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Gene: Gmfg (glia maturation factor, gamma) Rattus norvegicus

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Symbol:

Gmfg

Name:

glia maturation factor, gamma

RGD ID:

620506

Description:

Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Orthologous to human GMFG (glia maturation factor gamma); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glia maturation factor gamma; GMF-gamma

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GMFG (glia maturation factor gamma)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gmfg (glia maturation factor, gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gmfg (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GMFG (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GMFG (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gmfg (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GMFG (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GMFG (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gmfg (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gmfg (glia maturation factor gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GMFB (glia maturation factor beta)	HGNC	OrthoDB
Homo sapiens (human):	MFSD11 (major facilitator superfamily domain containing 11)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GMFG (glia maturation factor gamma)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gmfg (glia maturation factor, gamma)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gmfg (glia maturation factor, gamma)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AIM7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	AIM7	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	GMF	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y50D7A.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gmfg	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gmfg	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	92,856,154 - 92,866,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	92,854,995 - 92,866,723 (+)	Ensembl				GRCr8
mRatBN7.2	1	83,728,797 - 83,739,189 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	83,728,776 - 83,739,183 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	89,144,009 - 89,149,423 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,602,407 - 97,607,840 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	90,899,881 - 90,905,293 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	85,312,473 - 85,322,860 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	85,312,528 - 85,317,968 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	86,528,117 - 86,539,458 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	83,551,609 - 83,557,015 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	78,129,937 - 78,135,343 (+)	NCBI		Celera
RGSC_v3.1	1	83,630,142 - 83,635,126 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (EXP)

camptothecin (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dioxygen (EXP)

disodium selenite (ISO)

diuron (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

folic acid (ISO)

fonofos (ISO)

gentamycin (EXP)

glafenine (EXP)

ivermectin (ISO)

methimazole (EXP)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

Nutlin-3 (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorododecanoic acid (EXP)

phenylephrine (EXP)

pirinixic acid (ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

Soman (EXP)

terbufos (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

triadimefon (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament debranching (IBA,IEA,ISO)

negative regulation of Arp2/3 complex-mediated actin nucleation (IBA,ISO)

signal transduction (IEA)

Cellular Component

cortical actin cytoskeleton (IBA)

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

actin binding (IEA)

Arp2/3 complex binding (IBA,IEA)

growth factor activity (IEA)

kinase regulator activity (NAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning of a rat glia maturation factor-gamma (rGMFG) cDNA and expression of its mRNA and protein in rat organs.	Tsuiki H, etal., J Biochem (Tokyo) 2000 Mar;127(3):517-23.

Additional References at PubMed

PMID:23727094

Genomics

Comparative Map Data

Gmfg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	92,856,154 - 92,866,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	92,854,995 - 92,866,723 (+)	Ensembl				GRCr8
mRatBN7.2	1	83,728,797 - 83,739,189 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	83,728,776 - 83,739,183 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	89,144,009 - 89,149,423 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,602,407 - 97,607,840 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	90,899,881 - 90,905,293 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	85,312,473 - 85,322,860 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	85,312,528 - 85,317,968 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	86,528,117 - 86,539,458 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	83,551,609 - 83,557,015 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	78,129,937 - 78,135,343 (+)	NCBI		Celera
RGSC_v3.1	1	83,630,142 - 83,635,126 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

GMFG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	39,328,359 - 39,336,043 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	39,328,353 - 39,342,372 (-)	Ensembl			hg38	GRCh38
GRCh37	19	39,818,999 - 39,826,683 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	44,510,839 - 44,518,460 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	44,510,841 - 44,518,011	NCBI
Celera	19	36,620,680 - 36,628,409 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	36,265,890 - 36,273,428 (-)	NCBI		HuRef
CHM1_1	19	39,819,733 - 39,827,459 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	42,132,630 - 42,140,315 (-)	NCBI		T2T-CHM13v2.0

Gmfg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,136,894 - 28,147,655 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,136,872 - 28,147,658 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	28,437,469 - 28,448,230 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	28,437,447 - 28,448,233 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	29,222,466 - 29,231,914 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,146,207 - 28,155,655 (+)	NCBI		MGSCv36	mm8
Celera	7	22,999,046 - 23,008,689 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	16.76	NCBI

Gmfg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	213,010 - 222,464 (+)	Ensembl
ChiLan1.0	NW_004955468	213,010 - 222,464 (+)	NCBI	ChiLan1.0	ChiLan1.0

GMFG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	45,623,803 - 45,637,176 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	47,494,402 - 47,507,785 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	36,426,652 - 36,440,031 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	44,974,435 - 44,988,470 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	44,974,435 - 44,982,209 (-)	Ensembl			panPan2	panpan1.1

GMFG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	113,869,296 - 113,880,532 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	113,869,354 - 113,880,532 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	113,272,670 - 113,282,530 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	114,469,934 - 114,479,797 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	114,469,983 - 114,479,797 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,028,613 - 114,038,469 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,661,409 - 113,671,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,656,527 - 114,666,390 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gmfg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,757,818 - 13,762,867 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	2,185,812 - 2,192,273 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	2,185,891 - 2,190,938 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMFG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	47,990,237 - 47,997,260 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	47,990,241 - 47,997,332 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	143,743,997 - 143,752,509 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GMFG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	33,935,158 - 33,948,605 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	33,934,122 - 33,942,758 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	11,955,431 - 11,968,809 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmfg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	12,668,618 - 12,676,502 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	12,668,720 - 12,676,471 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gmfg
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	167,547,857 - 167,558,268 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gmfg
130 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	22
Count of miRNA genes:	21
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000026891
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_181091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_190702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006228606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB007364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC110862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026891 ⟹ ENSRNOP00000026891

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,861,669 - 92,866,723 (+)	Ensembl
mRatBN7.2 Ensembl	1	83,734,131 - 83,739,183 (+)	Ensembl
Rnor_6.0 Ensembl	1	85,312,528 - 85,317,968 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118560 ⟹ ENSRNOP00000089358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,861,339 - 92,866,720 (+)	Ensembl
mRatBN7.2 Ensembl	1	83,733,386 - 83,739,183 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118600 ⟹ ENSRNOP00000089766

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,856,001 - 92,866,723 (+)	Ensembl
mRatBN7.2 Ensembl	1	83,728,776 - 83,739,173 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000145836 ⟹ ENSRNOP00000100642

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,856,150 - 92,866,723 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153500 ⟹ ENSRNOP00000098922

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,854,995 - 92,866,723 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163341 ⟹ ENSRNOP00000100439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	92,856,001 - 92,866,723 (+)	Ensembl

RefSeq Acc Id:

NM_181091 ⟹ NP_851605

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,861,314 - 92,866,720 (+)	NCBI
mRatBN7.2	1	83,733,776 - 83,739,183 (+)	NCBI
Rnor_6.0	1	85,312,479 - 85,317,885 (-)	NCBI
Rnor_5.0	1	86,528,117 - 86,539,458 (-)	NCBI
RGSC_v3.4	1	83,551,609 - 83,557,015 (+)	RGD
Celera	1	78,129,937 - 78,135,343 (+)	RGD

Sequence:

show sequence

AAAACATGTCCGACTCCCTGGTGGTGTGTGACGTGGACCCGGAGCTAAAGGAAACACTGAGGAA
ATTCCGTTTCCGAAAAGAGACCAACAATGCCGCCATCATAATGAAAGTGGACAAAGACCGGCAG
ATGGTGGTGCTAGAAGATGAATTCCAGAATGTTTCCCCAGAGGAACTTAAGTTGGAGTTGCCAG
AGAGACAGCCCAGGTTCGTGGTCTACAGCTATAAGTACGTGCATGACGACGGCAGGGTGTCCTA
CCCTTTGTGTTTCATCTTCTCCAGCCCCGTGGGCTGCAAGCCTGAACAACAGATGATGTACGCG
GGAAGTAAAAACAGGCTGGTGCAGATCGCGGAGCTTACAAAGGTGTTTGAAATCCGCACCACAG
ACGACCTCAACGAGACCTGGCTTAAGGAAAAGTTAGCTTTCTTTCGTTGACGTTTGAGCCAGGG
ATTTGGAATCTTTACTTCGGAAGACTCAGACTGATAGGATATGAACATCCAAGAGCTAAATAAA
GATTAAAATTTCAGGAATGTT

hide sequence

RefSeq Acc Id:

XM_006228606 ⟹ XP_006228668

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,856,154 - 92,866,722 (+)	NCBI
mRatBN7.2	1	83,728,797 - 83,739,189 (+)	NCBI
Rnor_6.0	1	85,312,473 - 85,322,860 (-)	NCBI
Rnor_5.0	1	86,528,117 - 86,539,458 (-)	NCBI

Sequence:

show sequence

CCTTTTGCCATGGAGCGGAAGAGAAAAGTCCAGGACAAAGCCCTCTGGGAGACTGGGTCCCAGA
GGAGAAGCTCCGTGTGGGACACCCAACACTGAGGTCAAGAACACTGCCCCACCTCGGGCATAAA
TTGAAGCTGGAGACCAGGATTCAAGGATCATTAGAGATGTCCGACTCCCTGGTGGTGTGTGACG
TGGACCCGGAGCTAAAGGAAACACTGAGGAAATTCCGTTTCCGAAAAGAGACCAACAATGCCGC
CATCATAATGAAAGTGGACAAAGACCGGCAGATGGTGGTGCTAGAAGACGAATTCCAGAATGTT
TCCCCAGAGGAACTTAAGTTGGAGTTGCCAGAGAGACAGCCCAGGTTCGTGGTCTATAGCTATA
AGTACGTGCATGACGACGGCAGGGTGTCCTACCCTTTGTGTTTCATCTTCTCCAGCCCCGTGGG
CTGCAAGCCTGAACAACAGATGATGTACGCGGGAAGTAAAAACAGGCTGGTGCAGATCGCGGAG
CTTACAAAGGTGTTTGAAATCCGCACCACAGACGACCTCACCGAGACCTGGCTTAAGGAAAAGT
TAGCTTTCTTTCGTTGACGTTTGAGCCAGGGATTTGGAATCTTTACTTCGGAAGACTCAGACTG
ATAGGATATGAACATCCAAGAGCTAAATAAAGATTAAAATTTCAGGAATGTTAATTAA

hide sequence

RefSeq Acc Id:

XM_039105677 ⟹ XP_038961605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,861,261 - 92,866,722 (+)	NCBI
mRatBN7.2	1	83,733,844 - 83,739,189 (+)	NCBI

RefSeq Acc Id:

XM_063288517 ⟹ XP_063144587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,856,154 - 92,866,722 (+)	NCBI

RefSeq Acc Id:

XM_063288563 ⟹ XP_063144633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,861,184 - 92,866,722 (+)	NCBI

RefSeq Acc Id:

XM_063288604 ⟹ XP_063144674

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,861,300 - 92,866,722 (+)	NCBI

RefSeq Acc Id:

XM_063288623 ⟹ XP_063144693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,861,258 - 92,866,722 (+)	NCBI

RefSeq Acc Id:

XM_063288636 ⟹ XP_063144706

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,856,335 - 92,866,722 (+)	NCBI

RefSeq Acc Id:

XR_010066526

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	92,856,154 - 92,866,608 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416184	(Get FASTA)	NCBI Sequence Viewer
	NP_001416185	(Get FASTA)	NCBI Sequence Viewer
	NP_001416186	(Get FASTA)	NCBI Sequence Viewer
	NP_001416187	(Get FASTA)	NCBI Sequence Viewer
	NP_001416188	(Get FASTA)	NCBI Sequence Viewer
	NP_851605	(Get FASTA)	NCBI Sequence Viewer
	XP_006228668	(Get FASTA)	NCBI Sequence Viewer
	XP_038961605	(Get FASTA)	NCBI Sequence Viewer
	XP_063144587	(Get FASTA)	NCBI Sequence Viewer
	XP_063144633	(Get FASTA)	NCBI Sequence Viewer
	XP_063144674	(Get FASTA)	NCBI Sequence Viewer
	XP_063144693	(Get FASTA)	NCBI Sequence Viewer
	XP_063144706	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC76430	(Get FASTA)	NCBI Sequence Viewer
	EDM07890	(Get FASTA)	NCBI Sequence Viewer
	EDM07891	(Get FASTA)	NCBI Sequence Viewer
	EDM07892	(Get FASTA)	NCBI Sequence Viewer
	EDM07893	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026891
	ENSRNOP00000089358
	ENSRNOP00000089766
GenBank Protein	Q80T18	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_851605 ⟸ NM_181091
- UniProtKB:	Q80T18 (UniProtKB/Swiss-Prot), A6J9J2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDSLVVCDVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDEFQNVSPEELKLELPER QPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQIAELTKVFEIRTTDD LNETWLKEKLAFFR hide sequence

RefSeq Acc Id:	XP_006228668 ⟸ XM_006228606
- Peptide Label:	isoform X2
- Sequence:	show sequence MSDSLVVCDVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDEFQNVSPEELKLELPER QPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQIAELTKVFEIRTTDD LTETWLKEKLAFFR hide sequence

Ensembl Acc Id:

ENSRNOP00000026891 ⟸ ENSRNOT00000026891

RefSeq Acc Id:	XP_038961605 ⟸ XM_039105677
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000089358 ⟸ ENSRNOT00000118560

Ensembl Acc Id:

ENSRNOP00000089766 ⟸ ENSRNOT00000118600

RefSeq Acc Id:	XP_063144587 ⟸ XM_063288517
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063144706 ⟸ XM_063288636
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063144633 ⟸ XM_063288563
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063144693 ⟸ XM_063288623
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063144674 ⟸ XM_063288604
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000098922 ⟸ ENSRNOT00000153500

Ensembl Acc Id:

ENSRNOP00000100439 ⟸ ENSRNOT00000163341

Ensembl Acc Id:

ENSRNOP00000100642 ⟸ ENSRNOT00000145836

Protein Domains

ADF-H

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q80T18-F1-model_v2	AlphaFold	Q80T18	1-142	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689867

Promoter ID:

EPDNEW_R392

Type:

initiation region

Name:

Gmfg_1

Description:

glia maturation factor, gamma

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	85,317,933 - 85,317,993	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620506	AgrOrtholog
BioCyc Gene	G2FUF-60241	BioCyc
Ensembl Genes	ENSRNOG00000019838	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000026891	ENTREZGENE
	ENSRNOT00000118560	ENTREZGENE
	ENSRNOT00000118600	ENTREZGENE
Gene3D-CATH	3.40.20.10	UniProtKB/Swiss-Prot
InterPro	ADF-H	UniProtKB/Swiss-Prot
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot
	GMF	UniProtKB/Swiss-Prot
KEGG Report	rno:113940	UniProtKB/Swiss-Prot
NCBI Gene	113940	ENTREZGENE
PANTHER	PTHR11249	UniProtKB/Swiss-Prot
	PTHR11249:SF4	UniProtKB/Swiss-Prot
Pfam	Cofilin_ADF	UniProtKB/Swiss-Prot
PhenoGen	Gmfg	PhenoGen
PIRSF	GMF-beta	UniProtKB/Swiss-Prot
PROSITE	ADF_H	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019838	RatGTEx
SMART	ADF	UniProtKB/Swiss-Prot
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/Swiss-Prot
UniProt	A0A8I6AD83	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GI11	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LC78_RAT	UniProtKB/TrEMBL
	A0ABK0LGM8_RAT	UniProtKB/TrEMBL
	A0ABK0LHS7_RAT	UniProtKB/TrEMBL
	A6J9J2	ENTREZGENE, UniProtKB/TrEMBL
	A6J9J4	ENTREZGENE, UniProtKB/TrEMBL
	F1M8F4_RAT	UniProtKB/TrEMBL
	GMFG_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Gmfg	glia maturation factor, gamma			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Gmfg				Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in rat thymus, testis, and spleen	1299275

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD