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Gene: Bmal2 (basic helix-loop-helix ARNT like 2) Rattus norvegicus

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Symbol:

Bmal2

Name:

basic helix-loop-helix ARNT like 2

RGD ID:

620230

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in circadian regulation of gene expression; positive regulation of circadian rhythm; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within circadian rhythm. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of CLOCK-BMAL transcription complex and aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and type 2 diabetes mellitus. Orthologous to human BMAL2 (basic helix-loop-helix ARNT like 2); INTERACTS WITH 1,2-dimethylhydrazine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Arnt4; Arntl2; aryl hydrocarbon receptor nuclear translocator-like 2; aryl hydrocarbon receptor nuclear translocator-like protein 2; aryl hydrocarbon receptor nuclear translocator-like protein 2-like; basic helix-loop-helix ARNT-like protein 2; brain and muscle Arnt-like protein 2 variant d; hypothetical protein LOC362464; LOC102555341; LOC362464; similar to aryl hydrocarbon receptor nuclear translocator-like 2; transcription factor BMAL2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	181,429,097 - 181,478,384 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	181,430,159 - 181,478,382 (+)	Ensembl				GRCr8
mRatBN7.2	4	179,699,432 - 179,747,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	179,699,502 - 179,746,949 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	185,992,053 - 186,031,281 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	181,776,568 - 181,815,791 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	180,397,008 - 180,436,230 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	181,103,774 - 181,158,415 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	181,103,774 - 181,214,994 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	245,261,269 - 245,310,728 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	184,392,097 - 184,419,834 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	168,201,685 - 168,241,329 (+)	NCBI		Celera
RGSC_v3.1	4	184,637,241 - 184,664,934 (+)	NCBI
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (ISO)

chronic obstructive pulmonary disease (ISO)

COVID-19 (ISO)

hypertension (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

glycidol (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methyl methanesulfonate (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

okadaic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pirinixic acid (ISO)

pravastatin (EXP,ISO)

quercetin (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

trichostatin A (ISO)

troglitazone (EXP)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

circadian regulation of gene expression (IEA,ISO)

circadian rhythm (ISO)

positive regulation of circadian rhythm (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA,ISO)

rhythmic process (IEA)

Cellular Component

aryl hydrocarbon receptor complex (IBA)

CLOCK-BMAL transcription complex (IEA,ISO)

cytoplasm (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

transcription regulator complex (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

E-box binding (IEA,ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6.	Hung MS, etal., Hum Mol Genet. 2006 Sep 15;15(18):2732-42. Epub 2006 Aug 7.
4.	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.	Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication.	Okano T, etal., Neurosci Lett 2001 Mar 9;300(2):111-4.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.	Woon PY, etal., Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14412-7. Epub 2007 Aug 29.

Additional References at PubMed

PMID:10864977	PMID:12055078	PMID:12738229	PMID:15147242	PMID:19605937	PMID:23056539	PMID:24086613

Genomics

Comparative Map Data

Bmal2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	181,429,097 - 181,478,384 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	181,430,159 - 181,478,382 (+)	Ensembl				GRCr8
mRatBN7.2	4	179,699,432 - 179,747,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	179,699,502 - 179,746,949 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	185,992,053 - 186,031,281 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	181,776,568 - 181,815,791 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	180,397,008 - 180,436,230 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	181,103,774 - 181,158,415 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	181,103,774 - 181,214,994 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	245,261,269 - 245,310,728 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	184,392,097 - 184,419,834 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	168,201,685 - 168,241,329 (+)	NCBI		Celera
RGSC_v3.1	4	184,637,241 - 184,664,934 (+)	NCBI
Cytogenetic Map	4	q44	NCBI

BMAL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	27,332,836 - 27,425,286 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	27,332,836 - 27,425,289 (+)	Ensembl			hg38	GRCh38
GRCh37	12	27,485,769 - 27,578,219 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	27,377,255 - 27,464,733 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	27,377,254 - 27,464,733	NCBI
Celera	12	32,631,579 - 32,719,063 (+)	NCBI		Celera
Cytogenetic Map	12	p11.23	NCBI
HuRef	12	27,254,920 - 27,347,855 (+)	NCBI		HuRef
CHM1_1	12	27,449,651 - 27,543,757 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	27,204,471 - 27,296,954 (+)	NCBI		T2T-CHM13v2.0

Bmal2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	146,696,230 - 146,735,027 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	146,697,553 - 146,735,027 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	146,794,729 - 146,833,529 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	146,796,055 - 146,833,529 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	146,754,052 - 146,781,168 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	146,762,700 - 146,789,816 (+)	NCBI		MGSCv36	mm8
Celera	6	149,841,504 - 149,869,849 (+)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.7	NCBI

BMAL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	69,386,544 - 69,480,337 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	69,384,269 - 69,476,696 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	58,885,410 - 58,977,832 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	61,503,973 - 61,561,593 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	61,503,973 - 61,596,580 (-)	Ensembl			panPan2	panpan1.1

ARNTL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	20,304,404 - 20,420,086 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	20,306,705 - 20,420,736 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	25,968,425 - 26,091,877 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	20,496,884 - 20,615,111 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	20,500,348 - 20,615,153 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	20,303,185 - 20,419,962 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	20,331,034 - 20,448,791 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	26,131,070 - 26,254,445 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bmal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	82,255,018 - 82,318,685 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936548	182,075 - 225,856 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936548	181,793 - 241,050 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARNTL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	46,290,001 - 46,482,461 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	46,289,873 - 46,482,369 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	49,898,645 - 50,034,234 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMAL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	27,067,523 - 27,141,740 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	27,067,604 - 27,136,466 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666069	7,918,987 - 7,993,337 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmal2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	4,453,528 - 4,500,051 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bmal2
289 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	29
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000055473
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	160623982	184426481	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	176806581	181925369	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	138	72	72	44	21	44	6	237	119	10	118	50	85	28	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01033785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01033786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01033787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01033788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01033789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF327071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY014837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY014838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JQ361086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055473 ⟹ ENSRNOP00000052338

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	181,430,159 - 181,478,345 (+)	Ensembl
mRatBN7.2 Ensembl	4	179,708,335 - 179,746,949 (+)	Ensembl
Rnor_6.0 Ensembl	4	181,103,774 - 181,158,200 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077619 ⟹ ENSRNOP00000070632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	181,430,197 - 181,478,382 (+)	Ensembl
mRatBN7.2 Ensembl	4	179,699,502 - 179,746,949 (+)	Ensembl
Rnor_6.0 Ensembl	4	181,103,774 - 181,214,994 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084207 ⟹ ENSRNOP00000071979

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	181,430,197 - 181,478,382 (+)	Ensembl
mRatBN7.2 Ensembl	4	179,699,502 - 179,746,949 (+)	Ensembl
Rnor_6.0 Ensembl	4	181,103,774 - 181,158,200 (+)	Ensembl

RefSeq Acc Id:

NM_133391 ⟹ NP_596882

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,437,591 - 181,477,623 (+)	NCBI
mRatBN7.2	4	179,706,921 - 179,746,949 (+)	NCBI
Rnor_6.0	4	181,103,774 - 181,158,415 (+)	NCBI
Rnor_5.0	4	245,261,269 - 245,310,728 (+)	NCBI
Celera	4	168,201,685 - 168,241,329 (+)	NCBI

