Nos1ap (nitric oxide synthase 1 adaptor protein) - Rat Genome Database

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Gene: Nos1ap (nitric oxide synthase 1 adaptor protein) Rattus norvegicus
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Symbol: Nos1ap
Name: nitric oxide synthase 1 adaptor protein
RGD ID: 620106
Description: Enables PDZ domain binding activity; enzyme binding activity; and signaling adaptor activity. Involved in neuron projection regeneration; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; and regulation of cardiac muscle cell action potential. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynapse; and presynapse. Colocalizes with nuclear membrane. Used to study depressive disorder. Biomarker of congestive heart failure and sciatic neuropathy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C--terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ domain ligand of neuronal nitric oxide synthase; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Capon; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 (neuronal) adaptor protein
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,080,558 - 85,353,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1385,063,350 - 85,353,741 (-)EnsemblGRCr8
mRatBN7.21382,547,799 - 82,820,999 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,530,577 - 82,820,949 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1385,176,752 - 85,447,913 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,470,390 - 86,741,554 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,701,983 - 83,973,150 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1384,448,489 - 84,721,672 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1384,659,546 - 84,932,720 (-)NCBILyon_Normotensive
Lyon_Hypertensive1384,599,053 - 84,872,220 (-)NCBILyon_Hypertensive
F344_StmMcwi1384,654,748 - 84,927,934 (-)NCBIF344_StmMcwi
Rnor_6.01388,653,123 - 88,943,976 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01393,279,049 - 93,562,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41386,159,295 - 86,432,815 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1382,208,348 - 82,478,185 (-)NCBICelera
RGSC_v3.11386,173,482 - 86,447,003 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway. Carrel D, etal., J Neurosci. 2009 Jun 24;29(25):8248-58.
2. Changes in mRNA for post-synaptic density-95 (PSD-95) and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase following facial nerve transection. Che YH, etal., Brain Res Mol Brain Res. 2000 Mar 29;76(2):325-35.
3. Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury. Cui Z, etal., Vet J. 2011 Mar;187(3):374-80. Epub 2010 Mar 3.
4. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Fang M, etal., Neuron 2000 Oct;28(1):183-93.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Hardingham GE, etal., Mol Neurobiol. 2010 Aug;42(1):97-102. doi: 10.1007/s12035-010-8136-2. Epub 2010 Apr 30.
7. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Jaffrey SR, etal., Neuron 1998 Jan;20(1):115-24.
8. Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Jaffrey SR, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3199-204. Epub 2002 Feb 26.
9. Inhibition of nitric oxide-induced nuclear localization of CAPON by NMDA receptor antagonist in cultured rat primary astrocytes. Jiang J, etal., Neurochem Int. 2010 Mar;56(4):561-8. doi: 10.1016/j.neuint.2009.12.019. Epub 2010 Jan 11.
10. The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. Li LL, etal., J Neurosci. 2013 May 8;33(19):8185-201. doi: 10.1523/JNEUROSCI.4578-12.2013.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats. Orsetti M, etal., Pharmacogenet Genomics. 2009 Aug;19(8):600-12. doi: 10.1097/FPC.0b013e32832ee573.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. NOS1AP associates with Scribble and regulates dendritic spine development. Richier L, etal., J Neurosci. 2010 Mar 31;30(13):4796-805. doi: 10.1523/JNEUROSCI.3726-09.2010.
16. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II. Sharma NM, etal., Cardiovasc Res. 2011 Nov 1;92(2):348-57. doi: 10.1093/cvr/cvr217. Epub 2011 Aug 10.
17. Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Shen A, etal., J Chem Neuroanat. 2008 Jan;35(1):85-93. Epub 2007 Jul 31.
18. NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy. Treuer AV and Gonzalez DR, Int J Physiol Pathophysiol Pharmacol. 2014 Mar 13;6(1):37-46. eCollection 2014.
