Cap1 (cyclase associated actin cytoskeleton regulatory protein 1) - Rat Genome Database

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Gene: Cap1 (cyclase associated actin cytoskeleton regulatory protein 1) Rattus norvegicus
Analyze
Symbol: Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
RGD ID: 620309
Description: Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in several processes, including actin filament organization; cAMP-mediated signaling; and modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase associated protein 1; adenylyl cyclase-associated protein 1; CAP 1; CAP, adenylate cyclase-associated protein 1; CAP, adenylate cyclase-associated protein 1 (yeast); cyclase-associated protein homologue; Mch1; MGC108691
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,427,265 - 140,507,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,427,269 - 140,453,470 (-)EnsemblGRCr8
mRatBN7.25135,142,108 - 135,168,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,848,892 - 137,875,074 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,619,408 - 139,645,571 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,625,992 - 139,652,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,559,195 - 140,585,494 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)Ensemblrn6Rnor6.0
Rnor_5.05144,350,194 - 144,376,587 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,174,441 - 142,201,120 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,680,751 - 133,706,934 (-)NCBICelera
RGSC_v3.15142,179,669 - 142,206,346 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
haloperidol  (ISO)
hexane  (EXP)
imidacloprid  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
methapyrilene  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cortical actin cytoskeleton  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IEA)
postsynapse  (IEA,ISO)
presynapse  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. Yamazaki K, etal., Lab Invest. 2009 Apr;89(4):425-32. Epub 2009 Feb 2.
10. Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae. Zelicof A, etal., J Biol Chem 1993 Jun 25;268(18):13448-53.
Additional References at PubMed
PMID:7691848   PMID:12477932   PMID:15004221   PMID:15489334   PMID:19056867   PMID:19199708   PMID:20458337   PMID:21238513   PMID:21423176   PMID:22082260   PMID:23376485   PMID:23533145  
PMID:24006456   PMID:24272071   PMID:25060335   PMID:30682386   PMID:34099549  


Genomics

Comparative Map Data
Cap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,427,265 - 140,507,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,427,269 - 140,453,470 (-)EnsemblGRCr8
mRatBN7.25135,142,108 - 135,168,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,848,892 - 137,875,074 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,619,408 - 139,645,571 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,625,992 - 139,652,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,559,195 - 140,585,494 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)Ensemblrn6Rnor6.0
Rnor_5.05144,350,194 - 144,376,587 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,174,441 - 142,201,120 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,680,751 - 133,706,934 (-)NCBICelera
RGSC_v3.15142,179,669 - 142,206,346 (-)NCBI
Cytogenetic Map5q36NCBI
CAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,040,240 - 40,072,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,039,735 - 40,072,767 (+)Ensemblhg38GRCh38
GRCh37140,505,912 - 40,538,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,278,842 - 40,310,908 (+)NCBIBuild 36Build 36hg18NCBI36
Celera138,788,546 - 38,820,608 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,624,359 - 38,656,372 (+)NCBIHuRef
CHM1_1140,621,882 - 40,653,922 (+)NCBICHM1_1
T2T-CHM13v2.0139,909,560 - 39,942,077 (+)NCBIT2T-CHM13v2.0
Cap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,752,841 - 122,779,869 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,752,840 - 122,779,849 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384122,859,048 - 122,886,076 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,859,047 - 122,886,056 (-)Ensemblmm10GRCm38
MGSCv374122,536,471 - 122,563,124 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364122,361,358 - 122,374,759 (-)NCBIMGSCv36mm8
Celera4121,189,663 - 121,215,875 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.27NCBI
Cap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,503,531 - 17,528,049 (+)Ensembl
ChiLan1.0NW_00495545217,503,530 - 17,528,049 (+)NCBIChiLan1.0ChiLan1.0
CAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,753,897 - 186,786,869 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,891,517 - 185,926,819 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,325,715 - 39,358,365 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,651,089 - 40,683,777 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,651,262 - 40,683,777 (+)EnsemblpanPan2panpan1.1
CAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,886,661 - 2,913,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,143,694 - 3,171,063 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0152,973,496 - 3,000,882 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,973,512 - 3,000,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,880,544 - 2,907,904 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,940,448 - 2,967,801 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,956,849 - 2,984,219 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,029,613 - 56,056,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,854,330 - 21,881,622 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,854,454 - 21,881,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,812,179 - 95,840,570 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1695,811,485 - 95,840,576 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,122,573 - 89,128,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,833,112 - 92,865,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,829,735 - 92,864,697 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603323,973,782 - 24,006,213 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,517,315 - 22,542,351 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476422,517,254 - 22,542,356 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1135,366,123 - 35,392,451 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cap1
580 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:212
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000018711
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5140258140143398122Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH142418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,673 - 135,141,856 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,761 - 140,558,943NCBIRnor6.0
Rnor_5.05144,349,760 - 144,349,942UniSTSRnor5.0
RGSC_v3.45142,173,999 - 142,174,181UniSTSRGSC3.4
Celera5133,680,309 - 133,680,491UniSTS
RH 3.4 Map5890.0UniSTS
Cytogenetic Map5q36UniSTS
RH127550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,796 - 135,142,005 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,884 - 140,559,092NCBIRnor6.0
Rnor_5.05144,349,883 - 144,350,091UniSTSRnor5.0
RGSC_v3.45142,174,122 - 142,174,330UniSTSRGSC3.4
Celera5133,680,432 - 133,680,640UniSTS
RH 3.4 Map5876.9UniSTS
Cytogenetic Map5q36UniSTS
AA851880  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85140,427,338 - 140,427,529 (+)Marker Load Pipeline
mRatBN7.25135,142,185 - 135,142,377 (+)MAPPERmRatBN7.2
Rnor_6.05140,559,273 - 140,559,463NCBIRnor6.0
Rnor_5.05144,350,272 - 144,350,462UniSTSRnor5.0
RGSC_v3.45142,174,511 - 142,174,701UniSTSRGSC3.4
Celera5133,680,821 - 133,681,011UniSTS
RH 3.4 Map5900.7UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:237169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,143,159 - 135,144,585 (+)MAPPERmRatBN7.2
Rnor_6.05140,560,246 - 140,561,671NCBIRnor6.0
Rnor_5.05144,351,245 - 144,352,670UniSTSRnor5.0
RGSC_v3.45142,175,484 - 142,176,909UniSTSRGSC3.4
Celera5133,681,794 - 133,683,219UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018711   ⟹   ENSRNOP00000018711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5140,427,269 - 140,453,470 (-)Ensembl
mRatBN7.2 Ensembl5135,142,114 - 135,168,249 (-)Ensembl
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105284   ⟹   ENSRNOP00000081879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)Ensembl
RefSeq Acc Id: NM_022383   ⟹   NP_071778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,269 - 140,453,470 (-)NCBI
mRatBN7.25135,142,116 - 135,168,320 (-)NCBI
Rnor_6.05140,559,203 - 140,585,408 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
RGSC_v3.45142,174,441 - 142,201,120 (-)RGD
Celera5133,680,751 - 133,706,934 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238830   ⟹   XP_006238892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,673 (-)NCBI
mRatBN7.25135,142,108 - 135,168,396 (-)NCBI
Rnor_6.05140,559,195 - 140,585,493 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238831   ⟹   XP_006238893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,596 (-)NCBI
mRatBN7.25135,142,118 - 135,168,401 (-)NCBI
Rnor_6.05140,559,195 - 140,585,493 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238832   ⟹   XP_006238894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,612 (-)NCBI
mRatBN7.25135,142,119 - 135,168,394 (-)NCBI
Rnor_6.05140,559,195 - 140,585,494 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110702   ⟹   XP_038966630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,454,568 (-)NCBI
mRatBN7.25135,142,119 - 135,168,885 (-)NCBI
RefSeq Acc Id: XM_039110703   ⟹   XP_038966631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,446,070 (-)NCBI
mRatBN7.25135,142,119 - 135,160,919 (-)NCBI
RefSeq Acc Id: XM_063288340   ⟹   XP_063144410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,541 (-)NCBI
RefSeq Acc Id: XM_063288341   ⟹   XP_063144411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,459,264 (-)NCBI
RefSeq Acc Id: XM_063288342   ⟹   XP_063144412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,507,678 (-)NCBI
RefSeq Acc Id: XM_063288343   ⟹   XP_063144413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,446,406 (-)NCBI
RefSeq Acc Id: XM_063288344   ⟹   XP_063144414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,354 (-)NCBI
RefSeq Acc Id: XM_063288345   ⟹   XP_063144415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,453,348 (-)NCBI
