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Gene: Icos (inducible T-cell co-stimulator) Rattus norvegicus

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Symbol:

Icos

Name:

inducible T-cell co-stimulator

RGD ID:

620123

Description:

Predicted to enable signaling receptor activity. Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator); PARTICIPATES IN primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

activation-inducible lymphocyte immunomediatory molecule; Ailim; inducible T-cell costimulator

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ICOS (inducible T cell costimulator)	RGD	RGD
Mus musculus (house mouse):	Icos (inducible T cell co-stimulator)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Icos (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ICOS (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ICOS (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Icos (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ICOS (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ICOS (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Icos (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Icos (inducible T cell costimulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Icos (inducible T cell co-stimulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ICOS (inducible T cell costimulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	icos	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Tspe1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	69,862,042 - 69,900,864 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	69,877,785 - 69,900,960 (+)	Ensembl				GRCr8
mRatBN7.2	9	62,368,075 - 62,406,900 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	62,383,832 - 62,405,672 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	70,885,818 - 70,907,670 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	76,001,432 - 76,023,292 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	74,320,006 - 74,341,864 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	67,748,157 - 67,786,808 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	67,763,897 - 67,785,580 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	67,563,758 - 67,599,683 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	9	59,806,431 - 59,827,774 (+)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult T-cell leukemia/lymphoma (ISO)

arteriosclerosis (ISO)

celiac disease (ISO)

colitis (IEP)

common variable immunodeficiency (ISO,ISS)

common variable immunodeficiency 1 (ISO)

genetic disease (ISO)

Gram-Positive Bacterial Infections (ISO)

immunoglobulin alpha deficiency (ISO)

myocarditis (IDA)

primary immunodeficiency disease (ISO)

uveitis (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

choline (ISO)

dibutyl phthalate (ISO)

Didecyldimethylammonium (ISO)

dieldrin (ISO)

dimethylarsinic acid (ISO)

disodium selenite (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

GW 4064 (ISO)

L-methionine (ISO)

methylarsonic acid (ISO)

nickel atom (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

testosterone (EXP)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

trimellitic anhydride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell adhesion (IBA,IDA)

T cell costimulation (IBA,IDA,IEA)

T cell tolerance induction (IBA,IMP)

T follicular helper cell differentiation (IEA,ISO)

Cellular Component

external side of plasma membrane (ISO)

plasma membrane (IEA,ISO)

Molecular Function

protein binding (ISO)

signaling receptor activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

primary immunodeficiency pathway (IEA)

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway.	Futamatsu H, etal., Cardiovasc Res. 2003 Jul 1;59(1):95-104.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.	Gotsman I, etal., Circulation. 2006 Nov 7;114(19):2047-55. Epub 2006 Oct 23.
4.	Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade.	Guillonneau C, etal., Transplantation. 2005 Aug 27;80(4):546-54.
5.	The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.	Haimila K, etal., Genes Immun. 2009 Mar;10(2):151-61. doi: 10.1038/gene.2008.89. Epub 2008 Nov 20.
6.	Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis.	Ishii K, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):174-81.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes.	Mittrucker HW, etal., J Immunol. 2002 Nov 15;169(10):5813-7.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	AILIM/ICOS: a novel lymphocyte adhesion molecule.	Tamatani T, etal., Int Immunol. 2000 Jan;12(1):51-5.
16.	Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family.	Tezuka K, etal., Biochem Biophys Res Commun 2000 Sep 16;276(1):335-45.
17.	Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis.	Xing L, etal., Graefes Arch Clin Exp Ophthalmol. 2006 Apr 7;.

Additional References at PubMed

PMID:10760791	PMID:16227984	PMID:19008373	PMID:23583643	PMID:24909668	PMID:26436531	PMID:27323062	PMID:31153660

Genomics

Comparative Map Data

Icos
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	69,862,042 - 69,900,864 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	69,877,785 - 69,900,960 (+)	Ensembl				GRCr8
mRatBN7.2	9	62,368,075 - 62,406,900 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	62,383,832 - 62,405,672 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	70,885,818 - 70,907,670 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	76,001,432 - 76,023,292 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	74,320,006 - 74,341,864 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	67,748,157 - 67,786,808 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	67,763,897 - 67,785,580 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	67,563,758 - 67,599,683 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	9	59,806,431 - 59,827,774 (+)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

ICOS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	203,936,763 - 203,961,577 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	203,936,763 - 203,961,577 (+)	Ensembl			hg38	GRCh38
GRCh37	2	204,801,486 - 204,826,300 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	204,509,748 - 204,534,545 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	204,627,008 - 204,651,802	NCBI
Celera	2	198,556,278 - 198,581,105 (+)	NCBI		Celera
Cytogenetic Map	2	q33.2	NCBI
HuRef	2	196,648,626 - 196,673,332 (+)	NCBI		HuRef
CHM1_1	2	204,807,968 - 204,832,793 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	204,418,652 - 204,443,466 (+)	NCBI		T2T-CHM13v2.0

