Tnni3 (troponin I3, cardiac type) - Rat Genome Database

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Gene: Tnni3 (troponin I3, cardiac type) Rattus norvegicus
Analyze
Symbol: Tnni3
Name: troponin I3, cardiac type
RGD ID: 62052
Description: Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction and regulation of smooth muscle contraction. Located in sarcomere. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; (R,R)-tramadol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac troponin I; cTNI; TnI; troponin 1, type 3; Troponin I; troponin I cardiac; troponin I type 3 (cardiac); troponin I, cardiac; troponin I, cardiac muscle
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,342,571 - 78,346,255 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,342,592 - 78,346,253 (+)EnsemblGRCr8
mRatBN7.2169,299,900 - 69,303,582 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,658,817 - 74,662,501 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,223,130 - 83,226,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,372,704 - 76,376,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,882,806 - 72,886,490 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)Ensemblrn6Rnor6.0
Rnor_5.0175,665,119 - 75,668,803 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,028,198 - 68,031,882 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,824,338 - 67,828,022 (-)NCBICelera
RGSC_v3.1168,106,308 - 68,109,991 (+)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(S)-colchicine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetamiprid  (EXP)
acetylsalicylic acid  (ISO)
agomelatine  (EXP)
Alamandine  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (EXP)
Allylamine  (EXP)
alpha-Zearalanol  (EXP)
aluminium phosphide  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anethole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calycosin  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
celastrol  (EXP)
chelerythrine  (ISO)
chlordecone  (ISO)
cholic acid  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
corilagin  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
Cyanoginosin  (EXP)
cyclophosphamide  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dibromine  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferruginol  (EXP)
flavonoids  (EXP)
gefitinib  (EXP)
glucose  (ISO)
glyburide  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-acetic acid  (EXP)
isoprenaline  (EXP,ISO)
lead(0)  (ISO)
levocabastine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lithium atom  (EXP)
lithium carbonate  (EXP)
lithium hydride  (EXP)
loperamide  (EXP)
melphalan  (ISO)
metaproterenol  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrofen  (EXP)
O-acetyl-L-carnitine  (EXP)
orciprenaline  (EXP)
osimertinib  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
perphenazine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
plumbagin  (EXP)
ponatinib  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
protosappanin A  (ISO)
pyrvinium  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rosuvastatin calcium  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
taurine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tramadol  (EXP)
trans-anethole  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
Vinpocetine  (EXP)
vorinostat  (ISO)
xanthone  (EXP)
zidovudine  (ISO)
zingerone  (EXP)
zingiberene  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cardiac myofibril  (IEA,ISO)
cardiac Troponin complex  (IEA,ISO)
contractile muscle fiber  (IDA)
cytoplasm  (IDA)
myofibril  (IDA)
sarcomere  (IDA,IEA,ISO)
troponin complex  (IBA,IEA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Developmental expression of rat cardiac troponin I mRNA. Ausoni S, etal., Development 1991 Aug;112(4):1041-51.
2. Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Doolan A, etal., J Mol Cell Cardiol. 2005 Feb;38(2):387-93. Epub 2005 Jan 27.
3. Cardiac troponins and N-terminal pro-brain natriuretic peptide in acute ischemic stroke do not relate to clinical prognosis. Etgen T, etal., Stroke. 2005 Feb;36(2):270-5. Epub 2004 Dec 16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Kedar V, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18135-40. Epub 2004 Dec 15.
7. Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I. Martin AF and Orlowski J, J Mol Cell Cardiol 1991 May;23(5):583-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Murphy AM, etal., Biochem J 1997 Mar 1;322 ( Pt 2):393-401.
10. Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart. Murphy AM, etal., Biochemistry 1991 Jan 22;30(3):707-12.
11. Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Murphy RT, etal., Lancet. 2004 Jan 31;363(9406):371-2.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Titin isoform switch in ischemic human heart disease. Neagoe C, etal., Circulation. 2002 Sep 10;106(11):1333-41.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Medium perfusion enables engineering of compact and contractile cardiac tissue. Radisic M, etal., Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16. Epub 2003 Oct 9.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation. Rossmanith GH, etal., J Physiol. 1997 Nov 15;505 ( Pt 1):217-27.
22. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
23. Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. Westfall MV, etal., J Biol Chem. 2005 Dec 16;280(50):41324-31. Epub 2005 Oct 18.
24. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Wu LL, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R408-16.
25. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
26. Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy. Yumoto F, etal., Biochem Biophys Res Commun. 2005 Dec 23;338(3):1519-26. Epub 2005 Nov 2.
Additional References at PubMed
PMID:7957210   PMID:10642551   PMID:10806205   PMID:10850966   PMID:11158984   PMID:11356618   PMID:11735257   PMID:11815426   PMID:11984006   PMID:12093807   PMID:12531876   PMID:12551921  
PMID:12721663   PMID:12809519   PMID:15142843   PMID:15542288   PMID:15611140   PMID:16481394   PMID:16754800   PMID:17875210   PMID:18397962   PMID:18548271   PMID:18721805   PMID:18986304  
PMID:19278978   PMID:19801490   PMID:20161772   PMID:20594472   PMID:20945043   PMID:21613513   PMID:21876643   PMID:22052912   PMID:22207765   PMID:22364878   PMID:22500757   PMID:22684024  
PMID:22808244   PMID:23246786   PMID:23454346   PMID:23764111   PMID:23904327   PMID:24853739   PMID:24932661   PMID:25089838   PMID:25185555   PMID:25481661   PMID:25771144   PMID:26290107  
PMID:26869200   PMID:26944554   PMID:27150586   PMID:27974300   PMID:28587770   PMID:28864299   PMID:28958680   PMID:29544221   PMID:29642034   PMID:29704484   PMID:32066368   PMID:33080242  
PMID:33378032   PMID:34957754   PMID:35352799  


Genomics

Comparative Map Data
Tnni3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,342,571 - 78,346,255 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,342,592 - 78,346,253 (+)EnsemblGRCr8
mRatBN7.2169,299,900 - 69,303,582 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,658,817 - 74,662,501 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,223,130 - 83,226,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,372,704 - 76,376,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,882,806 - 72,886,490 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)Ensemblrn6Rnor6.0
Rnor_5.0175,665,119 - 75,668,803 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,028,198 - 68,031,882 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,824,338 - 67,828,022 (-)NCBICelera
RGSC_v3.1168,106,308 - 68,109,991 (+)NCBI
Cytogenetic Map1q12NCBI
TNNI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,151,767 - 55,157,732 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,151,767 - 55,157,773 (-)Ensemblhg38GRCh38
GRCh371955,663,135 - 55,669,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,354,947 - 60,360,912 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341960,354,949 - 60,360,858NCBI
Celera1952,704,329 - 52,710,294 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,986,278 - 51,992,090 (-)NCBIHuRef
CHM1_11955,656,700 - 55,662,665 (-)NCBICHM1_1
T2T-CHM13v2.01958,245,731 - 58,251,791 (-)NCBIT2T-CHM13v2.0
Tnni3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,521,304 - 4,526,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,521,304 - 4,527,228 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3874,518,305 - 4,522,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,518,305 - 4,524,229 (-)Ensemblmm10GRCm38
MGSCv3774,469,910 - 4,474,045 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3674,121,395 - 4,125,530 (-)NCBIMGSCv36mm8
Celera74,262,821 - 4,266,956 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.61NCBI
Tnni3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,037,462 - 1,042,039 (+)Ensembl
ChiLan1.0NW_0049555671,037,325 - 1,042,102 (+)NCBIChiLan1.0ChiLan1.0
TNNI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,288,194 - 61,293,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,017,317 - 63,023,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,193,061 - 52,198,782 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,887,630 - 60,892,875 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,887,630 - 60,894,219 (-)EnsemblpanPan2panpan1.1
TNNI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,475,146 - 102,478,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,475,146 - 102,478,318 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1102,532,199 - 102,535,372 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01103,128,720 - 103,131,893 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11102,765,644 - 102,768,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,477,237 - 102,480,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,241,266 - 103,244,439 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnni3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,117,982 - 2,121,466 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886437,754 - 440,458 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936886437,754 - 440,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,366,829 - 59,371,160 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl659,371,080 - 59,377,734 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1659,366,828 - 59,377,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,294,993 - 54,298,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNI3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,746,293 - 47,752,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,745,386 - 47,752,204 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666523445 - 2,272 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnni3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,088,589 - 2,092,771 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248322,088,455 - 2,092,774 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tnni3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12177,120,565 - 177,125,037 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tnni3
