Prok2 (prokineticin 2) - Rat Genome Database

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Gene: Prok2 (prokineticin 2) Rattus norvegicus
Analyze
Symbol: Prok2
Name: prokineticin 2
RGD ID: 620280
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including angiogenesis; endothelial cell proliferation; and positive regulation of smooth muscle contraction. Predicted to act upstream of or within circadian rhythm. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 4 with or without anosmia. Orthologous to human PROK2 (prokineticin 2); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bv8; homolog of mouse Bv8 (Bombina variegata 8 kDa); PK2; prokineticin 2 beta; prokineticin 2 precursor; prokineticin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84133,903,210 - 133,918,126 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4133,903,210 - 133,917,933 (-)EnsemblGRCr8
mRatBN7.24132,346,681 - 132,361,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4137,761,400 - 137,776,228 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04133,542,182 - 133,557,004 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04132,160,453 - 132,175,271 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04132,157,556 - 132,171,244 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensemblrn6Rnor6.0
Rnor_5.04196,648,637 - 196,662,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44134,561,300 - 134,574,487 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4121,207,301 - 121,220,343 (-)NCBICelera
RGSC_v3.14134,806,140 - 134,819,328 (-)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hexane  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pyrrolidine dithiocarbamate  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
streptozocin  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Masuda Y, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):396-402.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10580115   PMID:11259612   PMID:12024206   PMID:12604792   PMID:15014112   PMID:15772293   PMID:16819985   PMID:18614763   PMID:19667192   PMID:19933997   PMID:20053957   PMID:20800074  
PMID:21687716   PMID:22050240   PMID:22431614   PMID:22642848   PMID:24560704   PMID:25153663   PMID:26477583   PMID:26490969   PMID:29516577   PMID:31474981   PMID:31744994   PMID:31766244  
PMID:31899964   PMID:32572760   PMID:36804440   PMID:37934398  