Icos
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	60,999,909 - 61,039,481 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	61,017,086 - 61,039,479 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	60,960,773 - 61,000,322 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	60,977,927 - 61,000,320 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	61,034,758 - 61,057,164 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	60,922,469 - 60,943,665 (+)	NCBI		MGSCv36	mm8
Celera	1	61,493,037 - 61,515,464 (+)	NCBI		Celera
Cytogenetic Map	1	C2	NCBI
cM Map	1	30.6	NCBI

Icos
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	10,934,341 - 10,952,404 (-)	Ensembl
ChiLan1.0	NW_004955457	10,934,390 - 10,952,318 (-)	NCBI	ChiLan1.0	ChiLan1.0

ICOS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	106,541,524 - 106,566,298 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	106,556,516 - 106,581,290 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	91,168,998 - 91,193,808 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	209,307,938 - 209,332,734 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	209,307,938 - 209,332,734 (+)	Ensembl			panPan2	panpan1.1

ICOS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	12,663,839 - 12,735,266 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	12,670,999 - 12,733,458 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	13,596,013 - 13,616,605 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	12,600,441 - 12,671,981 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	12,607,586 - 12,670,174 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	12,606,503 - 12,627,090 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	12,569,911 - 12,590,566 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	12,571,149 - 12,591,783 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Icos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	160,927,573 - 160,937,186 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936631	551,394 - 570,804 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936631	562,650 - 572,263 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ICOS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	107,350,203 - 107,370,119 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	107,350,253 - 107,370,123 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	118,697,582 - 118,717,451 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ICOS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	89,706,755 - 89,732,600 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	89,726,489 - 89,732,944 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	109,655,109 - 109,680,201 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Icos
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	12,352,042 - 12,372,861 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624765	12,351,695 - 12,417,847 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Icos
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	135,033,429 - 135,067,539 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Icos
388 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	219
Count of miRNA genes:	145
Interacting mature miRNAs:	179
Transcripts:	ENSRNOT00000071226
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	57460497	78547958	Rat
1578659	Tspe1	Trichinella spiralis expulsion QTL 1	4.8		parasite quantity (VT:0010441)	logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)	9	68875497	73185088	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	67	157	91	90	59	92	59	6	353	189	10	134	81	92	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001431817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB023133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB023134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC112446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS008895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS008897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000071226 ⟹ ENSRNOP00000064455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	69,877,785 - 69,899,636 (+)	Ensembl
mRatBN7.2 Ensembl	9	62,383,832 - 62,405,672 (+)	Ensembl
Rnor_6.0 Ensembl	9	67,763,897 - 67,785,580 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091060 ⟹ ENSRNOP00000070990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	69,877,785 - 69,896,672 (+)	Ensembl
mRatBN7.2 Ensembl	9	62,383,832 - 62,402,706 (+)	Ensembl
Rnor_6.0 Ensembl	9	67,774,150 - 67,785,021 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119869 ⟹ ENSRNOP00000079452

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	69,877,785 - 69,896,126 (+)	Ensembl
mRatBN7.2 Ensembl	9	62,383,832 - 62,402,160 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000156653 ⟹ ENSRNOP00000099767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	69,877,785 - 69,900,960 (+)	Ensembl

RefSeq Acc Id:

NM_022610 ⟹ NP_072132

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,877,799 - 69,899,649 (+)	NCBI
mRatBN7.2	9	62,383,832 - 62,405,685 (+)	NCBI
Rnor_6.0	9	67,763,897 - 67,785,593 (+)	NCBI
Rnor_5.0	9	67,563,758 - 67,599,683 (+)	NCBI
Celera	9	59,806,431 - 59,827,774 (+)	RGD

Sequence:

show sequence

CTGGAGGGGAAGAGTGCAGCTGTTCCTGGCAGACATGAAGCCCTACTTCTCGTGCGTCTTTGTC
TTCTGCTTCCTAATCAAACTTTTAACAGGAGAACTCAATGACTTGGCCAATCACAGGATGTTTT
CGTTTCACGATGGAGGTGTACAGATTTCTTGTAACTACCCTGAGACTGTCCAGCAGTTAAAAAT
GCAGTTGTTCAAAGACAGAGAAGTCCTCTGCGACCTCACCAAGACCAAGGGAAGCGGAAACACC
GTGTCCATCAAGAATCCGATGTCCTGTCCATATCAGCTGTCCAACAACAGTGTCTCTTTTTTCC
TAGACAACGCAGACAGCTCCCAGGGCAGCTACTTTTTATGCAGCCTGTCGATTTTCGACCCACC
CCCTTTTCAAGAAAAGAACCTTAGTGGAGGATATTTGCTTATTTATGAATCCCAGCTTTGTTGC
CAGCTGAAGCTTTGGTTACCCGTAGGGTGTGCAGCTTTTGTGGCAGCGCTCCTTTTTGGATGCA
TATTTATCGTCTGGTTTGCAAAAAAGAAGTACAGATCCAGTGTGCACGACCCTAATAGCGAGTA
CATGTTCATGGCGGCAGTCAACACAAACAAAAAGTCCAGACTTGCAGGTATGACCTCATAATCT
GGAACACGGGAACCCATGGAGGAACTACACTGTCTAGTTCCCCTGAAACTTGAATGGAGAAAGT
CTTCTATTTTCTGGACCACAGGGCATCTGACTTGATTAACTACTGATACCTCCTTTTGGTGTTT
TGTTTGTCTGGATCAGTGACTATCAGTCACTCGGAATTTCAGCAGACTGCCCTGGGTTTGCTGA
GTCCTTTTAAGGCAAACCCCTTCTTATAGAAGACCCGGCTCATATGTATTCAACAAACAGACCT
CACTGGGATACAATCCCCTCTTTCTGCGCCTGCTTCTAGCTATGCACCGGCCAGCAAGACAAAC
ATATCTCCAGCATTTTTACAAAAATGCCAGGGTATGAATCTGTAAAGTACACAGGCAGCCATTG
ACCACCGTCTGTCCTCGTTTTTTCAGATTCTATTTTTTTCCATAGAGATCAGCATTCCTTCTAG
AATCAGACAGTAGAGGGAGATGCTTCACAACAGAAGCTCTTATGTTTCTGAGATGTTGATGAAT
TCATGCTTTAGTACCACCATGTTCTCTAACAACTTCTATATTCCAGCTGATCACTGCTTCAGGG
CTTAGATGCCTGCTTTTGCCTTCAAGTCTCCCCTTAAAGATACTCCCACAGGTCTACTTGGTGG
CCTGCAGCCACTCTGAATAGGAAGTTTGGTCTACAATTTCCCCCCTCTGCTGCTCAAAAAAAAA
AATTAGTAGATATGATTTTCCCATATTCTCCCTGCCAAAGTAATTTTTTCCAGCAAAGACATCT
AAATTCAGTTAATATGGTTTACTGTGTTGATATTAGTGGCAGTAAACATTTCTCAGAATCAAAA
GCAAATTAATTTTGCGGTGGTGTTTTTCTACCATTATCTTGGGTTTCCATGGTGCTATTACTCA
CAAGTTTAGCTATTTTTTTATGCATCATATTAAAGTTGCAAGCAAGCAGAGCAACCCTCGGTTA
ATGGGCAAACATTCTCCTGGGGTAGAATGAATTGTCTATTTAGCCCGAAAACTGCAGTTTCTGT
GGGTGGCTGCCAGACTACAGCCGTGCTTTGCTCTGGCTTTGACAGGTTGAAATAGTCCCCATGA
GCCTGGAACAGTACTCCAGACTGTGCTGGAGTCCCAAAGTTAGGAGGGCCATGGAGCCTGGGAC
AGGCTGCTGCTTTGGTCTTTAGGATCTAGGAAGAATTACAGAGGGGCCAAGACAGAGTTCCCTC
CCCTAGAAACTGTGCAGCCTGGAAGTCAGCCCTGGCACTTTAAGATAGCCTTCTTTAGAACATG
AGTTAGTTGGTAGTATTCTGACGTGTAAACAGCCTATGTTGCTCGGAGCTGGACCATTTTCTCC
ACTTCCCTGTCTGCATGCCTAAGACTTCTAGAGCAGCCAACGTATATGCAACATTAAAGAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006245037 ⟹ XP_006245099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,864,983 - 69,896,538 (+)	NCBI
mRatBN7.2	9	62,371,016 - 62,402,274 (+)	NCBI
Rnor_6.0	9	67,751,085 - 67,783,448 (+)	NCBI
Rnor_5.0	9	67,563,758 - 67,599,683 (+)	NCBI

Sequence:

show sequence

TCAGTCTGACGAGGCAGGATAGAGCCTTTCCCAGGAAGCCTTTCACTTCCTGCCGATCCGGAGG
GAAGAGGATGGAGTTACAAGGACCTTCTGACAGTCAAACAATGGTCCTTTGAGGTCACAGATAA
AATAATTTCTGAGCAGAGAAGTTAGACTTCTTTCCCAAGTTCCTGGACCTGGTAAATGATGGAG
CCGACTCTAGAATAAAACAGAAAACAACTGAGAACATGATTTCACTGCCACTTTTGAGCACTGG
AGGGGAAGAGTGCAGCTGTTCCTGGCAGACATGAAGCCCTACTTCTCGTGCGTCTTTGTCTTCT
GCTTCCTAATCAAACTTTTAACAGGAGAACTCAATGACTTGGCCAATCACAGGATGTTTTCGTT
TCACGATGGAGGTGTACAGATTTCTTGTAACTACCCTGAGACTGTCCAGCAGTTAAAAATGCAG
TTGTTCAAAGACAGAGAAGTCCTCTGCGACCTCACCAAGACCAAGGGAAGCGGAAACACCGTGT
CCATCAAGAATCCGATGTCCTGTCCATATCAGCTGTCCAACAACAGTGTCTCTTTTTTCCTAGA
CAACGCAGACAGCTCCCAGGGCAGCTACTTTTTATGCAGCCTGTCGATTTTCGACCCACCCCCT
TTTCAAGAAAAGAACCTTAGTGGAGGATATTTGCTTATTTATGAATCCCAGCTTTGTTGCCAGC
TGAAGCTTTGGTTACCCGTAGGGTGTGCAGCTTTTGTGGCAGCGCTCCTTTTTGGATGCATATT
TATCGTCTGGTTTGCAAAAAAGAAGTACAGATCCAGTGTGCACGACCCTAATAGCGAGTACATG
TTCATGGCGGCAGTCAACACAAACAAAAAGTCCAGACTTGCAGGTACAGCACCCCTTAGGGCTT
TGGGGAGAGGAGAACACTCTTCATGTCAAGACCGGAATTAATTTGTTTATTTCTATTTTAAAAG
AAAGACATTTTTTCCCCTAAAGATAATTTTTGTATTTTTATGTGAAAGTCTGAATCTTCATTTT
AACTGCACTTATATACTCTGTGGTATATTAAAAATAATGTTTGTGAATTGGTATTAATACATTA
CCAGGGGTCAAGGATGGAGTTCAACTAGTGTAACACAGACAAAGCCCTGGTTTCTAGCTCCGCA
CCACACAAATGGGCATGGTGTTACATACTTGTATTCCTAGCACTCGGGAGTTGGAGAATCAGAA
GGGCAAAGACATTTTTAGGTACATGGTGAGTTAGAGGCCAGTCTGTGATATATGAGTTACTGTT
TCAAGATTATCAGAGGATGGGGTGGTAGAGAAAGAAAAAGAAAAGAAAAGAAAAGAAAAGAAAA
AAGAAAGAAAAAGAAAAGAAAAGAAAAGGACAACAACCACAAAAAGCCCCAGATTGGAGTAAGA
GGATAGCAATTTAAGCCTAGCCTGGGCTATAGAATGAGTTGCACAAGGCCAAGCTGAGCCACTT
GACGAGTCCTTGTCTCCAAAGAAACAGTTAAAAGGGAGATACAGACACGTGCATCCCACAGGTA
GAGCACTTGCCTATCATGCCTGAGGGCTTAGTTCAAATCCTAGTACAAAAAAATAATCCATGGC
TCACAGTTGTTTTAAGGTGATCTTCAACTAATATTTAAACATCAGAGATGTATCTGGCTCTGAG
AGTAAAGGTCATGGAACCAGATGGTGGTCATCTATTGACTATCCTTTAAATGAAAGCTTTTGAG
TGAGGGTACTGTGTGGGTGATGGGAATTTTAGATGAGGCTGGGAAGAGAGGTTTAGGTGGATGC
TGGGTGGAGGGGAGTTGATGAAAACACTCGGTTGTTTGGAAAAACGTCCAAGGCTAGAGCACCT
TGGCACAGCTTCCACCTAGTCCATGGGGAGTTAGAGGGGAGTGCTGCCAGGTCTGGGAATATCC
AGAGAGCTTGAAACATCCACTGTGGAAAACTTTACGCATCTTGCGCCCATGGGTAGGAGGATGT
AGGTAGGGTAGGAAAGGAAACAGAAGCCACCGCATTCTTGCTACCACTCGGTGTCTCAGTAGCA
CACAGATTATCATGGAATCACTGCATGAATGAGGGTCTAGCCCTCACTGTTGGTCTTTACTCTC
CATTTAGATAACTGGAATTGAGGTCCAGACTGCCGGTGGCTCCCTTCCAGAAAGTTACTATCAC
AGCTTTGGCTCTTGTGATCACTTTTATTTGATTACTTTGCTCCTGAAAAAAGCTAAAACAAAAA
CAAAAACAAAAACAAAAACGACAACAACATTCTTCACCCCAATCACTGTCTTAATAATAATGCA
TTCTATCTTATTTTGGAGTTCCTTAAACAGA

hide sequence

RefSeq Acc Id:

XM_006245038 ⟹ XP_006245100

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,864,965 - 69,900,864 (+)	NCBI
mRatBN7.2	9	62,371,016 - 62,406,900 (+)	NCBI
Rnor_6.0	9	67,751,086 - 67,786,808 (+)	NCBI
Rnor_5.0	9	67,563,758 - 67,599,683 (+)	NCBI

Sequence:

show sequence

CAGTCTGACGAGGCAGGATAGAGCCTTTCCCAGGAAGCCTTTCACTTCCTGCCGATCCGGAGGG
AAGAGGATGGAGTTACAAGGACCTTCTGACAGTCAAACAATGGTCCTTTGAGGTCACAGATAAA
ATAATTTCTGAGCAGAGAAGTTAGACTTCTTTCCCAAGTTCCTGGACCTGGTAAATGATGGAGC
CGACTCTAGAATAAAACAGAAAACAACTGAGAACATGATTTCACTGCCACTTTTGAGCACTGGA
GGGGAAGAGTGCAGCTGTTCCTGGCAGACATGAAGCCCTACTTCTCGTGCGTCTTTGTCTTCTG
CTTCCTAATCAAACTTTTAACAGGAGAACTCAATGACTTGGCCAATCACAGGATGTTTTCGTTT
CACGATGGAGGTGTACAGATTTCTTGTAACTACCCTGAGACTGTCCAGCAGTTAAAAATGCAGT
TGTTCAAAGACAGAGAAGTCCTCTGCGACCTCACCAAGACCAAGGGAAGCGGAAACACCGTGTC
CATCAAGAATCCGATGTCCTGTCCATATCAGCTGTCCAACAACAGTGTCTCTTTTTTCCTAGAC
AACGCAGACAGCTCCCAGGGCAGCTACTTTTTATGCAGCCTGTCGATTTTCGACCCACCCCCTT
TTCAAGAAAAGAACCTTAGTGGAGGATATTTGCTTATTTATGAATCCCAGCTTTGTTGCCAGCT
GAAGCTTTGGTTACCCGTAGGGTGTGCAGCTTTTGTGGCAGCGCTCCTTTTTGGATGCATATTT
ATCGTCTGGTTTGCAAAAAAGAAGTACAGATCCAGTGTGCACGACCCTAATAGCGAGTACATGT
TCATGGCGGCAGTCAACACAAACAAAAAGTCCAGACTTGCAGGTATGACCTCATAATCTGGAAC
ACGGGAACCCATGGAGGAACTACACTGTCTAGTTCCCCTGAAACTTGAATGGAGAAAGTCTTCT
ATTTTCTGGACCACAGGGCATCTGACTTGATTAACTACTGATACCTCCTTTTGGTGTTTTGTTT
GTCTGGATCAGTGACTATCAGTCACTCGGAATTTCAGCAGACTGCCCTGGGTTTGCTGAGTCCT
TTTAAGGCAAACCCCTTCTTATAGAAGACCCGGCTCATATGTATTCAACAAACAGACCTCACTG
GGATACAATCCCCTCTTTCTGCGCCTGCTTCTAGCTATGCACCGGCCAGCAAGACAAACATATC
TCCAGCATTTTTACAAAAATGCCAGGGTATGAATCTGTAAAGTACACAGGCAGCCATTGACCAC
CGTCTGTCCTCGTTTTTTCAGATTCTATTTTTTTCCATAGAGATCAGCATTCCTTCTAGAATCA
GACAGTAGAGGGAGATGCTTCACAACAGAAGCTCTTATGTTTCTGAGATGTTGATGAATTCATG
CTTTAGTACCACCATGTTCTCTAACAACTTCTATATTCCAGCTGATCACTGCTTCAGGGCTTAG
ATGCCTGCTTTTGCCTTCAAGTCTCCCCTTAAAGATACTCCCACAGGTCTACTTGGTGGCCTGC
AGCCACTCTGAATAGGAAGTTTGGTCTACAATTTCCCCCCTCTGCTGCTCAAAAAAAAAATTAG
TAGATATGATTTTCCCATATTCTCCCTGCCAAAGTAATTTTTTCCAGCAAAGACATCTAAATTC
AGTTAATATGGTTTACTGTGTTGATATTAGTGGCAGTAAACATTTCTCAGAATCAAAAGCAAAT
TAATTTTGCGGTGGTGTTTTTCTACCATTATCTGGGTTTCCATGGTGCTATTACTCACAAGTTT
AGCTATTTTTATGCATCATATTAAAGTTGCAAGCAAGCAGAGCAACCCTCGGTTAATGGGCAAA
CATTCTCCTGGGGTAGAATGAATTGTCTATTTAGCCCGAAAACTGCAGTTTCTGTGGGTGGCTG
CCAGACTACAGCCGTGCTTTGCTCTGGCTTTGACAGGTTGAAATAGTCCCCATGAGCCTGGAAC
AGTACTCCAGACTGTGCTGGAGTCCCAAAGTTAGGAGGGCCATGGAGCCTGGGACAGGCTGCTG
CTTTGGTCTTTAGGATCTAGGAAGAATTACAGAGGGGCCAAGACAGAGTTCCCTCCCCTAGAAA
CTGTGCAGCCTGGAAGTCAGCCCTGGCACTTTAAGATAGCCTTCTTTAGAACATGAGTTAGTTG
GTAGTATTCTGACGTGTAAACAGCCTATGATTGCTCGGAGCTGGACCATTTTCTCCACTTCCCT
GTCTGCATGCCTAAGACTTCTAGAGCAGCCAACGTATATGCAACATTAAAGAAAAAAAAAGAAA
AGAAAAGAAACAGCAAAAAGCAGACAAACAAGATAAACCCCAAACTTAAATAAAATAGGGCTGC
TTCCTAGTTTTAAGTTATAGTTGCTTACTCAGTTTGCTTTACAAGTGAACTGGGTATCAACGGA
TACTTATTACATTAAGCATGTGTAATGCTGGCTATGTACAGTACAGTACTGACCTTAAGTATGG
TGTTCTCTCTCTTCCAATGACTCAGGCAGCCTGGCTGGCTCTGTGAGGGCATCCCCTGAGTTGG
ATGGACCTCTTTGTTTAGGGGGTGAGGGTACTTTACTCCGGTCCTTGAAGGATCCCCATCCCAA
CACTGAACACCTACCAATGAATTCTTGAAGAACAAAATTTCTGTGAAATAAAATCTGGCTTACA
GAGGAGCCATGTGCTAAAGATGTTAGCAATAATACCAAGTCACGGCTAAGCACGAGTGTGCAGC
AATGGGATAGAACCTTGCTGTGTTTTCTGGGGGCGAAGAAGTGATGACCTTAGCTACCACATGC
AAATTAGCCCTTGCTCTCCCATGACCTTGTGTGCTGCATAAGATAGTTGCTCCCTTTGCCTCGC
TTTCCCCCTTTTAAACTCTAAAATAGCCACAAACTTATAAAAGAGTCAGAAGCACAGGAAAAAG
TGTGTTCTGCGCCTGACTTAGTTTCTGCCTTGACCCCCCCGGCCCCACAGAATGGTGCCTATTT
CCTATGGAAATGAAGGCTGTATTCTTTGATGACTTGACAGTCACCAATGTCAGAAAATTATCGT
TGATATGTCACTATTCTCTATTCTTTGGTCTGCATTCAAGATCTTCCCCTCGGTTCTAGGATGT
CTGTAGGAGCCGAAGGTTCTGCTGGAGACTTCCCCCTGTGTTTGGCTGTCCAGTCTCTGGAGTA
TTCTTCAGTCTGGACAGTTCTCTTCAGTCTGTAGTCTGGGCTCTTTGTCTGATCGTGGGCCATT
GTTTTGTAGAATGTTTCTTTTGGGGGGGTCACTCTGATGTTTCTTCATGAATGAAATGAAGTTA
TTTGTCTTTAGCAGAAATAATACAGAAGTGGTGTTGCGCCCTGTAGGGCAGCTCACATTTCGGT
TCGTCAAGTTACTGCCAATGTTTGTTTTCATCTCTTGACTAAGCTCCTGTCAAGCTTCTCCATT
GCGAAGTGATTCTGCCCCTCCACCCCCAACAGCCAATAAATATGCTTTGTGAGAAAGTA

hide sequence

RefSeq Acc Id:

XM_008767136 ⟹ XP_008765358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,862,042 - 69,896,538 (+)	NCBI
mRatBN7.2	9	62,368,075 - 62,402,274 (+)	NCBI
Rnor_6.0	9	67,748,157 - 67,783,448 (+)	NCBI

Sequence:

show sequence

GTCCTTCTCAAATCTGAGTGGACGCTCCTGCACTTCTTCCTGAAACAAAGAGAGAGAAAAACCT
GCAGCTGTGCAGGTCATTGGCTCCTTTGAGGCTTACATAGAAATTTTAAGGAAGTAGGGTCCTT
TGAGGTCACAGATAAAATAATTTCTGAGCAGAGAAGTTAGACTTCTTTCCCAAGTTCCTGGACC
TGGTAAATGATGGAGCCGACTCTAGAATAAAACAGAAAACAACTGAGAACATGATTTCACTGCC
ACTTTTGAGCACTGGAGGGGAAGAGTGCAGCTGTTCCTGGCAGACATGAAGCCCTACTTCTCGT
GCGTCTTTGTCTTCTGCTTCCTAATCAAACTTTTAACAGGAGAACTCAATGACTTGGCCAATCA
CAGGATGTTTTCGTTTCACGATGGAGGTGTACAGATTTCTTGTAACTACCCTGAGACTGTCCAG
CAGTTAAAAATGCAGTTGTTCAAAGACAGAGAAGTCCTCTGCGACCTCACCAAGACCAAGGGAA
GCGGAAACACCGTGTCCATCAAGAATCCGATGTCCTGTCCATATCAGCTGTCCAACAACAGTGT
CTCTTTTTTCCTAGACAACGCAGACAGCTCCCAGGGCAGCTACTTTTTATGCAGCCTGTCGATT
TTCGACCCACCCCCTTTTCAAGAAAAGAACCTTAGTGGAGGATATTTGCTTATTTATGAATCCC
AGCTTTGTTGCCAGCTGAAGCTTTGGTTACCCGTAGGGTGTGCAGCTTTTGTGGCAGCGCTCCT
TTTTGGATGCATATTTATCGTCTGGTTTGCAAAAAAGAAGTACAGATCCAGTGTGCACGACCCT
AATAGCGAGTACATGTTCATGGCGGCAGTCAACACAAACAAAAAGTCCAGACTTGCAGGTACAG
CACCCCTTAGGGCTTTGGGGAGAGGAGAACACTCTTCATGTCAAGACCGGAATTAATTTGTTTA
TTTCTATTTTAAAAGAAAGACATTTTTTCCCCTAAAGATAATTTTTGTATTTTTATGTGAAAGT
CTGAATCTTCATTTTAACTGCACTTATATACTCTGTGGTATATTAAAAATAATGTTTGTGAATT
GGTATTAATACATTACCAGGGGTCAAGGATGGAGTTCAACTAGTGTAACACAGACAAAGCCCTG
GTTTCTAGCTCCGCACCACACAAATGGGCATGGTGTTACATACTTGTATTCCTAGCACTCGGGA
GTTGGAGAATCAGAAGGGCAAAGACATTTTTAGGTACATGGTGAGTTAGAGGCCAGTCTGTGAT
ATATGAGTTACTGTTTCAAGATTATCAGAGGATGGGGTGGTAGAGAAAGAAAAAGAAAAGAAAA
GAAAAGAAAAGAAAAAAGAAAGAAAAAGAAAAGAAAAGAAAAGGACAACAACCACAAAAAGCCC
CAGATTGGAGTAAGAGGATAGCAATTTAAGCCTAGCCTGGGCTATAGAATGAGTTGCACAAGGC
CAAGCTGAGCCACTTGACGAGTCCTTGTCTCCAAAGAAACAGTTAAAAGGGAGATACAGACACG
TGCATCCCACAGGTAGAGCACTTGCCTATCATGCCTGAGGGCTTAGTTCAAATCCTAGTACAAA
AAAATAATCCATGGCTCACAGTTGTTTTAAGGTGATCTTCAACTAATATTTAAACATCAGAGAT
GTATCTGGCTCTGAGAGTAAAGGTCATGGAACCAGATGGTGGTCATCTATTGACTATCCTTTAA
ATGAAAGCTTTTGAGTGAGGGTACTGTGTGGGTGATGGGAATTTTAGATGAGGCTGGGAAGAGA
GGTTTAGGTGGATGCTGGGTGGAGGGGAGTTGATGAAAACACTCGGTTGTTTGGAAAAACGTCC
AAGGCTAGAGCACCTTGGCACAGCTTCCACCTAGTCCATGGGGAGTTAGAGGGGAGTGCTGCCA
GGTCTGGGAATATCCAGAGAGCTTGAAACATCCACTGTGGAAAACTTTACGCATCTTGCGCCCA
TGGGTAGGAGGATGTAGGTAGGGTAGGAAAGGAAACAGAAGCCACCGCATTCTTGCTACCACTC
GGTGTCTCAGTAGCACACAGATTATCATGGAATCACTGCATGAATGAGGGTCTAGCCCTCACTG
TTGGTCTTTACTCTCCATTTAGATAACTGGAATTGAGGTCCAGACTGCCGGTGGCTCCCTTCCA
GAAAGTTACTATCACAGCTTTGGCTCTTGTGATCACTTTTATTTGATTACTTTGCTCCTGAAAA
AAGCTAAAACAAAAACAAAAACAAAAACAAAAACGACAACAACATTCTTCACCCCAATCACTGT
CTTAATAATAATGCATTCTATCTTATTTTGGAGTTCCTTAAACAGA

hide sequence

RefSeq Acc Id:

XM_039084171 ⟹ XP_038940099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,864,983 - 69,900,864 (+)	NCBI
mRatBN7.2	9	62,371,016 - 62,406,900 (+)	NCBI

RefSeq Acc Id:

XM_063267687 ⟹ XP_063123757

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	69,864,983 - 69,896,538 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001418746	(Get FASTA)	NCBI Sequence Viewer
	NP_001418747	(Get FASTA)	NCBI Sequence Viewer
	NP_001418748	(Get FASTA)	NCBI Sequence Viewer
	NP_072132	(Get FASTA)	NCBI Sequence Viewer
	XP_006245099	(Get FASTA)	NCBI Sequence Viewer
	XP_006245100	(Get FASTA)	NCBI Sequence Viewer
	XP_008765358	(Get FASTA)	NCBI Sequence Viewer
	XP_038940099	(Get FASTA)	NCBI Sequence Viewer
	XP_063123757	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA82127	(Get FASTA)	NCBI Sequence Viewer
	BAA82128	(Get FASTA)	NCBI Sequence Viewer
	CAI53652	(Get FASTA)	NCBI Sequence Viewer
	CAI53654	(Get FASTA)	NCBI Sequence Viewer
	EDL98921	(Get FASTA)	NCBI Sequence Viewer
	EDL98922	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064455
	ENSRNOP00000064455.1
	ENSRNOP00000079452
GenBank Protein	Q9R1T7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_072132 ⟸ NM_022610
- Peptide Label:	precursor
- UniProtKB:	Q9WVR9 (UniProtKB/Swiss-Prot), Q9R1T7 (UniProtKB/Swiss-Prot), A6IPD8 (UniProtKB/TrEMBL), A0A0G2JZC0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCD LTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGY LLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKK SRLAGMTS hide sequence

RefSeq Acc Id:

XP_006245100 ⟸ XM_006245038

- Peptide Label:

isoform X2

- Sequence:

show sequence

MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCD
LTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGY
LLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKK
SRLAGMTS

hide sequence

RefSeq Acc Id:	XP_006245099 ⟸ XM_006245037
- Peptide Label:	isoform X1
- UniProtKB:	A6IPD9 (UniProtKB/TrEMBL), A0A8I5ZN49 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCD LTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGY LLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKK SRLAGTAPLRALGRGEHSSCQDRN hide sequence

RefSeq Acc Id:	XP_008765358 ⟸ XM_008767136
- Peptide Label:	isoform X1
- UniProtKB:	A6IPD9 (UniProtKB/TrEMBL), A0A8I5ZN49 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCD LTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGY LLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKK SRLAGTAPLRALGRGEHSSCQDRN hide sequence

Ensembl Acc Id:

ENSRNOP00000070990 ⟸ ENSRNOT00000091060

Ensembl Acc Id:

ENSRNOP00000064455 ⟸ ENSRNOT00000071226

RefSeq Acc Id:	XP_038940099 ⟸ XM_039084171
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000079452 ⟸ ENSRNOT00000119869

RefSeq Acc Id:	XP_063123757 ⟸ XM_063267687
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000099767 ⟸ ENSRNOT00000156653

Protein Domains

Ig-like V-type Immunoglobulin V-set

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R1T7-F1-model_v2	AlphaFold	Q9R1T7	1-200	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696708

Promoter ID:

EPDNEW_R7233

Type:

multiple initiation site

Name:

Icos_1

Description:

inducible T-cell co-stimulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	67,763,883 - 67,763,943	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620123	AgrOrtholog
BioCyc Gene	G2FUF-27369	BioCyc
Ensembl Genes	ENSRNOG00000046196	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000071226	ENTREZGENE
	ENSRNOT00000071226.3	UniProtKB/Swiss-Prot
	ENSRNOT00000119869	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
InterPro	ICOS	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_V-set	UniProtKB/Swiss-Prot
KEGG Report	rno:64545	UniProtKB/Swiss-Prot
NCBI Gene	64545	ENTREZGENE
PANTHER	INDUCIBLE T-CELL COSTIMULATOR	UniProtKB/Swiss-Prot
	PTHR20904	UniProtKB/Swiss-Prot
Pfam	V-set_2	UniProtKB/Swiss-Prot
PhenoGen	Icos	PhenoGen
RatGTEx	ENSRNOG00000046196	RatGTEx
UniProt	A0A0G2JZC0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZN49	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L672_RAT	UniProtKB/TrEMBL
	A6IPD8	ENTREZGENE, UniProtKB/TrEMBL
	A6IPD9	ENTREZGENE, UniProtKB/TrEMBL
	ICOS_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9WVR9	ENTREZGENE
UniProt Secondary	Q9WVR9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Icos	inducible T-cell co-stimulator	Ailim	activation-inducible lymphocyte immunomediatory molecule	Symbol and Name updated	1299863	APPROVED
2002-08-07	Ailim	activation-inducible lymphocyte immunomediatory molecule			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	high level of cell surface expression is detected on CD45RA-positive B-cells	631942

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)