Cpz (carboxypeptidase Z) - Rat Genome Database

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Gene: Cpz (carboxypeptidase Z) Rattus norvegicus
Analyze
Symbol: Cpz
Name: carboxypeptidase Z
RGD ID: 620496
Description: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human CPZ (carboxypeptidase Z); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,448,242 - 79,471,557 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,448,139 - 79,471,556 (+)EnsemblGRCr8
mRatBN7.21475,223,692 - 75,246,946 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,223,605 - 75,246,945 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,677,279 - 79,700,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,918,147 - 80,941,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,363,131 - 77,386,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1479,983,460 - 80,006,712 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1478,608,385 - 78,631,641 (+)NCBILyon_Normotensive
Lyon_Hypertensive1480,130,985 - 80,154,237 (+)NCBILyon_Hypertensive
F344_StmMcwi1479,041,823 - 79,065,047 (+)NCBIF344_StmMcwi
Rnor_6.01480,402,946 - 80,426,203 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,403,001 - 80,426,245 (+)Ensemblrn6Rnor6.0
Rnor_5.01480,028,890 - 80,052,296 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,857,371 - 80,880,592 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,152,116 - 74,175,339 (+)NCBICelera
RGSC_v3.11480,859,761 - 80,882,982 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Dwarfism  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
Cuprizon  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
graphite  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
malathion  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mifepristone  (ISO)
Mono-carboxy isooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pioglitazone  (ISO)
progesterone  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetradecane  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular matrix  (IEA,ISO,ISS)
extracellular region  (IEA)
extracellular space  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Metallocarboxypeptidase Z is dynamically expressed in mouse development. Novikova E, etal., Mech Dev 2001 Apr;102(1-2):259-62.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9570147   PMID:10671522   PMID:12419858   PMID:18847325   PMID:23376485  


Genomics

Comparative Map Data
Cpz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,448,242 - 79,471,557 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,448,139 - 79,471,556 (+)EnsemblGRCr8
mRatBN7.21475,223,692 - 75,246,946 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,223,605 - 75,246,945 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,677,279 - 79,700,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,918,147 - 80,941,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,363,131 - 77,386,387 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1479,983,460 - 80,006,712 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1478,608,385 - 78,631,641 (+)NCBILyon_Normotensive
Lyon_Hypertensive1480,130,985 - 80,154,237 (+)NCBILyon_Hypertensive
F344_StmMcwi1479,041,823 - 79,065,047 (+)NCBIF344_StmMcwi
Rnor_6.01480,402,946 - 80,426,203 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,403,001 - 80,426,245 (+)Ensemblrn6Rnor6.0
Rnor_5.01480,028,890 - 80,052,296 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,857,371 - 80,880,592 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,152,116 - 74,175,339 (+)NCBICelera
RGSC_v3.11480,859,761 - 80,882,982 (+)NCBI
Cytogenetic Map14q21NCBI
CPZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3848,592,765 - 8,619,752 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl48,592,660 - 8,619,761 (+)Ensemblhg38GRCh38
GRCh3748,594,492 - 8,621,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,645,335 - 8,672,388 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3448,712,592 - 8,739,547NCBI
Celera48,487,239 - 8,514,366 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef48,513,792 - 8,540,980 (+)NCBIHuRef
CHM1_148,592,625 - 8,619,813 (+)NCBICHM1_1
T2T-CHM13v2.048,572,626 - 8,599,700 (+)NCBIT2T-CHM13v2.0
Cpz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,659,562 - 35,682,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,659,562 - 35,683,042 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,502,218 - 35,525,626 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,502,218 - 35,525,698 (-)Ensemblmm10GRCm38
MGSCv37535,844,867 - 35,868,275 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36535,819,196 - 35,842,396 (-)NCBIMGSCv36mm8
Celera532,977,576 - 33,000,943 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map518.16NCBI
Cpz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,572,173 - 2,586,038 (-)Ensembl
ChiLan1.0NW_0049555142,572,075 - 2,590,274 (-)NCBIChiLan1.0ChiLan1.0
CPZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,878,662 - 8,907,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan148,806,093 - 8,835,503 (+)NCBINHGRI_mPanPan1
PanPan1.148,623,879 - 8,684,722 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl48,656,029 - 8,684,722 (+)EnsemblpanPan2panpan1.1
CPZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,291,704 - 60,312,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,297,752 - 60,312,598 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,942,106 - 62,964,158 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0360,767,264 - 60,789,341 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,772,327 - 60,789,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,261,876 - 60,283,927 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0360,466,687 - 60,488,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,822,705 - 60,844,819 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cpz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,100,353 - 66,123,380 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,801,698 - 19,825,256 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,792,738 - 19,825,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,620,768 - 2,642,524 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.182,620,765 - 2,642,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CPZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12744,516,632 - 44,546,475 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2744,516,800 - 44,546,337 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666051842,345 - 872,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,075,939 - 24,088,088 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475524,069,650 - 24,088,180 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cpz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,545,651 - 69,568,728 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cpz
178 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:67
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000012109
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH134174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,246,738 - 75,246,930 (+)MAPPERmRatBN7.2
Rnor_6.01480,425,996 - 80,426,187NCBIRnor6.0
Rnor_5.01480,052,089 - 80,052,280UniSTSRnor5.0
RGSC_v3.41480,880,385 - 80,880,576UniSTSRGSC3.4
Celera1474,175,132 - 74,175,323UniSTS
RH 3.4 Map14454.08UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 148 227 91 90 65 84 59 22 427 274 11 204 80 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000012109   ⟹   ENSRNOP00000012109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,448,330 - 79,471,556 (+)Ensembl
mRatBN7.2 Ensembl1475,223,723 - 75,246,945 (+)Ensembl
Rnor_6.0 Ensembl1480,403,001 - 80,426,245 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108856   ⟹   ENSRNOP00000079374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,449,416 - 79,471,556 (+)Ensembl
mRatBN7.2 Ensembl1475,223,605 - 75,246,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113023   ⟹   ENSRNOP00000085858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,448,139 - 79,471,556 (+)Ensembl
mRatBN7.2 Ensembl1475,223,605 - 75,246,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119993   ⟹   ENSRNOP00000094872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,455,828 - 79,471,556 (+)Ensembl
mRatBN7.2 Ensembl1475,231,215 - 75,246,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000155502   ⟹   ENSRNOP00000112455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,455,320 - 79,471,556 (+)Ensembl
RefSeq Acc Id: NM_031766   ⟹   NP_113954
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,448,336 - 79,471,557 (+)NCBI
mRatBN7.21475,223,723 - 75,246,946 (+)NCBI
Dahl_SR_JrHsd1479,983,460 - 80,006,712 (+)NCBI
Lyon_Normotensive1478,608,385 - 78,631,641 (+)NCBI
Lyon_Hypertensive1480,130,985 - 80,154,237 (+)NCBI
F344_StmMcwi1479,041,823 - 79,065,047 (+)NCBI
Rnor_6.01480,402,982 - 80,426,203 (+)NCBI
Rnor_5.01480,028,890 - 80,052,296 (+)NCBI
RGSC_v3.41480,857,371 - 80,880,592 (+)RGD
Celera1474,152,116 - 74,175,339 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251151   ⟹   XP_006251213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,448,287 - 79,471,557 (+)NCBI
mRatBN7.21475,223,692 - 75,246,824 (+)NCBI
Rnor_6.01480,402,946 - 80,426,203 (+)NCBI
Rnor_5.01480,028,890 - 80,052,296 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063273679   ⟹   XP_063129749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,449,445 - 79,471,557 (+)NCBI
RefSeq Acc Id: XM_063273680   ⟹   XP_063129750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,448,242 - 79,471,557 (+)NCBI
RefSeq Acc Id: NP_113954   ⟸   NM_031766
- Peptide Label: precursor
- UniProtKB: O54859 (UniProtKB/Swiss-Prot),   O54858 (UniProtKB/Swiss-Prot),   A0A0G2JSJ7 (UniProtKB/TrEMBL),   A6IJZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251213   ⟸   XM_006251151
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A134 (UniProtKB/TrEMBL),   A0A0G2JSJ7 (UniProtKB/TrEMBL),   A6IJZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012109   ⟸   ENSRNOT00000012109
Ensembl Acc Id: ENSRNOP00000094872   ⟸   ENSRNOT00000119993
Ensembl Acc Id: ENSRNOP00000085858   ⟸   ENSRNOT00000113023
Ensembl Acc Id: ENSRNOP00000079374   ⟸   ENSRNOT00000108856
RefSeq Acc Id: XP_063129750   ⟸   XM_063273680
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129749   ⟸   XM_063273679
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLC7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112455   ⟸   ENSRNOT00000155502
Protein Domains
FZ   Peptidase M14

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54858-F1-model_v2 AlphaFold O54858 1-652 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699390
Promoter ID:EPDNEW_R9915
Type:initiation region
Name:Cpz_1
Description:carboxypeptidase Z
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01480,402,982 - 80,403,042EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620496 AgrOrtholog
BioCyc Gene G2FUF-15324 BioCyc
Ensembl Genes ENSRNOG00000008947 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012109 ENTREZGENE
  ENSRNOT00000113023 ENTREZGENE
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
  Carboxypeptidase-like, regulatory domain UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
InterPro CarboxyPept-like_regulatory UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  M14_CPZ_CPD UniProtKB/Swiss-Prot
  Peptidase_M14 UniProtKB/Swiss-Prot
  Peptidase_M14_domain UniProtKB/Swiss-Prot
KEGG Report rno:83575 UniProtKB/Swiss-Prot
NCBI Gene 83575 ENTREZGENE
PANTHER CARBOXYPEPTIDASE Z UniProtKB/Swiss-Prot
  PROTEASE M14 CARBOXYPEPTIDASE UniProtKB/Swiss-Prot
Pfam CarboxypepD_reg UniProtKB/Swiss-Prot
  Peptidase_M14 UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PhenoGen Cpz PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/Swiss-Prot
PROSITE CARBOXYPEPT_ZN_2 UniProtKB/Swiss-Prot
  PEPTIDASE_M14 UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008947 RatGTEx
SMART FRI UniProtKB/Swiss-Prot
  Zn_pept UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49464 UniProtKB/Swiss-Prot
  SSF63501 UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A0A0G2JSJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMK9_RAT UniProtKB/TrEMBL
  A0A8I6A134 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLC7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M974_RAT UniProtKB/TrEMBL
  A6IJZ7 ENTREZGENE, UniProtKB/TrEMBL
  CBPZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O54859 ENTREZGENE
UniProt Secondary O54859 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cpz  carboxypeptidase Z      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Cpz  carboxypeptidase Z      Symbol and Name status set to provisional 70820 PROVISIONAL