Ap2s1 (adaptor related protein complex 2 subunit sigma 1) - Rat Genome Database

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Gene: Ap2s1 (adaptor related protein complex 2 subunit sigma 1) Rattus norvegicus
Analyze
Symbol: Ap2s1
Name: adaptor related protein complex 2 subunit sigma 1
RGD ID: 620188
Description: Predicted to enable clathrin adaptor activity. Involved in postsynaptic neurotransmitter receptor internalization. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; Huntington's disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AP-2 complex subunit sigma; Ap17; clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; clathrin coat assembly protein AP17; clathrin coat-associated protein AP17; clathrin-associated protein 17; LOC360306; plasma membrane adaptor AP-2 17 kDa protein; sigma-adaptin 3b; sigma2-adaptin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,545,601 - 86,557,007 (+)NCBIGRCr8
mRatBN7.2177,417,496 - 77,428,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,417,477 - 77,428,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,798,123 - 82,809,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,362,165 - 91,373,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,553,217 - 84,564,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,671,238 - 78,682,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,918,162 - 79,929,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,069,144 - 77,081,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,147,255 - 77,159,301NCBI
Celera171,902,755 - 71,914,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Ap2s1RatCOVID-19  ISOAP2S1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
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Original Reference(s)
Ap2s1Ratfamilial hypocalciuric hypercalcemia 3  ISOAP2S1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:1524075 more ...
Ap2s1Ratgenetic disease  ISOAP2S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Ap2s1RatNeurodevelopmental Disorders  ISOAP2S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
Ap2s1Ratfamilial hypocalciuric hypercalcemia 3  ISOAP2S1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23222959
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Original Reference(s)
Ap2s1Ratfamilial hypocalciuric hypercalcemia 3  ISOAP2S1 (Homo sapiens)7240710 OMIM 

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Ap2s1Rat1,2-dimethylhydrazine increases expressionISOAp2s1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of AP2S1 mRNACTDPMID:22206623
Ap2s1Rat1,2-dimethylhydrazine multiple interactionsISOAp2s1 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of AP2S1 mRNA]CTDPMID:22206623
Ap2s1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of AP2S1 mRNACTDPMID:32145629
Ap2s1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOAp2s1 (Mus musculus)64804642 more ...CTDPMID:30294300
Ap2s1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOAP2S1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ap2s1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAp2s1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of AP2S1 mRNACTDPMID:21570461 and PMID:24680724
Ap2s1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of AP2S1 mRNACTDPMID:33387578 and PMID:34747641
Ap2s1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AP2S1 mRNACTDPMID:32109520
Ap2s1Rat2,4,6-tribromophenol decreases expressionISOAP2S1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ap2s1Rat2-bromohexadecanoic acid multiple interactionsISOAP2S1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of AP2S1 protein]CTDPMID:38195004
Ap2s1Rat2-hydroxypropanoic acid decreases expressionISOAP2S1 (Homo sapiens)6480464Lactic Acid results in decreased expression of AP2S1 mRNACTDPMID:30851411
Ap2s1Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of AP2S1 mRNACTDPMID:19162173
Ap2s1Rat4,4'-sulfonyldiphenol increases expressionISOAp2s1 (Mus musculus)6480464bisphenol S results in increased expression of AP2S1 mRNACTDPMID:39298647
Ap2s1Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of AP2S1 mRNACTDPMID:36041667
Ap2s1Rat5-fluorouracil multiple interactionsISOAP2S1 (Homo sapiens)6480464[Fluorouracil co-treated with irinotecan] results in decreased expression of AP2S1 mRNACTDPMID:16391804
Ap2s1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of AP2S1 mRNACTDPMID:30047161
Ap2s1Rataflatoxin B1 increases expressionISOAP2S1 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of AP2S1 mRNACTDPMID:27153756
Ap2s1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of AP2S1 mRNACTDPMID:16483693
Ap2s1Ratantirheumatic drug decreases expressionISOAP2S1 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of AP2S1 mRNACTDPMID:24449571
Ap2s1Ratarsane affects methylationISOAP2S1 (Homo sapiens)6480464Arsenic affects the methylation of AP2S1 geneCTDPMID:25304211

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Biological Process
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Original Reference(s)
Ap2s1Ratbiological_process  ND 159840711/2017: no relevant rat dataRGD 
Ap2s1Ratclathrin-dependent endocytosis involved_inIEAInterPro:IPR0271561600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratendocytosis involved_inIEAUniProtKB-KW:KW-02541600115GO_REF:0000043UniProtGO_REF:0000043
Ap2s1Ratintracellular protein transport involved_inIEAUniRule:UR0000015471600115GO_REF:0000104UniProtGO_REF:0000104
Ap2s1Ratintracellular protein transport involved_inIEAInterPro:IPR0008041600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratpostsynaptic neurotransmitter receptor internalization involved_inIMP 13432317PMID:17289840SynGO 
Ap2s1Ratpostsynaptic neurotransmitter receptor internalization involved_inIDA 13432317PMID:17289840SynGO 
Ap2s1Ratpostsynaptic neurotransmitter receptor internalization involved_inNAS 13432317PMID:17289840SynGO 
Ap2s1Ratpostsynaptic neurotransmitter receptor internalization involved_inEXP 13432317PMID:17289840SynGO 
Ap2s1Ratprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
Ap2s1Ratprotein transport involved_inIEAInterPro:IPR0166351600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratsynaptic vesicle endocytosis involved_inISOAP2S1 (Homo sapiens)1624291 PMID:11102472RGDPMID:11102472
Ap2s1Ratvesicle-mediated transport involved_inIEAInterPro:IPR0008041600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratvesicle-mediated transport involved_inIEAInterPro:IPR000804 and InterPro:IPR0271561600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratvesicle-mediated transport involved_inIBACGD:CAL0000182525 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
Ap2s1RatAP-2 adaptor complex part_ofIDA 727584PMID:2040623MGI 
Ap2s1RatAP-2 adaptor complex part_ofISOAp2s1 (Mus musculus)1624291 PMID:12086608RGDPMID:12086608
Ap2s1RatAP-2 adaptor complex part_ofIEAInterPro:IPR0271561600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1RatAP-2 adaptor complex  IDA 2306270 RGD 
Ap2s1Ratcell periphery located_inIEAARBA:ARBA000274431600115GO_REF:0000117UniProtGO_REF:0000117
Ap2s1Ratclathrin-coated pit located_inIEAUniProtKB-KW:KW-01681600115GO_REF:0000043UniProtGO_REF:0000043
Ap2s1Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Ap2s1Ratendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
Ap2s1Ratextrinsic component of presynaptic endocytic zone membrane is_active_inIDA 155230785PMID:8682861SynGO 
Ap2s1Ratextrinsic component of presynaptic endocytic zone membrane is_active_inNAS 155230785PMID:8682861SynGO 
Ap2s1Ratglutamatergic synapse is_active_inNAS 13432317PMID:17289840SynGO 
Ap2s1Ratglutamatergic synapse is_active_inIMP 13432317PMID:17289840SynGO 
Ap2s1Ratglutamatergic synapse is_active_inIDA 13432317PMID:17289840SynGO 
Ap2s1Ratglutamatergic synapse is_active_inEXP 13432317PMID:17289840SynGO 
Ap2s1Ratintracellular membrane-bounded organelle is_active_inIBAFB:FBgn0039132 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ap2s1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Ap2s1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ap2s1Ratmembrane coat part_ofIEAInterPro:IPR0008041600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Ap2s1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function

  
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Original Reference(s)
Ap2s1Ratclathrin adaptor activity enablesIEAInterPro:IPR0271561600115GO_REF:0000002InterProGO_REF:0000002
Ap2s1Ratprotein binding enablesISOAP2S1 (Homo sapiens)1624291UniProtKB:Q6PD74 more ...RGDPMID:25416956 more ...
Ap2s1Ratprotein binding enablesISOAp2s1 (Mus musculus)1624291UniProtKB:P18484 more ...RGDPMID:12086608

RGD Manual Annotations


  
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Original Reference(s)
Ap2s1Ratclathrin-dependent synaptic vesicle endocytosis  ISOAP2S1 (Homo sapiens)10450547 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Ap2s1Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Ap2s1RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016

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#
Reference Title
Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Kastning K, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6. Epub 2007 Feb 8.
5. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. Kirchhausen T, etal., J Biol Chem 1991 Jun 15;266(17):11153-7.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Targeting signals and subunit interactions in coated vesicle adaptor complexes. Page LJ and Robinson MS, J Cell Biol. 1995 Nov;131(3):619-30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
15. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, etal., J Cell Biol. 1996 Jun;133(6):1237-50. doi: 10.1083/jcb.133.6.1237.
16. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
17. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
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PMID:10908605   PMID:12086608   PMID:12477932   PMID:15489334   PMID:29476059  



Ap2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,545,601 - 86,557,007 (+)NCBIGRCr8
mRatBN7.2177,417,496 - 77,428,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,417,477 - 77,428,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,798,123 - 82,809,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,362,165 - 91,373,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,553,217 - 84,564,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,671,238 - 78,682,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,918,162 - 79,929,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,069,144 - 77,081,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,147,255 - 77,159,301NCBI
Celera171,902,755 - 71,914,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
AP2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,838,167 - 46,850,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,838,136 - 46,850,846 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,341,424 - 47,354,103 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,033,263 - 52,046,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,033,263 - 52,045,931NCBI
Celera1944,145,679 - 44,158,458 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,766,567 - 43,779,262 (-)NCBIHuRef
CHM1_11947,343,326 - 47,356,098 (-)NCBICHM1_1
T2T-CHM13v2.01949,664,001 - 49,676,674 (-)NCBIT2T-CHM13v2.0
Ap2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,472,369 - 16,483,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,472,335 - 16,483,219 (+)EnsemblGRCm39 Ensembl
GRCm38716,738,444 - 16,749,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,738,410 - 16,749,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,323,793 - 17,334,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,896,984 - 15,907,814 (+)NCBIMGSCv36mm8
Celera713,936,944 - 13,947,790 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Ap2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574830,910 - 846,161 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574835,272 - 845,710 (-)NCBIChiLan1.0ChiLan1.0
AP2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,985,343 - 52,998,184 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,856,517 - 54,869,298 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,827,907 - 43,840,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,357,145 - 52,357,805 (-)NCBIpanpan1.1PanPan1.1panPan2
AP2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,094,098 - 109,105,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,082,221 - 109,105,230 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,573,732 - 108,584,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,619,436 - 109,630,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,619,492 - 109,630,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,297,177 - 109,308,314 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,930,932 - 108,942,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,799,650 - 109,811,014 (+)NCBIUU_Cfam_GSD_1.0
AP2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,695,640 - 52,703,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,695,640 - 52,703,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,066,402 - 48,073,966 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,175,106 - 40,194,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607319,888,365 - 19,901,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,787,149 - 6,797,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,788,149 - 6,797,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ap2s1
132 total Variants

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:134
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000021310
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat

1 to 10 of 46 rows
RH128591  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,428,721 - 77,428,902 (+)MAPPERmRatBN7.2
Rnor_6.0178,682,666 - 78,682,846NCBIRnor6.0
Rnor_5.0179,929,321 - 79,929,501UniSTSRnor5.0
RGSC_v3.4177,081,009 - 77,081,189UniSTSRGSC3.4
Celera171,914,059 - 71,914,239UniSTS
Cytogenetic Map1q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021310   ⟹   ENSRNOP00000021310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,422,281 - 77,428,905 (+)Ensembl
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094499   ⟹   ENSRNOP00000096265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,417,487 - 77,428,851 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118847   ⟹   ENSRNOP00000095780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,418,049 - 77,428,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119694   ⟹   ENSRNOP00000083093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,417,477 - 77,428,903 (+)Ensembl
RefSeq Acc Id: NM_022952   ⟹   NP_075241
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,545,601 - 86,557,007 (+)NCBI
mRatBN7.2177,417,496 - 77,428,903 (+)NCBI
Rnor_6.0178,671,238 - 78,682,847 (+)NCBI
Rnor_5.0179,918,162 - 79,929,502 (+)NCBI
RGSC_v3.4177,069,144 - 77,081,190 (+)RGD
Celera171,902,755 - 71,914,240 (+)RGD
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_075241 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40742 (Get FASTA)   NCBI Sequence Viewer  
  AAB46980 (Get FASTA)   NCBI Sequence Viewer  
  AAH88138 (Get FASTA)   NCBI Sequence Viewer  
  EDM08310 (Get FASTA)   NCBI Sequence Viewer  
  EDM08311 (Get FASTA)   NCBI Sequence Viewer  
  EDM08312 (Get FASTA)   NCBI Sequence Viewer  
  EDM08313 (Get FASTA)   NCBI Sequence Viewer  
  EDM08314 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021310
  ENSRNOP00000083093.1
GenBank Protein P62744 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_075241   ⟸   NM_022952
- UniProtKB: Q00380 (UniProtKB/Swiss-Prot),   P97626 (UniProtKB/Swiss-Prot),   P70626 (UniProtKB/Swiss-Prot),   P62744 (UniProtKB/Swiss-Prot),   A6J8C1 (UniProtKB/TrEMBL),   A0A8L2QC47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021310   ⟸   ENSRNOT00000021310
Ensembl Acc Id: ENSRNOP00000083093   ⟸   ENSRNOT00000119694
Ensembl Acc Id: ENSRNOP00000095780   ⟸   ENSRNOT00000118847
Ensembl Acc Id: ENSRNOP00000096265   ⟸   ENSRNOT00000094499
AP complex mu/sigma subunit

Name Modeler Protein Id AA Range Protein Structure
AF-P62744-F1-model_v2 AlphaFold P62744 1-142 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689735
Promoter ID:EPDNEW_R260
Type:initiation region
Name:Ap2s1_1
Description:adaptor-related protein complex 2, sigma 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,671,213 - 78,671,273EPDNEW
RGD ID:13689742
Promoter ID:EPDNEW_R261
Type:initiation region
Name:AC127887_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,687,026 - 78,687,086EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60599 BioCyc
Ensembl Genes ENSRNOG00000015865 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021310 ENTREZGENE
  ENSRNOT00000119694.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7374432 IMAGE-MGC_LOAD
InterPro AP_complex_ssu UniProtKB/Swiss-Prot
  AP_mu_sigma_su UniProtKB/Swiss-Prot
  APS2 UniProtKB/Swiss-Prot
  Clathrin_sm-chain_CS UniProtKB/Swiss-Prot
  Longin-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:65046 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108685 IMAGE-MGC_LOAD
NCBI Gene 65046 ENTREZGENE
PANTHER PTHR11753 UniProtKB/Swiss-Prot
Pfam Clat_adaptor_s UniProtKB/Swiss-Prot
PhenoGen Ap2s1 PhenoGen
PIRSF AP_complex_sigma UniProtKB/Swiss-Prot
PROSITE CLAT_ADAPTOR_S UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015865 RatGTEx
Superfamily-SCOP SSF64356 UniProtKB/Swiss-Prot
UniProt A0A8I6AKF9_RAT UniProtKB/TrEMBL
  A0A8I6AT11_RAT UniProtKB/TrEMBL
  A0A8L2QC47 ENTREZGENE, UniProtKB/TrEMBL
  A6J8C1 ENTREZGENE, UniProtKB/TrEMBL
  A6J8C3_RAT UniProtKB/TrEMBL
  AP2S1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70626 ENTREZGENE
  P97626 ENTREZGENE
  Q00380 ENTREZGENE
UniProt Secondary P70626 UniProtKB/Swiss-Prot
  P97626 UniProtKB/Swiss-Prot
  Q00380 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap2s1  adaptor related protein complex 2 subunit sigma 1  Ap2s1  adaptor-related protein complex 2, sigma 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Ap2s1  adaptor-related protein complex 2, sigma 1 subunit  Ap2s1_predicted  adaptor-related protein complex 2, sigma 1 subunit (predicted)  Data merged from RGD:1309711 737654 APPROVED
2005-01-20 Ap2s1  adaptor-related protein complex 2, sigma 1 subunit    clathrin-associated protein 17  Name updated 1299863 APPROVED
2005-01-12 Ap2s1_predicted  adaptor-related protein complex 2, sigma 1 subunit (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Ap2s1  clathrin-associated protein 17      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_homology has similarity to yeast Yap17p 727584