane-bound cytochrome b5 reductase (methemoglobin reductase) in human erythrocytes. Study in normal and methemoglobinemic subjects. Choury D, etal., J Clin Invest. 1981 Jan;67(1):149-55.
4. Toward engineering the stability and hemin-binding properties of microsomal cytochromes b5 into rat outer mitochondrial membrane cytochrome b5: examining the influence of residues 25 and 71. Cowley AB, etal., Biochemistry 2002 Oct 1;41(39):11566-81.
5. Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands. Davis CA, etal., Arch Biochem Biophys 2002 Apr 1;400(1):63-75.
6. Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene. Fermo E, etal., Blood Cells Mol Dis. 2008 Jul-Aug;41(1):50-5. doi: 10.1016/j.bcmd.2008.02.002. Epub 2008 Mar 17.
7. Investigation of the electron-transfer mechanism by cross-linking between Zn-substituted myoglobin and cytochrome b(5). Furukawa Y, etal., J Am Chem Soc. 2002 Apr 17;124(15):4008-19.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Epidemiological evaluation of recurrent stomatitis, nitrates in drinking water, and cytochrome b5 reductase activity. Gupta SK, etal., Am J Gastroenterol. 1999 Jul;94(7):1808-12.
11. [Disorders of the processes of protein biosynthesis and a decrease in the content of cytochromes P-450 and b5 in the microsomal fraction of rat kidney in the dynamics of development of acute pyelonephritis] Karimov KhIa, etal., Ukr Biokhim Zh. 1998 Jul-Aug;70(4):139-42.
12. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
13. Serine-proline replacement at residue 127 of NADH-cytochrome b5 reductase causes hereditary methemoglobinemia, generalized type. Kobayashi Y, etal., Blood. 1990 Apr 1;75(7):1408-13.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model. Murugan RS, etal., Free Radic Res. 2008 Oct;42(10):873-84.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Effects of chronic exposure to cadmium on renal cytochrome P450-dependent monooxygenase system in rats. Plewka A, etal., Arch Toxicol. 2004 Apr;78(4):194-200. Epub 2003 Nov 1.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Integration of cytochrome b5 into endoplasmic reticulum membrane: participation of carboxy-terminal portion of the transmembrane domain. Tanaka S, etal., J Biochem (Tokyo). 2003 Feb;133(2):247-51.
23. Identification of two homologous cytochrome b5s in rat brain. Yoo M Biochem Biophys Res Commun 1997 Jul 30;236(3):641-2.
Additional References at PubMed
PMID:1396600   PMID:2752049   PMID:6840088   PMID:7093287   PMID:8639599   PMID:9363779   PMID:9425037   PMID:9622481   PMID:11294656   PMID:12477932   PMID:12668680   PMID:14563830  
PMID:14651853   PMID:15379561   PMID:15489334   PMID:15680923   PMID:16807901   PMID:18398853   PMID:18398854   PMID:19817686   PMID:19946888   PMID:20511233   PMID:22375059   PMID:23376485  
PMID:29227865   PMID:31006538  


Genomics

Comparative Map Data
Cyb5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,487,923 - 80,520,544 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1814,453,966 - 14,455,094 (+)EnsemblGRCr8
GRCr8 Ensembl1880,477,388 - 80,535,826 (+)EnsemblGRCr8
mRatBN7.21878,213,067 - 78,245,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1814,179,160 - 14,180,288 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1878,202,342 - 78,258,535 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1880,316,171 - 80,348,668 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01880,988,228 - 81,020,725 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,823,908 - 78,856,406 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,694,818 - 81,726,821 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,694,808 - 81,726,821 (+)Ensemblrn6Rnor6.0
Rnor_5.01880,739,215 - 80,770,883 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41881,415,972 - 81,452,606 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1876,829,153 - 76,861,638 (+)NCBICelera
RGSC_v3.11881,489,421 - 81,526,056 (+)NCBI
Cytogenetic Map18q12.3NCBI
CYB5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381874,250,846 - 74,291,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1874,250,846 - 74,291,995 (-)Ensemblhg38GRCh38
GRCh371871,918,081 - 71,959,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361870,071,507 - 70,110,201 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341870,071,507 - 70,110,201NCBI
