Abca2 (ATP binding cassette subfamily A member 2) - Rat Genome Database

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Gene: Abca2 (ATP binding cassette subfamily A member 2) Rattus norvegicus
Analyze
Symbol: Abca2
Name: ATP binding cassette subfamily A member 2
RGD ID: 620238
Description: Enables ATP binding activity. Involved in central nervous system myelin formation; negative regulation of lipid biosynthetic process; and positive regulation of amyloid-beta formation. Located in cytoplasmic vesicle; lysosomal membrane; and microtubule organizing center. Orthologous to human ABCA2 (ATP binding cassette subfamily A member 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abc2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A (ABC1), member 2; ATP-binding cassette, subfamily A (ABC1), member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,642,660 - 28,662,689 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,642,758 - 28,662,681 (+)EnsemblGRCr8
mRatBN7.238,244,515 - 8,264,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,349,736 - 11,369,666 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,935,958 - 19,955,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,125,806 - 18,145,736 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)Ensemblrn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,069,743 - 3,089,646 (+)NCBICelera
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
lead(0)  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
okadaic acid  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
rifampicin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
triclosan  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
central nervous system myelin formation  (IDA,IEA,ISO)
ceramide translocation  (IEA,ISO)
cholesterol homeostasis  (IEA,ISO,ISS)
ganglioside metabolic process  (ISO,ISS)
glycosphingolipid metabolic process  (ISO,ISS)
intracellular sphingolipid homeostasis  (IEA,ISO)
lipid transport  (IBA)
locomotory behavior  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of intracellular cholesterol transport  (ISO)
negative regulation of phospholipid biosynthetic process  (IEA,IMP,ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of sphingolipid biosynthetic process  (IEA,IMP,ISO)
negative regulation of steroid metabolic process  (IMP)
positive regulation of amyloid precursor protein biosynthetic process  (IEA,ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of amyloid-beta formation  (IMP,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (ISO)
positive regulation of protein metabolic process  (IEA)
regulation of cholesterol biosynthetic process  (ISO)
regulation of intracellular cholesterol transport  (IEA,ISO,ISS)
regulation of post-translational protein modification  (ISO)
regulation of protein localization to cell periphery  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of steroid metabolic process  (ISO)
response to cholesterol  (IEA,ISO)
response to steroid hormone  (IEA,ISO,ISS)
sphingomyelin metabolic process  (ISO,ISS)
sphingosine biosynthetic process  (ISO)
transmembrane transport  (IEA,NAS)

Cellular Component
cytoplasmic vesicle  (IDA)
endosome  (IEA,ISO,ISS)
endosome membrane  (IEA,ISO)
lysosomal membrane  (IDA,IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
microtubule organizing center  (IDA)
plasma membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. Broccardo C, etal., J Neurochem. 2006 Apr;97(2):345-55. Epub 2006 Mar 15.
2. The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Davis W, Biochim Biophys Acta. 2011 Dec;1811(12):1152-64. doi: 10.1016/j.bbalip.2011.07.010. Epub 2011 Jul 23.
3. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Davis W, Biochim Biophys Acta. 2014 Jan;1841(1):168-79. doi: 10.1016/j.bbalip.2013.10.019. Epub 2013 Nov 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. Michaki V, etal., J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. Tanaka Y, etal., J Comp Neurol 2003 Jan 13;455(3):353-67.
13. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Zhao LX, etal., Biochem J 2000 Sep 15;350 Pt 3:865-72.
14. Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. Zhou C, etal., J Neurosci. 2001 Feb 1;21(3):849-57.
15. ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination. Zhou CJ, etal., J Comp Neurol 2002 Sep 30;451(4):334-45.
Additional References at PubMed
PMID:11178988   PMID:11309290   PMID:15238223   PMID:15999530   PMID:17060448   PMID:19946888   PMID:20704561   PMID:22871113   PMID:26510981  


