Prpsap2 (phosphoribosyl pyrophosphate synthetase-associated protein 2) - Rat Genome Database

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Gene: Prpsap2 (phosphoribosyl pyrophosphate synthetase-associated protein 2) Rattus norvegicus
Analyze
Symbol: Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
RGD ID: 620207
Description: Predicted to enable enzyme regulator activity and identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to act upstream of or within bone development. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 41 kDa phosphoribosypyrophosphate synthetase-associated protein; MGC93257; Pap41; phosphoribosyl pyrophosphate synthase-associated protein 2; PRPP synthase-associated protein 2; PRPP synthetase-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Scl83
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,910,282 - 46,945,401 (-)NCBIGRCr8
mRatBN7.21046,410,817 - 46,445,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,410,835 - 46,445,849 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,114,262 - 51,149,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,604,795 - 50,639,567 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,108,208 - 46,142,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,008,799 - 48,044,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,008,802 - 48,044,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,801,645 - 47,837,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,890,667 - 47,925,430 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,904,289 - 47,939,053 (-)NCBI
Celera1045,658,797 - 45,693,561 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, etal., J Biochem. 1989 May;105(5):736-41.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein. Sonoda T, etal., Biochim Biophys Acta 1997 Jan 3;1350(1):6-10.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:22876197   PMID:24625528   PMID:31505169   PMID:35352799  


Genomics

Comparative Map Data
Prpsap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,910,282 - 46,945,401 (-)NCBIGRCr8
mRatBN7.21046,410,817 - 46,445,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,410,835 - 46,445,849 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,114,262 - 51,149,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,604,795 - 50,639,567 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,108,208 - 46,142,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,008,799 - 48,044,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,008,802 - 48,044,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,801,645 - 47,837,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,890,667 - 47,925,430 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,904,289 - 47,939,053 (-)NCBI
Celera1045,658,797 - 45,693,561 (-)NCBICelera
Cytogenetic Map10q22NCBI
PRPSAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,856,299 - 18,931,287 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,840,085 - 18,931,287 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,759,612 - 18,834,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,702,217 - 18,775,305 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,702,216 - 18,775,305NCBI
Celera1720,676,623 - 20,748,896 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,325,616 - 18,400,327 (+)NCBIHuRef
CHM1_11718,768,404 - 18,843,360 (+)NCBICHM1_1
T2T-CHM13v2.01718,802,453 - 18,877,802 (+)NCBIT2T-CHM13v2.0
Prpsap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,620,476 - 61,652,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,620,476 - 61,652,914 (-)EnsemblGRCm39 Ensembl
GRCm381161,729,650 - 61,762,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,729,650 - 61,762,088 (-)EnsemblGRCm38mm10GRCm38
MGSCv371161,543,152 - 61,575,590 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,545,849 - 61,578,257 (-)NCBIMGSCv36mm8
MGSCv361162,158,719 - 62,191,127 (-)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Prpsap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467676,195 - 722,233 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955467676,845 - 722,175 (-)NCBIChiLan1.0ChiLan1.0
PRPSAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,920,357 - 53,996,595 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11758,542,037 - 58,618,788 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,316,289 - 32,392,531 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,247,504 - 37,321,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,247,504 - 37,320,704 (-)Ensemblpanpan1.1panPan2
PRPSAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,118,591 - 41,167,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,039,015 - 41,167,568 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,259,690 - 41,308,531 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,226,139 - 41,275,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,222,994 - 41,275,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,193,893 - 41,242,719 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,141,286 - 41,190,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,333,180 - 41,382,030 (-)NCBIUU_Cfam_GSD_1.0
Prpsap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,871,181 - 59,905,264 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881682,530 - 715,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936881682,011 - 716,082 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPSAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,340,883 - 60,376,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,340,879 - 60,387,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,850,813 - 62,869,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRPSAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,573,627 - 17,634,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660593,238,732 - 3,312,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prpsap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,298,410 - 5,334,161 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,298,389 - 5,334,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prpsap2
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:134
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000003697
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
AA859332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,410,983 - 46,411,189 (+)MAPPERmRatBN7.2
Rnor_6.01048,008,966 - 48,009,171NCBIRnor6.0
Rnor_5.01047,801,812 - 47,802,017UniSTSRnor5.0
RGSC_v3.41047,890,574 - 47,890,779UniSTSRGSC3.4
Celera1045,658,704 - 45,658,909UniSTS
RH 3.4 Map10531.67UniSTS
Cytogenetic Map10q23UniSTS
AI237790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,446,944 - 46,447,143 (+)MAPPERmRatBN7.2
Rnor_6.01048,045,447 - 48,045,645NCBIRnor6.0
Rnor_5.01047,838,293 - 47,838,491UniSTSRnor5.0
RGSC_v3.41047,926,533 - 47,926,731UniSTSRGSC3.4
Celera1045,694,664 - 45,694,862UniSTS
RH 3.4 Map10531.99UniSTS
Cytogenetic Map10q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003697   ⟹   ENSRNOP00000003697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,410,835 - 46,445,849 (-)Ensembl
Rnor_6.0 Ensembl1048,009,059 - 48,044,344 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078448   ⟹   ENSRNOP00000071665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1048,008,802 - 48,038,647 (-)Ensembl
RefSeq Acc Id: NM_057131   ⟹   NP_476472
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,542 - 46,945,303 (-)NCBI
mRatBN7.21046,411,077 - 46,445,842 (-)NCBI
Rnor_6.01048,009,059 - 48,044,344 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
RGSC_v3.41047,890,667 - 47,925,430 (-)RGD
Celera1045,658,797 - 45,693,561 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246435   ⟹   XP_006246497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,351 (-)NCBI
mRatBN7.21046,410,817 - 46,445,891 (-)NCBI
Rnor_6.01048,008,799 - 48,044,345 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246436   ⟹   XP_006246498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,401 (-)NCBI
mRatBN7.21046,410,817 - 46,445,929 (-)NCBI
Rnor_6.01048,008,799 - 48,044,435 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246437   ⟹   XP_006246499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,361 (-)NCBI
mRatBN7.21046,410,817 - 46,445,898 (-)NCBI
Rnor_6.01048,008,799 - 48,044,343 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246439   ⟹   XP_006246501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,368 (-)NCBI
mRatBN7.21046,410,817 - 46,445,903 (-)NCBI
Rnor_6.01048,008,799 - 48,044,340 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246440   ⟹   XP_006246502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,369 (-)NCBI
mRatBN7.21046,410,817 - 46,445,903 (-)NCBI
Rnor_6.01048,008,799 - 48,044,340 (-)NCBI
Rnor_5.01047,801,645 - 47,837,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767764   ⟹   XP_008765986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,368 (-)NCBI
mRatBN7.21046,410,817 - 46,445,902 (-)NCBI
Rnor_6.01048,008,799 - 48,044,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085078   ⟹   XP_038941006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,323 (-)NCBI
mRatBN7.21046,410,817 - 46,445,835 (-)NCBI
RefSeq Acc Id: XM_039085080   ⟹   XP_038941008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,351 (-)NCBI
mRatBN7.21046,410,817 - 46,445,891 (-)NCBI
RefSeq Acc Id: XM_039085083   ⟹   XP_038941011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,369 (-)NCBI
mRatBN7.21046,410,817 - 46,445,903 (-)NCBI
RefSeq Acc Id: XM_063268326   ⟹   XP_063124396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,944,663 (-)NCBI
RefSeq Acc Id: XM_063268327   ⟹   XP_063124397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,351 (-)NCBI
RefSeq Acc Id: XM_063268328   ⟹   XP_063124398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,944,664 (-)NCBI
RefSeq Acc Id: XM_063268329   ⟹   XP_063124399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,944,664 (-)NCBI
RefSeq Acc Id: XM_063268330   ⟹   XP_063124400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,331 (-)NCBI
RefSeq Acc Id: XM_063268331   ⟹   XP_063124401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,318 (-)NCBI
RefSeq Acc Id: XM_063268332   ⟹   XP_063124402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,298 (-)NCBI
RefSeq Acc Id: XM_063268333   ⟹   XP_063124403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,319 (-)NCBI
RefSeq Acc Id: XM_063268335   ⟹   XP_063124405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,388 (-)NCBI
RefSeq Acc Id: XM_063268336   ⟹   XP_063124406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,329 (-)NCBI
RefSeq Acc Id: XM_063268337   ⟹   XP_063124407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,340 (-)NCBI
RefSeq Acc Id: XM_063268338   ⟹   XP_063124408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,910,282 - 46,945,329 (-)NCBI
Protein Sequences
Protein RefSeqs NP_476472 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246497 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246498 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246499 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246501 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246502 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765986 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941006 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941008 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941011 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124396 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124397 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124398 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124399 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124400 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124401 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124403 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124405 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124406 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124407 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124408 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78755 (Get FASTA)   NCBI Sequence Viewer  
  BAA19517 (Get FASTA)   NCBI Sequence Viewer  
  EDM04692 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003697.2
  ENSRNOP00055037063
  ENSRNOP00060041879
  ENSRNOP00065009032
GenBank Protein O08618 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476472   ⟸   NM_057131
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246498   ⟸   XM_006246436
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246502   ⟸   XM_006246440
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006246501   ⟸   XM_006246439
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006246499   ⟸   XM_006246437
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246497   ⟸   XM_006246435
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765986   ⟸   XM_008767764
- Peptide Label: isoform X4
- UniProtKB: Q6AZ40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071665   ⟸   ENSRNOT00000078448
Ensembl Acc Id: ENSRNOP00000003697   ⟸   ENSRNOT00000003697
RefSeq Acc Id: XP_038941011   ⟸   XM_039085083
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038941008   ⟸   XM_039085080
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941006   ⟸   XM_039085078
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124405   ⟸   XM_063268335
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124397   ⟸   XM_063268327
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124407   ⟸   XM_063268337
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124400   ⟸   XM_063268330
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124408   ⟸   XM_063268338
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063124406   ⟸   XM_063268336
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124403   ⟸   XM_063268333
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124401   ⟸   XM_063268331
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124402   ⟸   XM_063268332
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124399   ⟸   XM_063268329
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124398   ⟸   XM_063268328
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124396   ⟸   XM_063268326
- Peptide Label: isoform X1
- UniProtKB: O08618 (UniProtKB/Swiss-Prot),   A6HF87 (UniProtKB/TrEMBL)
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08618-F1-model_v2 AlphaFold O08618 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697265
Promoter ID:EPDNEW_R7790
Type:initiation region
Name:Prpsap2_1
Description:phosphoribosyl pyrophosphate synthetase-associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01048,044,347 - 48,044,407EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620207 AgrOrtholog
BioCyc Gene G2FUF-24789 BioCyc
Ensembl Genes ENSRNOG00000002724 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055026181 UniProtKB/Swiss-Prot
  ENSRNOG00060028930 UniProtKB/Swiss-Prot
  ENSRNOG00065007862 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003697.4 UniProtKB/Swiss-Prot
  ENSRNOT00055045194 UniProtKB/Swiss-Prot
  ENSRNOT00060050263 UniProtKB/Swiss-Prot
  ENSRNOT00065012332 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113134 IMAGE-MGC_LOAD
InterPro Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117272 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93257 IMAGE-MGC_LOAD
NCBI Gene 117272 ENTREZGENE
PANTHER PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prpsap2 PhenoGen
RatGTEx ENSRNOG00000002724 RatGTEx
  ENSRNOG00055026181 RatGTEx
  ENSRNOG00060028930 RatGTEx
  ENSRNOG00065007862 RatGTEx
SMART Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HF87 ENTREZGENE, UniProtKB/TrEMBL
  KPRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AZ40 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Prpsap2  phosphoribosyl pyrophosphate synthetase-associated protein 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Prpsap2  phosphoribosyl pyrophosphate synthetase-associated protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL