Vegp2 (von Ebners gland protein 2) - Rat Genome Database

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Gene: Vegp2 (von Ebners gland protein 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vegp2
Name: von Ebners gland protein 2
RGD ID: 620384
Description: Predicted to enable small molecule binding activity. Predicted to be involved in sensory perception of taste. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to several human genes including LCN1 (lipocalin 1); INTERACTS WITH ammonium chloride; bisphenol A; cocaine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911507; VEG protein 2; VEGP2 gene; von Ebner gland protein 2; von Ebner gland protein 2-like; von Ebner's gland protein 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,914,540 - 29,940,231 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.239,516,457 - 9,542,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,516,457 - 9,521,081 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx312,573,533 - 12,578,156 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,158,913 - 21,163,536 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,414,233 - 19,418,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.034,217,260 - 4,221,330 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl34,217,260 - 4,221,330 (-)Ensemblrn6Rnor6.0
Rnor_5.039,575,964 - 9,600,394 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.434,862,645 - 4,867,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera34,329,198 - 4,333,235 (-)NCBICelera
RGSC_v3.134,862,644 - 4,867,267 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins. Kock K, etal., Eur J Biochem 1994 May 1;221(3):905-16.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23580065  


Genomics

Variants

.
Variants in Vegp2
306 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:92
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000041399
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 4 1 1 4 3 3 1 33 4

Sequence


Ensembl Acc Id: ENSRNOT00000041399   ⟹   ENSRNOP00000043245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,532,915 - 9,536,577 (+)Ensembl
Rnor_6.0 Ensembl34,217,260 - 4,221,330 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042910   ⟹   ENSRNOP00000041023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,516,457 - 9,521,081 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090568   ⟹   ENSRNOP00000069308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl34,138,268 - 4,142,571 (-)Ensembl
RefSeq Acc Id: NM_053574   ⟹   NP_446026
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,914,540 - 29,919,162 (-)NCBI
mRatBN7.239,516,457 - 9,521,079 (-)NCBI
Rnor_6.034,217,260 - 4,221,330 (-)NCBI
Rnor_5.039,575,964 - 9,600,394 (-)NCBI
RGSC_v3.434,862,645 - 4,867,267 (-)RGD
Celera34,329,198 - 4,333,235 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106003   ⟹   XP_038961931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,914,540 - 29,940,231 (-)NCBI
mRatBN7.239,516,457 - 9,542,088 (-)NCBI
RefSeq Acc Id: XM_039106004   ⟹   XP_038961932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,914,540 - 29,940,231 (-)NCBI
mRatBN7.239,516,457 - 9,542,088 (-)NCBI
RefSeq Acc Id: NP_446026   ⟸   NM_053574
- Peptide Label: precursor
- UniProtKB: P41244 (UniProtKB/Swiss-Prot),   R9PXY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043245   ⟸   ENSRNOT00000041399
RefSeq Acc Id: XP_038961932   ⟸   XM_039106004
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961931   ⟸   XM_039106003
- Peptide Label: isoform X1
- UniProtKB: A6JTH3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000069308   ⟸   ENSRNOT00000090568
Ensembl Acc Id: ENSRNOP00000041023   ⟸   ENSRNOT00000042910
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JV11-F1-model_v2 AlphaFold A0A0G2JV11 1-142 view protein structure
AF-P41244-F1-model_v2 AlphaFold P41244 1-177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620384 AgrOrtholog
BioCyc Gene G2FUF-50347 BioCyc
Ensembl Genes ENSRNOG00000033020 Ensembl
  ENSRNOG00000033761 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000056675 Ensembl
  ENSRNOG00000074004 ENTREZGENE
Ensembl Transcript ENSRNOT00000042910 ENTREZGENE
  ENSRNOT00000042910.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
  von_Ebner_gland UniProtKB/Swiss-Prot
KEGG Report rno:94106 UniProtKB/Swiss-Prot
NCBI Gene 94106 ENTREZGENE
PANTHER LIPOCALIN 1-LIKE PROTEIN 1-RELATED UniProtKB/Swiss-Prot
  PTHR11430 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Vegp2 PhenoGen
PRINTS VNEBNERGLAND UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033020 RatGTEx
  ENSRNOG00000033761 RatGTEx
  ENSRNOG00000056675 RatGTEx
  ENSRNOG00000074004 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A6JTH3 ENTREZGENE, UniProtKB/TrEMBL
  P41244 ENTREZGENE
  R9PXY4 ENTREZGENE, UniProtKB/TrEMBL
  VEGP2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Vegp2  von Ebners gland protein 2  LOC100911507  von Ebner gland protein 2-like  Data merged from RGD:6492253 737654 PROVISIONAL
2012-07-05 LOC100911507  von Ebner gland protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Vegp2  von Ebners gland protein 2      Symbol and Name updated 1299863 APPROVED
2002-08-07 VEGP2  VEGP2 gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may be a secreted protein 730111
gene_product member of the lipocalin superfamily 730111