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000024640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Wox56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,301,051 - 69,301,153 (+)MAPPERmRatBN7.2
Rnor_6.0172,883,958 - 72,884,061NCBIRnor6.0
Rnor_5.0175,667,548 - 75,667,651UniSTSRnor5.0
RGSC_v3.4168,029,350 - 68,029,453UniSTSRGSC3.4
Celera167,826,767 - 67,826,870UniSTS
Cytogenetic Map1q12UniSTS
RH139764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,299,103 - 69,299,322 (+)MAPPERmRatBN7.2
Rnor_6.0172,882,010 - 72,882,228NCBIRnor6.0
Rnor_5.0175,669,381 - 75,669,599UniSTSRnor5.0
RGSC_v3.4168,027,402 - 68,027,620UniSTSRGSC3.4
Celera167,828,600 - 67,828,818UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 63 150 91 90 59 34 59 6 278 129 11 126 70 87 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000024640   ⟹   ENSRNOP00000024640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,342,592 - 78,346,253 (+)Ensembl
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)Ensembl
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110513   ⟹   ENSRNOP00000090895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)Ensembl
RefSeq Acc Id: NM_017144   ⟹   NP_058840
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,342,571 - 78,346,255 (+)NCBI
mRatBN7.2169,299,900 - 69,303,582 (+)NCBI
Rnor_6.0172,882,806 - 72,886,490 (+)NCBI
Rnor_5.0175,665,119 - 75,668,803 (-)NCBI
RGSC_v3.4168,028,198 - 68,031,882 (+)RGD
Celera167,824,338 - 67,828,022 (-)RGD
Sequence:
RefSeq Acc Id: XM_039103599   ⟹   XP_038959527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,343,302 - 78,346,255 (+)NCBI
mRatBN7.2169,300,635 - 69,303,582 (+)NCBI
RefSeq Acc Id: XM_063282921   ⟹   XP_063138991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,342,572 - 78,346,255 (+)NCBI
RefSeq Acc Id: NP_058840   ⟸   NM_017144
- UniProtKB: Q4PP23 (UniProtKB/Swiss-Prot),   P23693 (UniProtKB/Swiss-Prot),   A0A8I6ADH6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024640   ⟸   ENSRNOT00000024640
RefSeq Acc Id: XP_038959527   ⟸   XM_039103599
- Peptide Label: isoform X2
- UniProtKB: A6KNL9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090895   ⟸   ENSRNOT00000110513
RefSeq Acc Id: XP_063138991   ⟸   XM_063282921
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADH6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23693-F1-model_v2 AlphaFold P23693 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689705
Promoter ID:EPDNEW_R230
Type:single initiation site
Name:Tnni3_1
Description:troponin I3, cardiac type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,882,791 - 72,882,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62052 AgrOrtholog
BioCyc Gene G2FUF-60839 BioCyc
Ensembl Genes ENSRNOG00000018250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024640 ENTREZGENE
  ENSRNOT00000024640.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot
  6.10.250.180 UniProtKB/Swiss-Prot
InterPro Troponin UniProtKB/Swiss-Prot
  Troponin-I_N UniProtKB/Swiss-Prot
  Troponin_I UniProtKB/Swiss-Prot
  Troponin_sf UniProtKB/Swiss-Prot
KEGG Report rno:29248 UniProtKB/Swiss-Prot
NCBI Gene 29248 ENTREZGENE
PANTHER TROPONIN I UniProtKB/Swiss-Prot
  TROPONIN I, CARDIAC MUSCLE UniProtKB/Swiss-Prot
Pfam Troponin UniProtKB/Swiss-Prot
  Troponin-I_N UniProtKB/Swiss-Prot
PhenoGen Tnni3 PhenoGen
RatGTEx ENSRNOG00000018250 RatGTEx
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot
UniProt A0A8I6ADH6 ENTREZGENE
  A6KNL9 ENTREZGENE, UniProtKB/TrEMBL
  A6KNM0_RAT UniProtKB/TrEMBL
  P23693 ENTREZGENE
  Q4PP23 ENTREZGENE
  TNNI3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4PP23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnni3  troponin I3, cardiac type  Tnni3  troponin I type 3 (cardiac)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tnni3  troponin I type 3 (cardiac)    troponin I, cardiac  Name updated 1299863 APPROVED
2004-09-10 Tnni3  troponin I, cardiac    troponin 1, type 3  Name updated 1299863 APPROVED
2002-06-10 Tnni3  troponin 1, type 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the myocardium throughout development 730032
gene_regulation transcription is induced by transcription factor GATA-4 730167