Zfp347 (zinc finger protein 347) - Rat Genome Database

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Gene: Zfp347 (zinc finger protein 347) Rattus norvegicus
Analyze
Symbol: Zfp347
Name: zinc finger protein 347
RGD ID: 620185
Description: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF14 (zinc finger protein 14); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Giot2; gonadotropin inducible ovarian transcription factor 2
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,110,793 - 8,130,161 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl78,111,577 - 8,130,165 (+)EnsemblGRCr8
mRatBN7.277,460,543 - 7,479,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl77,459,701 - 7,484,430 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx710,392,480 - 10,404,636 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,268,159 - 12,280,315 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,079,883 - 10,092,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.079,974,310 - 9,990,960 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0710,136,354 - 10,153,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.478,930,166 - 8,940,590 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera75,678,604 - 5,690,762 (+)NCBICelera
RGSC_v3.178,930,165 - 8,940,590 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, etal., Mol Endocrinol 2001 Oct;15(10):1693-705.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:31904090  


Genomics

Comparative Map Data
Zfp347
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,110,793 - 8,130,161 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl78,111,577 - 8,130,165 (+)EnsemblGRCr8
mRatBN7.277,460,543 - 7,479,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl77,459,701 - 7,484,430 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx710,392,480 - 10,404,636 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,268,159 - 12,280,315 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,079,883 - 10,092,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.079,974,310 - 9,990,960 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0710,136,354 - 10,153,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.478,930,166 - 8,940,590 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera75,678,604 - 5,690,762 (+)NCBICelera
RGSC_v3.178,930,165 - 8,940,590 (+)NCBI
Cytogenetic Map7q11NCBI
ZNF14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381919,710,472 - 19,733,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1919,710,472 - 19,733,112 (-)Ensemblhg38GRCh38
GRCh371919,821,281 - 19,843,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,682,281 - 19,704,921 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341919,682,281 - 19,704,921NCBI
Celera1919,725,244 - 19,749,091 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1919,383,308 - 19,405,962 (-)NCBIHuRef
CHM1_11919,822,032 - 19,844,682 (-)NCBICHM1_1
T2T-CHM13v2.01919,847,997 - 19,870,637 (-)NCBIT2T-CHM13v2.0
4930522L14Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395109,845,026 - 109,899,559 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5109,844,839 - 109,899,584 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl5109,883,856 - 109,899,752 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385109,735,515 - 109,796,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5109,735,990 - 109,751,886 (-)Ensemblmm10GRCm38
MGSCv375110,119,606 - 110,178,024 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365110,211,643 - 110,225,204 (-)NCBIMGSCv36mm8
Celera5106,857,776 - 106,870,645 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.26NCBI
ZNF14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22024,554,361 - 24,596,430 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11923,560,635 - 23,602,640 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01919,147,832 - 19,170,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11920,142,023 - 20,164,120 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1920,142,108 - 20,145,586 (-)EnsemblpanPan2panpan1.1
LOC101964411
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,273,339 - 202,278,868 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365961,822,534 - 1,826,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1618,160,412 - 18,181,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl618,161,290 - 18,164,749 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660741,109,256 - 1,132,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11311,980,505 - 11,992,014 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp347
129 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000044241
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH134996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.277,334,082 - 7,334,266 (+)MAPPERmRatBN7.2
mRatBN7.2710,222,564 - 10,222,748 (+)MAPPERmRatBN7.2
mRatBN7.277,474,308 - 7,474,492 (-)MAPPERmRatBN7.2
Rnor_6.0713,108,812 - 13,108,995NCBIRnor6.0
Rnor_6.079,977,195 - 9,977,378NCBIRnor6.0
Rnor_5.0710,139,239 - 10,139,422UniSTSRnor5.0
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 66 137 94 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044241   ⟹   ENSRNOP00000050722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,111,584 - 8,130,151 (+)Ensembl
mRatBN7.2 Ensembl77,460,791 - 7,479,360 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095244   ⟹   ENSRNOP00000094026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl77,459,701 - 7,484,430 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103666   ⟹   ENSRNOP00000084293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,111,577 - 8,130,151 (+)Ensembl
mRatBN7.2 Ensembl77,461,213 - 7,481,175 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115828   ⟹   ENSRNOP00000085970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl77,460,140 - 7,484,430 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131530   ⟹   ENSRNOP00000103806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl78,111,598 - 8,130,165 (+)Ensembl
RefSeq Acc Id: NM_133390   ⟹   NP_596881
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,117,999 - 8,130,157 (+)NCBI
mRatBN7.277,467,216 - 7,479,374 (+)NCBI
Rnor_6.079,974,310 - 9,990,960 (-)NCBI
Rnor_5.0710,136,354 - 10,153,004 (-)NCBI
RGSC_v3.478,930,166 - 8,940,590 (+)RGD
Celera75,678,604 - 5,690,762 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078333   ⟹   XP_038934261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,111,148 - 8,130,161 (+)NCBI
mRatBN7.277,460,543 - 7,479,378 (+)NCBI
RefSeq Acc Id: XM_039078337   ⟹   XP_038934265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,123,099 - 8,130,161 (+)NCBI
mRatBN7.277,474,581 - 7,479,378 (+)NCBI
RefSeq Acc Id: XM_063262943   ⟹   XP_063119013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,110,793 - 8,130,161 (+)NCBI
RefSeq Acc Id: XM_063262944   ⟹   XP_063119014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,111,150 - 8,130,161 (+)NCBI
RefSeq Acc Id: XM_063262945   ⟹   XP_063119015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,111,150 - 8,130,161 (+)NCBI
RefSeq Acc Id: XM_063262946   ⟹   XP_063119016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,112,857 - 8,130,161 (+)NCBI
RefSeq Acc Id: NP_596881   ⟸   NM_133390
- UniProtKB: A6K849 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038934261   ⟸   XM_039078333
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934265   ⟸   XM_039078337
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GDJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000050722   ⟸   ENSRNOT00000044241
Ensembl Acc Id: ENSRNOP00000085970   ⟸   ENSRNOT00000115828
Ensembl Acc Id: ENSRNOP00000094026   ⟸   ENSRNOT00000095244
Ensembl Acc Id: ENSRNOP00000084293   ⟸   ENSRNOT00000103666
RefSeq Acc Id: XP_063119013   ⟸   XM_063262943
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119015   ⟸   XM_063262945
- Peptide Label: isoform X3
- UniProtKB: A6K849 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119014   ⟸   XM_063262944
- Peptide Label: isoform X3
- UniProtKB: A6K849 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119016   ⟸   XM_063262946
- Peptide Label: isoform X3
- UniProtKB: A6K849 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103806   ⟸   ENSRNOT00000131530
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNZ3-F1-model_v2 AlphaFold F1LNZ3 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620185 AgrOrtholog
BioCyc Gene G2FUF-35069 BioCyc
Ensembl Genes ENSRNOG00000071023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044241 ENTREZGENE
  ENSRNOT00000044241.5 UniProtKB/TrEMBL
  ENSRNOT00000103666 ENTREZGENE
  ENSRNOT00000103666.2 UniProtKB/TrEMBL
  ENSRNOT00000131530 ENTREZGENE
  ENSRNOT00000131530.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:170902 UniProtKB/TrEMBL
NCBI Gene 170902 ENTREZGENE
PANTHER EXPRESSED SEQUENCE AU041133 UniProtKB/TrEMBL
  GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR UniProtKB/TrEMBL
  RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 709-LIKE UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp347 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000071023 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6GDJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L3H2_RAT UniProtKB/TrEMBL
  A6K849 ENTREZGENE, UniProtKB/TrEMBL
  F1LNZ3_RAT UniProtKB/TrEMBL
  Q91XV1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Zfp347  zinc finger protein 347  Giot2  gonadotropin inducible ovarian transcription factor 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Giot2  gonadotropin inducible ovarian transcription factor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function functions as a transcriptional repressor 632669
gene_product member of the (Cys)(2)-(His)(2)-type zinc finger protein family and exists as two isoforms 632669