Additional References at PubMed
PMID:10623522   PMID:11043403   PMID:18074109   PMID:18157660   PMID:19247217   PMID:19800018   PMID:20962540   PMID:25542305   PMID:25916729   PMID:25918243   PMID:26869880   PMID:36012368  


Genomics

Comparative Map Data
Nos1ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,080,558 - 85,353,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1385,063,350 - 85,353,741 (-)EnsemblGRCr8
mRatBN7.21382,547,799 - 82,820,999 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,530,577 - 82,820,949 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1385,176,752 - 85,447,913 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,470,390 - 86,741,554 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,701,983 - 83,973,150 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1384,448,489 - 84,721,672 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1384,659,546 - 84,932,720 (-)NCBILyon_Normotensive
Lyon_Hypertensive1384,599,053 - 84,872,220 (-)NCBILyon_Hypertensive
F344_StmMcwi1384,654,748 - 84,927,934 (-)NCBIF344_StmMcwi
Rnor_6.01388,653,123 - 88,943,976 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01393,279,049 - 93,562,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41386,159,295 - 86,432,815 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1382,208,348 - 82,478,185 (-)NCBICelera
RGSC_v3.11386,173,482 - 86,447,003 (-)NCBI
Cytogenetic Map13q24NCBI
NOS1AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,069,691 - 162,370,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,069,691 - 162,370,475 (+)Ensemblhg38GRCh38
GRCh371162,039,481 - 162,340,265 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,306,205 - 160,604,864 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1135,142,979 - 135,442,880 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1133,284,045 - 133,584,478 (+)NCBIHuRef
CHM1_11163,461,578 - 163,761,499 (+)NCBICHM1_1
T2T-CHM13v2.01161,414,004 - 161,714,449 (+)NCBIT2T-CHM13v2.0
Nos1ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,143,039 - 170,417,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,130,237 - 170,417,430 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381170,315,467 - 170,589,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,302,668 - 170,589,861 (-)Ensemblmm10GRCm38
MGSCv371172,247,627 - 172,519,980 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,155,014 - 172,426,524 (-)NCBIMGSCv36mm8
Celera1172,749,789 - 173,028,224 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map176.84NCBI
NOS1AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,353,341 - 20,614,684 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,390,850 - 20,669,110 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03820,414,911 - 20,698,255 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,420,318 - 20,698,578 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,389,210 - 20,671,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,749,633 - 21,025,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,051,640 - 21,316,255 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
C4H1orf226
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,140,953 - 88,471,994 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1488,129,231 - 88,471,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,859,831 - 95,895,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Nos1ap
1669 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:97
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000032218
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Got59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21382,598,007 - 82,598,186 (+)MAPPERmRatBN7.2
Rnor_6.01388,701,345 - 88,701,521NCBIRnor6.0
Rnor_5.01393,327,271 - 93,327,447UniSTSRnor5.0
RGSC_v3.41386,208,055 - 86,208,232RGDRGSC3.4
RGSC_v3.41386,208,056 - 86,208,232UniSTSRGSC3.4
Celera1382,256,411 - 82,256,587UniSTS
RGSC_v3.11386,222,243 - 86,222,420RGD
Cytogenetic Map13q24UniSTS
RH142695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21382,560,237 - 82,560,381 (+)MAPPERmRatBN7.2
Rnor_6.01388,663,575 - 88,663,718NCBIRnor6.0
Rnor_5.01393,289,501 - 93,289,644UniSTSRnor5.0
RGSC_v3.41386,169,747 - 86,169,890UniSTSRGSC3.4
Celera1382,218,800 - 82,218,943UniSTS
RH 3.4 Map13545.1UniSTS
Cytogenetic Map13q24UniSTS
BF393830  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41386,311,755 - 86,311,912UniSTSRGSC3.4
Celera1382,359,152 - 82,359,309UniSTS
RH 3.4 Map13548.3UniSTS
Cytogenetic Map13q24UniSTS
BF399011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21382,751,130 - 82,751,324 (+)MAPPERmRatBN7.2
Rnor_6.01388,873,994 - 88,874,187NCBIRnor6.0
Rnor_5.01393,492,756 - 93,492,949UniSTSRnor5.0
RGSC_v3.41386,361,306 - 86,361,499UniSTSRGSC3.4
Celera1382,408,330 - 82,408,523UniSTS
RH 3.4 Map13545.9UniSTS
Cytogenetic Map13q24UniSTS