Sequence:

show sequence

ATGGAGTTTCCAAGGAAACGTAGAAGAAGTGATTCAGAGCTGCTCCAGTCAGAATTCAGGACAG
ATGCAATGGTGGAAAACCTTCCCCGGAGTCCCTTTACCTCTGTTCTTTCAACAAGAACAGGAGT
AGCAGTGCCCAATGGCATCAGGGAAGCTCACAGCCAGACAGAAAAGCGTCGGAGAGACAAGATG
AACCATCTGATTTGGAAACTGTCATCTATGATCCCTCCACACATCCCCACAGCCCACAAACTGG
ACAAACTGAGCATCCTGAGGAGGGCAGTGCAGTACTTGAGGTCTCAGAGAGGCATGACAGAGTT
TTATTTAGGAGAAAATGCTAAACCTTCATTTATTCAGGATAAGGAACTCAGCCACTTAATCCTC
AAGGCAGCAGAAGGCTTCCTACTTGTGGTTGGATGTGAAGGAGGGAGAATTCTTTTCGTTTCTA
AGTCTGTCTCCAAAACGCTGCATTATGATCAGGCTAGTTTGATGGGACAGAACTTGTTTGACTT
CTTACACCCAAAAGATGTCCCCAAAGTAAAGGAACAACTTTCTTGTGATGGTTTACTAAGAGTG
AAAGTTCACAGTCACTCCCATATTGGGCGATCACGCGTGCATTCTGGCTCCAGACGATCTTTCT
TCTTTAGAATGAAGAGCAGCTGTACAGTCCCCGTCAAAGAAGAGCAACGATGCTCGTCCTGTTC
AAAGAAGAAAGACCAGAGAAAATTCCACACCATCCATTGCACTGGATACTTGAGAAGCTGGCCA
CCGAATGTTGTGGGCACGGAGAAAGAGATGGGCAGTGGGAAAGACAGTGGTCCTCTTACCTGCC
TTGTGGCTATGGGACGGTTACAGCCATATACTGTCCCCCCGAAGAATGGCAAGATCAACGTGAG
ACCGGCTGAGTTCATAACCCGATTCGCAATGAACGGGAAATTCGTCTACGTCGACCAAAGGGCA
ACAGCAATTTTAGGATACCTGCCTGATGAACTTTTGGGAACTTCGTGTTATGAATATTTTCATC
AGGATGACCACAGTAATTTGAGTGACAAGCACAAAGCAGTTCTGCAGAGTAAGGAGAAAATACT
TACAGATTCATACAAATTCAGAGTGAAGGATGGCTCCTTTGTGACTCTGAAGAGCAAGTGGTTC
AGCTTCACTAACCCTTGGACCAAAAAGCTGGAGTACATCGTGTCTGTCAACACGCTGGTTTTGG
GGCGCAGTGAGACCGCAGTATCCGTGCCTCAGTGCCGCAGCAGCCAGTCCTCTGAAGACTCATT
TAGACAACCCTGCGTCAGTGTGCCGGGCATATCCACAGGGACCTTACTTGGCGCTGGGAGTATT
GGAACAGATATTGCAAATGAGGTTCTGAGTTTACAGAGGTCACACTCTTCATCCCCAGAAGACG
CAAACCCTTCAGGAGTAGTGAGAGATAAGCACAGTGTAAACTTCGGGAGCGCCCCTGTGCCCGT
GTCCACTGGGGAGCTCTTTGCACTGAGTCCTGAAACAGAGGGCCTGGAGGCTGCCAGGCAACAC
CAGAGTGCTGAGCCCGCCCACTGTCACAAACCACTCCTCAGTGACAGTACCCAGTTGGGTTTTG
ATGCCCTGTGTGACAGCGACGACACAGCCATGGCTACATTCATGAATTACCCCGAAGCAGAGGG
TGGCCTGGGTGACCCTGGGGACTTCAGTGACATCCAGTGGACACTCTAGCATTTTGACTTTGAA
CTCTAATGTGAGAATCATTTTAGAGTGTTTTTTTTATTTTTTTTCAGAGCTGGGAACCAAACCC
AGGGCCTTGCGCTTGCTAGGCAAGCGCCCTAACACTGAGCTGATCAACCCCAGGGTGTTTCATT
TACAAAATGCTTTACTCTTGAGCACTGTATTGATTGATACTTTGTATCTCTTATTAAGAGTCTA
CTGATTTT

hide sequence

RefSeq Acc Id:

XM_039107944 ⟹ XP_038963872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,429,097 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,699,432 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107945 ⟹ XP_038963873

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,429,109 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,699,437 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107946 ⟹ XP_038963874

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,429,098 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,699,432 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107947 ⟹ XP_038963875

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,429,111 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,699,437 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107948 ⟹ XP_038963876

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,442,915 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,712,250 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107949 ⟹ XP_038963877

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,454,811 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,724,156 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107950 ⟹ XP_038963878

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,454,825 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,724,165 - 179,747,710 (+)	NCBI

RefSeq Acc Id:

XM_039107951 ⟹ XP_038963879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	181,442,918 - 181,478,384 (+)	NCBI
mRatBN7.2	4	179,712,253 - 179,747,710 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_596882	(Get FASTA)	NCBI Sequence Viewer
	XP_038963872	(Get FASTA)	NCBI Sequence Viewer
	XP_038963873	(Get FASTA)	NCBI Sequence Viewer
	XP_038963874	(Get FASTA)	NCBI Sequence Viewer
	XP_038963875	(Get FASTA)	NCBI Sequence Viewer
	XP_038963876	(Get FASTA)	NCBI Sequence Viewer
	XP_038963877	(Get FASTA)	NCBI Sequence Viewer
	XP_038963878	(Get FASTA)	NCBI Sequence Viewer
	XP_038963879	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK12620	(Get FASTA)	NCBI Sequence Viewer
	AAK12621	(Get FASTA)	NCBI Sequence Viewer
	AAK93959	(Get FASTA)	NCBI Sequence Viewer
	AFC93435	(Get FASTA)	NCBI Sequence Viewer
	EDM01406	(Get FASTA)	NCBI Sequence Viewer
	EDM01407	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052338
	ENSRNOP00000052338.6
	ENSRNOP00000070632
	ENSRNOP00000070632.2
	ENSRNOP00000071979
	ENSRNOP00000071979.3

RefSeq Acc Id:

NP_596882 ⟸ NM_133391

- UniProtKB:

A0A0G2JYF4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEFPRKRRRSDSELLQSEFRTDAMVENLPRSPFTSVLSTRTGVAVPNGIREAHSQTEKRRRDKM
NHLIWKLSSMIPPHIPTAHKLDKLSILRRAVQYLRSQRGMTEFYLGENAKPSFIQDKELSHLIL
KAAEGFLLVVGCEGGRILFVSKSVSKTLHYDQASLMGQNLFDFLHPKDVPKVKEQLSCDGLLRV
KVHSHSHIGRSRVHSGSRRSFFFRMKSSCTVPVKEEQRCSSCSKKKDQRKFHTIHCTGYLRSWP
PNVVGTEKEMGSGKDSGPLTCLVAMGRLQPYTVPPKNGKINVRPAEFITRFAMNGKFVYVDQRA
TAILGYLPDELLGTSCYEYFHQDDHSNLSDKHKAVLQSKEKILTDSYKFRVKDGSFVTLKSKWF
SFTNPWTKKLEYIVSVNTLVLGRSETAVSVPQCRSSQSSEDSFRQPCVSVPGISTGTLLGAGSI
GTDIANEVLSLQRSHSSSPEDANPSGVVRDKHSVNFGSAPVPVSTGELFALSPETEGLEAARQH
QSAEPAHCHKPLLSDSTQLGFDALCDSDDTAMATFMNYPEAEGGLGDPGDFSDIQWTL

hide sequence

Ensembl Acc Id:

ENSRNOP00000052338 ⟸ ENSRNOT00000055473

Ensembl Acc Id:

ENSRNOP00000070632 ⟸ ENSRNOT00000077619

Ensembl Acc Id:

ENSRNOP00000071979 ⟸ ENSRNOT00000084207

RefSeq Acc Id:	XP_038963872 ⟸ XM_039107944
- Peptide Label:	isoform X1
- UniProtKB:	H9CTG8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963874 ⟸ XM_039107946
- Peptide Label:	isoform X3
- UniProtKB:	Q923L9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963873 ⟸ XM_039107945
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K1T7 (UniProtKB/TrEMBL), H9CTG8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963875 ⟸ XM_039107947
- Peptide Label:	isoform X4
- UniProtKB:	Q923L9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963876 ⟸ XM_039107948
- Peptide Label:	isoform X5
- UniProtKB:	A6IN33 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963879 ⟸ XM_039107951
- Peptide Label:	isoform X7
- UniProtKB:	A6IN33 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963877 ⟸ XM_039107949
- Peptide Label:	isoform X5
- UniProtKB:	A6IN33 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963878 ⟸ XM_039107950
- Peptide Label:	isoform X6
- UniProtKB:	A6IN33 (UniProtKB/TrEMBL)

Protein Domains

bHLH PAS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K1T7-F1-model_v2	AlphaFold	A0A0G2K1T7	1-581	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620230	AgrOrtholog
BioCyc Gene	G2FUF-42424	BioCyc
Ensembl Genes	ENSRNOG00000001830	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000055473	ENTREZGENE
	ENSRNOT00000055473.6	UniProtKB/TrEMBL
	ENSRNOT00000077619	ENTREZGENE
	ENSRNOT00000077619.3	UniProtKB/TrEMBL
	ENSRNOT00000084207	ENTREZGENE
	ENSRNOT00000084207.3	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
	PAS domain	UniProtKB/TrEMBL
InterPro	Circadian_TF	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	HLH_DNA_bd	UniProtKB/TrEMBL
	Nuc_translocat	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	PAS-like_dom_sf	UniProtKB/TrEMBL
	PAS_fold	UniProtKB/TrEMBL
NCBI Gene	Bmal2	ENTREZGENE
PANTHER	CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	PAS_11	UniProtKB/TrEMBL
PhenoGen	Bmal2	PhenoGen
PRINTS	NCTRNSLOCATR	UniProtKB/TrEMBL
PROSITE	HLH	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001830	RatGTEx
SMART	HLH	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
Superfamily-SCOP	HLH_basic	UniProtKB/TrEMBL
	SSF55785	UniProtKB/TrEMBL
UniProt	A0A0G2JYF4	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K1T7	ENTREZGENE, UniProtKB/TrEMBL
	A6IN32_RAT	UniProtKB/TrEMBL
	A6IN33	ENTREZGENE, UniProtKB/TrEMBL
	D4ADP3_RAT	UniProtKB/TrEMBL
	H9CTG8	ENTREZGENE, UniProtKB/TrEMBL
	Q923L9	ENTREZGENE, UniProtKB/TrEMBL
	Q924H3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-07-29	Bmal2	basic helix-loop-helix ARNT like 2	Arntl2	aryl hydrocarbon receptor nuclear translocator-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2021-03-09	Arntl2	aryl hydrocarbon receptor nuclear translocator-like 2	LOC102555341	aryl hydrocarbon receptor nuclear translocator-like protein 2-like	Data merged from RGD:7670714	737654	PROVISIONAL
2013-12-18	LOC102555341	aryl hydrocarbon receptor nuclear translocator-like protein 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-06-02	Arntl2	aryl hydrocarbon receptor nuclear translocator-like 2	LOC362464	similar to aryl hydrocarbon receptor nuclear translocator-like 2	Data merged from RGD:1586148	737654	APPROVED
2006-11-19	LOC362464	similar to aryl hydrocarbon receptor nuclear translocator-like 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Arntl2	aryl hydrocarbon receptor nuclear translocator-like 2		transcription factor BMAL2	Name updated	1299863	APPROVED
2002-08-07	Arntl2	transcription factor BMAL2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor	632267

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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