Spef2 (sperm flagellar 2) - Rat Genome Database

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Gene: Spef2 (sperm flagellar 2) Rattus norvegicus
Analyze
Symbol: Spef2
Name: sperm flagellar 2
RGD ID: 620450
Description: Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including brain morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm flagellum assembly. Predicted to be located in Golgi apparatus and sperm flagellum. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kpl2; LOC100912019; sperm flagellar protein 2; sperm flagellar protein 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,239,655 - 60,421,850 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl260,239,655 - 60,421,850 (-)EnsemblGRCr8
mRatBN7.2258,512,489 - 58,694,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,512,489 - 58,694,664 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx265,591,919 - 65,774,198 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,713,278 - 63,895,707 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,714,603 - 58,897,026 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,901,937 - 59,084,194 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl259,849,941 - 59,901,109 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl258,901,939 - 59,181,863 (-)Ensemblrn6Rnor6.0
Rnor_5.0277,996,981 - 78,179,170 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4259,163,063 - 59,333,207NCBIRGSC_v3.4RGSC_v3.4rn4
Celera254,117,091 - 54,298,828 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO)
extracellular region  (IEA)
Golgi apparatus  (IEA,ISO)
manchette  (IBA,ISO)
motile cilium  (IEA)
sperm flagellum  (IEA,ISO,ISS)
sperm midpiece  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells. Ostrowski LE, etal., Am J Respir Cell Mol Biol 1999 Apr;20(4):675-83.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19889948   PMID:21715716  


Genomics

Comparative Map Data
Spef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,239,655 - 60,421,850 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl260,239,655 - 60,421,850 (-)EnsemblGRCr8
mRatBN7.2258,512,489 - 58,694,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,512,489 - 58,694,664 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx265,591,919 - 65,774,198 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,713,278 - 63,895,707 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,714,603 - 58,897,026 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,901,937 - 59,084,194 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl259,849,941 - 59,901,109 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl258,901,939 - 59,181,863 (-)Ensemblrn6Rnor6.0
Rnor_5.0277,996,981 - 78,179,170 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4259,163,063 - 59,333,207NCBIRGSC_v3.4RGSC_v3.4rn4
Celera254,117,091 - 54,298,828 (-)NCBICelera
Cytogenetic Map2q16NCBI
SPEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38535,617,863 - 35,814,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl535,617,844 - 35,814,611 (+)Ensemblhg38GRCh38
GRCh37535,617,965 - 35,814,713 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,653,746 - 35,850,470 (+)NCBIBuild 36Build 36hg18NCBI36
Celera535,500,093 - 35,700,401 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef535,566,794 - 35,654,481 (+)ENTREZGENEHuRef
HuRef535,657,528 - 35,764,642 (+)NCBIHuRef
CHM1_1535,620,239 - 35,817,543 (+)NCBICHM1_1
T2T-CHM13v2.0535,864,856 - 36,063,018 (+)NCBIT2T-CHM13v2.0
Spef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,578,279 - 9,748,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,578,279 - 9,748,954 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38159,578,193 - 9,748,868 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,578,193 - 9,748,868 (-)Ensemblmm10GRCm38
MGSCv37159,592,491 - 9,678,561 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36159,522,918 - 9,693,593 (-)NCBIMGSCv36mm8
Celera159,461,772 - 9,547,905 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map154.24NCBI
Spef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,587,152 - 20,752,812 (+)Ensembl
ChiLan1.0NW_00495542620,587,312 - 20,747,034 (+)NCBIChiLan1.0ChiLan1.0
SPEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,520,360 - 74,718,250 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,674,001 - 72,871,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,554,017 - 74,751,921 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,834,675 - 80,031,753 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl579,834,733 - 80,031,599 (-)EnsemblpanPan2panpan1.1
SPEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,699,672 - 72,864,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,699,938 - 72,864,266 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha472,307,016 - 72,479,079 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0473,202,025 - 73,373,070 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl473,204,851 - 73,367,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,949,596 - 73,121,518 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0473,073,476 - 73,246,153 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0473,606,395 - 73,778,496 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,299,782 - 225,470,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365185,921,508 - 6,071,931 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365185,901,076 - 6,072,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,088,386 - 21,265,592 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11621,088,463 - 21,264,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,057,190 - 22,370,834 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1434,466,825 - 34,652,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl434,466,931 - 34,652,289 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607124,783,003 - 24,970,586 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475919,135,629 - 19,298,966 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Spef2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13170,952,825 - 171,129,875 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spef2
1366 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:798
Count of miRNA genes:218
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000023780, ENSRNOT00000060000, ENSRNOT00000068456
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
BF400125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2258,669,119 - 58,669,319 (+)MAPPERmRatBN7.2
Rnor_6.0259,058,581 - 59,058,780NCBIRnor6.0
Rnor_5.0278,153,625 - 78,153,824UniSTSRnor5.0
RGSC_v3.4259,319,685 - 59,319,884UniSTSRGSC3.4
Celera254,273,362 - 54,273,561UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 8 23 159 43 42 11 78 11 6 221 129 9 140 68 82 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF102129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000077266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl259,876,705 - 59,879,570 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079636   ⟹   ENSRNOP00000074904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl259,034,924 - 59,181,863 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl259,872,784 - 59,879,570 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl259,849,941 - 59,901,109 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086323   ⟹   ENSRNOP00000070321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl260,239,655 - 60,421,850 (-)Ensembl
mRatBN7.2 Ensembl258,512,497 - 58,694,664 (-)Ensembl
Rnor_6.0 Ensembl258,901,989 - 59,084,059 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088701   ⟹   ENSRNOP00000072940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl260,259,396 - 60,421,850 (-)Ensembl
mRatBN7.2 Ensembl258,512,489 - 58,694,664 (-)Ensembl
Rnor_6.0 Ensembl258,901,939 - 59,084,126 (-)Ensembl
RefSeq Acc Id: NM_001415008   ⟹   NP_001401937
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,421,850 (-)NCBI
mRatBN7.2258,512,495 - 58,694,694 (-)NCBI
RefSeq Acc Id: NM_001415009   ⟹   NP_001401938
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,372,624 - 60,421,850 (-)NCBI
mRatBN7.2258,645,468 - 58,694,694 (-)NCBI
RefSeq Acc Id: NM_022620   ⟹   NP_072142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,421,850 (-)NCBI
mRatBN7.2258,512,495 - 58,694,694 (-)NCBI
Rnor_6.0258,901,937 - 59,084,126 (-)NCBI
Rnor_5.0277,996,981 - 78,179,170 (-)NCBI
RGSC_v3.4259,163,063 - 59,333,207 (-)RGD
Celera254,117,091 - 54,298,828 (-)RGD
Sequence:
RefSeq Acc Id: XM_039103075   ⟹   XP_038959003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,421,850 (-)NCBI
mRatBN7.2258,512,489 - 58,694,694 (-)NCBI
RefSeq Acc Id: XM_039103076   ⟹   XP_038959004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,391,855 (-)NCBI
mRatBN7.2258,512,489 - 58,664,731 (-)NCBI
RefSeq Acc Id: XM_039103077   ⟹   XP_038959005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,353,312 (-)NCBI
mRatBN7.2258,512,489 - 58,626,291 (-)NCBI
RefSeq Acc Id: XM_063282493   ⟹   XP_063138563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,421,840 (-)NCBI
RefSeq Acc Id: XM_063282495   ⟹   XP_063138565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,239,655 - 60,421,840 (-)NCBI
RefSeq Acc Id: XM_063282496   ⟹   XP_063138566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,267,722 - 60,421,840 (-)NCBI
RefSeq Acc Id: NP_072142   ⟸   NM_022620
- Peptide Label: isoform 2
- UniProtKB: Q9R095 (UniProtKB/Swiss-Prot),   Q4V8M1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074904   ⟸   ENSRNOT00000079636
Ensembl Acc Id: ENSRNOP00000070321   ⟸   ENSRNOT00000086323
Ensembl Acc Id: ENSRNOP00000072940   ⟸   ENSRNOT00000088701
RefSeq Acc Id: XP_038959003   ⟸   XM_039103075
- Peptide Label: isoform X3
- UniProtKB: Q9R095 (UniProtKB/Swiss-Prot),   Q4V8M1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038959004   ⟸   XM_039103076
- Peptide Label: isoform X4
- UniProtKB: A6KGK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959005   ⟸   XM_039103077
- Peptide Label: isoform X6
- UniProtKB: A6KGK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401937   ⟸   NM_001415008
- Peptide Label: isoform 1
- UniProtKB: Q9R095 (UniProtKB/Swiss-Prot),   Q4V8M1 (UniProtKB/Swiss-Prot),   A0A0G2JXL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401938   ⟸   NM_001415009
- Peptide Label: isoform 3
RefSeq Acc Id: XP_063138565   ⟸   XM_063282495
- Peptide Label: isoform X2
- UniProtKB: Q9R095 (UniProtKB/Swiss-Prot),   Q4V8M1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138563   ⟸   XM_063282493
- Peptide Label: isoform X1
- UniProtKB: Q9R095 (UniProtKB/Swiss-Prot),   Q4V8M1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138566   ⟸   XM_063282496
- Peptide Label: isoform X5
Protein Domains
Calponin-homology (CH)   CPC1/SPEF2   SPEF2 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R095-F1-model_v2 AlphaFold Q9R095 1-1801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691190
Promoter ID:EPDNEW_R1705
Type:single initiation site
Name:Spef2_1
Description:sperm flagellar 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0259,084,115 - 59,084,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620450 AgrOrtholog
BioCyc Gene G2FUF-54096 BioCyc
Ensembl Genes ENSRNOG00000058275 Ensembl, ENTREZGENE
  ENSRNOG00000060305 Ensembl
Ensembl Transcript ENSRNOT00000086323 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro CH-domain UniProtKB/Swiss-Prot
  CH_2 UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SPEF2_C UniProtKB/Swiss-Prot
  SPEF2_D5 UniProtKB/Swiss-Prot
  Sperm_flagellar-bone_growth UniProtKB/Swiss-Prot
KEGG Report rno:64555 UniProtKB/Swiss-Prot
NCBI Gene 64555 ENTREZGENE
PANTHER KPL2-RELATED UniProtKB/Swiss-Prot
  SPERM FLAGELLAR PROTEIN 2 UniProtKB/Swiss-Prot
Pfam ADK UniProtKB/Swiss-Prot
  CH_2 UniProtKB/Swiss-Prot
  SPEF2_C UniProtKB/Swiss-Prot
  SPEF2_D5 UniProtKB/Swiss-Prot
PhenoGen Spef2 PhenoGen
PROSITE PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058275 RatGTEx
  ENSRNOG00000060305 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JXL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K481_RAT UniProtKB/TrEMBL
  A6KGK0 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8M1 ENTREZGENE
  Q9R095 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4V8M1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spef2  sperm flagellar 2  LOC100912019  sperm flagellar protein 2-like  Data merged from RGD:6489419 737654 PROVISIONAL
2012-07-05 LOC100912019  sperm flagellar protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-25 Spef2  sperm flagellar 2  Kpl2  KPL2 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Kpl2  KPL2 protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kpl2  KPL2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript a single-copy gene with a mRNA transcript of 6kb 633099