RH138049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21382,550,264 - 82,550,399 (+)MAPPERmRatBN7.2
Rnor_6.01388,653,602 - 88,653,736NCBIRnor6.0
Rnor_5.01393,279,528 - 93,279,662UniSTSRnor5.0
RGSC_v3.41386,159,774 - 86,159,908UniSTSRGSC3.4
Celera1382,208,827 - 82,208,961UniSTS
RH 3.4 Map13545.1UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 50 64 134 92 11 49 35 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032218   ⟹   ENSRNOP00000038197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,063,350 - 85,353,741 (-)Ensembl
mRatBN7.2 Ensembl1382,530,577 - 82,820,949 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096244   ⟹   ENSRNOP00000090505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,063,350 - 85,074,140 (-)Ensembl
mRatBN7.2 Ensembl1382,530,587 - 82,743,198 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116023   ⟹   ENSRNOP00000079910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,063,350 - 85,072,279 (-)Ensembl
mRatBN7.2 Ensembl1382,530,587 - 82,539,774 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123902   ⟹   ENSRNOP00000109489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,065,298 - 85,275,881 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147100   ⟹   ENSRNOP00000111935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,065,298 - 85,341,752 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148429   ⟹   ENSRNOP00000107868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,065,298 - 85,172,049 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166887   ⟹   ENSRNOP00000107118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,065,298 - 85,353,506 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171871   ⟹   ENSRNOP00000104003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,063,350 - 85,071,634 (-)Ensembl
RefSeq Acc Id: NM_138922   ⟹   NP_620277
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,080,558 - 85,353,741 (-)NCBI
mRatBN7.21382,547,799 - 82,820,999 (-)NCBI
Dahl_SR_JrHsd1384,448,489 - 84,721,672 (-)NCBI
Lyon_Normotensive1384,659,546 - 84,932,720 (-)NCBI
Lyon_Hypertensive1384,599,053 - 84,872,220 (-)NCBI
F344_StmMcwi1384,654,748 - 84,927,934 (-)NCBI
Rnor_6.01388,653,123 - 88,943,976 (-)NCBI
Rnor_5.01393,279,049 - 93,562,008 (-)NCBI
RGSC_v3.41386,159,295 - 86,432,815 (-)RGD
Celera1382,208,348 - 82,478,185 (-)RGD
Sequence:
RefSeq Acc Id: NP_620277   ⟸   NM_138922
- UniProtKB: O54960 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038197   ⟸   ENSRNOT00000032218
Ensembl Acc Id: ENSRNOP00000079910   ⟸   ENSRNOT00000116023
Ensembl Acc Id: ENSRNOP00000090505   ⟸   ENSRNOT00000096244
Ensembl Acc Id: ENSRNOP00000104003   ⟸   ENSRNOT00000171871
Ensembl Acc Id: ENSRNOP00000109489   ⟸   ENSRNOT00000123902
Ensembl Acc Id: ENSRNOP00000111935   ⟸   ENSRNOT00000147100
Ensembl Acc Id: ENSRNOP00000107868   ⟸   ENSRNOT00000148429
Ensembl Acc Id: ENSRNOP00000107118   ⟸   ENSRNOT00000166887
Protein Domains
PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54960-F1-model_v2 AlphaFold O54960 1-503 view protein structure
AF-F1M9N8-F1-model_v2 AlphaFold F1M9N8 1-773 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620106 AgrOrtholog
BioCyc Gene G2FUF-17477 BioCyc
Ensembl Genes ENSRNOG00000042929 Ensembl
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
InterPro Adapter_Engulfment-Domain UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
KEGG Report rno:192363 UniProtKB/Swiss-Prot
NCBI Gene 192363 ENTREZGENE
PANTHER CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN UniProtKB/Swiss-Prot
  PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam PID UniProtKB/Swiss-Prot
PhenoGen Nos1ap PhenoGen
PROSITE PID UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042929 RatGTEx
SMART PTB UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
UniProt A0A0F7L1S7_RAT UniProtKB/TrEMBL
  A0A0F7L1W1_RAT UniProtKB/TrEMBL
  A0A8I6GIX7_RAT UniProtKB/TrEMBL
  A0ABK0L9I9_RAT UniProtKB/TrEMBL
  A0ABK0LBA9_RAT UniProtKB/TrEMBL
  A0ABK0LZL5_RAT UniProtKB/TrEMBL
  A0ABK0M3C2_RAT UniProtKB/TrEMBL
  CAPON_RAT UniProtKB/Swiss-Prot
  D5LG85_RAT UniProtKB/TrEMBL
  F1M9N8_RAT UniProtKB/TrEMBL
  O54960 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Nos1ap  nitric oxide synthase 1 adaptor protein  Nos1ap  nitric oxide synthase 1 (neuronal) adaptor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Nos1ap  nitric oxide synthase 1 (neuronal) adaptor protein  Capon  C-terminal PDZ domain ligand of neuronal nitric oxide synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Capon  C-terminal PDZ domain ligand of neuronal nitric oxide synthase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Capon  C-terminal PDZ domain ligand of neuronal nitric oxide synthase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression results in a loss of PSD95/nNOS complexes in transfected cells 632364