Genomics

Comparative Map Data
Abca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,642,660 - 28,662,689 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,642,758 - 28,662,681 (+)EnsemblGRCr8
mRatBN7.238,244,515 - 8,264,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,349,736 - 11,369,666 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,935,958 - 19,955,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,125,806 - 18,145,736 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)Ensemblrn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,069,743 - 3,089,646 (+)NCBICelera
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Cytogenetic Map3p13NCBI
ABCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,007,234 - 137,028,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,007,234 - 137,028,915 (-)Ensemblhg38GRCh38
GRCh379139,901,686 - 139,923,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,021,507 - 139,043,195 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349137,177,522 - 137,199,211NCBI
Celera9110,414,121 - 110,431,191 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,360,841 - 109,382,226 (-)NCBIHuRef
CHM1_19140,050,436 - 140,072,137 (-)NCBICHM1_1
T2T-CHM13v2.09149,241,651 - 149,263,357 (-)NCBIT2T-CHM13v2.0
Abca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,318,611 - 25,338,556 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,318,715 - 25,338,552 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,428,599 - 25,448,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,428,703 - 25,448,540 (+)Ensemblmm10GRCm38
MGSCv37225,284,194 - 25,304,059 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,250,779 - 25,270,208 (+)NCBIMGSCv36mm8
Celera225,156,185 - 25,176,102 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.25NCBI
Abca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)Ensembl
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBIChiLan1.0ChiLan1.0
ABCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,369,797 - 2,391,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,372,769 - 2,393,970 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,067,633 - 108,089,742 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,039,264 - 137,057,527 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,036,696 - 137,057,776 (-)EnsemblpanPan2panpan1.1
ABCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,610,906 - 48,630,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,613,996 - 48,629,857 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,824,500 - 47,844,585 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,488,905 - 49,509,018 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1948,265,133 - 48,285,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,563,850 - 48,583,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,611,199 - 48,631,304 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,433,062 - 202,454,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669926,622 - 942,167 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669922,978 - 941,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA2
(Sus scrofa - pig)		 No map positions available.
ABCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,161,340 - 1,183,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,162,865 - 1,183,113 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,118,329 - 4,134,713 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760880,148 - 898,751 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760880,216 - 898,753 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Abca2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,734,070 - 11,753,850 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abca2
130 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:210
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000020339
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH70531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,257,185 - 8,258,825 (+)MAPPERmRatBN7.2
Rnor_6.032,661,411 - 2,663,050NCBIRnor6.0
Rnor_5.032,642,824 - 2,644,463UniSTSRnor5.0
RGSC_v3.433,607,969 - 3,609,608UniSTSRGSC3.4
Celera33,082,289 - 3,083,928UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020339   ⟹   ENSRNOP00000020339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,642,758 - 28,662,681 (+)Ensembl
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)Ensembl
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109279   ⟹   ENSRNOP00000088059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,642,758 - 28,662,681 (+)Ensembl
mRatBN7.2 Ensembl38,248,427 - 8,264,537 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131325   ⟹   ENSRNOP00000099940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,642,758 - 28,662,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154816   ⟹   ENSRNOP00000099497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,642,758 - 28,662,681 (+)Ensembl
RefSeq Acc Id: NM_024396   ⟹   NP_077372
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,642,784 - 28,662,689 (+)NCBI
mRatBN7.238,244,639 - 8,264,545 (+)NCBI
Rnor_6.032,648,865 - 2,668,770 (+)NCBI
Rnor_5.032,630,237 - 2,650,183 (+)NCBI
RGSC_v3.433,595,423 - 3,615,328 (+)RGD
Celera33,069,743 - 3,089,646 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284604   ⟹   XP_063140674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,642,663 - 28,662,689 (+)NCBI
RefSeq Acc Id: XM_063284605   ⟹   XP_063140675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,642,662 - 28,662,689 (+)NCBI
RefSeq Acc Id: XM_063284606   ⟹   XP_063140676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,646,127 - 28,662,689 (+)NCBI
RefSeq Acc Id: XM_063284607   ⟹   XP_063140677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,642,660 - 28,660,944 (+)NCBI
RefSeq Acc Id: NP_077372   ⟸   NM_024396
- UniProtKB: Q9ESR9 (UniProtKB/Swiss-Prot),   A6JT60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020339   ⟸   ENSRNOT00000020339
Ensembl Acc Id: ENSRNOP00000088059   ⟸   ENSRNOT00000109279
RefSeq Acc Id: XP_063140677   ⟸   XM_063284607
- Peptide Label: isoform X4
- UniProtKB: A6JT60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140675   ⟸   XM_063284605
- Peptide Label: isoform X2
- UniProtKB: A6JT60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140674   ⟸   XM_063284604
- Peptide Label: isoform X1
- UniProtKB: G3V7X4 (UniProtKB/TrEMBL),   A6JT60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140676   ⟸   XM_063284606
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5D9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099940   ⟸   ENSRNOT00000131325
Ensembl Acc Id: ENSRNOP00000099497   ⟸   ENSRNOT00000154816
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESR9-F1-model_v2 AlphaFold Q9ESR9 1-2434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691878
Promoter ID:EPDNEW_R2402
Type:multiple initiation site
Name:Abca2_1
Description:ATP binding cassette subfamily A member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,648,835 - 2,648,895EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620238 AgrOrtholog
BioCyc Gene G2FUF-50453 BioCyc
Ensembl Genes ENSRNOG00000014268 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020339 ENTREZGENE
  ENSRNOT00000109279 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC2_TM UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCA UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  R2_ABCA1-4-like UniProtKB/Swiss-Prot
KEGG Report rno:79248 UniProtKB/Swiss-Prot
NCBI Gene 79248 ENTREZGENE
PANTHER ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/Swiss-Prot
  PTHR19229 UniProtKB/Swiss-Prot
Pfam ABC2_membrane_3 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
  R1_ABCA1 UniProtKB/Swiss-Prot
PhenoGen Abca2 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014268 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6A5D9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4V8_RAT UniProtKB/TrEMBL
  A0ABK0L825_RAT UniProtKB/TrEMBL
  A6JT60 ENTREZGENE, UniProtKB/TrEMBL
  ABCA2_RAT UniProtKB/Swiss-Prot
  G3V7X4 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESR9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abca2  ATP binding cassette subfamily A member 2  Abca2  ATP-binding cassette, subfamily A (ABC1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abca2  ATP-binding cassette, subfamily A (ABC1), member 2  Abca2  ATP-binding cassette, sub-family A (ABC1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Abca2  ATP-binding cassette, sub-family A (ABC1), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abca2  ATP-binding cassette, sub-family A (ABC1), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the ABC1 subfamily of the ATP-binding casette (ABC) transporter superfamily 631993
gene_protein 2434 amino acids 631993