Genomics

Comparative Map Data
Prok2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84133,903,210 - 133,918,126 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4133,903,210 - 133,917,933 (-)EnsemblGRCr8
mRatBN7.24132,346,681 - 132,361,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4137,761,400 - 137,776,228 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04133,542,182 - 133,557,004 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04132,160,453 - 132,175,271 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04132,157,556 - 132,171,244 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensemblrn6Rnor6.0
Rnor_5.04196,648,637 - 196,662,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44134,561,300 - 134,574,487 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4121,207,301 - 121,220,343 (-)NCBICelera
RGSC_v3.14134,806,140 - 134,819,328 (-)NCBI
Cytogenetic Map4q34NCBI
PROK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38371,771,655 - 71,785,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl371,771,655 - 71,785,206 (-)Ensemblhg38GRCh38
GRCh37371,820,806 - 71,834,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36371,903,497 - 71,916,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34371,903,496 - 71,916,902NCBI
Celera371,751,377 - 71,764,927 (-)NCBICelera
Cytogenetic Map3p13NCBI
HuRef371,822,789 - 71,836,340 (-)NCBIHuRef
CHM1_1371,772,193 - 71,785,741 (-)NCBICHM1_1
T2T-CHM13v2.0371,810,890 - 71,824,379 (-)NCBIT2T-CHM13v2.0
Prok2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39699,687,833 - 99,703,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl699,688,260 - 99,703,353 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38699,711,299 - 99,726,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl699,711,299 - 99,726,392 (-)Ensemblmm10GRCm38
MGSCv37699,661,293 - 99,676,386 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36699,676,762 - 99,691,855 (-)NCBIMGSCv36mm8
Celera6101,575,424 - 101,590,523 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map646.29NCBI
Prok2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542116,325,519 - 16,337,980 (+)Ensembl
ChiLan1.0NW_00495542116,325,519 - 16,339,458 (+)NCBIChiLan1.0ChiLan1.0
PROK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2271,729,996 - 71,744,472 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1371,734,783 - 71,749,259 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0371,711,334 - 71,724,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1373,067,609 - 73,080,897 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl373,068,599 - 73,080,897 (-)EnsemblpanPan2panpan1.1
PROK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2020,223,646 - 20,237,384 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02020,280,503 - 20,294,239 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2020,280,467 - 20,294,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12019,967,457 - 19,981,222 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.02020,382,640 - 20,396,378 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prok2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049423,298,129 - 3,310,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366033,299,736 - 3,310,011 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366033,299,736 - 3,419,539 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1353,169,524 - 53,185,171 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11353,169,040 - 53,184,695 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21358,857,144 - 58,872,870 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12232,721,188 - 32,739,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041134,040,511 - 134,054,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prok2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247736,307,653 - 6,323,208 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247736,310,025 - 6,323,245 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prok2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1647,347,085 - 47,361,289 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prok2
167 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000015058, ENSRNOT00000015075
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
Prok2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84133,904,683 - 133,904,750 (+)Marker Load Pipeline
mRatBN7.24132,348,155 - 132,348,221 (+)MAPPERmRatBN7.2
Rnor_6.04132,157,580 - 132,157,645NCBIRnor6.0
Rnor_5.04196,648,818 - 196,648,883UniSTSRnor5.0
RGSC_v3.44134,561,324 - 134,561,389UniSTSRGSC3.4
Celera4121,207,325 - 121,207,390UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 4 28 141 58 64 35 83 35 6 237 134 11 123 52 74 29 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000015058   ⟹   ENSRNOP00000015058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4133,903,210 - 133,917,933 (-)Ensembl
mRatBN7.2 Ensembl4132,347,132 - 132,361,385 (-)Ensembl
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000015075   ⟹   ENSRNOP00000015075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4133,903,210 - 133,917,933 (-)Ensembl
mRatBN7.2 Ensembl4132,347,132 - 132,361,385 (-)Ensembl
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111899   ⟹   ENSRNOP00000092204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4133,903,210 - 133,917,933 (-)Ensembl
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138506   ⟹   ENSRNOP00000102073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4133,904,505 - 133,917,920 (-)Ensembl
RefSeq Acc Id: NM_001037541   ⟹   NP_001032630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,917,933 (-)NCBI
mRatBN7.24132,346,681 - 132,361,407 (-)NCBI
Rnor_6.04132,157,556 - 132,171,153 (-)NCBI
Rnor_5.04196,648,637 - 196,662,531 (-)NCBI
RGSC_v3.44134,561,300 - 134,574,487 (-)RGD
Celera4121,207,301 - 121,220,343 (-)RGD
Sequence:
RefSeq Acc Id: NM_138852   ⟹   NP_620207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,917,933 (-)NCBI
mRatBN7.24132,346,681 - 132,361,407 (-)NCBI
Rnor_6.04132,157,556 - 132,171,153 (-)NCBI
Rnor_5.04196,648,637 - 196,662,531 (-)NCBI
RGSC_v3.44134,561,300 - 134,574,487 (-)RGD
Celera4121,207,301 - 121,220,343 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106990   ⟹   XP_038962918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,918,126 (-)NCBI
mRatBN7.24132,346,681 - 132,361,614 (-)NCBI
RefSeq Acc Id: XM_063285462   ⟹   XP_063141532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,913,658 - 133,918,125 (-)NCBI
RefSeq Acc Id: NP_620207   ⟸   NM_138852
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8R413 (UniProtKB/Swiss-Prot),   A6IBH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032630   ⟸   NM_001037541
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6V8J7 (UniProtKB/TrEMBL),   A6IBH4 (UniProtKB/TrEMBL),   F7EWJ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015075   ⟸   ENSRNOT00000015075
Ensembl Acc Id: ENSRNOP00000015058   ⟸   ENSRNOT00000015058
RefSeq Acc Id: XP_038962918   ⟸   XM_039106990
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGP5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092204   ⟸   ENSRNOT00000111899
RefSeq Acc Id: XP_063141532   ⟸   XM_063285462
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000102073   ⟸   ENSRNOT00000138506
Protein Domains
Prokineticin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R413-F1-model_v2 AlphaFold Q8R413 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693274
Promoter ID:EPDNEW_R3799
Type:initiation region
Name:Prok2_1
Description:prokineticin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04132,171,179 - 132,171,239EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620280 AgrOrtholog
BioCyc Gene G2FUF-43580 BioCyc
Ensembl Genes ENSRNOG00000010898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015058 ENTREZGENE
  ENSRNOT00000015075 ENTREZGENE
  ENSRNOT00000015075.3 UniProtKB/Swiss-Prot
  ENSRNOT00000111899 ENTREZGENE
Gene3D-CATH Lipase, subunit A UniProtKB/Swiss-Prot
InterPro Prokineticin UniProtKB/Swiss-Prot
  Prokineticin_domain UniProtKB/Swiss-Prot
KEGG Report rno:192206 UniProtKB/Swiss-Prot
NCBI Gene 192206 ENTREZGENE
PANTHER PROKINETICIN-2 UniProtKB/Swiss-Prot
  PTHR18821 UniProtKB/Swiss-Prot
Pfam Prokineticin UniProtKB/Swiss-Prot
PhenoGen Prok2 PhenoGen
RatGTEx ENSRNOG00000010898 RatGTEx
Superfamily-SCOP Colipase-like UniProtKB/Swiss-Prot
UniProt A0A8I6AGP5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGN1_RAT UniProtKB/TrEMBL
  A6IBH2_RAT UniProtKB/TrEMBL
  A6IBH3 ENTREZGENE, UniProtKB/TrEMBL
  A6IBH4 ENTREZGENE, UniProtKB/TrEMBL
  F7EWJ2 ENTREZGENE, UniProtKB/TrEMBL
  PROK2_RAT UniProtKB/Swiss-Prot
  Q6V8J7 ENTREZGENE
  Q8R413 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Prok2  prokineticin 2    homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor  Name updated 1299863 APPROVED
2004-09-10 Prok2  homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor  Bv8    Symbol and Name updated 1299863 APPROVED
2002-08-07 Bv8  homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process provokes the rapid phosphorylation of p44/42 MAP kinase and DNA synthesis 632409