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Gene: Fbxo6 (F-box protein 6) Rattus norvegicus

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Symbol:

Fbxo6

Name:

F-box protein 6

RGD ID:

620418

Description:

Predicted to enable carbohydrate binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum quality control compartment. Orthologous to human FBXO6 (F-box protein 6); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

F-box only protein 6; F-box only protein 6 b; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2; Fbg2; Fbxo6b

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO6 (F-box protein 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fbxo6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbxo6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbxo6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBXO6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBXO6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo6 (F-box protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Fbxo6 (F-box protein 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FBXO6 (F-box protein 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:114081	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbxo44 (F-box protein 44)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C14B1.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C14B1.3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	fbxo6.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbxo44.7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbxo6.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbxo44.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fbxo44	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,859,909 - 163,865,693 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,859,916 - 163,865,574 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,576,729 - 158,582,520 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,576,759 - 158,582,525 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	161,293,652 - 161,297,063 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,115,443 - 163,118,858 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	163,071,790 - 163,075,208 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,956,285 - 164,962,075 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,956,280 - 164,959,851 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,223,009 - 165,226,420 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,856,162 - 156,859,573 (-)	NCBI		Celera
RGSC_v3.1	5	165,233,196 - 165,236,608 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Stevens-Johnson syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorotoluron (ISO)

chlorpyrifos (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

diuron (EXP,ISO)

doxorubicin (ISO)

fenthion (ISO)

finasteride (EXP)

flavonoids (EXP)

FR900359 (ISO)

gentamycin (EXP)

glyphosate (ISO)

inulin (ISO)

lead diacetate (EXP)

methapyrilene (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

nitrates (ISO)

p-toluidine (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

silver atom (ISO)

silver(0) (ISO)

sulindac (EXP)

sunitinib (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IEA)

DNA repair (IEA)

ERAD pathway (IBA,IEA,ISO,ISS)

glycoprotein catabolic process (IBA,IEA,ISO)

protein ubiquitination (IEA)

response to unfolded protein (IEA)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA,IEA,ISO,ISS)

ubiquitin-dependent protein catabolic process (IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

endoplasmic reticulum quality control compartment (IBA,IEA,ISO)

SCF ubiquitin ligase complex (IBA,IEA,ISO,ISS)

Molecular Function

carbohydrate binding (IEA,ISO)

protein binding (ISO,ISS)

ubiquitin protein ligase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	A new subfamily of structurally related human F-box proteins.	Ilyin GP, etal., Gene 2002 Aug 21;296(1-2):11-20.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12939278	PMID:15489334	PMID:15723043	PMID:19028597	PMID:19716789	PMID:21062743	PMID:31505169

Genomics

Comparative Map Data

Fbxo6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,859,909 - 163,865,693 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,859,916 - 163,865,574 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,576,729 - 158,582,520 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,576,759 - 158,582,525 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	161,293,652 - 161,297,063 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,115,443 - 163,118,858 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	163,071,790 - 163,075,208 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,956,285 - 164,962,075 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,956,280 - 164,959,851 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,223,009 - 165,226,420 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,856,162 - 156,859,573 (-)	NCBI		Celera
RGSC_v3.1	5	165,233,196 - 165,236,608 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

FBXO6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,664,200 - 11,674,354 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	11,664,189 - 11,674,354 (+)	Ensembl			hg38	GRCh38
GRCh37	1	11,724,257 - 11,734,411 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,646,768 - 11,656,998 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	11,658,446 - 11,668,673	NCBI
Celera	1	10,836,207 - 10,846,475 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	10,878,308 - 10,888,516 (+)	NCBI		HuRef
CHM1_1	1	11,712,136 - 11,722,413 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,208,255 - 11,218,422 (+)	NCBI		T2T-CHM13v2.0

Fbxo6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,230,173 - 148,236,592 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,230,173 - 148,236,597 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	148,145,716 - 148,152,135 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,145,716 - 148,152,140 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	147,519,825 - 147,526,244 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	146,989,587 - 146,995,624 (-)	NCBI		MGSCv36	mm8
Celera	4	150,407,047 - 150,413,479 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.67	NCBI

