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Gene: Pkn2 (protein kinase N2) Rattus norvegicus

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Symbol:

Pkn2

Name:

protein kinase N2

RGD ID:

620146

Description:

Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Predicted to be located in several cellular components, including cleavage furrow; lamellipodium; and midbody. Predicted to be part of protein-containing complex. Orthologous to human PKN2 (protein kinase N2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cardiolipin-activated protein kinase Pak2; p140 kinase; Pak-2; PKN gamma; Prkcl2; protease-activated kinase 2; protein kinase C-like 2; protein-kinase C-related kinase 2; serine/threonine-protein kinase N2; similar to human PRKCL2 (protein kinase C-like 2)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PKN2 (protein kinase N2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Pkn2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pkn2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PKN2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PKN2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pkn2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PKN2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PKN2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pkn2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pkn2 (protein kinase N2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PKN2 (protein kinase N2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pkn2 (protein kinase N2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:153916	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:153916	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	pkn2 (protein kinase N2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Pkn	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pkn-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pkn-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pkn1	Alliance	DIOPT (OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pkn2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	234,454,001 - 234,559,369 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	234,454,001 - 234,594,649 (-)	Ensembl				GRCr8
mRatBN7.2	2	231,793,584 - 231,898,953 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	239,572,538 - 239,677,842 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	237,466,818 - 237,572,120 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	232,330,191 - 232,435,493 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	248,735,699 - 248,840,735 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,735,699 - 248,840,735 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	267,265,825 - 267,370,861 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	240,903,608 - 241,009,063 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	223,803,766 - 223,906,746 (-)	NCBI		Celera
RGSC_v3.1	2	240,892,652 - 240,944,091 (-)	NCBI
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

fasudil (ISO)

folic acid (ISO)

FR900359 (ISO)

glafenine (EXP)

glyphosate (ISO)

GSK-J4 (ISO)

ivermectin (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

nicotine (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

tamoxifen (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Y-27632 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apical junction assembly (ISO,ISS)

apoptotic process (IEA)

cell adhesion (IEA)

cell division (IEA)

cell projection organization (IEA)

epithelial cell migration (ISO,ISS)

intracellular signal transduction (IBA)

positive regulation of cytokinesis (ISO,ISS)

positive regulation of mitotic cell cycle (ISO,ISS)

positive regulation of viral genome replication (ISO)

protein phosphorylation (ISO,ISS)

regulation of cell motility (ISO,ISS)

signal transduction (IEA)

Cellular Component

anchoring junction (IEA)

apical junction complex (ISO,ISS)

cleavage furrow (IEA,ISO,ISS)

cytoplasm (IEA,ISO,ISS)

cytoskeleton (IEA)

intermediate filament cytoskeleton (ISO)

lamellipodium (IEA,ISO,ISS)

membrane (IEA)

microtubule cytoskeleton (IEA)

midbody (IEA,ISO,ISS)

nucleoplasm (ISO)

nucleus (IEA,ISO,ISS)

perinuclear region of cytoplasm (ISO)

protein-containing complex (ISO)

Molecular Function

ATP binding (IEA)

diacylglycerol-dependent serine/threonine kinase activity (IEA)

histone deacetylase binding (ISO,ISS)

kinase activity (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,IEA,ISO,ISS)

RNA polymerase binding (ISO)

small GTPase binding (IEA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	A cardiolipin-activated protein kinase from rat liver structurally distinct from the protein kinases C.	Morrice NA, etal., J Biol Chem 1994 Aug 5;269(31):20040-6.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9092545	PMID:11356191	PMID:12783890	PMID:15057822	PMID:15364941	PMID:17332740	PMID:20188095	PMID:20974804	PMID:21754995	PMID:22658674	PMID:25468996

Genomics

Comparative Map Data

Pkn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	234,454,001 - 234,559,369 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	234,454,001 - 234,594,649 (-)	Ensembl				GRCr8
mRatBN7.2	2	231,793,584 - 231,898,953 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	239,572,538 - 239,677,842 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	237,466,818 - 237,572,120 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	232,330,191 - 232,435,493 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	248,735,699 - 248,840,735 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,735,699 - 248,840,735 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	267,265,825 - 267,370,861 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	240,903,608 - 241,009,063 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	223,803,766 - 223,906,746 (-)	NCBI		Celera
RGSC_v3.1	2	240,892,652 - 240,944,091 (-)	NCBI
Cytogenetic Map	2	q44	NCBI

PKN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	88,684,273 - 88,836,255 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	88,684,222 - 88,836,255 (+)	Ensembl			hg38	GRCh38
GRCh37	1	89,149,956 - 89,301,938 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	88,922,510 - 89,074,526 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	88,862,276 - 89,011,443	NCBI
Celera	1	87,395,729 - 87,547,728 (+)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,267,203 - 87,419,414 (+)	NCBI		HuRef
CHM1_1	1	89,265,019 - 89,416,992 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	88,527,688 - 88,679,643 (+)	NCBI		T2T-CHM13v2.0

Pkn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	142,496,663 - 142,587,765 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	142,496,663 - 142,587,765 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	142,790,902 - 142,882,004 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	142,790,902 - 142,882,004 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	142,453,866 - 142,544,968 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	142,730,845 - 142,819,376 (-)	NCBI		MGSCv36	mm8
Celera	3	149,222,971 - 149,314,408 (-)	NCBI		Celera
Cytogenetic Map	3	H1	NCBI
cM Map	3	66.69	NCBI

