Prl2b1 (prolactin family 2, subfamily B, member 1) - Rat Genome Database

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Gene: Prl2b1 (prolactin family 2, subfamily B, member 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl2b1
Name: prolactin family 2, subfamily B, member 1
RGD ID: 620118
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ghd11; growth hormone d11; placental prolactin-like protein K; PLP-K; PRL-like protein K; Prlpk; prolactin-2B1; prolactin-like protein K
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81737,799,545 - 37,806,572 (+)NCBIGRCr8
mRatBN7.21737,591,159 - 37,598,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,591,197 - 37,598,183 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1737,460,934 - 37,467,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01739,064,954 - 39,071,974 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01737,408,681 - 37,415,701 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,542,058 - 39,549,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,542,096 - 39,549,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01741,459,527 - 41,466,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41744,180,979 - 44,188,002 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11744,183,819 - 44,190,843 (+)NCBI
Celera1737,095,125 - 37,102,141 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Three novel paralogs of the rodent prolactin gene family. Dai G, etal., J Endocrinol 2000 Jul;166(1):63-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of four new members of the rat prolactin/growth hormone gene family. Ishibashi K and Imai M, Biochem Biophys Res Commun 1999 Sep 7;262(3):575-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:26697363   PMID:26862561  


Genomics

Variants

.
Variants in Prl2b1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000022871
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hepatobiliary system nervous system reproductive system
High
Medium
Low 2
Below cutoff 1 1 1 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022871   ⟹   ENSRNOP00000022871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,592,989 - 37,598,183 (+)Ensembl
Rnor_6.0 Ensembl1739,544,281 - 39,549,082 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090652   ⟹   ENSRNOP00000069833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,591,197 - 37,598,183 (+)Ensembl
Rnor_6.0 Ensembl1739,542,096 - 39,548,971 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114832   ⟹   ENSRNOP00000084002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,593,087 - 37,598,183 (+)Ensembl
RefSeq Acc Id: NM_138861   ⟹   NP_620216
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,799,545 - 37,806,572 (+)NCBI
mRatBN7.21737,591,159 - 37,598,186 (+)NCBI
Rnor_6.01739,542,058 - 39,549,080 (+)NCBI
Rnor_5.01741,459,527 - 41,466,549 (+)NCBI
RGSC_v3.41744,180,979 - 44,188,002 (+)RGD
Celera1737,095,125 - 37,102,141 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620216 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF40434 (Get FASTA)   NCBI Sequence Viewer  
  BAA84971 (Get FASTA)   NCBI Sequence Viewer  
  CDW51451 (Get FASTA)   NCBI Sequence Viewer  
  EDL98423 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022871.3
  ENSRNOP00000069833
  ENSRNOP00000069833.1
  ENSRNOP00000084002.1
GenBank Protein Q9JKL9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_620216   ⟸   NM_138861
- Peptide Label: precursor
- UniProtKB: Q9R0R8 (UniProtKB/Swiss-Prot),   Q9JKL9 (UniProtKB/Swiss-Prot),   A0A0G2JWD1 (UniProtKB/TrEMBL),   A6J7S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069833   ⟸   ENSRNOT00000090652
RefSeq Acc Id: ENSRNOP00000022871   ⟸   ENSRNOT00000022871
RefSeq Acc Id: ENSRNOP00000084002   ⟸   ENSRNOT00000114832

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKL9-F1-model_v2 AlphaFold Q9JKL9 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620118 AgrOrtholog
BioCyc Gene G2FUF-9453 BioCyc
Ensembl Genes ENSRNOG00000017007 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022871.4 UniProtKB/TrEMBL
  ENSRNOT00000090652 ENTREZGENE
  ENSRNOT00000090652.2 UniProtKB/TrEMBL
  ENSRNOT00000114832.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192224 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 192224 ENTREZGENE
PANTHER PROLACTIN-2B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prl2b1 PhenoGen
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017007 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWD1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWB8_RAT UniProtKB/TrEMBL
  A6J7S3 ENTREZGENE, UniProtKB/TrEMBL
  G3V873_RAT UniProtKB/TrEMBL
  PR2B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R0R8 ENTREZGENE
UniProt Secondary Q9R0R8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl2b1  prolactin family 2, subfamily B, member 1  Prl2b1  Prolactin family 2, subfamily b, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-04 Prl2b1  Prolactin family 2, subfamily b, member 1  Prlpk  prolactin-like protein K  Symbol and Name updated 1624237 APPROVED
2005-01-20 Prlpk  prolactin-like protein K      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Prlpk  prolactin-like protein K      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a 31 amino acid signal peptide and one putative N-linked glycosylation site 633806
gene_protein 228 amino acid 633806