Snap23 (synaptosome associated protein 23) - Rat Genome Database

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Gene: Snap23 (synaptosome associated protein 23) Rattus norvegicus
Analyze
Symbol: Snap23
Name: synaptosome associated protein 23
RGD ID: 620221
Description: Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including exocytic insertion of neurotransmitter receptor to postsynaptic membrane; membrane fusion; and regulation of exocytosis. Located in terminal bouton. Part of SNARE complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human SNAP23 (synaptosome associated protein 23); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SNAP-23; synaptosomal-associated protein 23; synaptosomal-associated protein 23 kD; synaptosomal-associated protein, 23 kD; vesicle-membrane fusion protein SNAP-23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,966,184 - 127,999,929 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3127,967,886 - 127,998,067 (+)EnsemblGRCr8
mRatBN7.23107,514,088 - 107,546,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3107,514,131 - 107,544,320 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,188,811 - 111,219,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,784,379 - 119,814,692 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03117,444,773 - 117,475,086 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3125,833,631 - 125,863,942 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3132,750,136 - 132,780,432 (+)NCBILyon_Normotensive
Lyon_Hypertensive3124,629,960 - 124,660,271 (+)NCBILyon_Hypertensive
F344_StmMcwi3105,934,483 - 105,964,794 (+)NCBIF344_StmMcwi
Rnor_6.03112,333,972 - 112,362,960 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03118,880,898 - 118,909,856 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43107,361,066 - 107,362,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3106,422,362 - 106,451,900 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP)
finasteride  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
graphite  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nicotinamide  (EXP)
nitrates  (ISO)
oleic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)
SNAP receptor activity  (IBA,IDA)
syntaxin binding  (IBA,IEA,IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Banerjee A, etal., Am J Physiol Cell Physiol. 2001 Apr;280(4):C775-81.
2. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Differential vesicular sorting of AMPA and GABAA receptors. Gu Y, etal., Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.1073/pnas.1525726113. Epub 2016 Feb 2.
5. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
9. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. Rao SK, etal., J Biol Chem. 2004 May 7;279(19):20471-9. Epub 2004 Mar 1.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Membrane fusion between liposomes containing SNARE proteins involved in mast cell exocytosis. Sakiyama H, etal., Inflamm Res. 2009 Mar;58(3):139-42.
14. SNAP-23 participates in SNARE complex assembly in rat adipose cells. St-Denis JF, etal., Biochem J 1999 Mar 15;338 ( Pt 3):709-15.
15. A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking. Suh YH, etal., Nat Neurosci. 2010 Mar;13(3):338-43. doi: 10.1038/nn.2488. Epub 2010 Jan 31.
16. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Suzuki K and Verma IM, Cell. 2008 Aug 8;134(3):485-95. doi: 10.1016/j.cell.2008.05.050.
17. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
18. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
Additional References at PubMed
PMID:10510169   PMID:10825299   PMID:12477932   PMID:15035620   PMID:15542596   PMID:15611044   PMID:16516346   PMID:16677249   PMID:17575076   PMID:18253931   PMID:18457912   PMID:18505797  
PMID:18535671   PMID:18588921   PMID:18973100   PMID:19056867   PMID:19515809   PMID:19735702   PMID:20458337   PMID:20519516   PMID:21423176   PMID:22713544   PMID:23376485   PMID:23380067  
PMID:25468996   PMID:26733245   PMID:26930561   PMID:28119011   PMID:28240595   PMID:29485121   PMID:33213278   PMID:34147527   PMID:37057886  


Genomics

Comparative Map Data
Snap23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,966,184 - 127,999,929 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3127,967,886 - 127,998,067 (+)EnsemblGRCr8
mRatBN7.23107,514,088 - 107,546,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3107,514,131 - 107,544,320 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,188,811 - 111,219,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03119,784,379 - 119,814,692 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03117,444,773 - 117,475,086 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3125,833,631 - 125,863,942 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3132,750,136 - 132,780,432 (+)NCBILyon_Normotensive
Lyon_Hypertensive3124,629,960 - 124,660,271 (+)NCBILyon_Hypertensive
F344_StmMcwi3105,934,483 - 105,964,794 (+)NCBIF344_StmMcwi
Rnor_6.03112,333,972 - 112,362,960 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03118,880,898 - 118,909,856 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43107,361,066 - 107,362,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3106,422,362 - 106,451,900 (+)NCBICelera
Cytogenetic Map3q35NCBI
SNAP23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381542,491,129 - 42,533,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1542,491,233 - 42,545,356 (+)Ensemblhg38GRCh38
GRCh371542,787,832 - 42,825,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361540,575,127 - 40,612,548 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1519,555,540 - 19,592,958 (+)NCBICelera
Cytogenetic Map15q15.1-q15.2NCBI
HuRef1519,635,345 - 19,673,071 (+)NCBIHuRef
CHM1_11542,905,940 - 42,943,698 (+)NCBICHM1_1
T2T-CHM13v2.01540,297,171 - 40,339,102 (+)NCBIT2T-CHM13v2.0
Snap23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392120,398,137 - 120,436,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2120,398,152 - 120,431,736 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382120,567,655 - 120,601,255 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2120,567,671 - 120,601,255 (+)Ensemblmm10GRCm38
MGSCv372120,393,407 - 120,426,458 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362120,259,112 - 120,292,163 (+)NCBIMGSCv36mm8
Celera2121,720,414 - 121,753,492 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
Snap23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554169,190,623 - 9,225,103 (+)Ensembl
ChiLan1.0NW_0049554169,191,123 - 9,225,103 (+)NCBIChiLan1.0ChiLan1.0
SNAP23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21631,741,494 - 31,783,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11535,898,461 - 35,940,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01521,456,247 - 21,494,340 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11539,608,479 - 39,650,759 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1539,612,445 - 39,650,759 (+)EnsemblpanPan2panpan1.1
SNAP23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1309,453,931 - 9,493,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl309,456,084 - 9,492,329 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha309,511,812 - 9,550,895 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0309,589,363 - 9,628,453 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl309,591,559 - 9,629,150 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1309,508,701 - 9,547,616 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0309,615,029 - 9,654,170 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0309,747,912 - 9,786,884 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Snap23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864087,932,868 - 87,970,585 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364715,784,054 - 5,820,571 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364715,784,070 - 5,818,644 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAP23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1128,847,931 - 128,888,947 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11128,849,465 - 128,888,972 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21143,742,362 - 143,781,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNAP23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12640,443,478 - 40,485,211 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2640,442,615 - 40,482,346 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048100,526,825 - 100,568,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snap23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248049,610,308 - 9,641,933 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248049,609,777 - 9,643,670 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Snap23
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1598,698,534 - 98,727,185 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Snap23
226 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:113
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000074392
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BF386077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23107,530,721 - 107,530,875 (+)MAPPERmRatBN7.2
Rnor_6.03112,350,559 - 112,350,712NCBIRnor6.0
Rnor_5.03118,897,455 - 118,897,608UniSTSRnor5.0
Celera3106,438,944 - 106,439,097UniSTS
RH 3.4 Map3941.3UniSTS
Cytogenetic Map3q25UniSTS
RH127866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23107,543,975 - 107,544,166 (+)MAPPERmRatBN7.2
Rnor_6.03112,362,616 - 112,362,806NCBIRnor6.0
Rnor_5.03118,909,512 - 118,909,702UniSTSRnor5.0
RGSC_v3.43107,362,534 - 107,362,724UniSTSRGSC3.4
Celera3106,451,556 - 106,451,746UniSTS
RH 3.4 Map3939.8UniSTS
Cytogenetic Map3q25UniSTS
RH140008  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83127,997,226 - 127,997,413 (+)Marker Load Pipeline
mRatBN7.23107,543,477 - 107,543,664 (+)MAPPERmRatBN7.2
Rnor_6.03112,362,118 - 112,362,304NCBIRnor6.0
Rnor_5.03118,909,014 - 118,909,200UniSTSRnor5.0
RGSC_v3.43107,362,036 - 107,362,222UniSTSRGSC3.4
Celera3106,451,058 - 106,451,244UniSTS
RH 3.4 Map3946.7UniSTS
Cytogenetic Map3q25UniSTS
RH141559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23107,543,039 - 107,543,237 (+)MAPPERmRatBN7.2
Rnor_6.03112,361,680 - 112,361,877NCBIRnor6.0
Rnor_5.03118,908,576 - 118,908,773UniSTSRnor5.0
RGSC_v3.43107,361,598 - 107,361,795UniSTSRGSC3.4
Celera3106,450,620 - 106,450,817UniSTS
RH 3.4 Map3940.5UniSTS
Cytogenetic Map3q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074392   ⟹   ENSRNOP00000064401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3107,514,150 - 107,542,815 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096953   ⟹   ENSRNOP00000091304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3107,514,131 - 107,544,320 (+)Ensembl
RefSeq Acc Id: NM_001429469   ⟹   NP_001416398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd3125,833,631 - 125,863,942 (+)NCBI
Lyon_Normotensive3132,750,136 - 132,780,432 (+)NCBI
Lyon_Hypertensive3124,629,960 - 124,660,271 (+)NCBI
F344_StmMcwi3105,934,483 - 105,964,794 (+)NCBI
RefSeq Acc Id: NM_001429470   ⟹   NP_001416399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd3125,833,631 - 125,863,942 (+)NCBI
Lyon_Normotensive3132,750,136 - 132,780,432 (+)NCBI
Lyon_Hypertensive3124,629,960 - 124,660,271 (+)NCBI
F344_StmMcwi3105,934,483 - 105,964,794 (+)NCBI
RefSeq Acc Id: NM_022689   ⟹   NP_073180
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,967,886 - 127,998,069 (+)NCBI
mRatBN7.23107,514,138 - 107,544,320 (+)NCBI
Dahl_SR_JrHsd3125,833,631 - 125,863,942 (+)NCBI
Lyon_Normotensive3132,750,136 - 132,780,432 (+)NCBI
Lyon_Hypertensive3124,629,960 - 124,660,271 (+)NCBI
F344_StmMcwi3105,934,483 - 105,964,794 (+)NCBI
Rnor_6.03112,333,972 - 112,362,960 (+)NCBI
Rnor_5.03118,880,898 - 118,909,856 (+)NCBI
RGSC_v3.43107,361,066 - 107,362,878 (+)RGD
Celera3106,422,362 - 106,451,900 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105811   ⟹   XP_038961739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,966,184 - 127,999,929 (+)NCBI
mRatBN7.23107,514,088 - 107,546,177 (+)NCBI
RefSeq Acc Id: XM_039105812   ⟹   XP_038961740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,967,838 - 127,997,456 (+)NCBI
mRatBN7.23107,514,091 - 107,546,177 (+)NCBI
RefSeq Acc Id: XM_039105813   ⟹   XP_038961741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,966,184 - 127,999,929 (+)NCBI
mRatBN7.23107,514,093 - 107,546,177 (+)NCBI
RefSeq Acc Id: XM_063284525   ⟹   XP_063140595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,966,184 - 127,999,929 (+)NCBI
RefSeq Acc Id: XM_063284526   ⟹   XP_063140596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,968,969 - 127,999,929 (+)NCBI
RefSeq Acc Id: NP_073180   ⟸   NM_022689
- UniProtKB: A0JPL8 (UniProtKB/Swiss-Prot),   O70377 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038961739   ⟸   XM_039105811
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961740   ⟸   XM_039105812
- Peptide Label: isoform X1
- UniProtKB: M0R4V3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961741   ⟸   XM_039105813
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000064401   ⟸   ENSRNOT00000074392
Ensembl Acc Id: ENSRNOP00000091304   ⟸   ENSRNOT00000096953
RefSeq Acc Id: XP_063140595   ⟸   XM_063284525
- Peptide Label: isoform X2
- UniProtKB: O70377 (UniProtKB/Swiss-Prot),   A0JPL8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140596   ⟸   XM_063284526
- Peptide Label: isoform X2
- UniProtKB: O70377 (UniProtKB/Swiss-Prot),   A0JPL8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001416398   ⟸   NM_001429469
RefSeq Acc Id: NP_001416399   ⟸   NM_001429470
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4V3-F1-model_v2 AlphaFold M0R4V3 1-210 view protein structure
AF-O70377-F1-model_v2 AlphaFold O70377 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620221 AgrOrtholog
BioCyc Gene G2FUF-48161 BioCyc
Ensembl Genes ENSRNOG00000050552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074392 ENTREZGENE
  ENSRNOT00000096953 ENTREZGENE
  ENSRNOT00000096953.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8361815 IMAGE-MGC_LOAD
InterPro SNAP-25 UniProtKB/Swiss-Prot
  T_SNARE_dom UniProtKB/Swiss-Prot
KEGG Report rno:64630 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156644 IMAGE-MGC_LOAD
NCBI Gene 64630 ENTREZGENE
PANTHER SYNAPTOSOMAL ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  SYNAPTOSOMAL-ASSOCIATED PROTEIN 23 UniProtKB/Swiss-Prot
Pfam SNAP-25 UniProtKB/Swiss-Prot
PhenoGen Snap23 PhenoGen
PROSITE T_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050552 RatGTEx
SMART t_SNARE UniProtKB/Swiss-Prot
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot
UniProt A0JPL8 ENTREZGENE
  A6HPK2_RAT UniProtKB/TrEMBL
  M0R4V3 ENTREZGENE, UniProtKB/TrEMBL
  O70377 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Snap23  synaptosome associated protein 23  Snap23  synaptosomal-associated protein 23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Snap23  synaptosomal-associated protein 23    synaptosomal-associated protein, 23 kD  Name updated 1299863 APPROVED
2002-08-07 Snap23  synaptosomal-associated protein, 23 kD      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with syntaxin 4 in the plasma membrane 634161
gene_process involved in the process of membrane fusion and synaptic vesicle exocytosis 634161