Gene:	Siah1a ( Rattus norvegicus ) seven in absentia 1A
Description:	synaptophysin binding protein and function as E3 ubiquitin-protein ligases to regulate the ubiquitination and degradation of synaptophysin
Synonyms:	SIAH;
ArrayIDs:	rc_AA923973_at; 6651431; 1387266_at; A_44_P290424; GE1113182; 6495688; A_43_P13099; 6746391; 6378565; A_44_P355582; 6676261;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Siah1a genome assembly 3.1 19 21723004 - 21745060     Rat Celera Assembly 19 20251923 - 20275533     RGSC genome assembly v3.4 19 21717141 - 21740751     Cytogenetic 19 p11   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  zinc ion binding,  ubiquitin-protein ligase activity ...  (details...)
Biological Process	Gene Ontology multicellular organismal development,  cell differentiation,  apoptosis ...  (details...)
Cellular Component	Note Reference localized to both cytosolic and membrane-associated pools 633984 Gene Ontology nucleus,  early endosome,  cytoplasm ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RING IPI PROSITE: ZF_SIAH IPI PROSITE: ZF_RING_2 IPI UNIPARC: UPI000000B9B3 IPI KEGG Report: rno:140941 ENTREZGENE HomoloGene Group ID: 20654 ENTREZGENE Germonline: 620449 Pfam: Sina IPI KEGG Pathway: 04310 ENTREZGENE InterPro: Znf_SIAH. IPI InterPro: TRAF-type. IPI InterPro: TRAF-like. IPI InterPro: SIAH-type. IPI InterPro: 7-in-absentia-prot_TRAF-dom. IPI InterPro: 7-in-absentia-prot. IPI InterPro: Znf_RING. IPI IPI: IPI00200708 IPI Ensembl Protein: ENSRNOP00000020329 IPI Gene3D-CATH: SIAH-type IPI Gene3D-CATH: TRAF-type IPI Entrez Gene: Siah1a ENTREZGENE UniProt: A9UK92_RAT IPI UniProt: SIAH1_RAT IPI Ensembl Genes: ENSRNOG00000015143 IPI Superfamily-SCOP: Traf_like IPI PANTHER: Sina IPI
Sequences	Nucleotide: BQ780107 Get FASTA Search GEO Profiles Nucleotide: DV213782 Get FASTA Search GEO Profiles Nucleotide: CH474037 Get FASTA Search GEO Profiles Nucleotide: AB067814 Get FASTA Search GEO Profiles Nucleotide: AF389476 Get FASTA Search GEO Profiles Nucleotide: AY681965 Get FASTA Search GEO Profiles Nucleotide: NM_080905 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: EDL87506 Get FASTA Protein: AAL91362 Get FASTA Protein: Q920M9 Get FASTA Protein: AAV87215 Get FASTA Protein: EDL87505 Get FASTA Protein: BAB70753 Get FASTA Protein: NP_543181 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 73937
References
Curated References	4 references in RGD related to Siah1a
Other References	8 other references at PubMed related to Siah1a
Database Information
RGD ID	620449
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 17-NOV-05: Siah1a seven in absentia 1A APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Siah1a seven in absentia 1A PROVISIONAL Symbol and Name status set to provisional 70820