Ap2s1 (adaptor related protein complex 2 subunit sigma 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ap2s1 (adaptor related protein complex 2 subunit sigma 1) Rattus norvegicus
Analyze
Symbol: Ap2s1
Name: adaptor related protein complex 2 subunit sigma 1
RGD ID: 620188
Description: Predicted to enable clathrin adaptor activity. Involved in postsynaptic neurotransmitter receptor internalization. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; Huntington's disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AP-2 complex subunit sigma; Ap17; clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; clathrin coat assembly protein AP17; clathrin coat-associated protein AP17; clathrin-associated protein 17; LOC360306; plasma membrane adaptor AP-2 17 kDa protein; sigma-adaptin 3b; sigma2-adaptin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,545,601 - 86,557,007 (+)NCBIGRCr8
mRatBN7.2177,417,496 - 77,428,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,417,477 - 77,428,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,798,123 - 82,809,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,362,165 - 91,373,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,553,217 - 84,564,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,671,238 - 78,682,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,918,162 - 79,929,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,069,144 - 77,081,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,147,255 - 77,159,301NCBI
Celera171,902,755 - 71,914,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Kastning K, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6. Epub 2007 Feb 8.
5. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. Kirchhausen T, etal., J Biol Chem 1991 Jun 15;266(17):11153-7.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Targeting signals and subunit interactions in coated vesicle adaptor complexes. Page LJ and Robinson MS, J Cell Biol. 1995 Nov;131(3):619-30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
15. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, etal., J Cell Biol. 1996 Jun;133(6):1237-50. doi: 10.1083/jcb.133.6.1237.
16. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
17. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
Additional References at PubMed
PMID:10908605   PMID:12086608   PMID:12477932   PMID:15489334   PMID:29476059  


Genomics

Comparative Map Data
Ap2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,545,601 - 86,557,007 (+)NCBIGRCr8
mRatBN7.2177,417,496 - 77,428,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,417,477 - 77,428,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,798,123 - 82,809,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,362,165 - 91,373,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,553,217 - 84,564,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,671,238 - 78,682,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,918,162 - 79,929,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,069,144 - 77,081,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,147,255 - 77,159,301NCBI
Celera171,902,755 - 71,914,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
AP2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,838,167 - 46,850,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,838,136 - 46,850,846 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,341,424 - 47,354,103 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,033,263 - 52,046,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,033,263 - 52,045,931NCBI
Celera1944,145,679 - 44,158,458 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,766,567 - 43,779,262 (-)NCBIHuRef
CHM1_11947,343,326 - 47,356,098 (-)NCBICHM1_1
T2T-CHM13v2.01949,664,001 - 49,676,674 (-)NCBIT2T-CHM13v2.0
Ap2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,472,369 - 16,483,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,472,335 - 16,483,219 (+)EnsemblGRCm39 Ensembl
GRCm38716,738,444 - 16,749,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,738,410 - 16,749,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,323,793 - 17,334,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,896,984 - 15,907,814 (+)NCBIMGSCv36mm8
Celera713,936,944 - 13,947,790 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Ap2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574830,910 - 846,161 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574835,272 - 845,710 (-)NCBIChiLan1.0ChiLan1.0
AP2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,985,343 - 52,998,184 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,856,517 - 54,869,298 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,827,907 - 43,840,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,357,145 - 52,357,805 (-)NCBIpanpan1.1PanPan1.1panPan2
AP2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,094,098 - 109,105,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,082,221 - 109,105,230 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,573,732 - 108,584,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,619,436 - 109,630,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,619,492 - 109,630,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,297,177 - 109,308,314 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,930,932 - 108,942,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,799,650 - 109,811,014 (+)NCBIUU_Cfam_GSD_1.0
AP2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,695,640 - 52,703,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,695,640 - 52,703,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,066,402 - 48,073,966 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,175,106 - 40,194,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607319,888,365 - 19,901,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,787,149 - 6,797,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,788,149 - 6,797,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ap2s1
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:134
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000021310
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
RH128591  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,428,721 - 77,428,902 (+)MAPPERmRatBN7.2
Rnor_6.0178,682,666 - 78,682,846NCBIRnor6.0
Rnor_5.0179,929,321 - 79,929,501UniSTSRnor5.0
RGSC_v3.4177,081,009 - 77,081,189UniSTSRGSC3.4
Celera171,914,059 - 71,914,239UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021310   ⟹   ENSRNOP00000021310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,422,281 - 77,428,905 (+)Ensembl
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094499   ⟹   ENSRNOP00000096265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,417,487 - 77,428,851 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118847   ⟹   ENSRNOP00000095780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,418,049 - 77,428,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119694   ⟹   ENSRNOP00000083093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,417,477 - 77,428,903 (+)Ensembl
RefSeq Acc Id: NM_022952   ⟹   NP_075241
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,545,601 - 86,557,007 (+)NCBI
mRatBN7.2177,417,496 - 77,428,903 (+)NCBI
Rnor_6.0178,671,238 - 78,682,847 (+)NCBI
Rnor_5.0179,918,162 - 79,929,502 (+)NCBI
RGSC_v3.4177,069,144 - 77,081,190 (+)RGD
Celera171,902,755 - 71,914,240 (+)RGD
Sequence:
RefSeq Acc Id: NP_075241   ⟸   NM_022952
- UniProtKB: P62744 (UniProtKB/Swiss-Prot),   A6J8C1 (UniProtKB/TrEMBL),   A0A8L2QC47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021310   ⟸   ENSRNOT00000021310
Ensembl Acc Id: ENSRNOP00000083093   ⟸   ENSRNOT00000119694
Ensembl Acc Id: ENSRNOP00000095780   ⟸   ENSRNOT00000118847
Ensembl Acc Id: ENSRNOP00000096265   ⟸   ENSRNOT00000094499
Protein Domains
AP complex mu/sigma subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62744-F1-model_v2 AlphaFold P62744 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689735
Promoter ID:EPDNEW_R260
Type:initiation region
Name:Ap2s1_1
Description:adaptor-related protein complex 2, sigma 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,671,213 - 78,671,273EPDNEW
RGD ID:13689742
Promoter ID:EPDNEW_R261
Type:initiation region
Name:AC127887_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,687,026 - 78,687,086EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620188 AgrOrtholog
BioCyc Gene G2FUF-60599 BioCyc
Ensembl Genes ENSRNOG00000015865 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030844 UniProtKB/Swiss-Prot
  ENSRNOG00060021554 UniProtKB/Swiss-Prot
  ENSRNOG00065031779 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021310.6 UniProtKB/TrEMBL
  ENSRNOT00000094499.1 UniProtKB/TrEMBL
  ENSRNOT00000118847.1 UniProtKB/TrEMBL
  ENSRNOT00000119694.1 UniProtKB/Swiss-Prot
  ENSRNOT00055053545 UniProtKB/Swiss-Prot
  ENSRNOT00060037498 UniProtKB/Swiss-Prot
  ENSRNOT00065054781 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7374432 IMAGE-MGC_LOAD
InterPro AP_complex_ssu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_sm-chain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Longin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65046 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108685 IMAGE-MGC_LOAD
NCBI Gene 65046 ENTREZGENE
PANTHER PTHR11753 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11753:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ap2s1 PhenoGen
PIRSF AP_complex_sigma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015865 RatGTEx
  ENSRNOG00055030844 RatGTEx
  ENSRNOG00060021554 RatGTEx
  ENSRNOG00065031779 RatGTEx
Superfamily-SCOP SSF64356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKF9_RAT UniProtKB/TrEMBL
  A0A8I6AT11_RAT UniProtKB/TrEMBL
  A0A8L2QC47 ENTREZGENE, UniProtKB/TrEMBL
  A6J8C1 ENTREZGENE, UniProtKB/TrEMBL
  A6J8C3_RAT UniProtKB/TrEMBL
  AP2S1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70626 UniProtKB/Swiss-Prot
  P97626 UniProtKB/Swiss-Prot
  Q00380 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap2s1  adaptor related protein complex 2 subunit sigma 1  Ap2s1  adaptor-related protein complex 2, sigma 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Ap2s1  adaptor-related protein complex 2, sigma 1 subunit  Ap2s1_predicted  adaptor-related protein complex 2, sigma 1 subunit (predicted)  Data merged from RGD:1309711 737654 APPROVED
2005-01-20 Ap2s1  adaptor-related protein complex 2, sigma 1 subunit    clathrin-associated protein 17  Name updated 1299863 APPROVED
2005-01-12 Ap2s1_predicted  adaptor-related protein complex 2, sigma 1 subunit (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Ap2s1  clathrin-associated protein 17      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity to yeast Yap17p 727584