Celera1868,787,880 - 68,826,566 (-)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1868,652,932 - 68,691,654 (-)NCBIHuRef
CHM1_11871,915,750 - 71,954,471 (-)NCBICHM1_1
T2T-CHM13v2.01874,478,400 - 74,519,513 (-)NCBIT2T-CHM13v2.0
Cyb5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,869,463 - 84,897,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,856,829 - 84,897,996 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381884,851,338 - 84,879,871 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,838,704 - 84,879,871 (+)Ensemblmm10GRCm38
MGSCv371885,020,806 - 85,049,255 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361884,985,607 - 85,014,056 (+)NCBIMGSCv36mm8
Celera1885,916,355 - 85,944,796 (+)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
LOC102012144
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540257,701,931 - 57,739,163 (-)Ensembl
ChiLan1.0NW_00495540257,701,931 - 57,739,163 (-)NCBIChiLan1.0ChiLan1.0
LOC100968898
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21791,788,331 - 91,827,345 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11877,480,954 - 77,519,968 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01867,638,406 - 67,677,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11870,919,329 - 70,957,873 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1870,919,617 - 70,957,732 (-)EnsemblpanPan2panpan1.1
LOC476167
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115,070,817 - 5,106,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15,070,865 - 5,106,932 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0 Ensembl14,881,337 - 4,922,028 (+)EnsemblROS_Cfam_1.0 Ensembl
LOC101960314
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,855,437 - 18,885,877 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366164,176,576 - 4,210,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYB5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,737,571 - 149,773,219 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11149,737,584 - 149,773,222 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21165,902,066 - 165,937,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYB5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,599,198 - 5,636,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,599,206 - 5,640,012 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606020,247,043 - 20,284,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101711375
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248066,399,460 - 6,436,735 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248066,399,708 - 6,434,667 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116884580
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11547,492,887 - 47,524,975 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyb5a
203 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:141
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000020446, ENSRNOT00000064490
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187627210481806852Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
70172Eae15Experimental allergic encephalomyelitis QTL 150.001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)187948431184129249Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat

Markers in Region
RH140952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21814,179,275 - 14,179,492 (+)MAPPERmRatBN7.2
Rnor_6.01813,903,992 - 13,904,208NCBIRnor6.0
Rnor_5.01813,686,964 - 13,687,180UniSTSRnor5.0
RGSC_v3.41814,598,173 - 14,598,389UniSTSRGSC3.4
Celera1814,157,870 - 14,158,086UniSTS
RH 3.4 Map18167.4UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020446   ⟹   ENSRNOP00000020446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1880,487,992 - 80,535,826 (+)Ensembl
mRatBN7.2 Ensembl1878,213,054 - 78,258,535 (+)Ensembl
Rnor_6.0 Ensembl1881,694,808 - 81,726,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098124   ⟹   ENSRNOP00000089416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1880,478,287 - 80,520,549 (+)Ensembl
mRatBN7.2 Ensembl1878,213,106 - 78,245,427 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102664   ⟹   ENSRNOP00000088469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1878,202,342 - 78,246,646 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105279   ⟹   ENSRNOP00000086849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1880,477,388 - 80,520,549 (+)Ensembl
mRatBN7.2 Ensembl1878,202,342 - 78,246,646 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106026   ⟹   ENSRNOP00000084531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1878,213,086 - 78,246,646 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110451   ⟹   ENSRNOP00000094995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1814,453,966 - 14,455,094 (+)Ensembl
mRatBN7.2 Ensembl1814,179,160 - 14,180,288 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112034   ⟹   ENSRNOP00000084294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1878,213,671 - 78,246,646 (+)Ensembl
RefSeq Acc Id: NM_022245   ⟹   NP_071581
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81880,488,009 - 80,520,544 (+)NCBI
mRatBN7.21878,213,137 - 78,245,674 (+)NCBI
Rnor_6.01881,694,818 - 81,726,821 (+)NCBI
Rnor_5.01880,739,215 - 80,770,883 (+)NCBI
RGSC_v3.41881,415,972 - 81,452,606 (+)RGD
Celera1876,829,153 - 76,861,638 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097081   ⟹   XP_038953009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81880,487,923 - 80,520,210 (+)NCBI
mRatBN7.21878,213,068 - 78,245,677 (+)NCBI
RefSeq Acc Id: XM_063277544   ⟹   XP_063133614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81880,487,923 - 80,517,521 (+)NCBI
RefSeq Acc Id: NP_071581   ⟸   NM_022245
- UniProtKB: O35768 (UniProtKB/Swiss-Prot),   P00173 (UniProtKB/Swiss-Prot),   A6K5L8 (UniProtKB/TrEMBL),   A0A8I6A8N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020446   ⟸   ENSRNOT00000020446
RefSeq Acc Id: XP_038953009   ⟸   XM_039097081
- Peptide Label: isoform X2
- UniProtKB: A6K5L9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084294   ⟸   ENSRNOT00000112034
Ensembl Acc Id: ENSRNOP00000086849   ⟸   ENSRNOT00000105279
Ensembl Acc Id: ENSRNOP00000084531   ⟸   ENSRNOT00000106026
Ensembl Acc Id: ENSRNOP00000088469   ⟸   ENSRNOT00000102664
Ensembl Acc Id: ENSRNOP00000094995   ⟸   ENSRNOT00000110451
Ensembl Acc Id: ENSRNOP00000089416   ⟸   ENSRNOT00000098124
RefSeq Acc Id: XP_063133614   ⟸   XM_063277544
- Peptide Label: isoform X1
Protein Domains
Cytochrome b5 heme-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00173-F1-model_v2 AlphaFold P00173 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700895
Promoter ID:EPDNEW_R11419
Type:initiation region
Name:Cyb5a_1
Description:cytochrome b5 type A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01881,694,809 - 81,694,869EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620558 AgrOrtholog
BioCyc Gene G2FUF-6743 BioCyc
Ensembl Genes ENSRNOG00000015205 Ensembl
  ENSRNOG00000070068 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000098124 ENTREZGENE
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7322141 IMAGE-MGC_LOAD
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot
  Cyt_B5_heme-BS UniProtKB/Swiss-Prot
  Cytochrome_b5 UniProtKB/Swiss-Prot
KEGG Report rno:64001 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108694 IMAGE-MGC_LOAD
NCBI Gene 64001 ENTREZGENE
PANTHER CYTOCHROME B5 UniProtKB/Swiss-Prot
  CYTOCHROME B5 UniProtKB/Swiss-Prot
Pfam Cyt-b5 UniProtKB/Swiss-Prot
PharmGKB CYB5A RGD
PhenoGen Cyb5a PhenoGen
PRINTS CYTOCHROMEB5 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_B5_1 UniProtKB/Swiss-Prot
  CYTOCHROME_B5_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015205 RatGTEx
  ENSRNOG00000070068 RatGTEx
SMART Cyt-b5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot
UniProt A0A8I6A321_RAT UniProtKB/TrEMBL
  A0A8I6A8N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AM61_RAT UniProtKB/TrEMBL
  A0A8L2QAA3_RAT UniProtKB/TrEMBL
  A6K5L8 ENTREZGENE, UniProtKB/TrEMBL
  A6K5L9 ENTREZGENE, UniProtKB/TrEMBL
  CYB5_RAT UniProtKB/Swiss-Prot
  O35768 ENTREZGENE
  P00173 ENTREZGENE
UniProt Secondary O35768 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Cyb5a  cytochrome b5 type A  Cyb5a  cytochrome b5 type A (microsomal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cyb5a  cytochrome b5 type A (microsomal)  Cyb5  cytochrome b-5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cyb5  cytochrome b-5    cytochrome b5  Name updated 1299863 APPROVED
2002-08-07 Cyb5  cytochrome b5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains both heme and FAD prosthetic groups 632262