Fbxo6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,197,467 - 2,201,256 (-)	Ensembl
ChiLan1.0	NW_004955486	2,197,296 - 2,205,947 (-)	NCBI	ChiLan1.0	ChiLan1.0

FBXO6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,549,519 - 84,554,176 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,549,560 - 84,580,756 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,081,851 - 81,088,009 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,212,668 - 85,218,810 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,212,675 - 85,218,790 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,961,418 - 81,967,576 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,962,035 - 82,968,196 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	84,024,909 - 84,031,072 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Fbxo6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,707,679 - 34,713,814 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	533,254 - 542,907 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	531,873 - 538,596 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,768,498 - 71,774,243 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	71,755,335 - 71,774,264 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,674,308 - 65,693,217 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXO6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	120,116,125 - 120,127,025 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	120,116,169 - 120,126,920 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	23,984,628 - 23,995,338 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbxo6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,286,820 - 1,292,755 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624818	1,286,819 - 1,292,565 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Fbxo6
28 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	44
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000012301
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	160111176	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

BE114020

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	158,578,242 - 158,578,401 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	164,957,800 - 164,957,958	NCBI	Rnor6.0
Rnor_5.0	5	168,615,838 - 168,615,996	UniSTS	Rnor5.0
RGSC_v3.4	5	165,224,373 - 165,224,531	UniSTS	RGSC3.4
Celera	5	156,857,526 - 156,857,684	UniSTS
RH 3.4 Map	5	1108.2	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH133258

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	158,576,936 - 158,577,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	164,956,494 - 164,956,674	NCBI	Rnor6.0
Rnor_5.0	5	168,614,532 - 168,614,712	UniSTS	Rnor5.0
RGSC_v3.4	5	165,223,067 - 165,223,247	UniSTS	RGSC3.4
Celera	5	156,856,220 - 156,856,400	UniSTS
RH 3.4 Map	5	1104.4	UniSTS
Cytogenetic Map	5	q36	UniSTS

AA848404

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	5	1108.2	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF393484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC063148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012301 ⟹ ENSRNOP00000012301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,859,916 - 163,865,574 (-)	Ensembl
mRatBN7.2 Ensembl	5	158,576,764 - 158,581,616 (-)	Ensembl
Rnor_6.0 Ensembl	5	164,956,280 - 164,959,851 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096248 ⟹ ENSRNOP00000082391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,576,759 - 158,582,525 (-)	Ensembl

RefSeq Acc Id:

NM_138917 ⟹ NP_620272

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,860,032 - 163,863,443 (-)	NCBI
mRatBN7.2	5	158,576,879 - 158,580,290 (-)	NCBI
Rnor_6.0	5	164,956,436 - 164,959,847 (-)	NCBI
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI
RGSC_v3.4	5	165,223,009 - 165,226,420 (-)	RGD
Celera	5	156,856,162 - 156,859,573 (-)	RGD

Sequence:

show sequence

GAACATAGCTCCACTGCCATCATGGTCAACATCAACGAGCTGCCGGAGAACATTCTACTGGAAC
TGTTCACCCACGTCCCGGCCCCACAGCTGCTGCGCAACTGCCGCCTGGTCTGCAGCCTCTGGCG
AGACCTCATCGATGTGATGACCCTCTGGAAGCGCAAGAGCCTTCGAGAGGGCTTTGTCACCAAA
GACCGGGACGAGCCTGTGGATGACTGGAAGATCTTCTATATCCTGTGCAGTCTGCAAAGGAACC
TCCTTCGGAACCCGTGTGCCGAAGAGAACCTGAGATCATGGCGGATAGACTCCAATGGGGGAGA
TGAGTGGAAGGTGGAGAGCCTCCCTGGGGACCACGGCACAAGCTTTCCTGACACCAAGGTCAAG
AAGTATTTTGTCACCTCTTATGGGATGTGCCTCAAGTCCCAGATGGTGGACCTCAAAGCCGAGG
GCTACTCTGAAAAGCTGCTGGACACCGTTCGGCCGGACATTGTGGTTAAAGACTGGTTTGCCCC
ACGAGCAGACTGCGGCTGTACCTATCACCTCCGGGTACAGCTGGCCTCTGCCGACTACATTGTC
CTAGCCTCCTTTGAGCCTCCGCCTGTGACCATCGAACAGTGGAATGACGCCAGCTGGCAAGAGA
TCTCCCACACCTTCTCCAATTACCCTCCTGGCGTCCGTCACATCCTTTTTCAACATGGGGGCAA
GGACACACAGTTCTGGAAAGGCTGGTATGGTCCCCGTGTCACCAACAGCAGCATCATCGTCAGC
CACAGGACAGCCAAGAACCCCGCCCCTGCCAGAACTCTACCGGAGGAAGACACTAGTAATAGGA
GGAAGATACTCAGCTTTGGCTCCTGGGAAGACCTAAGCCCTTAG

hide sequence

RefSeq Acc Id:

XM_006239372 ⟹ XP_006239434

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,859,909 - 163,865,507 (-)	NCBI
mRatBN7.2	5	158,576,729 - 158,582,330 (-)	NCBI
Rnor_6.0	5	164,956,285 - 164,961,886 (-)	NCBI
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI

Sequence:

show sequence

GGCAGGACGGGGCGGGGCGAGGCGACAGAGGATCGCGTAGCCAAGGTCCAGGCCCAAGGCCGAG
GATAGCCGAGGCCACCGGGTGCCCAGGTCGCGGCCGCTGGGGTAGCGGGGACCGCGGTGGCTGG
CGGGGCCGGGAGCCGGGCGCAGGTCACGCGCTCGTGGGGAGACTCGGGCGGGGCGCGGCTGGTG
CTCTCGAGTCCGGTGCCGGGACGCGGGGTCGCCGGGCCTGCTGTAGGTACGCGAGGGCCCCGGA
CGGTGGCGACACCGGCTTCTCCTTGAGGCACAGGGCTTCAAGCGTTAGGGCCCTGGAACATAGC
TCCACTGCCATCATGGTCAACATCAACGAGCTGCCGGAGAACATTCTACTGGAACTGTTCACCC
ACGTCCCGGCCCCACAGCTGCTGCGCAACTGCCGCCTGGTCTGCAGCCTCTGGCGAGACCTCAT
CGATGTGATGACCCTCTGGAAGCGCAAGAGCCTTCGAGAGGGCTTTGTCACCAAAGACCGGGAC
GAGCCTGTGGATGACTGGAAGATCTTCTATATCCTGTGCAGTCTGCAAAGGAACCTCCTTCGGA
ACCCGTGTGCCGAAGAGAACCTGAGATCATGGCGGATAGACTCCAATGGGGGAGATGAGTGGAA
GGTGGAGAGCCTCCCTGGGGACCACGGCACAAGCTTTCCTGACACCAAGGTCAAGAAGTATTTT
GTCACCTCTTATGGGATGTGCCTCAAGTCCCAGATGGTGGACCTCAAAGCCGAGGGCTACTCTG
AAAAGCTGCTGGACACCGTTCGGCCGGACATTGTGGTTAAAGACTGGTTTGCCCCACGAGCAGA
CTGCGGCTGTACCTATCACCTCCGGGTACAGCTGGCCTCTGCCGACTACATTGTCCTAGCCTCC
TTTGAGCCTCCGCCTGTGACCATCGAACAGTGGAATGACGCCAGCTGGCAAGAGATCTCCCACA
CCTTCTCCAATTACCCTCCTGGCGTCCGTCACATCCTTTTTCAACATGGGGGCAAGGACACACA
GTTCTGGAAAGGCTGGTATGGTCCCCGTGTCACCAACAGCAGCATCATCGTCAGCCACAGGACA
GCCAAGAACCCCGCCCCTGCCAGAACTCTACCGGAGGAAGACACTAGTAATAGGAGGAAGATAC
TCAGCTTTGGCTCCTGGGAAGACCTAAGCCCTTAGCGGGCAGTCAGGTCCCCAGTCCCACGAGT
AGGTCCCCTGCCCTATACAACTTTGGTCAAGCCCAAATCAACTCGGTCACACAGCGCTGACATT
TTGTTGTAATAAATGTTTTCAGTAAATCCAGCCTATTTGGGGCTTGATGGAGATCAGG

hide sequence

RefSeq Acc Id:

XM_006239373 ⟹ XP_006239435

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,859,909 - 163,865,483 (-)	NCBI
mRatBN7.2	5	158,576,729 - 158,582,330 (-)	NCBI
Rnor_6.0	5	164,956,285 - 164,961,886 (-)	NCBI
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI

Sequence:

show sequence

GGCAGGACGGGGCGGGGCGAGGCGACAGAGGATCGCGTAGCCAAGGTCCAGGCCCAAGGCCGAG
GATAGCCGAGGCCACCGGGTGCCCAGGTCGCGGCCGCTGGGGTAGCGGGGACCGCGGTGGCTGG
CGGGGCCGGGAGCCGGGCGCAGGTCACGCGCTCGTGGGGAGACTCGGGCGGGGCGCGGCTGGTG
CTCTCGAGTCCGGTGCCGGGACGCGGGGTCGCCGGGCCTGCTGTAGGCCCTGGAACATAGCTCC
ACTGCCATCATGGTCAACATCAACGAGCTGCCGGAGAACATTCTACTGGAACTGTTCACCCACG
TCCCGGCCCCACAGCTGCTGCGCAACTGCCGCCTGGTCTGCAGCCTCTGGCGAGACCTCATCGA
TGTGATGACCCTCTGGAAGCGCAAGAGCCTTCGAGAGGGCTTTGTCACCAAAGACCGGGACGAG
CCTGTGGATGACTGGAAGATCTTCTATATCCTGTGCAGTCTGCAAAGGAACCTCCTTCGGAACC
CGTGTGCCGAAGAGAACCTGAGATCATGGCGGATAGACTCCAATGGGGGAGATGAGTGGAAGGT
GGAGAGCCTCCCTGGGGACCACGGCACAAGCTTTCCTGACACCAAGGTCAAGAAGTATTTTGTC
ACCTCTTATGGGATGTGCCTCAAGTCCCAGATGGTGGACCTCAAAGCCGAGGGCTACTCTGAAA
AGCTGCTGGACACCGTTCGGCCGGACATTGTGGTTAAAGACTGGTTTGCCCCACGAGCAGACTG
CGGCTGTACCTATCACCTCCGGGTACAGCTGGCCTCTGCCGACTACATTGTCCTAGCCTCCTTT
GAGCCTCCGCCTGTGACCATCGAACAGTGGAATGACGCCAGCTGGCAAGAGATCTCCCACACCT
TCTCCAATTACCCTCCTGGCGTCCGTCACATCCTTTTTCAACATGGGGGCAAGGACACACAGTT
CTGGAAAGGCTGGTATGGTCCCCGTGTCACCAACAGCAGCATCATCGTCAGCCACAGGACAGCC
AAGAACCCCGCCCCTGCCAGAACTCTACCGGAGGAAGACACTAGTAATAGGAGGAAGATACTCA
GCTTTGGCTCCTGGGAAGACCTAAGCCCTTAGCGGGCAGTCAGGTCCCCAGTCCCACGAGTAGG
TCCCCTGCCCTATACAACTTTGGTCAAGCCCAAATCAACTCGGTCACACAGCGCTGACATTTTG
TTGTAATAAATGTTTTCAGTAAATCCAGCCTATTTGGGGCTTGATGGAGATCAGG

hide sequence

RefSeq Acc Id:

XM_006239374 ⟹ XP_006239436

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,859,909 - 163,865,693 (-)	NCBI
mRatBN7.2	5	158,576,729 - 158,582,520 (-)	NCBI
Rnor_6.0	5	164,956,285 - 164,962,075 (-)	NCBI
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI

Sequence:

show sequence

AAGGAGGCAGGCCCGGTGTGGCAGCAGGCTGCTGAGCCGCTTGTCGCCTGGAGGGGGAGACGGA
AGCCCAAGAAACCCGGCCGGTGGAGCCCGGGCTGTAGCAGCTTGGCGAGAGGTGATTCGAGGGC
TCAGAGCCCACCATCTTCGCACTGACGCGGAAGGCCCTGGAACATAGCTCCACTGCCATCATGG
TCAACATCAACGAGCTGCCGGAGAACATTCTACTGGAACTGTTCACCCACGTCCCGGCCCCACA
GCTGCTGCGCAACTGCCGCCTGGTCTGCAGCCTCTGGCGAGACCTCATCGATGTGATGACCCTC
TGGAAGCGCAAGAGCCTTCGAGAGGGCTTTGTCACCAAAGACCGGGACGAGCCTGTGGATGACT
GGAAGATCTTCTATATCCTGTGCAGTCTGCAAAGGAACCTCCTTCGGAACCCGTGTGCCGAAGA
GAACCTGAGATCATGGCGGATAGACTCCAATGGGGGAGATGAGTGGAAGGTGGAGAGCCTCCCT
GGGGACCACGGCACAAGCTTTCCTGACACCAAGGTCAAGAAGTATTTTGTCACCTCTTATGGGA
TGTGCCTCAAGTCCCAGATGGTGGACCTCAAAGCCGAGGGCTACTCTGAAAAGCTGCTGGACAC
CGTTCGGCCGGACATTGTGGTTAAAGACTGGTTTGCCCCACGAGCAGACTGCGGCTGTACCTAT
CACCTCCGGGTACAGCTGGCCTCTGCCGACTACATTGTCCTAGCCTCCTTTGAGCCTCCGCCTG
TGACCATCGAACAGTGGAATGACGCCAGCTGGCAAGAGATCTCCCACACCTTCTCCAATTACCC
TCCTGGCGTCCGTCACATCCTTTTTCAACATGGGGGCAAGGACACACAGTTCTGGAAAGGCTGG
TATGGTCCCCGTGTCACCAACAGCAGCATCATCGTCAGCCACAGGACAGCCAAGAACCCCGCCC
CTGCCAGAACTCTACCGGAGGAAGACACTAGTAATAGGAGGAAGATACTCAGCTTTGGCTCCTG
GGAAGACCTAAGCCCTTAGCGGGCAGTCAGGTCCCCAGTCCCACGAGTAGGTCCCCTGCCCTAT
ACAACTTTGGTCAAGCCCAAATCAACTCGGTCACACAGCGCTGACATTTTGTTGTAATAAATGT
TTTCAGTAAATCCAGCCTATTTGGGGCTTGATGGAGATCAGG

hide sequence

RefSeq Acc Id:

XM_006239375 ⟹ XP_006239437

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,859,909 - 163,865,673 (-)	NCBI
mRatBN7.2	5	158,576,729 - 158,582,506 (-)	NCBI
Rnor_6.0	5	164,956,285 - 164,962,075 (-)	NCBI
Rnor_5.0	5	168,614,323 - 168,620,072 (-)	NCBI

Sequence:

show sequence

AAGGAGGCAGGCCCGGTGTGGCAGCAGGCTGCTGAGCCGCTTGTCGCCTGGAGGGGGAGACGGA
AGCCCAAGAAACCCGGCCGGTGGAGCCCGGGCTGTAGCAGCTTGGCGAGAGGTGATTCGAGGGC
TCAGAGCCCACCATCTTCGCACTGACGCGGAAGGTCGGCCCTGGAACATAGCTCCACTGCCATC
ATGGTCAACATCAACGAGCTGCCGGAGAACATTCTACTGGAACTGTTCACCCACGTCCCGGCCC
CACAGCTGCTGCGCAACTGCCGCCTGGTCTGCAGCCTCTGGCGAGACCTCATCGATGTGATGAC
CCTCTGGAAGCGCAAGAGCCTTCGAGAGGGCTTTGTCACCAAAGACCGGGACGAGCCTGTGGAT
GACTGGAAGATCTTCTATATCCTGTGCAGTCTGCAAAGGAACCTCCTTCGGAACCCGTGTGCCG
AAGAGAACCTGAGATCATGGCGGATAGACTCCAATGGGGGAGATGAGTGGAAGGTGGAGAGCCT
CCCTGGGGACCACGGCACAAGCTTTCCTGACACCAAGGTCAAGAAGTATTTTGTCACCTCTTAT
GGGATGTGCCTCAAGTCCCAGATGGTGGACCTCAAAGCCGAGGGCTACTCTGAAAAGCTGCTGG
ACACCGTTCGGCCGGACATTGTGGTTAAAGACTGGTTTGCCCCACGAGCAGACTGCGGCTGTAC
CTATCACCTCCGGGTACAGCTGGCCTCTGCCGACTACATTGTCCTAGCCTCCTTTGAGCCTCCG
CCTGTGACCATCGAACAGTGGAATGACGCCAGCTGGCAAGAGATCTCCCACACCTTCTCCAATT
ACCCTCCTGGCGTCCGTCACATCCTTTTTCAACATGGGGGCAAGGACACACAGTTCTGGAAAGG
CTGGTATGGTCCCCGTGTCACCAACAGCAGCATCATCGTCAGCCACAGGACAGCCAAGAACCCC
GCCCCTGCCAGAACTCTACCGGAGGAAGACACTAGTAATAGGAGGAAGATACTCAGCTTTGGCT
CCTGGGAAGACCTAAGCCCTTAGCGGGCAGTCAGGTCCCCAGTCCCACGAGTAGGTCCCCTGCC
CTATACAACTTTGGTCAAGCCCAAATCAACTCGGTCACACAGCGCTGACATTTTGTTGTAATAA
ATGTTTTCAGTAAATCCAGCCTATTTGGGGCTTGATGGAGATCAGG

hide sequence

RefSeq Acc Id:

XM_063287150 ⟹ XP_063143220

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,859,909 - 163,865,481 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_620272	(Get FASTA)	NCBI Sequence Viewer
	XP_006239434	(Get FASTA)	NCBI Sequence Viewer
	XP_006239435	(Get FASTA)	NCBI Sequence Viewer
	XP_006239436	(Get FASTA)	NCBI Sequence Viewer
	XP_006239437	(Get FASTA)	NCBI Sequence Viewer
	XP_063143220	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH63148	(Get FASTA)	NCBI Sequence Viewer
	AAK70899	(Get FASTA)	NCBI Sequence Viewer
	EDL81102	(Get FASTA)	NCBI Sequence Viewer
	EDL81103	(Get FASTA)	NCBI Sequence Viewer
	EDL81104	(Get FASTA)	NCBI Sequence Viewer
	EDL81105	(Get FASTA)	NCBI Sequence Viewer
	EDL81106	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012301
	ENSRNOP00000082391.1
GenBank Protein	Q923V4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620272 ⟸ NM_138917

- UniProtKB:

Q6P512 (UniProtKB/Swiss-Prot), Q923V4 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVD
DWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSY
GMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPP
PVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNP
APARTLPEEDTSNRRKILSFGSWEDLSP

hide sequence

RefSeq Acc Id:	XP_006239436 ⟸ XM_006239374
- Peptide Label:	isoform X1
- UniProtKB:	Q6P512 (UniProtKB/Swiss-Prot), Q923V4 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVD DWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSY GMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPP PVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNP APARTLPEEDTSNRRKILSFGSWEDLSP hide sequence

