Icos (inducible T-cell co-stimulator) - Rat Genome Database

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Pathways
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Gene: Icos (inducible T-cell co-stimulator) Rattus norvegicus
Analyze
Symbol: Icos
Name: inducible T-cell co-stimulator
RGD ID: 620123
Description: Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator); PARTICIPATES IN primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activation-inducible lymphocyte immunomediatory molecule; Ailim; inducible T-cell costimulator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Tspe1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8969,862,042 - 69,900,864 (+)NCBIGRCr8
mRatBN7.2962,368,075 - 62,406,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,383,832 - 62,405,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,885,818 - 70,907,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0976,001,432 - 76,023,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,320,006 - 74,341,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,748,157 - 67,786,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,763,897 - 67,785,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,563,758 - 67,599,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera959,806,431 - 59,827,774 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell-cell adhesion  (IBA,IDA,IEA)
T cell costimulation  (IBA,IDA,IEA)
T cell tolerance induction  (IBA,IEA,IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway. Futamatsu H, etal., Cardiovasc Res. 2003 Jul 1;59(1):95-104.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Gotsman I, etal., Circulation. 2006 Nov 7;114(19):2047-55. Epub 2006 Oct 23.
4. Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Guillonneau C, etal., Transplantation. 2005 Aug 27;80(4):546-54.
5. The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency. Haimila K, etal., Genes Immun. 2009 Mar;10(2):151-61. doi: 10.1038/gene.2008.89. Epub 2008 Nov 20.
6. Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. Ishii K, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):174-81.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes. Mittrucker HW, etal., J Immunol. 2002 Nov 15;169(10):5813-7.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. AILIM/ICOS: a novel lymphocyte adhesion molecule. Tamatani T, etal., Int Immunol. 2000 Jan;12(1):51-5.
16. Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family. Tezuka K, etal., Biochem Biophys Res Commun 2000 Sep 16;276(1):335-45.
17. Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis. Xing L, etal., Graefes Arch Clin Exp Ophthalmol. 2006 Apr 7;.
Additional References at PubMed
PMID:10760791   PMID:16227984   PMID:19008373   PMID:23583643   PMID:24909668   PMID:26436531   PMID:27323062   PMID:31153660  


Genomics

Comparative Map Data
Icos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8969,862,042 - 69,900,864 (+)NCBIGRCr8
mRatBN7.2962,368,075 - 62,406,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,383,832 - 62,405,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,885,818 - 70,907,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0976,001,432 - 76,023,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,320,006 - 74,341,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,748,157 - 67,786,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,763,897 - 67,785,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,563,758 - 67,599,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera959,806,431 - 59,827,774 (+)NCBICelera
Cytogenetic Map9q32NCBI
ICOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382203,936,763 - 203,961,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2203,936,763 - 203,961,577 (+)EnsemblGRCh38hg38GRCh38
GRCh372204,801,486 - 204,826,300 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,509,748 - 204,534,545 (+)NCBINCBI36Build 36hg18NCBI36
Build 342204,627,008 - 204,651,802NCBI
Celera2198,556,278 - 198,581,105 (+)NCBICelera
Cytogenetic Map2q33.2NCBI
HuRef2196,648,626 - 196,673,332 (+)NCBIHuRef
CHM1_12204,807,968 - 204,832,793 (+)NCBICHM1_1
T2T-CHM13v2.02204,418,652 - 204,443,466 (+)NCBIT2T-CHM13v2.0
Icos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,999,909 - 61,039,481 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl161,017,086 - 61,039,479 (+)EnsemblGRCm39 Ensembl
GRCm38160,960,773 - 61,000,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,977,927 - 61,000,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37161,034,758 - 61,057,164 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36160,922,469 - 60,943,665 (+)NCBIMGSCv36mm8
Celera161,493,037 - 61,515,464 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.6NCBI
Icos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545710,934,341 - 10,952,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545710,934,390 - 10,952,318 (-)NCBIChiLan1.0ChiLan1.0
ICOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213106,541,524 - 106,566,298 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B106,556,516 - 106,581,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B91,168,998 - 91,193,808 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B209,307,938 - 209,332,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,307,938 - 209,332,734 (+)Ensemblpanpan1.1panPan2
ICOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,663,839 - 12,735,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,670,999 - 12,733,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,596,013 - 13,616,605 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03712,600,441 - 12,671,981 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,607,586 - 12,670,174 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,606,503 - 12,627,090 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,569,911 - 12,590,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,571,149 - 12,591,783 (+)NCBIUU_Cfam_GSD_1.0
Icos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,927,573 - 160,937,186 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936631551,394 - 570,804 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936631562,650 - 572,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,350,203 - 107,370,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,350,253 - 107,370,123 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,697,582 - 118,717,451 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ICOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,706,755 - 89,732,600 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,726,489 - 89,732,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040109,655,109 - 109,680,201 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Icos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476512,352,042 - 12,372,861 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476512,351,695 - 12,417,847 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Icos
279 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:145
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000071226
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96138143465691299Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 1
Low 1 11 41 38 38 19 35 35 10
Below cutoff 32 8 3 3 8 9 55 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071226   ⟹   ENSRNOP00000064455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,383,832 - 62,405,672 (+)Ensembl
Rnor_6.0 Ensembl967,763,897 - 67,785,580 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091060   ⟹   ENSRNOP00000070990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,383,832 - 62,402,706 (+)Ensembl
Rnor_6.0 Ensembl967,774,150 - 67,785,021 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119869   ⟹   ENSRNOP00000079452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,383,832 - 62,402,160 (+)Ensembl
RefSeq Acc Id: NM_022610   ⟹   NP_072132
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,877,799 - 69,899,649 (+)NCBI
mRatBN7.2962,383,832 - 62,405,685 (+)NCBI
Rnor_6.0967,763,897 - 67,785,593 (+)NCBI
Rnor_5.0967,563,758 - 67,599,683 (+)NCBI
Celera959,806,431 - 59,827,774 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245037   ⟹   XP_006245099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,864,983 - 69,896,538 (+)NCBI
mRatBN7.2962,371,016 - 62,402,274 (+)NCBI
Rnor_6.0967,751,085 - 67,783,448 (+)NCBI
Rnor_5.0967,563,758 - 67,599,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245038   ⟹   XP_006245100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,864,965 - 69,900,864 (+)NCBI
mRatBN7.2962,371,016 - 62,406,900 (+)NCBI
Rnor_6.0967,751,086 - 67,786,808 (+)NCBI
Rnor_5.0967,563,758 - 67,599,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767136   ⟹   XP_008765358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,862,042 - 69,896,538 (+)NCBI
mRatBN7.2962,368,075 - 62,402,274 (+)NCBI
Rnor_6.0967,748,157 - 67,783,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084171   ⟹   XP_038940099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,864,983 - 69,900,864 (+)NCBI
mRatBN7.2962,371,016 - 62,406,900 (+)NCBI
RefSeq Acc Id: XM_063267687   ⟹   XP_063123757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8969,864,983 - 69,896,538 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072132   ⟸   NM_022610
- Peptide Label: precursor
- UniProtKB: Q9WVR9 (UniProtKB/Swiss-Prot),   Q9R1T7 (UniProtKB/Swiss-Prot),   A6IPD8 (UniProtKB/TrEMBL),   A0A0G2JZC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245100   ⟸   XM_006245038
- Peptide Label: isoform X2
- UniProtKB: Q9WVR9 (UniProtKB/Swiss-Prot),   Q9R1T7 (UniProtKB/Swiss-Prot),   A6IPD8 (UniProtKB/TrEMBL),   A0A0G2JZC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245099   ⟸   XM_006245037
- Peptide Label: isoform X1
- UniProtKB: A6IPD9 (UniProtKB/TrEMBL),   A0A8I5ZN49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765358   ⟸   XM_008767136
- Peptide Label: isoform X1
- UniProtKB: A6IPD9 (UniProtKB/TrEMBL),   A0A8I5ZN49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070990   ⟸   ENSRNOT00000091060
RefSeq Acc Id: ENSRNOP00000064455   ⟸   ENSRNOT00000071226
RefSeq Acc Id: XP_038940099   ⟸   XM_039084171
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000079452   ⟸   ENSRNOT00000119869
RefSeq Acc Id: XP_063123757   ⟸   XM_063267687
- Peptide Label: isoform X3
Protein Domains
Ig-like V-type   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1T7-F1-model_v2 AlphaFold Q9R1T7 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696708
Promoter ID:EPDNEW_R7233
Type:multiple initiation site
Name:Icos_1
Description:inducible T-cell co-stimulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0967,763,883 - 67,763,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620123 AgrOrtholog
BioCyc Gene G2FUF-27369 BioCyc
Ensembl Genes ENSRNOG00000046196 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021865 UniProtKB/Swiss-Prot
  ENSRNOG00060023212 UniProtKB/Swiss-Prot
  ENSRNOG00065026477 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071226 ENTREZGENE
  ENSRNOT00000071226.3 UniProtKB/Swiss-Prot
  ENSRNOT00000091060.2 UniProtKB/TrEMBL
  ENSRNOT00000119869.1 UniProtKB/TrEMBL
  ENSRNOT00055037554 UniProtKB/Swiss-Prot
  ENSRNOT00060040250 UniProtKB/Swiss-Prot
  ENSRNOT00065045757 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ICOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64545 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64545 ENTREZGENE
PANTHER INDUCIBLE T-CELL COSTIMULATOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR20904 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Icos PhenoGen
RatGTEx ENSRNOG00000046196 RatGTEx
  ENSRNOG00055021865 RatGTEx
  ENSRNOG00060023212 RatGTEx
  ENSRNOG00065026477 RatGTEx
UniProt A0A0G2JZC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZN49 ENTREZGENE, UniProtKB/TrEMBL
  A6IPD8 ENTREZGENE, UniProtKB/TrEMBL
  A6IPD9 ENTREZGENE, UniProtKB/TrEMBL
  ICOS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WVR9 ENTREZGENE
UniProt Secondary Q9WVR9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Icos  inducible T-cell co-stimulator  Ailim  activation-inducible lymphocyte immunomediatory molecule  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ailim  activation-inducible lymphocyte immunomediatory molecule      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression high level of cell surface expression is detected on CD45RA-positive B-cells 631942