RefSeq Acc Id: XM_063288346   ⟹   XP_063144416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,427,265 - 140,454,476 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001417009 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417010 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417011 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417012 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417013 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417014 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417015 (Get FASTA)   NCBI Sequence Viewer  
  NP_001417016 (Get FASTA)   NCBI Sequence Viewer  
  NP_071778 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238892 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238893 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238894 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966630 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966631 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144410 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144411 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144412 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144413 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144414 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144415 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144416 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41579 (Get FASTA)   NCBI Sequence Viewer  
  AAH89801 (Get FASTA)   NCBI Sequence Viewer  
  EDL80361 (Get FASTA)   NCBI Sequence Viewer  
  EDL80362 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018711
GenBank Protein Q08163 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071778   ⟸   NM_022383
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238894   ⟸   XM_006238832
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006238893   ⟸   XM_006238831
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006238892   ⟸   XM_006238830
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000018711   ⟸   ENSRNOT00000018711
RefSeq Acc Id: XP_038966630   ⟸   XM_039110702
- Peptide Label: isoform X1
- UniProtKB: Q08163 (UniProtKB/Swiss-Prot),   Q5FVS8 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966631   ⟸   XM_039110703
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081879   ⟸   ENSRNOT00000105284
RefSeq Acc Id: XP_063144412   ⟸   XM_063288342
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144411   ⟸   XM_063288341
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144416   ⟸   XM_063288346
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144410   ⟸   XM_063288340
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144414   ⟸   XM_063288344
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144415   ⟸   XM_063288345
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144413   ⟸   XM_063288343
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
Protein Domains
C-CAP/cofactor C-like   CAP N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08163-F1-model_v2 AlphaFold Q08163 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693999
Promoter ID:EPDNEW_R4524
Type:initiation region
Name:Cap1_1
Description:cyclase associated actin cytoskeleton regulatory protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,585,313 - 140,585,373EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620309 AgrOrtholog
BioCyc Gene G2FUF-40028 BioCyc
Ensembl Genes ENSRNOG00000013492 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018711 ENTREZGENE
Gene3D-CATH 1.25.40.330 UniProtKB/Swiss-Prot
  2.160.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7381845 IMAGE-MGC_LOAD
InterPro Adenylate_cyclase-assoc_CAP UniProtKB/Swiss-Prot
  Adenylate_cyclase-assoc_CAP_C UniProtKB/Swiss-Prot
  Adenylate_cyclase-assoc_CAP_N UniProtKB/Swiss-Prot
  C-CAP_CF_C-like UniProtKB/Swiss-Prot
  CAP/MinC_C UniProtKB/Swiss-Prot
  CAP_C_sf UniProtKB/Swiss-Prot
  CAP_CS_C UniProtKB/Swiss-Prot
  CAP_CS_N UniProtKB/Swiss-Prot
  CAP_N UniProtKB/Swiss-Prot
  CAP_N_sf UniProtKB/Swiss-Prot
  CARP_motif UniProtKB/Swiss-Prot
KEGG Report rno:64185 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108691 IMAGE-MGC_LOAD
NCBI Gene 64185 ENTREZGENE
PANTHER PTHR10652 UniProtKB/Swiss-Prot
  PTHR10652:SF1 UniProtKB/Swiss-Prot
Pfam CAP_C UniProtKB/Swiss-Prot
  CAP_N UniProtKB/Swiss-Prot
  CAP_N UniProtKB/Swiss-Prot
PhenoGen Cap1 PhenoGen
PROSITE C_CAP_COFACTOR_C UniProtKB/Swiss-Prot
  CAP_1 UniProtKB/Swiss-Prot
  CAP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013492 RatGTEx
SMART CARP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101278 UniProtKB/Swiss-Prot
  SSF69340 UniProtKB/Swiss-Prot
UniProt A0A8L2QAE6 ENTREZGENE, UniProtKB/TrEMBL
  A6IS10_RAT UniProtKB/TrEMBL
  A6IS11 ENTREZGENE, UniProtKB/TrEMBL
  CAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVS8 ENTREZGENE
UniProt Secondary Q5FVS8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-24 Cap1  cyclase associated actin cytoskeleton regulatory protein 1  Cap1  adenylate cyclase associated protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Cap1  adenylate cyclase associated protein 1  Cap1  CAP, adenylate cyclase-associated protein 1 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cap1  CAP, adenylate cyclase-associated protein 1 (yeast)    cyclase-associated protein homologue  Name updated 1299863 APPROVED
2002-08-07 Cap1  cyclase-associated protein homologue      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is constitutively expressed in all tissue types examined 632445
gene_homology protein aa sequence is 36% identical to S. cerevisiae CAP 632445
gene_protein predicted protein contains 474 aa residues 632445