Tgfb1i1 (transforming growth factor beta 1 induced transcript 1) - Rat Genome Database

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Gene: Tgfb1i1 (transforming growth factor beta 1 induced transcript 1) Rattus norvegicus
Analyze
Symbol: Tgfb1i1
Name: transforming growth factor beta 1 induced transcript 1
RGD ID: 620173
Description: Enables I-SMAD binding activity. Predicted to be involved in positive regulation of epithelial to mesenchymal transition; positive regulation of macromolecule metabolic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell differentiation; morphogenesis of embryonic epithelium; and negative regulation of fat cell differentiation. Predicted to be located in focal adhesion. Orthologous to human TGFB1I1 (transforming growth factor beta 1 induced transcript 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: androgen receptor-associated protein of 55 kDa; Ara55; Hic-5; hydrogen peroxide-inducible clone 5 protein; transforming growth factor beta-1-induced transcript 1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,258,992 - 192,265,903 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,258,598 - 192,265,903 (+)EnsemblGRCr8
mRatBN7.21182,828,553 - 182,835,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,828,544 - 182,837,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,179,152 - 191,185,949 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,365,243 - 198,372,040 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,035,717 - 191,042,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,664,039 - 199,670,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,664,173 - 199,670,961 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,710,120 - 206,716,917 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,504,715 - 187,511,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,474,643 - 180,481,440 (+)NCBICelera
RGSC_v3.11187,656,500 - 187,660,841 (+)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fucoxanthin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipoic acid  (ISO)
mancozeb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IBA)
cytoskeleton  (IEA)
focal adhesion  (IBA,IEA,ISO,TAS)
nuclear matrix  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and characterization of hic-5/ARA55 as an hsp27 binding protein. Jia Y, etal., J Biol Chem 2001 Oct 26;276(43):39911-8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Wang H, etal., Oncogene. 2008 Nov 20;27(54):6791-805. doi: 10.1038/onc.2008.291. Epub 2008 Sep 1.
Additional References at PubMed
PMID:10075738   PMID:11784865   PMID:15561701   PMID:15687259   PMID:16624805   PMID:17550607   PMID:18083901   PMID:19540241   PMID:19855388   PMID:20551380   PMID:21423176   PMID:21996749  
PMID:23508044   PMID:26405299   PMID:26759173   PMID:37156857  


Genomics

Comparative Map Data
Tgfb1i1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,258,992 - 192,265,903 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,258,598 - 192,265,903 (+)EnsemblGRCr8
mRatBN7.21182,828,553 - 182,835,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,828,544 - 182,837,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,179,152 - 191,185,949 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,365,243 - 198,372,040 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,035,717 - 191,042,532 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,664,039 - 199,670,970 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,664,173 - 199,670,961 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,710,120 - 206,716,917 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,504,715 - 187,511,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,474,643 - 180,481,440 (+)NCBICelera
RGSC_v3.11187,656,500 - 187,660,841 (+)NCBI
Cytogenetic Map1q37NCBI
TGFB1I1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,472,152 - 31,477,960 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,471,585 - 31,478,727 (+)Ensemblhg38GRCh38
GRCh371631,483,473 - 31,489,281 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,390,985 - 31,396,781 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341631,392,026 - 31,396,781NCBI
Celera1628,819,110 - 28,824,915 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1629,043,677 - 29,049,482 (+)NCBIHuRef
CHM1_11632,802,125 - 32,807,930 (+)NCBICHM1_1
T2T-CHM13v2.01631,859,540 - 31,865,348 (+)NCBIT2T-CHM13v2.0
Tgfb1i1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,845,963 - 127,852,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,845,984 - 127,854,871 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387128,246,812 - 128,255,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,246,812 - 128,255,699 (+)Ensemblmm10GRCm38
MGSCv377135,390,385 - 135,397,226 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367128,038,019 - 128,044,860 (+)NCBIMGSCv36mm8
Celera7128,082,355 - 128,089,196 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.07NCBI
Tgfb1i1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,309,505 - 8,315,668 (+)Ensembl
ChiLan1.0NW_0049554938,309,480 - 8,315,378 (+)NCBIChiLan1.0ChiLan1.0
TGFB1I1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,677,976 - 34,687,350 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,480,365 - 39,488,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,487,561 - 23,493,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,842,437 - 31,848,327 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,842,437 - 31,848,327 (+)EnsemblpanPan2panpan1.1
TGFB1I1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,775,438 - 16,781,695 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,775,836 - 16,780,935 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha618,384,792 - 18,390,345 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0616,900,261 - 16,905,818 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,890,717 - 16,905,803 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,703,863 - 16,709,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,623,496 - 16,629,008 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,935,200 - 16,940,744 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tgfb1i1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,683,623 - 125,689,224 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,347,329 - 8,353,051 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,347,343 - 8,352,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB1I1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,090,116 - 17,099,020 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1317,093,275 - 17,099,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TGFB1I1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1528,172,246 - 28,178,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660681,261,904 - 1,268,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb1i1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,471,415 - 14,476,914 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478214,471,427 - 14,476,792 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tgfb1i1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1273,683,375 - 73,690,089 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tgfb1i1
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:59
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000054980
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000054980   ⟹   ENSRNOP00000051863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,259,993 - 192,265,903 (+)Ensembl
mRatBN7.2 Ensembl1182,828,666 - 182,835,230 (+)Ensembl
Rnor_6.0 Ensembl1199,664,173 - 199,670,961 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097108   ⟹   ENSRNOP00000082835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,259,794 - 192,265,903 (+)Ensembl
mRatBN7.2 Ensembl1182,829,358 - 182,835,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111476   ⟹   ENSRNOP00000081391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,258,901 - 192,265,344 (+)Ensembl
mRatBN7.2 Ensembl1182,829,362 - 182,834,906 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111679   ⟹   ENSRNOP00000080035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,259,106 - 192,265,903 (+)Ensembl
mRatBN7.2 Ensembl1182,829,817 - 182,835,226 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115394   ⟹   ENSRNOP00000082747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,258,901 - 192,265,344 (+)Ensembl
mRatBN7.2 Ensembl1182,828,544 - 182,837,080 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115598   ⟹   ENSRNOP00000078945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,258,598 - 192,265,903 (+)Ensembl
mRatBN7.2 Ensembl1182,829,523 - 182,837,080 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124679   ⟹   ENSRNOP00000106188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,258,919 - 192,265,903 (+)Ensembl
RefSeq Acc Id: NM_001191840   ⟹   NP_001178769
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,259,106 - 192,265,903 (+)NCBI
mRatBN7.21182,828,668 - 182,835,465 (+)NCBI
Rnor_6.01199,664,173 - 199,670,970 (+)NCBI
Rnor_5.01206,710,120 - 206,716,917 (+)NCBI
Celera1180,474,643 - 180,481,440 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230349   ⟹   XP_006230411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,259,179 - 192,265,665 (+)NCBI
mRatBN7.21182,829,497 - 182,835,232 (+)NCBI
Rnor_6.01199,664,219 - 199,670,737 (+)NCBI
Rnor_5.01206,710,120 - 206,716,917 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230350   ⟹   XP_006230412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,258,992 - 192,265,665 (+)NCBI
mRatBN7.21182,828,553 - 182,835,171 (+)NCBI
Rnor_6.01199,664,127 - 199,670,737 (+)NCBI
Rnor_5.01206,710,120 - 206,716,917 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589800   ⟹   XP_017445289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,258,997 - 192,265,665 (+)NCBI
mRatBN7.21182,828,576 - 182,835,171 (+)NCBI
Rnor_6.01199,664,039 - 199,670,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092864   ⟹   XP_038948792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,259,177 - 192,265,665 (+)NCBI
mRatBN7.21182,829,511 - 182,835,171 (+)NCBI
RefSeq Acc Id: XM_063275859   ⟹   XP_063131929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,259,017 - 192,265,665 (+)NCBI
RefSeq Acc Id: XM_063275861   ⟹   XP_063131931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,259,102 - 192,265,665 (+)NCBI
RefSeq Acc Id: NP_001178769   ⟸   NM_001191840
- UniProtKB: Q99PD6 (UniProtKB/Swiss-Prot),   A6I9Z1 (UniProtKB/TrEMBL),   A6I9Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230412   ⟸   XM_006230350
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QR72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230411   ⟸   XM_006230349
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLR8 (UniProtKB/TrEMBL),   A6I9Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445289   ⟸   XM_017589800
- Peptide Label: isoform X3
- UniProtKB: A6I9Z3 (UniProtKB/TrEMBL),   A0A8L2QR72 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051863   ⟸   ENSRNOT00000054980
RefSeq Acc Id: XP_038948792   ⟸   XM_039092864
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QR72 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082835   ⟸   ENSRNOT00000097108
Ensembl Acc Id: ENSRNOP00000082747   ⟸   ENSRNOT00000115394
Ensembl Acc Id: ENSRNOP00000081391   ⟸   ENSRNOT00000111476
Ensembl Acc Id: ENSRNOP00000080035   ⟸   ENSRNOT00000111679
Ensembl Acc Id: ENSRNOP00000078945   ⟸   ENSRNOT00000115598
RefSeq Acc Id: XP_063131929   ⟸   XM_063275859
- Peptide Label: isoform X3
- UniProtKB: A6I9Z3 (UniProtKB/TrEMBL),   A0A8L2QR72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131931   ⟸   XM_063275861
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000106188   ⟸   ENSRNOT00000124679
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PD6-F1-model_v2 AlphaFold Q99PD6 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690454
Promoter ID:EPDNEW_R979
Type:multiple initiation site
Name:Tgfb1i1_1
Description:transforming growth factor beta 1 induced transcript 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,664,177 - 199,664,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620173 AgrOrtholog
BioCyc Gene G2FUF-57307 BioCyc
Ensembl Genes ENSRNOG00000019965 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097108 ENTREZGENE
  ENSRNOT00000115598 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
InterPro Paxillin_TGFB1I1_LIM_dom1 UniProtKB/Swiss-Prot
  PDZ-LIM_domain UniProtKB/Swiss-Prot
  Tgfb1i1/Leupaxin/TGFB1I1 UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:84574 UniProtKB/Swiss-Prot
NCBI Gene 84574 ENTREZGENE
PANTHER LEUPAXIN UniProtKB/Swiss-Prot
  PDZ AND LIM DOMAIN PROTEIN ZASP UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  Paxillin UniProtKB/Swiss-Prot
PhenoGen Tgfb1i1 PhenoGen
PIRSF Leupaxin UniProtKB/Swiss-Prot
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019965 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
UniProt A0A8I5ZLR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNV5_RAT UniProtKB/TrEMBL
  A0A8I5ZSV1_RAT UniProtKB/TrEMBL
  A0A8I5ZUP6_RAT UniProtKB/TrEMBL
  A0A8I5ZVH3_RAT UniProtKB/TrEMBL
  A0A8L2QR72 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSG9_RAT UniProtKB/TrEMBL
  A6I9Z1 ENTREZGENE, UniProtKB/TrEMBL
  A6I9Z2 ENTREZGENE, UniProtKB/TrEMBL
  A6I9Z3 ENTREZGENE, UniProtKB/TrEMBL
  Q99PD6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tgfb1i1  transforming growth factor beta 1 induced transcript 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tgfb1i1  transforming growth factor beta 1 induced transcript 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology 42% amino acid identity to the focal adhesion adaptor protein paxillin 634226