Vamp8 (vesicle-associated membrane protein 8) - Rat Genome Database

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Gene: Vamp8 (vesicle-associated membrane protein 8) Rattus norvegicus
Analyze
Symbol: Vamp8
Name: vesicle-associated membrane protein 8
RGD ID: 620421
Description: Enables SNAP receptor activity and syntaxin binding activity. Involved in protein-containing complex assembly and vesicle fusion. Located in endosome; lysosomal membrane; and midbody. Part of SNARE complex. Orthologous to human VAMP8 (vesicle associated membrane protein 8); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EDB; endobrevin; VAMP-8; vesicle-associated membrane protein 8 (endobrevin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,000,570 - 106,011,081 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4106,000,570 - 106,011,073 (-)EnsemblGRCr8
mRatBN7.24104,442,383 - 104,452,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,822,062 - 109,827,133 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,597,175 - 105,602,246 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,210,202 - 104,215,278 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,250,301 - 100,252,756 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)Ensemblrn6Rnor6.0
Rnor_5.04165,020,594 - 165,023,049 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,692,451 - 105,694,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,595,511 - 93,597,967 (-)NCBICelera
RGSC_v3.14105,936,931 - 105,939,387 (-)NCBI
Cytogenetic Map4q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
camptothecin  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
Torularhodin  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Antonin W, etal., Nat Struct Biol 2002 Feb;9(2):107-11.
2. Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. Fasshauer D, etal., J Biol Chem 1999 May 28;274(22):15440-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells. Kadowaki T, etal., FEBS Open Bio. 2021 Apr;11(4):1165-1185. doi: 10.1002/2211-5463.13133. Epub 2021 Mar 19.
5. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Low SH, etal., Dev Cell 2003 May;4(5):753-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. Pryor PR, etal., EMBO Rep. 2004 Jun;5(6):590-5. Epub 2004 May 7.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Richardson SC, etal., Mol Biol Cell 2004 Mar;15(3):1197-210. Epub 2003 Dec 10.
12. Membrane fusion between liposomes containing SNARE proteins involved in mast cell exocytosis. Sakiyama H, etal., Inflamm Res. 2009 Mar;58(3):139-42.
13. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
Additional References at PubMed
PMID:9614193   PMID:11029036   PMID:11101518   PMID:11208143   PMID:12130530   PMID:12414999   PMID:16677249   PMID:17272274   PMID:17618625   PMID:18227281   PMID:18253931   PMID:18321981  
PMID:18535671   PMID:18570918   PMID:18614015   PMID:19056867   PMID:19144319   PMID:20458337   PMID:21151919   PMID:22144578   PMID:22589474   PMID:23217709   PMID:23376485   PMID:24550300  
PMID:25686604   PMID:27402227   PMID:27628032   PMID:28242757  


Genomics

Comparative Map Data
Vamp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,000,570 - 106,011,081 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4106,000,570 - 106,011,073 (-)EnsemblGRCr8
mRatBN7.24104,442,383 - 104,452,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,822,062 - 109,827,133 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,597,175 - 105,602,246 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,210,202 - 104,215,278 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,250,301 - 100,252,756 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)Ensemblrn6Rnor6.0
Rnor_5.04165,020,594 - 165,023,049 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,692,451 - 105,694,908 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,595,511 - 93,597,967 (-)NCBICelera
RGSC_v3.14105,936,931 - 105,939,387 (-)NCBI
Cytogenetic Map4q32NCBI
VAMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,577,586 - 85,582,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,561,562 - 85,582,031 (+)Ensemblhg38GRCh38
GRCh37285,804,709 - 85,809,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,658,228 - 85,662,665 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34285,716,374 - 85,720,811NCBI
Celera285,632,880 - 85,637,440 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,701,916 - 85,706,329 (+)NCBIHuRef
CHM1_1285,734,420 - 85,738,962 (+)NCBICHM1_1
T2T-CHM13v2.0285,579,646 - 85,584,091 (+)NCBIT2T-CHM13v2.0
Vamp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,362,204 - 72,367,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,362,206 - 72,367,686 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38672,385,221 - 72,390,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,385,223 - 72,390,703 (-)Ensemblmm10GRCm38
MGSCv37672,335,215 - 72,340,661 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36672,314,732 - 72,320,090 (-)NCBIMGSCv36mm8
Celera674,475,546 - 74,480,987 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Vamp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,923,092 - 1,926,728 (-)Ensembl
ChiLan1.0NW_0049554241,922,830 - 1,926,844 (-)NCBIChiLan1.0ChiLan1.0
VAMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,800,606 - 40,805,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,803,367 - 40,807,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,627,678 - 85,632,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,180,681 - 87,185,195 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,180,681 - 87,185,195 (+)EnsemblpanPan2panpan1.1
VAMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,497,628 - 39,501,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,497,785 - 39,501,739 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1739,169,004 - 39,173,102 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01740,244,282 - 40,248,381 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,244,432 - 40,248,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,373,788 - 39,377,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,445,831 - 39,449,930 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,845,443 - 39,849,546 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vamp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,167,736 - 79,170,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,688,093 - 1,689,816 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,688,126 - 1,689,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,185,735 - 59,193,128 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1359,187,900 - 59,193,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,249,017 - 62,254,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,575,057 - 21,580,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,575,161 - 21,579,820 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604590,888,891 - 90,893,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vamp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,558,429 - 17,562,723 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474917,558,429 - 17,562,765 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Vamp8
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000017301
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000017301   ⟹   ENSRNOP00000017301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4106,000,570 - 106,011,073 (-)Ensembl
mRatBN7.2 Ensembl4104,442,393 - 104,452,897 (-)Ensembl
Rnor_6.0 Ensembl4100,250,301 - 100,252,755 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096938   ⟹   ENSRNOP00000083978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4106,000,570 - 106,005,642 (-)Ensembl
mRatBN7.2 Ensembl4104,442,393 - 104,447,514 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115330   ⟹   ENSRNOP00000088625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,442,393 - 104,445,670 (-)Ensembl
RefSeq Acc Id: NM_031827   ⟹   NP_114015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,000,570 - 106,005,642 (-)NCBI
mRatBN7.24104,442,383 - 104,447,457 (-)NCBI
Rnor_6.04100,250,301 - 100,252,756 (-)NCBI
Rnor_5.04165,020,594 - 165,023,049 (-)NCBI
RGSC_v3.44105,692,451 - 105,694,908 (-)RGD
Celera493,595,511 - 93,597,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108449   ⟹   XP_038964377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,000,574 - 106,011,081 (-)NCBI
mRatBN7.24104,442,387 - 104,452,884 (-)NCBI
Protein Sequences
Protein RefSeqs NP_114015 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964377 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD33595 (Get FASTA)   NCBI Sequence Viewer  
  EDL91035 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017301
  ENSRNOP00000083978
  ENSRNOP00000083978.1
GenBank Protein Q9WUF4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114015   ⟸   NM_031827
- UniProtKB: Q9WUF4 (UniProtKB/Swiss-Prot),   A6IAB7 (UniProtKB/TrEMBL),   A0A8I6AB54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017301   ⟸   ENSRNOT00000017301
RefSeq Acc Id: XP_038964377   ⟸   XM_039108449
- Peptide Label: isoform X1
- UniProtKB: F1LNT8 (UniProtKB/TrEMBL),   A0A8I6AB54 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083978   ⟸   ENSRNOT00000096938
Ensembl Acc Id: ENSRNOP00000088625   ⟸   ENSRNOT00000115330
Protein Domains
v-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUF4-F1-model_v2 AlphaFold Q9WUF4 1-100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620421 AgrOrtholog
BioCyc Gene G2FUF-44148 BioCyc
Ensembl Genes ENSRNOG00000012748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017301 ENTREZGENE
  ENSRNOT00000096938 ENTREZGENE
  ENSRNOT00000096938.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
InterPro Synaptobrevin UniProtKB/Swiss-Prot
  Synaptobrevin/VAMP UniProtKB/Swiss-Prot
  V_SNARE_CC UniProtKB/Swiss-Prot
KEGG Report rno:83730 UniProtKB/Swiss-Prot
NCBI Gene 83730 ENTREZGENE
PANTHER PTHR45701 UniProtKB/Swiss-Prot
Pfam Synaptobrevin UniProtKB/Swiss-Prot
PhenoGen Vamp8 PhenoGen
PIRSF Synaptobrevin_euk UniProtKB/Swiss-Prot
PRINTS SYNAPTOBREVN UniProtKB/Swiss-Prot
PROSITE SYNAPTOBREVIN UniProtKB/Swiss-Prot
  V_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012748 RatGTEx
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot
UniProt A0A8I6AB54 ENTREZGENE
  A6IAB7 ENTREZGENE, UniProtKB/TrEMBL
  F1LNT8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUF4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Vamp8  vesicle-associated membrane protein 8    vesicle-associated membrane protein 8 (endobrevin)  Name updated 1299863 APPROVED
2002-08-07 Vamp8  vesicle-associated membrane protein 8 (endobrevin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with other SNARE proteins and forms stable ternary complex, reversibly dissociated by the soluble ATPase NSF 634238