Plk3 (polo-like kinase 3) - Rat Genome Database

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Gene: Plk3 (polo-like kinase 3) Rattus norvegicus
Analyze
Symbol: Plk3
Name: polo-like kinase 3
RGD ID: 62039
Description: Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of protein catabolic process; and regulation of cell cycle process. Located in dendrite and neuronal cell body. Orthologous to human PLK3 (polo like kinase 3); PARTICIPATES IN tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cnk; cytokine inducible kinase; cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Fnk; PLK-3; polo-like kinase 3 (Drosophila); serine-threonine kinase; serine/threonine-protein kinase PLK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,843,725 - 135,848,900 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,843,725 - 135,848,900 (-)EnsemblGRCr8
mRatBN7.25130,607,142 - 130,612,317 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,607,142 - 130,612,317 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5133,231,568 - 133,236,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,986,175 - 134,991,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05135,008,600 - 135,013,816 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,997,725 - 136,002,900 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,997,725 - 136,002,900 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,790,975 - 139,796,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45137,443,540 - 137,448,715 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5129,128,599 - 129,133,774 (-)NCBICelera
RGSC_v3.15137,449,104 - 137,453,736 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-nitrophenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
monocrotaline  (ISO)
N-methylformamide  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,IEA,ISO,ISS)
chromatin  (ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
dendrite  (IDA,IEA)
Golgi apparatus  (IEA)
Golgi stack  (IEA,ISO,ISS)
kinetochore  (IBA)
neuronal cell body  (IDA)
nucleolus  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)
spindle pole  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. Kauselmann G, etal., EMBO J 1999 Oct 15;18(20):5528-39.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Weichert W, etal., Br J Cancer. 2004 Feb 23;90(4):815-21.
10. Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Weichert W, etal., Virchows Arch. 2005 Apr;446(4):442-50. Epub 2005 Mar 23.
Additional References at PubMed
PMID:11447225   PMID:14576440   PMID:14968113   PMID:14980500   PMID:16478733   PMID:16481012   PMID:17264206   PMID:19103756   PMID:19490146   PMID:20889502   PMID:20940307   PMID:20951827  
PMID:21098032   PMID:21376736   PMID:21840391   PMID:22854038   PMID:22870256   PMID:27344333   PMID:38906226  


Genomics

Comparative Map Data
Plk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,843,725 - 135,848,900 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,843,725 - 135,848,900 (-)EnsemblGRCr8
mRatBN7.25130,607,142 - 130,612,317 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,607,142 - 130,612,317 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5133,231,568 - 133,236,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,986,175 - 134,991,385 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05135,008,600 - 135,013,816 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,997,725 - 136,002,900 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,997,725 - 136,002,900 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,790,975 - 139,796,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45137,443,540 - 137,448,715 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5129,128,599 - 129,133,774 (-)NCBICelera
RGSC_v3.15137,449,104 - 137,453,736 (-)NCBI
Cytogenetic Map5q36NCBI
PLK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38144,800,377 - 44,805,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl144,800,346 - 44,805,995 (+)Ensemblhg38GRCh38
GRCh37145,266,049 - 45,271,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,038,623 - 45,044,254 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34144,935,128 - 44,940,759NCBI
Celera143,548,916 - 43,554,547 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef143,379,053 - 43,384,685 (+)NCBIHuRef
CHM1_1145,382,197 - 45,387,864 (+)NCBICHM1_1
T2T-CHM13v2.0144,671,531 - 44,677,144 (+)NCBIT2T-CHM13v2.0
Plk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,985,852 - 116,991,244 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,985,852 - 116,991,160 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384117,128,655 - 117,133,963 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4117,128,655 - 117,133,963 (-)Ensemblmm10GRCm38
MGSCv374116,801,260 - 116,806,557 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364116,626,587 - 116,631,884 (-)NCBIMGSCv36mm8
Celera4115,866,446 - 115,871,745 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.41NCBI
Plk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546413,419,562 - 13,424,104 (-)Ensembl
ChiLan1.0NW_00495546413,419,562 - 13,424,104 (-)NCBIChiLan1.0ChiLan1.0
PLK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21182,001,303 - 182,008,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11181,142,791 - 181,149,743 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,104,564 - 44,110,162 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1145,469,973 - 45,476,021 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl145,470,016 - 45,476,021 (+)EnsemblpanPan2panpan1.1
PLK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,519,042 - 15,523,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1515,519,026 - 15,524,230 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1515,639,248 - 15,644,072 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01515,674,448 - 15,679,275 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,674,432 - 15,679,641 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11515,471,657 - 15,476,475 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01515,539,179 - 15,544,005 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01515,611,969 - 15,616,798 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,202,092 - 60,207,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,026,842 - 26,032,218 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,026,878 - 26,032,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6166,528,765 - 166,533,731 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16166,528,760 - 166,533,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26154,046,111 - 154,051,069 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,989,573 - 87,995,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,989,574 - 87,994,478 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603328,945,519 - 28,950,952 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624906688,707 - 693,326 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624906678,517 - 693,644 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Plk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1140,754,206 - 40,759,422 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plk3
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:50
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000025197
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH129163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25130,607,151 - 130,607,343 (+)MAPPERmRatBN7.2
Rnor_6.05135,997,735 - 135,997,926NCBIRnor6.0
Rnor_5.05139,790,985 - 139,791,176UniSTSRnor5.0
RGSC_v3.45137,443,550 - 137,443,741UniSTSRGSC3.4
Celera5129,128,609 - 129,128,800UniSTS
RH 3.4 Map5837.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 91 59 6 355 191 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025197   ⟹   ENSRNOP00000025197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,843,725 - 135,848,900 (-)Ensembl
mRatBN7.2 Ensembl5130,607,142 - 130,612,317 (-)Ensembl
Rnor_6.0 Ensembl5135,997,725 - 136,002,900 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160582   ⟹   ENSRNOP00000101735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,843,725 - 135,848,900 (-)Ensembl
RefSeq Acc Id: NM_022187   ⟹   NP_071523
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,843,725 - 135,848,900 (-)NCBI
mRatBN7.25130,607,142 - 130,612,317 (-)NCBI
Rnor_6.05135,997,725 - 136,002,900 (-)NCBI
Rnor_5.05139,790,975 - 139,796,149 (-)NCBI
RGSC_v3.45137,443,540 - 137,448,715 (-)RGD
Celera5129,128,599 - 129,133,774 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110694   ⟹   XP_038966622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,843,725 - 135,848,273 (-)NCBI
mRatBN7.25130,607,142 - 130,611,690 (-)NCBI
RefSeq Acc Id: XM_039110695   ⟹   XP_038966623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,845,428 - 135,848,891 (-)NCBI
mRatBN7.25130,608,780 - 130,612,301 (-)NCBI
RefSeq Acc Id: NP_071523   ⟸   NM_022187
- UniProtKB: Q9R011 (UniProtKB/Swiss-Prot),   A6JZC5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025197   ⟸   ENSRNOT00000025197
RefSeq Acc Id: XP_038966622   ⟸   XM_039110694
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966623   ⟸   XM_039110695
- Peptide Label: isoform X2
- UniProtKB: A6JZC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101735   ⟸   ENSRNOT00000160582
Protein Domains
POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R011-F1-model_v2 AlphaFold Q9R011 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693948
Promoter ID:EPDNEW_R4473
Type:single initiation site
Name:Plk3_1
Description:polo-like kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05136,002,893 - 136,002,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62039 AgrOrtholog
BioCyc Gene G2FUF-40217 BioCyc
Ensembl Genes ENSRNOG00000018484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025197 ENTREZGENE
  ENSRNOT00000025197.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PLK3_STKc UniProtKB/Swiss-Prot
  POLO_box_1 UniProtKB/Swiss-Prot
  POLO_box_2 UniProtKB/Swiss-Prot
  POLO_box_dom UniProtKB/Swiss-Prot
  POLO_box_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:58936 UniProtKB/Swiss-Prot
NCBI Gene 58936 ENTREZGENE
PANTHER PTHR24345:SF42 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  POLO_box UniProtKB/Swiss-Prot
PhenoGen Plk3 PhenoGen
PROSITE POLO_BOX UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018484 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC220701
UniProt A0ABK0L9X5_RAT UniProtKB/TrEMBL
  A6JZC5 ENTREZGENE, UniProtKB/TrEMBL
  A6JZC6 ENTREZGENE, UniProtKB/TrEMBL
  PLK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk3  polo-like kinase 3  Plk3  polo-like kinase 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Plk3  polo-like kinase 3 (Drosophila)  Cnk  cytokine inducible kinase  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cnk  cytokine inducible kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction C-terminal domain interacts with Ca(2+)- and integrin-binding protein 61555
gene_regulation mRNA expression is regulated by level of neuronal activity 61555