Spam1 (sperm adhesion molecule 1) - Rat Genome Database

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Gene: Spam1 (sperm adhesion molecule 1) Rattus norvegicus
Analyze
Symbol: Spam1
Name: sperm adhesion molecule 1
RGD ID: 620547
Description: Predicted to enable hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to act upstream of or within single fertilization. Predicted to be located in external side of plasma membrane and membrane raft. Predicted to be active in acrosomal vesicle. Orthologous to human SPAM1 (sperm adhesion molecule 1); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH ammonium chloride; bisphenol A; fenvalerate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hyal-PH20; hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; MGC93268; Spam; sperm adhesion molecule; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface antigen 2B1; sperm surface protein PH-20
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,268,287 - 54,278,455 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,268,295 - 54,278,512 (+)EnsemblGRCr8
mRatBN7.2453,302,745 - 53,312,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,302,745 - 53,312,908 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,289,582 - 58,299,738 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0454,203,130 - 54,213,288 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,624,479 - 52,634,638 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0452,194,201 - 52,204,369 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl452,199,416 - 52,204,425 (+)Ensemblrn6Rnor6.0
Rnor_5.0451,963,972 - 51,974,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,278,513 - 51,288,681 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,466,224 - 48,476,392 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning and characterization of rat sperm surface antigen 2B1, a glycoprotein implicated in sperm-zona binding. Hou ST, etal., Mol Reprod Dev 1996 Oct;45(2):193-203.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12065596   PMID:15062858   PMID:15489334   PMID:16330764   PMID:16925524   PMID:19144954  


Genomics

Comparative Map Data
Spam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,268,287 - 54,278,455 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,268,295 - 54,278,512 (+)EnsemblGRCr8
mRatBN7.2453,302,745 - 53,312,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,302,745 - 53,312,908 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,289,582 - 58,299,738 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0454,203,130 - 54,213,288 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,624,479 - 52,634,638 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0452,194,201 - 52,204,369 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl452,199,416 - 52,204,425 (+)Ensemblrn6Rnor6.0
Rnor_5.0451,963,972 - 51,974,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,278,513 - 51,288,681 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,466,224 - 48,476,392 (+)NCBICelera
Cytogenetic Map4q22NCBI
SPAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,925,241 - 123,971,414 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,925,237 - 123,971,414 (+)Ensemblhg38GRCh38
GRCh377123,565,295 - 123,611,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,352,565 - 123,398,700 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347123,159,279 - 123,194,051NCBI
Celera7118,369,061 - 118,415,251 (+)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,928,616 - 117,974,816 (+)NCBIHuRef
CHM1_17123,498,618 - 123,544,809 (+)NCBICHM1_1
T2T-CHM13v2.07125,241,959 - 125,288,129 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,953,904 - 123,000,093 (+)NCBI
Spam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,791,187 - 24,801,047 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,791,187 - 24,801,047 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38624,791,188 - 24,801,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,791,188 - 24,801,048 (+)Ensemblmm10GRCm38
MGSCv37624,741,199 - 24,751,048 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36624,741,209 - 24,751,058 (+)NCBIMGSCv36mm8
Celera624,801,998 - 24,811,775 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
SPAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,771,458 - 160,813,361 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,781,707 - 12,823,611 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,916,304 - 115,951,103 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,598,686 - 128,633,353 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,623,193 - 128,643,550 (+)EnsemblpanPan2panpan1.1
SPAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,704,766 - 11,723,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,704,757 - 11,712,570 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1411,388,764 - 11,407,202 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01411,482,189 - 11,500,628 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,482,191 - 11,500,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,671,617 - 11,690,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,409,770 - 11,428,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,650,286 - 11,668,734 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,570,267 - 50,608,145 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,595,481 - 1,602,236 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,595,969 - 1,602,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,589,952 - 23,598,739 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11823,589,947 - 23,598,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,183,127 - 25,196,268 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,738,082 - 92,744,794 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,738,287 - 92,744,715 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604210,709,088 - 10,758,465 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Spam1
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000009537
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)45014392658080146Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 10 7 9 5 5 5 19 7 10 3 26 4

Sequence


Ensembl Acc Id: ENSRNOT00000009537   ⟹   ENSRNOP00000009537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,268,295 - 54,278,512 (+)Ensembl
mRatBN7.2 Ensembl453,302,745 - 53,312,908 (+)Ensembl
Rnor_6.0 Ensembl452,199,416 - 52,204,425 (+)Ensembl
RefSeq Acc Id: NM_053967   ⟹   NP_446419
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,268,287 - 54,278,455 (+)NCBI
mRatBN7.2453,302,745 - 53,312,913 (+)NCBI
Rnor_6.0452,194,201 - 52,204,369 (+)NCBI
Rnor_5.0451,963,972 - 51,974,140 (+)NCBI
RGSC_v3.4451,278,513 - 51,288,681 (+)RGD
Celera448,466,224 - 48,476,392 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446419 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81748 (Get FASTA)   NCBI Sequence Viewer  
  CAA62016 (Get FASTA)   NCBI Sequence Viewer  
  EDM15179 (Get FASTA)   NCBI Sequence Viewer  
  EDM15180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009537
  ENSRNOP00000009537.3
GenBank Protein Q62803 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446419   ⟸   NM_053967
- Peptide Label: precursor
- UniProtKB: Q62803 (UniProtKB/Swiss-Prot),   A6IE93 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009537   ⟸   ENSRNOT00000009537

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62803-F1-model_v2 AlphaFold Q62803 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620547 AgrOrtholog
BioCyc Gene G2FUF-45473 BioCyc
Ensembl Genes ENSRNOG00000007231 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009537 ENTREZGENE
  ENSRNOT00000009537.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134081 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Hyaluronidase UniProtKB/Swiss-Prot
  Hyaluronidase_PH20/Hyal5 UniProtKB/Swiss-Prot
KEGG Report rno:117037 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93268 IMAGE-MGC_LOAD
NCBI Gene 117037 ENTREZGENE
PANTHER HYALURONIDASE PH-20 UniProtKB/Swiss-Prot
  PTHR11769 UniProtKB/Swiss-Prot
Pfam Glyco_hydro_56 UniProtKB/Swiss-Prot
PhenoGen Spam1 PhenoGen
PIRSF Hyaluronidase UniProtKB/Swiss-Prot
  Hyaluronidase_PH20_Hyal5 UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE56 UniProtKB/Swiss-Prot
  SPERMPH20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007231 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
UniProt A6IE93 ENTREZGENE, UniProtKB/TrEMBL
  HYALP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Spam1  sperm adhesion molecule 1  Spam1  sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Spam1  sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)  Spam1  sperm adhesion molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Spam1  sperm adhesion molecule 1  Spam  sperm adhesion molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Spam  sperm adhesion molecule      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Spam  sperm adhesion molecule      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains has a C-terminal transmembrane domain and a strong candidate signal sequence 634179
gene_process a bifunctional protein which participates in the dispersion of cumulus oophorus cells as well as zona adhesion 634179
gene_protein protein is 512 amino-acid in size 634179