Prok2 (prokineticin 2) - Rat Genome Database

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Gene: Prok2 (prokineticin 2) Rattus norvegicus
Analyze
Symbol: Prok2
Name: prokineticin 2
RGD ID: 620280
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including angiogenesis; endothelial cell proliferation; and positive regulation of smooth muscle contraction. Predicted to act upstream of or within circadian rhythm. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 4 with or without anosmia. Orthologous to human PROK2 (prokineticin 2); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bv8; homolog of mouse Bv8 (Bombina variegata 8 kDa); PK2; prokineticin 2 beta; prokineticin 2 precursor; prokineticin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84133,903,210 - 133,918,126 (-)NCBIGRCr8
mRatBN7.24132,346,681 - 132,361,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4137,761,400 - 137,776,228 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04133,542,182 - 133,557,004 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04132,160,453 - 132,175,271 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04132,157,556 - 132,171,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04196,648,637 - 196,662,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44134,561,300 - 134,574,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14134,806,140 - 134,819,328 (-)NCBI
Celera4121,207,301 - 121,220,343 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Masuda Y, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):396-402.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10580115   PMID:11259612   PMID:12024206   PMID:12604792   PMID:15014112   PMID:15772293   PMID:16819985   PMID:18614763   PMID:19667192   PMID:19933997   PMID:20053957   PMID:20800074  
PMID:21687716   PMID:22050240   PMID:22431614   PMID:22642848   PMID:24560704   PMID:25153663   PMID:26477583   PMID:26490969   PMID:29516577   PMID:31474981   PMID:31744994   PMID:31766244  
PMID:31899964   PMID:32572760   PMID:36804440  


Genomics

Comparative Map Data
Prok2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84133,903,210 - 133,918,126 (-)NCBIGRCr8
mRatBN7.24132,346,681 - 132,361,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4137,761,400 - 137,776,228 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04133,542,182 - 133,557,004 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04132,160,453 - 132,175,271 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04132,157,556 - 132,171,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04196,648,637 - 196,662,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44134,561,300 - 134,574,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14134,806,140 - 134,819,328 (-)NCBI
Celera4121,207,301 - 121,220,343 (-)NCBICelera
Cytogenetic Map4q34NCBI
PROK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38371,771,655 - 71,785,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl371,771,655 - 71,785,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37371,820,806 - 71,834,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36371,903,497 - 71,916,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34371,903,496 - 71,916,902NCBI
Celera371,751,377 - 71,764,927 (-)NCBICelera
Cytogenetic Map3p13NCBI
HuRef371,822,789 - 71,836,340 (-)NCBIHuRef
CHM1_1371,772,193 - 71,785,741 (-)NCBICHM1_1
T2T-CHM13v2.0371,810,890 - 71,824,379 (-)NCBIT2T-CHM13v2.0
Prok2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39699,687,833 - 99,703,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl699,688,260 - 99,703,353 (-)EnsemblGRCm39 Ensembl
GRCm38699,711,299 - 99,726,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl699,711,299 - 99,726,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37699,661,293 - 99,676,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36699,676,762 - 99,691,855 (-)NCBIMGSCv36mm8
Celera6101,575,424 - 101,590,523 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map646.29NCBI
Prok2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542116,325,519 - 16,337,980 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542116,325,519 - 16,339,458 (+)NCBIChiLan1.0ChiLan1.0
PROK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2271,729,996 - 71,744,472 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1371,734,783 - 71,749,259 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0371,711,334 - 71,724,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1373,067,609 - 73,080,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl373,068,599 - 73,080,897 (-)Ensemblpanpan1.1panPan2
PROK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2020,223,646 - 20,237,384 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02020,280,503 - 20,294,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2020,280,467 - 20,294,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12019,967,457 - 19,981,222 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.02020,382,640 - 20,396,378 (+)NCBIUU_Cfam_GSD_1.0
Prok2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049423,298,129 - 3,310,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366033,299,736 - 3,310,011 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366033,299,736 - 3,419,539 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1353,169,524 - 53,185,171 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11353,169,040 - 53,184,695 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21358,857,144 - 58,872,870 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12232,721,188 - 32,739,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041134,040,511 - 134,054,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prok2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247736,307,653 - 6,323,208 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247736,310,025 - 6,323,245 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prok2
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000015058, ENSRNOT00000015075
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat

Markers in Region
Prok2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24132,348,155 - 132,348,221 (+)MAPPERmRatBN7.2
Rnor_6.04132,157,580 - 132,157,645NCBIRnor6.0
Rnor_5.04196,648,818 - 196,648,883UniSTSRnor5.0
RGSC_v3.44134,561,324 - 134,561,389UniSTSRGSC3.4
Celera4121,207,325 - 121,207,390UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 3 2 12 2 38 1 4 11
Below cutoff 1 9 21 15 5 15 2 3 26 12 14 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015058   ⟹   ENSRNOP00000015058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4132,347,132 - 132,361,385 (-)Ensembl
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000015075   ⟹   ENSRNOP00000015075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4132,347,132 - 132,361,385 (-)Ensembl
Rnor_6.0 Ensembl4132,157,556 - 132,171,153 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111899   ⟹   ENSRNOP00000092204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4132,347,103 - 132,361,385 (-)Ensembl
RefSeq Acc Id: NM_001037541   ⟹   NP_001032630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,917,933 (-)NCBI
mRatBN7.24132,346,681 - 132,361,407 (-)NCBI
Rnor_6.04132,157,556 - 132,171,153 (-)NCBI
Rnor_5.04196,648,637 - 196,662,531 (-)NCBI
RGSC_v3.44134,561,300 - 134,574,487 (-)RGD
Celera4121,207,301 - 121,220,343 (-)RGD
Sequence:
RefSeq Acc Id: NM_138852   ⟹   NP_620207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,917,933 (-)NCBI
mRatBN7.24132,346,681 - 132,361,407 (-)NCBI
Rnor_6.04132,157,556 - 132,171,153 (-)NCBI
Rnor_5.04196,648,637 - 196,662,531 (-)NCBI
RGSC_v3.44134,561,300 - 134,574,487 (-)RGD
Celera4121,207,301 - 121,220,343 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106990   ⟹   XP_038962918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,903,210 - 133,918,126 (-)NCBI
mRatBN7.24132,346,681 - 132,361,614 (-)NCBI
RefSeq Acc Id: XM_063285462   ⟹   XP_063141532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84133,913,658 - 133,918,125 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_620207   ⟸   NM_138852
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8R413 (UniProtKB/Swiss-Prot),   A6IBH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032630   ⟸   NM_001037541
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6V8J7 (UniProtKB/TrEMBL),   A6IBH4 (UniProtKB/TrEMBL),   F7EWJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015075   ⟸   ENSRNOT00000015075
RefSeq Acc Id: ENSRNOP00000015058   ⟸   ENSRNOT00000015058
RefSeq Acc Id: XP_038962918   ⟸   XM_039106990
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092204   ⟸   ENSRNOT00000111899
RefSeq Acc Id: XP_063141532   ⟸   XM_063285462
- Peptide Label: isoform X2
Protein Domains
Prokineticin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R413-F1-model_v2 AlphaFold Q8R413 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693274
Promoter ID:EPDNEW_R3799
Type:initiation region
Name:Prok2_1
Description:prokineticin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04132,171,179 - 132,171,239EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620280 AgrOrtholog
BioCyc Gene G2FUF-43580 BioCyc
Ensembl Genes ENSRNOG00000010898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019567 UniProtKB/Swiss-Prot
  ENSRNOG00060003985 UniProtKB/Swiss-Prot
  ENSRNOG00065024545 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015058 ENTREZGENE
  ENSRNOT00000015058.5 UniProtKB/TrEMBL
  ENSRNOT00000015075 ENTREZGENE
  ENSRNOT00000015075.3 UniProtKB/Swiss-Prot
  ENSRNOT00000111899.1 UniProtKB/TrEMBL
  ENSRNOT00055033407 UniProtKB/Swiss-Prot
  ENSRNOT00060006661 UniProtKB/Swiss-Prot
  ENSRNOT00065042152 UniProtKB/Swiss-Prot
Gene3D-CATH Lipase, subunit A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prokineticin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prokineticin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 192206 ENTREZGENE
PANTHER PROKINETICIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prokineticin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prok2 PhenoGen
RatGTEx ENSRNOG00000010898 RatGTEx
  ENSRNOG00055019567 RatGTEx
  ENSRNOG00060003985 RatGTEx
  ENSRNOG00065024545 RatGTEx
Superfamily-SCOP Colipase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AGP5 ENTREZGENE, UniProtKB/TrEMBL
  A6IBH2_RAT UniProtKB/TrEMBL
  A6IBH3 ENTREZGENE, UniProtKB/TrEMBL
  A6IBH4 ENTREZGENE, UniProtKB/TrEMBL
  F7EWJ2 ENTREZGENE, UniProtKB/TrEMBL
  PROK2_RAT UniProtKB/Swiss-Prot
  Q6V8J7 ENTREZGENE
  Q8R413 ENTREZGENE
UniProt Secondary Q6V8J7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Prok2  prokineticin 2    homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor  Name updated 1299863 APPROVED
2004-09-10 Prok2  homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor  Bv8    Symbol and Name updated 1299863 APPROVED
2002-08-07 Bv8  homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process provokes the rapid phosphorylation of p44/42 MAP kinase and DNA synthesis 632409