Icos Rat Gene (inducible T-cell co-stimulator)

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Keyword

Gene:
Icos ( Rattus norvegicus )
inducible T-cell co-stimulator
Description: activation-inducible lymphocyte immunomediatory molecule; involved in the immune response in CD45RA-positive B-cells
Synonyms: Ailim; activation-inducible lymphocyte immunomediatory molecule;
ArrayIDs: 1370769_a_at; 1368783_at;  (details...)
Gene Type: protein-coding

Additional Data

Candidate gene for: Tspe1 - Trichinella spiralis expulsion QTL 1

Homologs

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Icos Rat Celera Assembly 9 59806431 - 59827774

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Genome
View:

Annotation
Molecular Function

Gene Ontology

molecular_function (details...)
Biological Process

Gene Ontology

cell-cell adhesion,  T cell costimulation,  T cell tolerance induction (details...)
Cellular Component

Gene Ontology

integral to plasma membrane (details...)
Disease

Ontology

Myocarditis,  Colitis,  Uveitis ... (details...)
Expression

Note Reference

high level of cell surface expression is detected on CD45RA-positive B-cells 631942

External Links
Databases
DATABASE ID SOURCE
IPI: IPI00207669 IPI
IPI: IPI00454381 IPI
Germonline: 620123
Entrez Gene: Icos ENTREZGENE
UNIPARC: UPI00000E616A IPI
UNIPARC: UPI00000E6A59 IPI
UniProt: ICOS_RAT IPI
UniProt: ICOS_RAT IPI
Sequences
Nucleotide: NM_022610 Get FASTA Search GEO Profiles
Nucleotide: AB023134 Get FASTA Search GEO Profiles
Nucleotide: CS008895 Get FASTA Search GEO Profiles
Nucleotide: CH473965 Get FASTA Search GEO Profiles
Nucleotide: AB023133 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: EDL98922 Get FASTA
Protein: NP_072132 Get FASTA
Protein: EDL98921 Get FASTA
Protein: CAI53652 Get FASTA
Protein: BAA82127 Get FASTA
Protein: BAA82128 Get FASTA
Protein: Q9R1T7 Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene: 168816

References
Curated References
11 references in RGD related to Icos

Other References
3 other references at PubMed related to Icos

Database Information
RGD ID 620123
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

20-JAN-05: Icos inducible T-cell co-stimulator Ailim activation-inducible lymphocyte immunomediatory molecule APPROVED Symbol and Name updated 1299863

07-AUG-02: Ailim activation-inducible lymphocyte immunomediatory molecule PROVISIONAL Symbol and Name status set to provisional 70820