Advanced Search (OLGA)

Gene: Rasgrp4 (RAS guanyl releasing protein 4) Rattus norvegicus

Analyze

Symbol:

Rasgrp4

Name:

RAS guanyl releasing protein 4

RGD ID:

620476

Description:

Predicted to enable diacylglycerol binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Ras protein signal transduction; antibacterial innate immune response; and positive regulation of natural killer cell mediated immunity. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Predicted to be active in plasma membrane. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

RAS guanyl-releasing protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASGRP4 (RAS guanyl releasing protein 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Rasgrp4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasgrp4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASGRP4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASGRP4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasgrp4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASGRP4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASGRP4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasgrp4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rasgrp4 (RAS guanyl releasing protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RASGRP4 (RAS guanyl releasing protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rasgrp4 (RAS guanyl releasing protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rasgrp4 (RAS guanyl releasing protein 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	LTE1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	rgef-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,560,513 - 93,580,321 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	93,560,513 - 93,580,323 (+)	Ensembl				GRCr8
mRatBN7.2	1	84,433,033 - 84,452,841 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	89,844,488 - 89,863,166 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	98,304,088 - 98,322,737 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,600,329 - 91,619,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,078,350 - 88,094,331 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,078,350 - 88,094,330 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	89,253,162 - 89,269,484 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	84,265,741 - 84,284,684 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	78,823,636 - 78,839,576 (+)	NCBI		Celera
RGSC_v3.1	1	84,343,851 - 84,362,794 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxyphenyl retinamide (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dioxygen (EXP)

glycidol (EXP)

glyphosate (EXP)

indometacin (ISO)

nickel atom (ISO)

ozone (ISO)

PCB138 (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial innate immune response (ISO,ISS)

cell differentiation (IEA)

immune response (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO,ISS)

positive regulation of natural killer cell mediated immunity (IBA,ISO,ISS)

Ras protein signal transduction (IBA)

small GTPase-mediated signal transduction (IEA)

Cellular Component

cytoplasm (IEA)

cytoplasmic side of plasma membrane (ISO,ISS)

cytosol (ISO,ISS)

membrane (ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

calcium ion binding (IEA)

diacylglycerol binding (ISO,ISS)

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO,ISS)

lipid binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.	Li L, etal., Mol Immunol 2002 Sep;38(16-18):1283-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11880369	PMID:12493770	PMID:25330932

Genomics

Comparative Map Data

Rasgrp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,560,513 - 93,580,321 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	93,560,513 - 93,580,323 (+)	Ensembl				GRCr8
mRatBN7.2	1	84,433,033 - 84,452,841 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	89,844,488 - 89,863,166 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	98,304,088 - 98,322,737 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,600,329 - 91,619,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,078,350 - 88,094,331 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,078,350 - 88,094,330 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	89,253,162 - 89,269,484 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	84,265,741 - 84,284,684 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	78,823,636 - 78,839,576 (+)	NCBI		Celera
RGSC_v3.1	1	84,343,851 - 84,362,794 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

RASGRP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	38,409,058 - 38,426,219 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	38,409,051 - 38,426,305 (-)	Ensembl			hg38	GRCh38
GRCh37	19	38,899,698 - 38,916,859 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	43,591,538 - 43,608,785 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	43,592,319 - 43,608,785	NCBI
Celera	19	35,701,935 - 35,719,058 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	35,347,291 - 35,364,084 (-)	NCBI		HuRef
CHM1_1	19	38,900,057 - 38,917,304 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	41,211,234 - 41,228,392 (-)	NCBI		T2T-CHM13v2.0

Rasgrp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,834,358 - 28,853,386 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,834,276 - 28,853,386 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	29,134,607 - 29,153,961 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	29,134,851 - 29,153,961 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	29,919,952 - 29,938,980 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,843,747 - 28,862,713 (+)	NCBI		MGSCv36	mm8
Celera	7	23,705,156 - 23,724,041 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	16.94	NCBI

Rasgrp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	1,007,211 - 1,020,290 (+)	Ensembl
ChiLan1.0	NW_004955468	1,007,082 - 1,020,744 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASGRP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	44,700,406 - 44,722,948 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	46,570,744 - 46,593,279 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	35,503,314 - 35,520,787 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	44,074,039 - 44,091,623 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	44,074,039 - 44,091,623 (-)	Ensembl			panPan2	panpan1.1

RASGRP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	114,584,535 - 114,598,870 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	114,584,006 - 114,598,568 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	113,988,244 - 114,002,561 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	115,186,218 - 115,200,542 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	115,186,108 - 115,200,240 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,759,219 - 114,773,533 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	114,376,822 - 114,391,131 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	115,415,448 - 115,429,762 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rasgrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,001,235 - 13,015,246 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936801	1,167,708 - 1,180,508 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936801	1,166,676 - 1,180,508 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASGRP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	47,319,464 - 47,333,123 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	47,319,457 - 47,333,341 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	42,820,059 - 42,833,620 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASGRP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	33,055,161 - 33,073,153 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	33,055,499 - 33,072,413 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	10,999,212 - 11,016,655 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasgrp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	11,870,431 - 11,882,212 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	11,868,390 - 11,886,722 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rasgrp4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	166,842,763 - 166,861,196 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rasgrp4
254 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	74
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000048677
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	355	192	11	140	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_130824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005488959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005488960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005488962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005488973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF465263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF465264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000048677 ⟹ ENSRNOP00000046440

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,560,529 - 93,580,323 (+)	Ensembl
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl
Rnor_6.0 Ensembl	1	88,078,350 - 88,094,330 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096765 ⟹ ENSRNOP00000078907

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,560,513 - 93,580,319 (+)	Ensembl
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097201 ⟹ ENSRNOP00000083767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,560,513 - 93,580,319 (+)	Ensembl
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102221 ⟹ ENSRNOP00000093731

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,562,888 - 93,577,409 (+)	Ensembl
mRatBN7.2 Ensembl	1	84,435,409 - 84,449,926 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104105 ⟹ ENSRNOP00000088115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,560,513 - 93,580,319 (+)	Ensembl
mRatBN7.2 Ensembl	1	84,433,064 - 84,451,896 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127958 ⟹ ENSRNOP00000107351

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	93,563,030 - 93,580,323 (+)	Ensembl

RefSeq Acc Id:

NM_130824 ⟹ NP_570837

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,648 - 93,579,377 (+)	NCBI
mRatBN7.2	1	84,433,168 - 84,451,897 (+)	NCBI
Rnor_6.0	1	88,078,350 - 88,094,331 (+)	NCBI
Rnor_5.0	1	89,253,162 - 89,269,484 (+)	NCBI
RGSC_v3.4	1	84,265,741 - 84,284,684 (+)	RGD
Celera	1	78,823,636 - 78,839,576 (+)	RGD

Sequence:

show sequence

ATGAACCGGAAAGACATCAAAAGGAAGTCTCATCAGGAATGCTCTGGGAAGGCAGGAGGGCATG
GTCGGCCGAGACAGGCCCGCCGCCACAAGACGTGTCCCACCCCCCGGGAAATCAGCAAGGTCAT
GGCTTCCCTGAACCTGGGCGTGCTGAGTGAGAGCAGCTGCAGTGTGGATGAGCTACTGGAGGAA
TGCATCCGGTGCTTTGATTCAGCTGGCAGCTTACACCGAGGGGACCACATTCTCAAGATGGTGC
TTACCATGCACAGCTGGGTGCTGCCATCCTCAGACCTTGCCGCCCGCCTGCTGACTTCGTATCA
GAAGGCTGCCAAAGATGCCCGGGAGCTAAGACAGCTACAGATCTGTTACCTGGTCAGGTACTGG
CTGACCCATCACCCCGAGGTAGTGCACCAGGAACCCCAGCTGGAAGCAATCATAAACCGGTTTT
GGACCACTGTAGCTCAGGAGGGCAACATGGCCCAAAGGAGCCTAGGAGATGCCTCCAATCTGCT
GAGTCCTGGAGGGCCCGGTCCCCCACCTCTCATGAGCAGCCCAGGCCTGGGCAAAAAGCGGAAA
GTGTCCTTGCTGTTCGATCACCTGGAGACAGAGGAGCTGGCACAGCACCTTACTTACCTGGAGT
TCCGGTCCTTCCAGGCCATCACGCCCCAAGACCTGCGGGGCTATGTTTTGCAGGGCTCGGTGAG
AGGTTGTCCTGCTCTGGAAGGTTCTGTGGGTCTGAGCAACAGTGTGTCCCGCTGGGTACAGGTC
ATGGTGCTGAGTCGTCCTGGGCCTGCGCAGCGTGCCCAGGTACTGGACAAATTCATTCGTGTGG
CACAGAGGCTTCGCCAGATGCAGAATTTCAACACGCTGATGGCGGTCACGGGGGGTCTGTGTCA
TAGCGCCATCTCCAGACTCAAGGACTCCCACGTCCATCTGAGCCCTGACAGCACTAAGGCCCTG
CTGGAGCTGACAGAGCTTCTCTCTTCCCACAACAACTATGCCTACTACCGCCGCACCTGGGCCA
GCTGCACTGACTTCCGGCTGCCAGTACTGGGTGTTCACCTCAAGGACCTGGTATCTCTGTATGA
GGCCCATCCAGACAGGTTGCCAGATGGCCGCCTGCACCTACCCAAGCTGAATAGCCTCTATCTA
CGGCTGCAGGAGCTGGCAGCACTCCAGAGACAGCATCCCCCGTGCAGTGCCAATGAGGACCTGC
TACACCTGCTGACGCTCTCCCTGGATCTCTTCTACACGGAAGATGAGATCTACGAGCTTTCTTA
TGCCCGGGAGCCACGTTGTCCCAAGAGTCTGCCCCTATCCCCCTTCAAAGCGCCTGTGGTGGTA
GAGTGGGCCCATGGTGTGACGCCAAAGCCAGACAGTGCGACTCTGGGTCAGCATGTGGAACAGC
TAGTGGAGTCCGTGTTCAAGAACTATGACCCAGAAGGCCATGGCTCTATTTCTCTGGAGGACTT
TGAGAAGCTGTCAGCCAACTTCCCCTTTGCCTGCCATGGGCTTCACCCACCTCCCCGCCACGGG
AGTGGCTCCTTCAGCAGAGAGGAGCTGACCAAGTATCTGCTCCATGCCAGCGCCATCTGCTCCA
AGCTGGGCCTGGCTTTCCTGCACGCCTTCCAGGAGGTCACCTTCCGCAAGCCCACCTTCTGTCA
CAGCTGCAACGGCTTCGTGAGCACTGGCCCTCTCTGGGGCGTCACCAAGCGAGGCTATCGCTGT
CAGGACTGTGGGCTGTGTTGTCACAGACACTGCAGGGATCAAGTGAGAGTGGAGTGTAAGAAGA
GGCCAGAGACTAAAGGTGACCCGGGTCCCCCTGGCGCACCCGGGCCAGCCACACCACTTCCTCC
TACCGGCTGTGGCTCCGAGGAAGGTCTCTCCTATACACTCTCCCCGCATCTGGAGTCTGGTTGC
CACCTTCACCATGCTTGGACTCAGACGGAGTCCTCACACTCTTCCTGGGAGCCAGAGATGGTGC
CCTGCCCAGCACCAGTTTTACCATCCAAAGCTTCCTCAAAGTCCAGTGTCTGAACAGCATCTGG
GCCTCTTCCCTTACTCCCCTACCCAATGCCTCTTCCACATCTGCGCTGCCTCTGACGAGGTACC
TGCCATCTTTCCCCCTAAAAAAATGTTCTGTTGGCAGTGCAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039084022 ⟹ XP_038939950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,525 - 93,580,321 (+)	NCBI
mRatBN7.2	1	84,433,045 - 84,452,841 (+)	NCBI

RefSeq Acc Id:

XM_039084068 ⟹ XP_038939996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,525 - 93,580,321 (+)	NCBI
mRatBN7.2	1	84,433,045 - 84,452,841 (+)	NCBI

RefSeq Acc Id:

XM_039084122 ⟹ XP_038940050

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,513 - 93,580,321 (+)	NCBI
mRatBN7.2	1	84,433,033 - 84,452,841 (+)	NCBI

RefSeq Acc Id:

XM_039084209 ⟹ XP_038940137

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,524 - 93,577,007 (+)	NCBI
mRatBN7.2	1	84,433,042 - 84,449,524 (+)	NCBI

RefSeq Acc Id:

XM_039084266 ⟹ XP_038940194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,564,474 - 93,580,321 (+)	NCBI
mRatBN7.2	1	84,436,994 - 84,452,841 (+)	NCBI

RefSeq Acc Id:

XR_005488959

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,524 - 93,577,244 (+)	NCBI
mRatBN7.2	1	84,433,043 - 84,449,761 (+)	NCBI

RefSeq Acc Id:

XR_005488960

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,524 - 93,577,244 (+)	NCBI
mRatBN7.2	1	84,433,043 - 84,449,761 (+)	NCBI

RefSeq Acc Id:

XR_005488962

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,524 - 93,577,244 (+)	NCBI
mRatBN7.2	1	84,433,043 - 84,449,761 (+)	NCBI

RefSeq Acc Id:

XR_005488973

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,560,524 - 93,577,244 (+)	NCBI
mRatBN7.2	1	84,433,044 - 84,449,761 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_570837	(Get FASTA)	NCBI Sequence Viewer
	XP_038939950	(Get FASTA)	NCBI Sequence Viewer
	XP_038939996	(Get FASTA)	NCBI Sequence Viewer
	XP_038940050	(Get FASTA)	NCBI Sequence Viewer
	XP_038940137	(Get FASTA)	NCBI Sequence Viewer
	XP_038940194	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL76250	(Get FASTA)	NCBI Sequence Viewer
	AAL76251	(Get FASTA)	NCBI Sequence Viewer
	EDM07854	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046440
	ENSRNOP00000088115
	ENSRNOP00000107351
GenBank Protein	Q8R5I4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_570837 ⟸ NM_130824

- UniProtKB:

Q8R5I3 (UniProtKB/Swiss-Prot), Q8R5I4 (UniProtKB/Swiss-Prot), F1LMG1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEE
CIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLLTSYQKAAKDARELRQLQICYLVRYW
LTHHPEVVHQEPQLEAIINRFWTTVAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPGLGKKRK
VSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQV
MVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKAL
LELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYL
RLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVV
EWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHG
SGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRC
QDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGC
HLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV

hide sequence

Ensembl Acc Id:

ENSRNOP00000046440 ⟸ ENSRNOT00000048677

RefSeq Acc Id:	XP_038940050 ⟸ XM_039084122
- Peptide Label:	isoform X3
- UniProtKB:	F1LMG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940137 ⟸ XM_039084209
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038939950 ⟸ XM_039084022
- Peptide Label:	isoform X1
- UniProtKB:	F1LMG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038939996 ⟸ XM_039084068
- Peptide Label:	isoform X2
- UniProtKB:	F1LMG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940194 ⟸ XM_039084266
- Peptide Label:	isoform X5
- UniProtKB:	A6J9N0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078907 ⟸ ENSRNOT00000096765

Ensembl Acc Id:

ENSRNOP00000093731 ⟸ ENSRNOT00000102221

Ensembl Acc Id:

ENSRNOP00000088115 ⟸ ENSRNOT00000104105

Ensembl Acc Id:

ENSRNOP00000083767 ⟸ ENSRNOT00000097201

Ensembl Acc Id:

ENSRNOP00000107351 ⟸ ENSRNOT00000127958

Protein Domains

EF-hand N-terminal Ras-GEF Phorbol-ester/DAG-type Ras-GEF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R5I4-F1-model_v2	AlphaFold	Q8R5I4	1-678	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620476	AgrOrtholog
BioCyc Gene	G2FUF-60194	BioCyc
Ensembl Genes	ENSRNOG00000033744	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000048677	ENTREZGENE
	ENSRNOT00000104105	ENTREZGENE
	ENSRNOT00000127958	ENTREZGENE
Gene3D-CATH	1.10.840.10	UniProtKB/Swiss-Prot
	3.30.60.20	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/Swiss-Prot
InterPro	C1-like_sf	UniProtKB/Swiss-Prot
	EF_hand_dom	UniProtKB/Swiss-Prot
	PE/DAG-bd	UniProtKB/Swiss-Prot
	Ras-like_GEF	UniProtKB/Swiss-Prot
	Ras-like_Gua-exchang_fac_N	UniProtKB/Swiss-Prot
	Ras_GEF_dom_sf	UniProtKB/Swiss-Prot
	RASGEF_cat_dom	UniProtKB/Swiss-Prot
	RASGEF_cat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:170668	UniProtKB/Swiss-Prot
NCBI Gene	170668	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/Swiss-Prot
	RAS GUANYL-RELEASING PROTEIN 4	UniProtKB/Swiss-Prot
Pfam	C1_1	UniProtKB/Swiss-Prot
	RasGEF	UniProtKB/Swiss-Prot
PhenoGen	Rasgrp4	PhenoGen
PROSITE	EF_HAND_2	UniProtKB/Swiss-Prot
	RASGEF_CAT	UniProtKB/Swiss-Prot
	RASGEF_NTER	UniProtKB/Swiss-Prot
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000033744	RatGTEx
SMART	RasGEF	UniProtKB/Swiss-Prot
	SM00109	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48366	UniProtKB/Swiss-Prot
	SSF57889	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZLP3_RAT	UniProtKB/TrEMBL
	A0A8I5ZWG4_RAT	UniProtKB/TrEMBL
	A0A8I6A7B4_RAT	UniProtKB/TrEMBL
	A0A8I6AJC6_RAT	UniProtKB/TrEMBL
	A0ABK0LXT3_RAT	UniProtKB/TrEMBL
	A6J9N0	ENTREZGENE, UniProtKB/TrEMBL
	F1LMG1	ENTREZGENE, UniProtKB/TrEMBL
	GRP4_RAT	UniProtKB/Swiss-Prot
	Q8R5I3	ENTREZGENE
	Q8R5I4	ENTREZGENE
UniProt Secondary	Q8R5I3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Rasgrp4	RAS guanyl releasing protein 4			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Rasgrp4	RAS guanyl releasing protein 4			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	alternatively spliced transcripts are detected in spleen	633886
gene_product	member of the RasGRP family of guanine nucleotide exchange factors	633886

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Annotations - KEGG (archival)