Pkn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	5,467,017 - 5,575,620 (-)	Ensembl
ChiLan1.0	NW_004955423	5,467,017 - 5,575,435 (-)	NCBI	ChiLan1.0	ChiLan1.0

PKN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	138,134,707 - 138,292,307 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	137,290,425 - 137,447,311 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	91,395,885 - 91,551,347 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	90,147,949 - 90,302,741 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	90,202,299 - 90,302,741 (+)	Ensembl			panPan2	panpan1.1

PKN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	59,556,668 - 59,638,626 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	59,559,124 - 59,709,926 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	62,264,725 - 62,394,692 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	60,067,704 - 60,197,746 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	60,067,567 - 60,220,888 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	59,633,009 - 59,762,681 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	59,588,332 - 59,718,360 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	60,074,127 - 60,204,202 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pkn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	99,124,068 - 99,240,257 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936732	198,647 - 314,947 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936732	199,208 - 315,094 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	127,573,703 - 127,709,942 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	127,579,097 - 127,709,982 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	139,804,474 - 139,934,537 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	44,582,227 - 44,739,892 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	44,584,576 - 44,739,761 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	73,164,387 - 73,324,100 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	8,742,473 - 8,865,281 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	8,740,102 - 8,865,483 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pkn2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	17,847,346 - 17,947,076 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pkn2
635 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	544
Count of miRNA genes:	268
Interacting mature miRNAs:	344
Transcripts:	ENSRNOT00000031748
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	219814164	239320906	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	223810546	243965570	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat

Markers in Region

D2Rat103

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	234,531,451 - 234,531,660 (+)	Marker Load Pipeline
mRatBN7.2	2	231,871,034 - 231,871,243 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,812,081 - 248,812,289	NCBI	Rnor6.0
Rnor_5.0	2	267,342,207 - 267,342,415	UniSTS	Rnor5.0
RGSC_v3.4	2	240,981,145 - 240,981,354	RGD	RGSC3.4
RGSC_v3.4	2	240,981,146 - 240,981,354	UniSTS	RGSC3.4
Celera	2	223,878,766 - 223,878,974	UniSTS
RGSC_v3.1	2	240,967,886 - 240,968,094	RGD
RH 3.4 Map	2	1580.1	UniSTS
RH 3.4 Map	2	1580.1	RGD
SHRSP x BN Map	2	98.7698	UniSTS
SHRSP x BN Map	2	98.7698	RGD
FHH x ACI Map	2	112.9599	RGD
Cytogenetic Map	2	q44	UniSTS

BB448270

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,794,764 - 231,794,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,736,880 - 248,736,965	NCBI	Rnor6.0
Rnor_5.0	2	267,267,006 - 267,267,091	UniSTS	Rnor5.0
RGSC_v3.4	2	240,904,789 - 240,904,874	UniSTS	RGSC3.4
Celera	2	223,804,947 - 223,805,032	UniSTS
Cytogenetic Map	2	q44	UniSTS

RH134039

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,793,678 - 231,793,887 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,735,794 - 248,736,002	NCBI	Rnor6.0
Rnor_5.0	2	267,265,920 - 267,266,128	UniSTS	Rnor5.0
RGSC_v3.4	2	240,903,703 - 240,903,911	UniSTS	RGSC3.4
Celera	2	223,803,861 - 223,804,069	UniSTS
RH 3.4 Map	2	1580.5	UniSTS
Cytogenetic Map	2	q44	UniSTS

BI290487

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,827,639 - 231,827,829 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,769,753 - 248,769,942	NCBI	Rnor6.0
Rnor_5.0	2	267,299,879 - 267,300,068	UniSTS	Rnor5.0
RGSC_v3.4	2	240,937,662 - 240,937,851	UniSTS	RGSC3.4
Celera	2	223,837,820 - 223,838,009	UniSTS
RH 3.4 Map	2	1581.2	UniSTS
Cytogenetic Map	2	q44	UniSTS

AA996831

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,795,477 - 231,795,692 (+)	MAPPER	mRatBN7.2
mRatBN7.2	17	15,677,457 - 15,677,671 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	16,099,171 - 16,099,384	NCBI	Rnor6.0
Rnor_6.0	2	248,737,593 - 248,737,807	NCBI	Rnor6.0
Rnor_5.0	17	18,161,378 - 18,161,591	UniSTS	Rnor5.0
Rnor_5.0	2	267,267,719 - 267,267,933	UniSTS	Rnor5.0
RGSC_v3.4	2	240,905,502 - 240,905,716	UniSTS	RGSC3.4
RGSC_v3.4	17	21,666,726 - 21,666,939	UniSTS	RGSC3.4
Celera	17	15,406,860 - 15,407,073	UniSTS
Celera	2	223,805,660 - 223,805,874	UniSTS
RH 3.4 Map	17	180.5	UniSTS
Cytogenetic Map	2	q44	UniSTS

AI507382

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	231,795,904 - 231,796,020 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	248,738,020 - 248,738,135	NCBI	Rnor6.0
Rnor_5.0	2	267,268,146 - 267,268,261	UniSTS	Rnor5.0
RGSC_v3.4	2	240,905,929 - 240,906,044	UniSTS	RGSC3.4
Celera	2	223,806,087 - 223,806,202	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U75358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031748 ⟹ ENSRNOP00000034133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,559,369 (-)	Ensembl
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl
Rnor_6.0 Ensembl	2	248,735,699 - 248,840,735 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090705 ⟹ ENSRNOP00000073835

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,507,810 (-)	Ensembl
mRatBN7.2 Ensembl	2	231,793,584 - 231,847,446 (-)	Ensembl
Rnor_6.0 Ensembl	2	248,737,983 - 248,789,508 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094293 ⟹ ENSRNOP00000080575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,559,369 (-)	Ensembl
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107422 ⟹ ENSRNOP00000076880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,594,649 (-)	Ensembl
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114434 ⟹ ENSRNOP00000082937

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,559,369 (-)	Ensembl
mRatBN7.2 Ensembl	2	231,793,584 - 231,898,953 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140589 ⟹ ENSRNOP00000101976

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	234,454,001 - 234,575,742 (-)	Ensembl

RefSeq Acc Id:

NM_001105755 ⟹ NP_001099225

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	234,454,001 - 234,559,369 (-)	NCBI
mRatBN7.2	2	231,793,584 - 231,898,953 (-)	NCBI
Rnor_6.0	2	248,735,699 - 248,840,735 (-)	NCBI
Rnor_5.0	2	267,265,825 - 267,370,861 (-)	NCBI
RGSC_v3.4	2	240,903,608 - 241,009,063 (-)	RGD
Celera	2	223,803,766 - 223,906,746 (-)	RGD

Sequence:

show sequence

TTTTGCGACACGGTGACAGCCAAATGGTGCGACAGGAGGAGCTGCCGCCGCGGCCGCTGCGCCC
CGCACCGAGAGCTCTGAGGCGGCTCCCGGCGTCGCCCTGAGGGAGCGGCTGAGGGAACAGAGTC
CGGCGGGCGGCGGCGGGCGGCGAGGGGAGCCGCGCCGAGGGCCCTCGCTCCCCGCCGCTCTCCA
TGAGCCGGGCCGCCTGAGCCGCGCCTGCAGCCGGGCCGCGCCTCCATGACTCCCTAGTTGCTGC
TTTCTCTCCGGTCCTCACCCCCCCGCCCGGCTCCCGTCCCGCCTTCTCCCTCGGCCGCGCCGCT
GGCCGCTTTCAGGTGCGGAGTCCCGAGCGGAGCGCCATGGCGTCCAACCCCGACCGGGGGGAGA
TCCTCCTCACGGAGCTGCAGGGAGATTCCCGACCTCTTCCATTTTCTGAGAATGTGAGTGCTGT
TCAGAAATTAGACTTTTCAGATACAATAGTGCAACAGAAATTGGATGACGTCAAGGATCGAATA
AAGAGAGAAATAAGGAAAGAACTGAAAATCAAAGAAGGAGCTGAAAACCTGAGGAAAGTTACAA
CAGATAAGAAAAATTTGGCTTATGTAGACAACATTTTGAAAAAGTCAAATAAAAAATTAGAAGA
ATTACATCACAAGCTACAAGAATTAAATGCACACATTGTTGTATCGGATCCAGAGGACTCTGCA
GATTGTCCGAGGACTCCAGATACTCCAAATAGTGACTCTCGTAGTTCTACTAGCAACAATAGAT
TGATGGCCTTACAGAAACAACTGGATATAGAACTTAAAGTAAAGCAAGGTGCAGAGAACATGAT
ACAGATGTACTCAAATGGCCCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTC
CAGGATAGCAAGACAAAAATAGAAGTCATCCGAATGCAGATTCTTCAGGCCGTCCAGACCAATG
AGCTGGCTTTTGATAATGCAAAACCTGTGATAAGCCCTCTTGAGCTTCGAATGGAAGAATTAAG
ACATCATTTTAGGATAGAATTTGCAGTAGCCGAAGGTGCAAAGAATGTCATGAAATTACTTGGC
TCAGGAAAAGTAACAGACAGAAAAGCGCTTTCAGAAGCCCAAGCAAGATTTAATGAATCAAGTC
AGAAGTTGGACCTTTTAAAATATTCACTAGAGCAGAGGTTAAATGAACTCCCCAAGAATCACCC
CAAAAGCAGTGTCGTCATTGAGGAGCTCTCCCTTGTTGCATCGCCAACCCTGAGTCCACGACAG
AGTATGCTGTCCACGCAGAACCAGTACAGCACACTGTCCAAGCCAGCAGCACTAACCGGTACTT
TGGAAGTTCGTCTCATGGGGTGCCAAGATATCCTGGAGAATGTCCCTGGACGGTCAAAAGCGAC
ATCCGTAGCACTGCCTGGATGGAGTCCAAGTGAAAACAGATCATCGTTTATGAGCAGAACTAGT
AAAAGTAAAAGTGGAAGCAGTCGCAACCTCCTGAAAACCGACGACTTGTCCAATGATGTTTGTG
CTGTTTTGAAGCTAGATAATACTGTGGTTGGTCAAACTATCTGGAAGCCCATTTCCAATCAGTC
GTGGGACCAGAAGTTTACACTGGAACTAGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGG
CGTGATTGGAGATCTCTGTGTGCTGTAAAATTTCTGAGGTTAGAAGATTTTTTAGACAACCAGC
GGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTGTTTGCAGAGGTTACTTTTTTTAA
TCCAGTTATTGAAAGACGACCAAAACTCCAAAGACAAAAGAAAATTTTTTCAAAACAACAAGGC
AAAACATTTCTCAGAGCCCCTCAAATGAATATTAATATTGCCACTTGGGGAAGGCTAGTGAGAC
GAGCTATTCCCACAGTAAATCATTCTGGCACGTTCAGCCCTCAGACTCCTGTGCCCGCTACAGT
GCCAGTGGTGGATGCACGCACTCCTGAACTCGCACCTCCAGCCAGTGATTCTACAGTAACCAAA
TTGGACTTTGATCTTGAACCTGAAGCTCCTCCAGCCCCACCACGTGCTTCTTCCCTTGGAGAGA
TAGATGACTCTTCTGAATTGAGAGTTTTGGATATACCTGGACAGGGTTCAGAAACTGTTTTCGA
TATTGAGAATGACAGAAATAACATGCGTCCAAAATCCAAATCTGAATATGAGCTTAACATTCCT
GACTCAAGTCGAAGCTGTTGGAGTGTTGGAGAACTTGAGGACAAGAGATCTCAACAGAGGTTTC
AGTTTAATCTACAAGACTTCAGGTGCTGTGCTGTCTTGGGGAGAGGACACTTTGGAAAGGTGCT
GTTGGCAGAATATAAACACACAAATGAAATGTTTGCAATAAAAGCCTTAAAGAAAGGGGACATT
GTGGCACGAGATGAAGTAGACAGCTTGATGTGTGAAAAAAGAATTTTTGAGACTGTGAACAGTG
TCCGGCATCCTTTCCTAGTGAACCTGTTTGCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGT
GATGGAGTACGCTGCTGGTGGGGACCTGATGATGCACATCCACACTGACGTCTTCTCTGAACCC
AGAGCTGTATTTTATGCAGCATGTGTAGTTCTTGGATTGCAATATTTACATGAACACAAAATTG
TTTATAGAGACTTGAAGTTGGATAACCTGTTGCTGGATACAGAAGGCTTCGTGAAGATTGCTGA
CTTTGGTCTTTGCAAAGAAGGAATGGGGTATGGAGATAGGACAAGCACATTTTGTGGTACTCCT
GAATTTCTTGCCCCAGAAGTATTAACAGAAACGTCGTACACAAGGGCTGTAGATTGGTGGGGCC
TTGGCGTACTTATATATGAAATGCTCGTCGGAGAGTCTCCCTTTCCTGGTGATGATGAAGAAGA
GGTTTTTGACAGTATTGTAAATGACGAAGTAAGGTATCCAAGGTTCTTATCTACAGAAGCCATT
TCCATAATGAGAAGGCTGTTGAGGAGGAATCCTGAGCGGCGCCTGGGAGCTGGTGAGAAAGATG
CCGAGGATGTAAAGAAGCACCCGTTTTTCCGGCTAACCGACTGGAGTGCACTACTGGACAAGAA
AGTAAAGCCACCATTTGTACCTACCATTAGAGGACGGGAAGATGTTAGTAACTTTGATGATGAA
TTTACCTCAGAAGCACCTATTCTGACTCCCCCTCGAGAACCGAGGATACTCTTGGAGGAGGAGC
AGGAGATGTTCCGCGATTTTGACTACGTTGCTGATTGGTGTTAAGTTTCTGGACACGGAGACCA
AGCGGACTGACAGACAAGAAGACCTCTAGAGAACAGCAGCCTTTCATTTGCTTTCCGTGCCCAG
GAGCTTTTGAGGCCATATAAAGCACATGAAGATGTGGTTACAGCACTGTTCATACCTTCTTAAT
GTTTTCAACGGAAATCTGAACACTGGAAGCAGTTTCACGGAGTTTAGGCTGAGTGAACATTGGC
CATGGAAATCCATTACAAATAAATACTTTTACATCAATACTCTATTTTTAAAAAGAAGAGGAAC
CACTCTTTTATAGTCCCCATCTTTGCCCTAGCCTGCCTTAAGTGGAAGGAAGATTAATCACTTA
ACTGTATTTTACAAAAGAAAAAATAGGGCTTTGGATGCTATTACTAGTCATATAAAAAGTATGA
TTCTGTTTGACTAAGGCAATTATTCTTTAAGAAATCACTATAATATGAAAAACTGTGGCAGTTT
GTACACCCTTGGTGGCTTGATTTTAAGAAAAAAATGAGAATGTACTGATGTGTAGTTTGATGAA
TTTTCTGTATTTATCAGGAGAACACTTCATTGCCTTAACGTTACCAACCATGCAGCAGAGCCTC
ACGGCTTCCAGCTGCGCTGCCTGCCACACGAGCTGTGCTTATTAACAGTGCTGCAGAACGATAG
GAGCGCCAGCGCCCACTCACAGTCTCAGCCAGGCTCTGGGCAGCCGGGACCAAGGTACCGTGCT
GACTGTGTGCACTCCCCAAGTCCAGGCCCCACGGAGGATGTTCTGTCGGGTCTTCCCAAGTCAG
AGCCCGATGGACCCTTATCATTCTATGCATTCTACACGGATTTCAACCGAGACATCTTGTTCTT
GTGTCTGCTGTAGGAGGGAACTCTATCTTTGTTAAAAAAACCATAGAGATTATCATGGTATACA
TGCTGTGAACATGTATATGTACAAGTTGTAATGTATTCTGTGTTGTAGGCATATTATTTAATTT
CACCAAATCATCACTTTTGTACAGTGGCCAAGCAGACACCTCCAACTCCAGCATTTCTATTAAG
TGCATTTGTACATTTTAGGCCGCTGGATCCAGACTTTATATTGGCAGTTACTGAGGGCAAAAGC
AATATATTGTAACAGAATGTATAAATATTTTTGATAAAACAGTCTATATTTTATAAAAAGTTAT
TATAACACTAAAGCTGTACCTCAAAAGTCTCACAAATAATTTGATCAAATACTCTACACATCCT
CAGAGGATCCGTTTGTGGCTTTTTATCGCTCTCATCATATGCCGTTTTGCAAATCATGATCTTC
ACTGGGCTGGAAATTTTTTAGGTTTTTGTTTTGTTTTTCTCTTGCCTGTCACTCCATTGTTCTC
CCTCAGTTCAGTAATATCATTGATAACACTGTGCTTAGCATGTTAGGGCCATGATACCTCAGGA
ACAGCAAGTTGGCCACTAACCACACTTGAATTAACCATGTAATCACAGTGAGCTCATCTCTTAC
AATTGTCCAGATCTGAGTCAATGAGAAACAGGAAAGCACACAAATACATGAAGAGTTGAGCTTG
AGACAGCCTTGCTGAGATACATTGGCCTGTTGTCACTGTACTCTGAGAATAATTAAATTTGTCC
AGAGATAGTTTATAATACCTTCCAAATTCATTACCATTTTTCTCCCAAGATCCTTTGGAAGAAA
TTTTCTAAAAAGAGGAGCAATATGTTGCTGTAAGTTGCTTTAAATGCCAGTTAATTGCCTTGGA
AAAGAACAATAGAAAAAATAGCATAATTGTCTAGCTTCAATTTGAACAGTGTTAACACAATCTG
AAAATAAAACGCTAACTACTTTTGAGGTACAGTCTGCATACCTTTGTTGGTTCTGAAATATGCA
CAGAAAGCAGCGTTTCAAATGGGCTTTTAGCATTAAAAACTGACAGAGTTATATATACAGTGTA
CAAAAACTTTTTTAATTGAGGTCAATCACTAAAAAAATTAGCGATCAGGGTATAGTCACACAAT
TATGCTGAAAAAAAAAGCACTCATTTTTCTGTAGTTTAAAAAATATATATATTAGCCAGATTTT
AAATTTTAAGAGTGTAAATAGATGTTGCTATTACTGTATGTGTACTGGCTGCTCAAGCACTTTG
TAAGGAGAGCGGATACTTTAGAATGGTACCCTATGCATCCAAATGAAATGTGTGCCTTTACGTC
ATTCTGAGAAAGAGGGGGTTTGCAGTTATAAGTTTCCACAAATGCACAAATTAAAGTTCAAAAT
AGATTGAAATTTGTAACTTTGGTT

hide sequence

RefSeq Acc Id:

XM_017590603 ⟹ XP_017446092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	234,454,009 - 234,534,403 (-)	NCBI
mRatBN7.2	2	231,793,592 - 231,873,575 (-)	NCBI
Rnor_6.0	2	248,735,707 - 248,811,031 (-)	NCBI

Sequence:

show sequence

GGAGATTCCCGACCTCTTCCATTTTCTGAGAATGTGAGTGCTGTTCAGAAATTAGACTTTTCAG
ATACAATAGTGCAACAGAAATTGGATGACGTCAAGGATCGAATAAAGAGAGAAATAAGGAAAGA
ACTGAAAATCAAAGAAGGAGCTGAAAACCTGAGGAAAGTTACAACAGATAAGAAAAATTTGGCT
TATGTAGACAACATTTTGAAAAAGTCAAATAAAAAATTAGAAGAATTACATCACAAGCTACAAG
AATTAAATGCACACATTGTTGTATCGGATCCAGAGGACTCTGCAGATTGTCCGAGGACTCCAGA
TACTCCAAATAGTGACTCTCGTAGTTCTACTAGCAACAATAGATTGATGGCCTTACAGAAACAA
CTGGATATAGAACTTAAAGTAAAGCAAGGTGCAGAGAACATGATACAGATGTACTCAAATGGCC
CTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTCCAGGATAGCAAGACAAAAAT
AGAAGTCATCCGAATGCAGATTCTTCAGGCCGTCCAGACCAATGAGCTGGCTTTTGATAATGCA
AAACCTGTGATAAGCCCTCTTGAGCTTCGAATGGAAGAATTAAGACATCATTTTAGGATAGAAT
TTGCAGTAGCCGAAGGTGCAAAGAATGTCATGAAATTACTTGGCTCAGGAAAAGTAACAGACAG
AAAAGCGCTTTCAGAAGCCCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGACCTTTTAAAA
TATTCACTAGAGCAGAGGTTAAATGAACTCCCCAAGAATCACCCCAAAAGCAGTGTCGTCATTG
AGGAGCTCTCCCTTGTTGCATCGCCAACCCTGAGTCCACGACAGAGTATGCTGTCCACGCAGAA
CCAGTACAGCACACTGTCCAAGCCAGCAGCACTAACCGGTACTTTGGAAGTTCGTCTCATGGGG
TGCCAAGATATCCTGGAGAATGTCCCTGGACGGTCAAAAGCGACATCCGTAGCACTGCCTGGAT
GGAGTCCAAGTGAAAACAGATCATCGTTTATGAGCAGAACTAGTAAAAGTAAAAGTGGAAGCAG
TCGCAACCTCCTGAAAACCGACGACTTGTCCAATGATGTTTGTGCTGTTTTGAAGCTAGATAAT
ACTGTGGTTGGTCAAACTATCTGGAAGCCCATTTCCAATCAGTCGTGGGACCAGAAGTTTACAC
TGGAACTAGACAGGGTTACTTTTTTTAATCCAGTTATTGAAAGACGACCAAAACTCCAAAGACA
AAAGAAAATTTTTTCAAAACAACAAGGCAAAACATTTCTCAGAGCCCCTCAAATGAATATTAAT
ATTGCCACTTGGGGAAGGCTAGTGAGACGAGCTATTCCCACAGTAAATCATTCTGGCACGTTCA
GCCCTCAGACTCCTGTGCCCGCTACAGTGCCAGTGGTGGATGCACGCACTCCTGAACTCGCACC
TCCAGCCAGTGATTCTACAGTAACCAAATTGGACTTTGATCTTGAACCTGAAGCTCCTCCAGCC
CCACCACGTGCTTCTTCCCTTGGAGAGATAGATGACTCTTCTGAATTGAGAGTTTTGGATATAC
CTGGACAGGGTTCAGAAACTGTTTTCGATATTGAGAATGACAGAAATAACATGCGTCCAAAATC
CAAATCTGAATATGAGCTTAACATTCCTGACTCAAGTCGAAGCTGTTGGAGTGTTGGAGAACTT
GAGGACAAGAGATCTCAACAGAGGTTTCAGTTTAATCTACAAGACTTCAGGTGCTGTGCTGTCT
TGGGGAGAGGACACTTTGGAAAGGTGCTGTTGGCAGAATATAAACACACAAATGAAATGTTTGC
AATAAAAGCCTTAAAGAAAGGGGACATTGTGGCACGAGATGAAGTAGACAGCTTGATGTGTGAA
AAAAGAATTTTTGAGACTGTGAACAGTGTCCGGCATCCTTTCCTAGTGAACCTGTTTGCATGTT
TCCAAACCAAAGAGCATGTTTGCTTTGTGATGGAGTACGCTGCTGGTGGGGACCTGATGATGCA
CATCCACACTGACGTCTTCTCTGAACCCAGAGCTGTATTTTATGCAGCATGTGTAGTTCTTGGA
TTGCAATATTTACATGAACACAAAATTGTTTATAGAGACTTGAAGTTGGATAACCTGTTGCTGG
ATACAGAAGGCTTCGTGAAGATTGCTGACTTTGGTCTTTGCAAAGAAGGAATGGGGTATGGAGA
TAGGACAAGCACATTTTGTGGTACTCCTGAATTTCTTGCCCCAGAAGTATTAACAGAAACGTCG
TACACAAGGGCTGTAGATTGGTGGGGCCTTGGCGTACTTATATATGAAATGCTCGTCGGAGAGT
CTCCCTTTCCTGGTGATGATGAAGAAGAGGTTTTTGACAGTATTGTAAATGACGAAGTAAGGTA
TCCAAGGTTCTTATCTACAGAAGCCATTTCCATAATGAGAAGGCTGTTGAGGAGGAATCCTGAG
CGGCGCCTGGGAGCTGGTGAGAAAGATGCCGAGGATGTAAAGAAGCACCCGTTTTTCCGGCTAA
CCGACTGGAGTGCACTACTGGACAAGAAAGTAAAGCCACCATTTGTACCTACCATTAGAGGACG
GGAAGATGTTAGTAACTTTGATGATGAATTTACCTCAGAAGCACCTATTCTGACTCCCCCTCGA
GAACCGAGGATACTCTTGGAGGAGGAGCAGGAGATGTTCCGCGATTTTGACTACGTTGCTGATT
GGTGTTAAGTTTCTGGACACGGAGACCAAGCGGACTGACAGACAAGAAGACCTCTAGAGAACAG
CAGCCTTTCATTTGCTTTCCGTGCCCAGGAGCTTTTGAGGCCATATAAAGCACATGAAGATGTG
GTTACAGCACTGTTCATACCTTCTTAATGTTTTCAACGGAAATCTGAACACTGGAAGCAGTTTC
ACGGAGTTTAGGCTGAGTGAACATTGGCCATGGAAATCCATTACAAATAAATACTTTTACATCA
ATACTCTATTTTTAAAAAGAAGAGGAACCACTCTTTTATAGTCCCCATCTTTGCCCTAGCCTGC
CTTAAGTGGAAGGAAGATTAATCACTTAACTGTATTTTACAAAAGAAAAAATAGGGCTTTGGAT
GCTATTACTAGTCATATAAAAAGTATGATTCTGTTTGACTAAGGCAATTATTCTTTAAGAAATC
ACTATAATATGAAAAACTGTGGCAGTTTGTACACCCTTGGTGGCTTGATTTTAAGAAAAAAATG
AGAATGTACTGATGTGTAGTTTGATGAATTTTCTGTATTTATCAGGAGAACACTTCATTGCCTT
AACGTTACCAACCATGCAGCAGAGCCTCACGGCTTCCAGCTGCGCTGCCTGCCACACGAGCTGT
GCTTATTAACAGTGCTGCAGAACGATAGGAGCGCCAGCGCCCACTCACAGTCTCAGCCAGGCTC
TGGGCAGCCGGGACCAAGGTACCGTGCTGACTGTGTGCACTCCCCAAGTCCAGGCCCCACGGAG
GATGTTCTGTCGGGTCTTCCCAAGTCAGAGCCCGATGGACCCTTATCATTCTATGCATTCTACA
CGGATTTCAACCGAGACATCTTGTTCTTGTGTCTGCTGTAGGAGGGAACTCTATCTTTGTTAAA
AAAACCATAGAGATTATCATGGTATACATGCTGTGAACATGTATATGTACAAGTTGTAATGTAT
TCTGTGTTGTAGGCATATTATTTAATTTCACCAAATCATCACTTTTGTACAGTGGCCAAGCAGA
CACCTCCAACTCCAGCATTTCTATTAAGTGCATTTGTACATTTTAGGCCGCTGGATCCAGACTT
TATATTGGCAGTTACTGAGGGCAAAAGCAATATATTGTAACAGAATGTATAAATATTTTTGATA
AAACAGTCTATATTTTATAAAAAGTTATTATAACACTAAAGCTGTACCTCAAAAGTCTCACAAA
TAATTTGATCAAATACTCTACACATCCTCAGAGGATCCGTTTGTGGCTTTTTATCGCTCTCATC
ATATGCCGTTTTGCAAATCATGATCTTCACTGGGCTGGAAATTTTTTAGGTTTTTGTTTTGTTT
TTCTCTTGCCTGTCACTCCATTGTTCTCCCTCAGTTCAGTAATATCATTGATAACACTGTGCTT
AGCATGTTAGGGCCATGATACCTCAGGAACAGCAAGTTGGCCACTAACCACACTTGAATTAACC
ATGTAATCACAGTGAGCTCATCTCTTACAATTGTCCAGATCTGAGTCAATGAGAAACAGGAAAG
CACACAAATACATGAAGAGTTGAGCTTGAGACAGCCTTGCTGAGATACATTGGCCTGTTGTCAC
TGTACTCTGAGAATAATTAAATTTGTCCAGAGATAGTTTATAATACCTTCCAAATTCATTACCA
TTTTTCTCCCAAGATCCTTTGGAAGAAATTTTCTAAAAAGAGGAGCAATATGTTGCTGTAAGTT
GCTTTAAATGCCAGTTAATTGCCTTGGAAAAGAACAATAGAAAAAATAGCATAATTGTCTAGCT
TCAATTTGAACAGTGTTAACACAATCTGAAAATAAAACGCTAACTACTTTTGAGGTACAGTCTG
CATACCTTTGTTGGTTCTGAAATATGCACAGAAAGCAGCGTTTCAAATGGGCTTTTAGCATTAA
AAACTGACAGAGTTATATATACAGTGTACAAAAACTTTTTTAATTGAGGTCAATCACTAAAAAA
ATTAGCGATCAGGGTATAGTCACACAATTATGCTGAAAAAAAAAGCACTCATTTTTCTGTAGTT
TAAAAAATATATATATTAGCCAGATTTTAAATTTTAAGAGTGTAAATAGATGTTGCTATTACTG
TATGTGTACTGGCTGCTCAAGCACTTTGTAAGGAGAGCGGATACTTTAGAATGGTACCCTATGC
ATCCAAATGAAATGTGTGCCTTTACGTCATTCTGAGAAAGAGGGGGTTTGCAGTTATAAGTTTC
CACAAATGCACAAATTAAAGTTCAAAATAGATTGAAATTTGTAA

hide sequence

RefSeq Acc Id:

XM_063281277 ⟹ XP_063137347

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	234,454,009 - 234,558,737 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099225	(Get FASTA)	NCBI Sequence Viewer
	XP_017446092	(Get FASTA)	NCBI Sequence Viewer
	XP_063137347	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB53364	(Get FASTA)	NCBI Sequence Viewer
	EDL82361	(Get FASTA)	NCBI Sequence Viewer
	EDL82362	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034133
	ENSRNOP00000073835
	ENSRNOP00000101976
GenBank Protein	O08874	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001099225 ⟸ NM_001105755

- UniProtKB:

O08874 (UniProtKB/Swiss-Prot), F1LPA4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNPDRGEILLTELQGDSRPLPFSENVSAVQKLDFSDTIVQQKLDDVKDRIKREIRKELKIKE
GAENLRKVTTDKKNLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDSADCPRTPDTPNSD
SRSSTSNNRLMALQKQLDIELKVKQGAENMIQMYSNGPSKDRKLHGTAQQLLQDSKTKIEVIRM
QILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSE
AQARFNESSQKLDLLKYSLEQRLNELPKNHPKSSVVIEELSLVASPTLSPRQSMLSTQNQYSTL
SKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSENRSSFMSRTSKSKSGSSRNLLK
TDDLSNDVCAVLKLDNTVVGQTIWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFL
RLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNIN
IATWGRLVRRAIPTVNHSGTFSPQTPVPATVPVVDARTPELAPPASDSTVTKLDFDLEPEAPPA
PPRASSLGEIDDSSELRVLDIPGQGSETVFDIENDRNNMRPKSKSEYELNIPDSSRSCWSVGEL
EDKRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCE
KRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLG
LQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS
YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPE
RRLGAGEKDAEDVKKHPFFRLTDWSALLDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPR
EPRILLEEEQEMFRDFDYVADWC

hide sequence

RefSeq Acc Id:	XP_017446092 ⟸ XM_017590603
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZV08 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALQKQLDIELKVKQGAENMIQMYSNGPSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNE LAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQ KLDLLKYSLEQRLNELPKNHPKSSVVIEELSLVASPTLSPRQSMLSTQNQYSTLSKPAALTGTL EVRLMGCQDILENVPGRSKATSVALPGWSPSENRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCA VLKLDNTVVGQTIWKPISNQSWDQKFTLELDRVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRA PQMNINIATWGRLVRRAIPTVNHSGTFSPQTPVPATVPVVDARTPELAPPASDSTVTKLDFDLE PEAPPAPPRASSLGEIDDSSELRVLDIPGQGSETVFDIENDRNNMRPKSKSEYELNIPDSSRSC WSVGELEDKRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEV DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYA ACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL LRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALLDKKVKPPFVPTIRGREDVSNFDDEFTSEAP ILTPPREPRILLEEEQEMFRDFDYVADWC hide sequence

Ensembl Acc Id:

ENSRNOP00000034133 ⟸ ENSRNOT00000031748

Ensembl Acc Id:

ENSRNOP00000073835 ⟸ ENSRNOT00000090705

Ensembl Acc Id:

ENSRNOP00000080575 ⟸ ENSRNOT00000094293

Ensembl Acc Id:

ENSRNOP00000082937 ⟸ ENSRNOT00000114434

Ensembl Acc Id:

ENSRNOP00000076880 ⟸ ENSRNOT00000107422

RefSeq Acc Id:	XP_063137347 ⟸ XM_063281277
- Peptide Label:	isoform X2
- UniProtKB:	A6HW75 (UniProtKB/TrEMBL), A0A0G2K6J2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101976 ⟸ ENSRNOT00000140589

Protein Domains

AGC-kinase C-terminal C2 Protein kinase REM-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08874-F1-model_v2	AlphaFold	O08874	1-985	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691797

Promoter ID:

EPDNEW_R2321

Type:

initiation region

Name:

Pkn2_1

Description:

protein kinase N2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	248,840,686 - 248,840,746	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620146	AgrOrtholog
BioCyc Gene	G2FUF-50975	BioCyc
Ensembl Genes	ENSRNOG00000011317	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000031748	ENTREZGENE
	ENSRNOT00000090705	ENTREZGENE
	ENSRNOT00000140589	ENTREZGENE
Gene3D-CATH	HR1 repeat	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot
	C2_dom	UniProtKB/Swiss-Prot
	C2_domain_sf	UniProtKB/Swiss-Prot
	C2_PKN	UniProtKB/Swiss-Prot
	HR1_rho-bd	UniProtKB/Swiss-Prot
	HR1_rpt_sf	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
	PKN_HR1_1	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
NCBI Gene	207122	ENTREZGENE
PANTHER	RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/Swiss-Prot
Pfam	HR1	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
PhenoGen	Pkn2	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
	PS50004	UniProtKB/Swiss-Prot
	REM_1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011317	RatGTEx
SMART	Hr1	UniProtKB/Swiss-Prot
	S_TK_X	UniProtKB/Swiss-Prot
	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46585	UniProtKB/Swiss-Prot
	SSF49562	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A0G2K6J2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZK64_RAT	UniProtKB/TrEMBL
	A0A8I5ZQ41_RAT	UniProtKB/TrEMBL
	A0A8I5ZV08	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LLU6_RAT	UniProtKB/TrEMBL
	A6HW75	ENTREZGENE, UniProtKB/TrEMBL
	A6HW76_RAT	UniProtKB/TrEMBL
	F1LPA4	ENTREZGENE, UniProtKB/TrEMBL
	O08874	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-11-17	Pkn2	protein kinase N2	Prkcl2	protein kinase C-like 2	Symbol and Name updated	1299863	APPROVED
2004-02-11	Prkcl2	protein kinase C-like 2	Pak-2	cardiolipin-activated protein kinase Pak2	Symbol and Name updated to reflect Human and Mouse nomenclature	625702	APPROVED
2002-08-07	Pak-2	cardiolipin-activated protein kinase Pak2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	enriched in liver	633689
gene_protein	116 kDa	633689

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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