RefSeq Acc Id:	XP_006239437 ⟸ XM_006239375
- Peptide Label:	isoform X1
- UniProtKB:	Q6P512 (UniProtKB/Swiss-Prot), Q923V4 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVD DWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSY GMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPP PVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNP APARTLPEEDTSNRRKILSFGSWEDLSP hide sequence

RefSeq Acc Id:	XP_006239435 ⟸ XM_006239373
- Peptide Label:	isoform X1
- UniProtKB:	Q6P512 (UniProtKB/Swiss-Prot), Q923V4 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVD DWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSY GMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPP PVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNP APARTLPEEDTSNRRKILSFGSWEDLSP hide sequence

RefSeq Acc Id:	XP_006239434 ⟸ XM_006239372
- Peptide Label:	isoform X1
- UniProtKB:	Q6P512 (UniProtKB/Swiss-Prot), Q923V4 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVD DWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSY GMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPP PVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNP APARTLPEEDTSNRRKILSFGSWEDLSP hide sequence

Ensembl Acc Id:

ENSRNOP00000012301 ⟸ ENSRNOT00000012301

Ensembl Acc Id:

ENSRNOP00000082391 ⟸ ENSRNOT00000096248

RefSeq Acc Id:	XP_063143220 ⟸ XM_063287150
- Peptide Label:	isoform X1
- UniProtKB:	Q923V4 (UniProtKB/Swiss-Prot), Q6P512 (UniProtKB/Swiss-Prot), A6IU51 (UniProtKB/TrEMBL)

Protein Domains

F-box FBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q923V4-F1-model_v2	AlphaFold	Q923V4	1-284	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620418	AgrOrtholog
BioCyc Gene	G2FUF-39174	BioCyc
Ensembl Genes	ENSRNOG00000009217	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012301	ENTREZGENE
	ENSRNOT00000096248.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1280.50	UniProtKB/Swiss-Prot
	Galactose-binding domain-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6921385	IMAGE-MGC_LOAD
InterPro	F-box-assoc_dom	UniProtKB/Swiss-Prot
	F-box-like_dom_sf	UniProtKB/Swiss-Prot
	F-box_dom	UniProtKB/Swiss-Prot
	F-box_only	UniProtKB/Swiss-Prot
	Galactose-bd-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:192351	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72682	IMAGE-MGC_LOAD
NCBI Gene	192351	ENTREZGENE
PANTHER	F-BOX ONLY PROTEIN 6	UniProtKB/Swiss-Prot
	PTHR12125	UniProtKB/Swiss-Prot
Pfam	F-box-like	UniProtKB/Swiss-Prot
	FBA	UniProtKB/Swiss-Prot
PhenoGen	Fbxo6	PhenoGen
PROSITE	FBA	UniProtKB/Swiss-Prot
	FBOX	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009217	RatGTEx
SMART	FBA	UniProtKB/Swiss-Prot
	FBOX	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49785	UniProtKB/Swiss-Prot
	SSF81383	UniProtKB/Swiss-Prot
UniProt	A0A8L2Q5V0_RAT	UniProtKB/TrEMBL
	A6IU51	ENTREZGENE, UniProtKB/TrEMBL
	FBX6_RAT	UniProtKB/Swiss-Prot
	Q6P512	ENTREZGENE
	Q923V4	ENTREZGENE
UniProt Secondary	Q6P512	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Fbxo6	F-box protein 6	Fbxo6b	F-box only protein 6b	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Fbxo6b	F-box only protein 6b		F-box only protein 6 b	Name updated	1299863	APPROVED
2002-08-07	Fbxo6b	F-box only protein 6 b			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_drugs	okadaic acid inhibits the expression in hepatoma cells	632656
gene_expression	mRNA expressed in foetal liver which decreases after birth and re-accumalates in adult liver	632656
gene_product	member of the third subfamily of mammalian F-box proteins	632656
gene_protein	180 amino-acid protein with six exons and five introns and a conserved C-terminal domain	632656

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)