Myo1c (myosin 1C) - Rat Genome Database

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Gene: Myo1c (myosin 1C) Rattus norvegicus
Analyze
Symbol: Myo1c
Name: myosin 1C
RGD ID: 620443
Description: Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC); PARTICIPATES IN auditory mechanotransduction pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100365624; LOC686250; MMI-beta; MMIb; myosin heavy chain myr 2; myosin I beta; myosin IC; myosin IC-like; myosin-Ic; Myr2; similar to unconventional myosin Myr2 I heavy chain; unconventional myosin Myr2 I heavy chain; unconventional myosin-Ic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,996,642 - 61,019,022 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1060,996,638 - 61,019,022 (+)EnsemblGRCr8
mRatBN7.21060,498,372 - 60,520,752 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1065,150,370 - 65,167,442 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,655,787 - 64,672,859 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,118,363 - 60,135,435 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,803,311 - 63,819,614 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)Ensemblrn6Rnor6.0
Rnor_5.01064,185,628 - 64,201,931 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41062,990,673 - 63,006,974 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1059,530,993 - 59,546,121 (+)NCBICelera
RGSC_v3.11063,004,293 - 63,020,597 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
eugenol  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
nitrates  (ISO)
Nivalenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Adamek N, etal., Biochemistry. 2010 Feb 9;49(5):958-71. doi: 10.1021/bi901803j.
2. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Arif E, etal., Mol Cell Biol. 2011 May;31(10):2134-50. doi: 10.1128/MCB.05051-11. Epub 2011 Mar 14.
3. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters C, etal., Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1895-905.
4. Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. Boguslavsky S, etal., Mol Biol Cell. 2012 Oct;23(20):4065-78. doi: 10.1091/mbc.E12-04-0263. Epub 2012 Aug 23.
5. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi K, etal., J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.
6. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin. Lieto-Trivedi A and Coluccio LM, Biochemistry. 2008 Sep 23;47(38):10218-26. doi: 10.1021/bi8011059. Epub 2008 Aug 26.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Information Derived from GenBank Report RGD, Sept. 2003
17. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
18. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
Additional References at PubMed
PMID:8719884   PMID:9858156   PMID:11208135   PMID:12490950   PMID:15758024   PMID:15976448   PMID:16957816   PMID:17050716   PMID:17994197   PMID:19046570   PMID:19056867   PMID:19144319  
PMID:19199708   PMID:19946888   PMID:20089841   PMID:20458337   PMID:21362503   PMID:22114352   PMID:23262137   PMID:23376485   PMID:23533145   PMID:24056301   PMID:24625528   PMID:26940917  
PMID:35352799   PMID:36513634  


Genomics

Comparative Map Data
Myo1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,996,642 - 61,019,022 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1060,996,638 - 61,019,022 (+)EnsemblGRCr8
mRatBN7.21060,498,372 - 60,520,752 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1065,150,370 - 65,167,442 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,655,787 - 64,672,859 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,118,363 - 60,135,435 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,803,311 - 63,819,614 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)Ensemblrn6Rnor6.0
Rnor_5.01064,185,628 - 64,201,931 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41062,990,673 - 63,006,974 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1059,530,993 - 59,546,121 (+)NCBICelera
RGSC_v3.11063,004,293 - 63,020,597 (+)NCBI
Cytogenetic Map10q24NCBI
MYO1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,464,186 - 1,492,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,464,186 - 1,492,698 (-)Ensemblhg38GRCh38
GRCh37171,367,480 - 1,395,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,314,230 - 1,342,751 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34171,314,874 - 1,342,745NCBI
Celera171,382,666 - 1,411,498 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,267,587 - 1,296,167 (-)NCBIHuRef
CHM1_1171,376,234 - 1,404,693 (-)NCBICHM1_1
T2T-CHM13v2.0171,352,909 - 1,381,443 (-)NCBIT2T-CHM13v2.0
Myo1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,541,345 - 75,565,450 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,541,330 - 75,564,736 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381175,650,519 - 75,674,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,650,504 - 75,673,910 (+)Ensemblmm10GRCm38
MGSCv371175,465,011 - 75,488,145 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361175,467,773 - 75,490,838 (+)NCBIMGSCv36mm8
Celera1183,160,567 - 83,183,742 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Myo1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,676,728 - 1,703,488 (+)Ensembl
ChiLan1.0NW_0049554811,676,788 - 1,701,421 (+)NCBIChiLan1.0ChiLan1.0
MYO1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,034,149 - 9,063,270 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,000,420 - 11,029,540 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,446,506 - 1,475,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,345,143 - 1,375,540 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,345,143 - 1,375,540 (-)EnsemblpanPan2panpan1.1
MYO1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,635,295 - 45,658,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,636,208 - 45,658,035 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha944,787,550 - 44,810,320 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0946,463,244 - 46,486,023 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,463,244 - 46,485,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,233,730 - 45,256,432 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,528,186 - 45,550,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,581,598 - 45,604,345 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myo1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,733,124 - 44,761,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,611,008 - 7,639,581 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,614,985 - 7,639,603 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,691,256 - 47,718,337 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11247,691,252 - 47,715,670 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,785,597 - 49,802,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,137,469 - 1,167,497 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,819,456 - 20,849,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,188,143 - 4,211,732 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247864,188,143 - 4,211,712 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Myo1c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1994,369,902 - 94,387,021 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myo1c
185 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:149
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000036666
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000036666   ⟹   ENSRNOP00000028929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1061,001,666 - 61,019,018 (+)Ensembl
mRatBN7.2 Ensembl1060,503,411 - 60,520,752 (+)Ensembl
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101210   ⟹   ENSRNOP00000097261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1060,996,638 - 61,019,018 (+)Ensembl
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108756   ⟹   ENSRNOP00000080420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1060,997,617 - 61,019,022 (+)Ensembl
mRatBN7.2 Ensembl1060,503,692 - 60,520,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117022   ⟹   ENSRNOP00000096158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1061,000,123 - 61,019,022 (+)Ensembl
mRatBN7.2 Ensembl1060,501,879 - 60,520,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000155184   ⟹   ENSRNOP00000102184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1060,997,617 - 61,019,018 (+)Ensembl
RefSeq Acc Id: NM_001414168   ⟹   NP_001401097
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,996,642 - 61,019,022 (+)NCBI
mRatBN7.21060,498,372 - 60,520,752 (+)NCBI
RefSeq Acc Id: NM_023092   ⟹   NP_075580
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,001,953 - 61,019,022 (+)NCBI
mRatBN7.21060,503,683 - 60,520,752 (+)NCBI
Rnor_6.01063,803,311 - 63,819,614 (+)NCBI
Rnor_5.01064,185,628 - 64,201,931 (-)NCBI
RGSC_v3.41062,990,673 - 63,006,974 (+)RGD
Celera1059,530,993 - 59,546,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086809   ⟹   XP_038942737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,997,600 - 61,019,020 (+)NCBI
mRatBN7.21060,499,330 - 60,520,750 (+)NCBI
RefSeq Acc Id: XM_039086811   ⟹   XP_038942739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,003,366 - 61,019,020 (+)NCBI
mRatBN7.21060,505,094 - 60,520,750 (+)NCBI
RefSeq Acc Id: XM_063269827   ⟹   XP_063125897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,000,209 - 61,019,020 (+)NCBI
RefSeq Acc Id: NP_075580   ⟸   NM_023092
- Peptide Label: isoform 2
- UniProtKB: Q63355 (UniProtKB/Swiss-Prot),   A0A8I5ZQN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028929   ⟸   ENSRNOT00000036666
RefSeq Acc Id: XP_038942737   ⟸   XM_039086809
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942739   ⟸   XM_039086811
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QFL2 (UniProtKB/TrEMBL),   A0A8I5ZQN4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096158   ⟸   ENSRNOT00000117022
Ensembl Acc Id: ENSRNOP00000080420   ⟸   ENSRNOT00000108756
Ensembl Acc Id: ENSRNOP00000097261   ⟸   ENSRNOT00000101210
RefSeq Acc Id: NP_001401097   ⟸   NM_001414168
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ASB9 (UniProtKB/TrEMBL),   A0A8I5ZQN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125897   ⟸   XM_063269827
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQB5 (UniProtKB/TrEMBL),   A0A8I5ZQN4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102184   ⟸   ENSRNOT00000155184
Protein Domains
IQ   Myosin motor   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63355-F1-model_v2 AlphaFold Q63355 1-1044 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697443
Promoter ID:EPDNEW_R7967
Type:initiation region
Name:Myo1c_1
Description:myosin 1C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,803,333 - 63,803,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620443 AgrOrtholog
BioCyc Gene G2FUF-24191 BioCyc
Ensembl Genes ENSRNOG00000004072 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000036666 ENTREZGENE
  ENSRNOT00000101210 ENTREZGENE
  ENSRNOT00000108756 ENTREZGENE
  ENSRNOT00000117022 ENTREZGENE
  ENSRNOT00000155184 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.190 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.20.240.20 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  MYSc_Myo1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:65261 UniProtKB/Swiss-Prot
NCBI Gene 65261 ENTREZGENE
PANTHER MYOSIN UniProtKB/Swiss-Prot
  UNCONVENTIONAL MYOSIN-IC UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_TH1 UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Myo1c PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  TH1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004072 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
  SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZQN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QFL2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGY1_RAT UniProtKB/TrEMBL
  A6HGT0_RAT UniProtKB/TrEMBL
  MYO1C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Myo1c  myosin 1C  Myo1c  myosin IC  Name changed 629549 APPROVED
2013-04-17 Myo1c  myosin IC  LOC100365624  myosin IC-like  Data merged from RGD:2318660 737654 PROVISIONAL
2013-04-17 Myo1c  myosin IC  LOC686250  similar to unconventional myosin Myr2 I heavy chain  Data merged from RGD:1584314 737654 PROVISIONAL
2010-05-05 LOC100365624  myosin IC-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686250  similar to unconventional myosin Myr2 I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-02 Myo1c  myosin IC  Myr2  unconventional myosin Myr2 I heavy chain  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Myr2  unconventional myosin Myr2 I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL