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Gene: Slc1a6 (solute carrier family 1 member 6) Rattus norvegicus

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Symbol:

Slc1a6

Name:

solute carrier family 1 member 6

RGD ID:

620340

Description:

Enables high-affinity L-glutamate transmembrane transporter activity and monoatomic anion transmembrane transporter activity. Involved in L-glutamate import across plasma membrane. Located in plasma membrane. Part of membrane protein complex. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Orthologous to human SLC1A6 (solute carrier family 1 member 6); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EAAT4; excitatory amino acid transporter 4; high affinity aspartate/glutamate transporter; high-affinity neuronal glutamate transporter; MGC114297; sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	11,492,422 - 11,521,007 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	11,492,422 - 11,553,997 (-)	Ensembl				GRCr8
mRatBN7.2	7	10,841,836 - 10,870,424 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	10,841,837 - 10,870,449 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	13,661,837 - 13,690,559 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	15,539,283 - 15,568,001 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,417,320 - 13,445,815 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	13,730,101 - 13,758,170 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	13,730,253 - 13,751,271 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	13,893,841 - 13,921,839 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	12,393,284 - 12,419,893 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	8,958,917 - 8,988,056 (-)	NCBI		Celera
RGSC_v3.1	7	12,393,284 - 12,419,880 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

3,4-dichloroaniline (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Ampullosporin (EXP)

androgen antagonist (EXP)

arsenite(3-) (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

Butylbenzyl phthalate (ISO)

Butylparaben (EXP)

calcitriol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

DDE (EXP)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

dichlorine (EXP)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

diuron (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzacamene (EXP)

epoxiconazole (EXP)

ethanol (EXP)

fenvalerate (EXP)

folic acid (ISO)

furan (EXP)

glycidol (EXP)

indometacin (ISO)

ketamine (EXP)

lead(0) (ISO)

linuron (EXP)

lipopolysaccharide (ISO)

methoxychlor (EXP)

omega-6 fatty acid (ISO)

ozone (EXP)

paracetamol (EXP)

PCB138 (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

prochloraz (EXP)

procymidone (EXP)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

tamibarotene (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acidic amino acid transport (IEA)

amino acid transport (IEA)

dicarboxylic acid transport (IEA)

L-alpha-amino acid transmembrane transport (IEA)

L-aspartate import across plasma membrane (ISO,ISS)

L-glutamate import across plasma membrane (IDA,ISO)

L-glutamate transmembrane transport (IBA,IDA,IEA,ISO)

monoatomic anion transmembrane transport (IEA)

neurotransmitter uptake (ISO)

neutral amino acid transport (IEA)

regulation of membrane potential (ISO)

transmembrane transport (IEA)

Cellular Component

glutamatergic synapse (ISO)

Golgi apparatus (ISO)

membrane (IEA,ISO)

membrane protein complex (IDA)

parallel fiber to Purkinje cell synapse (IDA)

plasma membrane (IBA,IEA,IMP,ISO)

postsynaptic membrane (IDA)

presynaptic membrane (ISO)

synapse (IEA)

Molecular Function

acidic amino acid transmembrane transporter activity (IEA)

glutamate:sodium symporter activity (IBA,ISO)

high-affinity L-glutamate transmembrane transporter activity (IDA)

L-amino acid transmembrane transporter activity (IEA)

L-aspartate transmembrane transporter activity (ISO,ISS)

L-glutamate transmembrane transporter activity (IBA,IEA,ISO,TAS)

metal ion binding (IEA)

monoatomic anion transmembrane transporter activity (IDA)

neutral L-amino acid transmembrane transporter activity (IBA)

symporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.	Abousaab A, etal., J Membr Biol. 2016 Jun;249(3):239-49. doi: 10.1007/s00232-015-9863-0. Epub 2015 Dec 21.
2.	Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex.	Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
3.	The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia.	Dehnes Y, etal., J Neurosci. 1998 May 15;18(10):3606-19.
4.	Glutamate transporter protein subtypes are expressed differentially during rat CNS development.	Furuta A, etal., J Neurosci. 1997 Nov 1;17(21):8363-75.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7791878	PMID:12477932	PMID:14506254	PMID:14715943	PMID:14727177	PMID:16601148	PMID:16837599	PMID:17490622	PMID:18540911	PMID:18770868	PMID:19747495	PMID:20110679
PMID:20231455	PMID:21070388	PMID:21127051	PMID:21572047	PMID:21700703	PMID:23049999	PMID:29476059

Genomics

Comparative Map Data

Slc1a6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	11,492,422 - 11,521,007 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	11,492,422 - 11,553,997 (-)	Ensembl				GRCr8
mRatBN7.2	7	10,841,836 - 10,870,424 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	10,841,837 - 10,870,449 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	13,661,837 - 13,690,559 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	15,539,283 - 15,568,001 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,417,320 - 13,445,815 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	13,730,101 - 13,758,170 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	13,730,253 - 13,751,271 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	13,893,841 - 13,921,839 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	12,393,284 - 12,419,893 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	8,958,917 - 8,988,056 (-)	NCBI		Celera
RGSC_v3.1	7	12,393,284 - 12,419,880 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

SLC1A6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	14,950,033 - 15,010,643 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	14,950,033 - 15,022,990 (-)	Ensembl			hg38	GRCh38
GRCh37	19	15,060,845 - 15,121,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	14,921,991 - 14,944,730 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	14,921,990 - 14,944,730	NCBI
Celera	19	14,956,703 - 14,979,425 (-)	NCBI		Celera
Cytogenetic Map	19	p13.12	NCBI
HuRef	19	14,628,668 - 14,688,622 (-)	NCBI		HuRef
CHM1_1	19	15,060,322 - 15,120,899 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	15,074,841 - 15,135,544 (-)	NCBI		T2T-CHM13v2.0

Slc1a6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	78,615,923 - 78,650,659 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	78,616,330 - 78,650,599 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	78,780,086 - 78,814,825 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	78,780,496 - 78,814,765 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	78,243,241 - 78,277,570 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	78,183,631 - 78,217,894 (+)	NCBI		MGSCv36	mm8
Celera	10	79,802,330 - 79,836,572 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Slc1a6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	8,289,734 - 8,314,874 (+)	Ensembl
ChiLan1.0	NW_004955495	8,270,601 - 8,314,874 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC1A6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	19,865,671 - 19,896,124 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	18,882,684 - 18,913,146 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	14,499,333 - 14,529,781 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	15,470,222 - 15,498,980 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	15,470,222 - 15,526,471 (-)	Ensembl			panPan2	panpan1.1

SLC1A6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	47,133,237 - 47,143,512 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	47,097,593 - 47,143,512 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,976,526 - 46,993,225 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	47,618,429 - 47,635,339 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	47,589,356 - 47,635,118 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,849,336 - 46,866,041 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	47,267,243 - 47,284,105 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	47,539,683 - 47,556,398 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc1a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	205,914,191 - 205,929,855 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	5,464,862 - 5,478,641 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	5,464,850 - 5,478,763 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC1A6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	62,601,758 - 62,623,371 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	62,601,763 - 62,623,597 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	62,160,514 - 62,181,952 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC1A6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	13,537,902 - 13,567,333 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	13,538,064 - 13,558,959 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	6,023,993 - 6,056,899 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc1a6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	2,017,381 - 2,048,282 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624901	2,021,097 - 2,048,456 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc1a6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	156,775,070 - 156,803,164 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc1a6
299 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	151
Count of miRNA genes:	120
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000009931
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	2	28	121	67	70	44	13	44	6	135	54	1	107	24	84	26	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_032065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY286330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U80915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U89608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009931 ⟹ ENSRNOP00000009931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	11,492,423 - 11,521,032 (-)	Ensembl
mRatBN7.2 Ensembl	7	10,841,837 - 10,870,449 (-)	Ensembl
Rnor_6.0 Ensembl	7	13,730,253 - 13,751,271 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108905 ⟹ ENSRNOP00000096116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	11,492,423 - 11,521,032 (-)	Ensembl
mRatBN7.2 Ensembl	7	10,841,837 - 10,870,449 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165630 ⟹ ENSRNOP00000100912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	11,492,422 - 11,553,997 (-)	Ensembl

RefSeq Acc Id:

NM_032065 ⟹ NP_114454

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	11,492,422 - 11,521,007 (-)	NCBI
mRatBN7.2	7	10,841,836 - 10,870,424 (-)	NCBI
Rnor_6.0	7	13,730,101 - 13,758,099 (-)	NCBI
Rnor_5.0	7	13,893,841 - 13,921,839 (-)	NCBI
RGSC_v3.4	7	12,393,284 - 12,419,893 (-)	RGD
Celera	7	8,958,917 - 8,988,056 (-)	RGD

Sequence:

show sequence

GAATTCGGCACGAGCGCAGACACAGAGCGGGTCCCTGGCGGGTCCCTGCGGACCCGGCCAGGCG
CTTCCGCGGGTTCTGGCTTTTGCATCCCGGCGCAGCGCGCAGGCGGAGGCGCAGGCAAGGCGGC
CCCGCTGACCCGAGGCTGAGACGCGATGAGCAGCCACGGCAACAGTCTGTTCCTGAGGGAGAGC
GGCGCTGGCGGGGGCTGTCTGCAAGGCCTGCAGGACAGTCTGCAGCAGAGAGCACTGCGCACGC
GCTTGCGCCTGCAGACCATGACCCGAGAGCACGTGCGGCGCTTCCTGCGCCGAAATGCCTTCAT
CTTGCTCACAGTCAGCGCTGTGATCATTGGCGTCAGCCTGGCATTTGCCTTGCGCCCATATCAG
CTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGTGAGCTGCTCATGAGGATGCTGCAGA
TGCTGGTGCTACCCCTCATTGTCTCCAGCCGGGTCACAGGTATGGCATCCTTGGACAACAAGGC
AACAGGGAGGATGGGAATGAGGGCAGCTGTGTACTACATGGTGACGACCGTCATTGCAGTTTTC
ATCGGCATCCTAATGGTTACCATCATACATCCTGGGAAGGGCTCCAAGGAGGGGCTGCACCGTG
AGGGCCGAATTGAGACTGTTCCAACAGCTGATGCTTTCATGGACCTGGTCAGAAATATGTTTCC
ACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTTAAAACACAGTACAGCACACGAGTGGTAACA
AGGACGATTGTAAGGACAGACAACGGGTCAGAGTTGGGGGCCTCCATTTCTCCTCCATCCTCAG
CAGAAAATGAAACCAGCATCCTGGAAAATGTCACCCGGGCCTTGGGCACCCTGCAGGAGGTGAT
AAGCTTTGAGGAGACTGTGCCTGTACCTGGCTCAGCTAATGGCATCAACGCTTTGGGCCTCGTG
GTCTTCTCTGTGGCCTTCGGGCTGGTCATCGGTGGCATGAAGCACAAAGGCCGTGTCCTGAGGG
ATTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCTGGTGGGCATCATCATCTGGTATGCACC
AGTGGGCATCCTGTTCCTGATTGCTGGAAAGATTCTGGAAATGGAAGACATGGCTGTCCTTGGA
GGTCAGCTGGGCATGTACACGCTGACTGTCATTGTCGGCTTATTTCTTCATGCTGGTGGTGTGT
TACCCCTCATCTACTTCCTTGTCACACATCGGAACCCCTTTCCCTTCATCGGTGGTATACTACA
GGCACTCATCACAGCCATGGGTACCTCTTCCAGCTCTGCAACTCTGCCTATCACTTTCCGATGC
CTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGATTCGTGTTGCCTGTGGGGGCCACTG
TCAACATGGACGGCACCGCGCTCTATGAGGCCTTGGCAGCCATCTTTATTGCTCAAGTCAACAA
CTATGAGCTGAACCTTGGTCAGATCACCACAATCAGCATCACAGCCACAGCTGCCAGCGTAGGA
GCAGCTGGCATCCCCCAGGCAGGACTGGTTACCATGGTGATTGTGCTCACGTCTGTCGGCCTGC
CCACAGAGGACATCACATTGATCATAGCTGTGGATTGGTTCCTTGATCGACTTCGTACGATGAC
CAATGTACTTGGGGACTCAATTGGAGCAGCTGTCATTGAGCATTTGTCCCAACGGGAGCTGGAG
CTGCAAGAGGCTGAGCTGACTCTACCCAGCCTGGGGAAACCCTATAAGTCACTCATGGCACAAG
CCAAGGGGGCATCAAGGGGTCGGGGAGGTAATGAGAGTGTCATGTGAGAAGCTTCTAGCTCTTT
GTCCAGGGCGGAGGGAAGGGGCTGGGAGGGGAGTCCTGGGGACAATCTGTTGCACAACTGACTG
TGGGCTGCACAAACATGTTCTGTGTGGGTTCTCTGGGGACTGCTGAGATAAAAGAGAAGGAATG
AAAGGTAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_114454	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB40997	(Get FASTA)	NCBI Sequence Viewer
	AAB72086	(Get FASTA)	NCBI Sequence Viewer
	AAH98912	(Get FASTA)	NCBI Sequence Viewer
	AAP37181	(Get FASTA)	NCBI Sequence Viewer
	EDL89444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000096116
GenBank Protein	O35921	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114454 ⟸ NM_032065

- UniProtKB:

P97683 (UniProtKB/Swiss-Prot), O35921 (UniProtKB/Swiss-Prot), Q7TSX6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTVSAVI
IGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATGRMGMRA
AVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNMFPPNLVEACF
KQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRALGTLQEVISFEETVPV
PGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIA
GKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGT
SSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQI
TTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIG
AAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM

hide sequence

Ensembl Acc Id:

ENSRNOP00000009931 ⟸ ENSRNOT00000009931

Ensembl Acc Id:

ENSRNOP00000096116 ⟸ ENSRNOT00000108905

Ensembl Acc Id:

ENSRNOP00000100912 ⟸ ENSRNOT00000165630

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35921-F1-model_v2	AlphaFold	O35921	1-561	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620340	AgrOrtholog
BioCyc Gene	G2FUF-34849	BioCyc
Ensembl Genes	ENSRNOG00000007509	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000108905	ENTREZGENE
Gene3D-CATH	1.10.3860.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7315936	IMAGE-MGC_LOAD
InterPro	DAACS	UniProtKB/Swiss-Prot
	Na-dicarboxylate_symporter	UniProtKB/Swiss-Prot
	Na-dicarboxylate_symporter_CS	UniProtKB/Swiss-Prot
	Na:dicarbo_symporter_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:84012	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114297	IMAGE-MGC_LOAD
NCBI Gene	84012	ENTREZGENE
PANTHER	EXCITATORY AMINO ACID TRANSPORTER 4	UniProtKB/Swiss-Prot
	SODIUM/DICARBOXYLATE SYMPORTER-RELATED	UniProtKB/Swiss-Prot
Pfam	SDF	UniProtKB/Swiss-Prot
PhenoGen	Slc1a6	PhenoGen
PRINTS	EDTRNSPORT	UniProtKB/Swiss-Prot
PROSITE	NA_DICARBOXYL_SYMP_1	UniProtKB/Swiss-Prot
	NA_DICARBOXYL_SYMP_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000007509	RatGTEx
Superfamily-SCOP	SSF118215	UniProtKB/Swiss-Prot
UniProt	A0ABK0L8R0_RAT	UniProtKB/TrEMBL
	A6K924_RAT	UniProtKB/TrEMBL
	EAA4_RAT	UniProtKB/Swiss-Prot
	F1LR26_RAT	UniProtKB/TrEMBL
	O35921	ENTREZGENE
	P97683	ENTREZGENE
	Q7TSX6	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	P97683	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc1a6	solute carrier family 1 member 6	Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)