Cyp2t1 (cytochrome P450, family 2, subfamily t, polypeptide 1) - Rat Genome Database

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Gene: Cyp2t1 (cytochrome P450, family 2, subfamily t, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2t1
Name: cytochrome P450, family 2, subfamily t, polypeptide 1
RGD ID: 620086
Description: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450 monooxygenase CYP2T1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,573,923 - 91,579,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,574,572 - 91,579,215 (+)EnsemblGRCr8
mRatBN7.2182,446,321 - 82,451,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,446,921 - 82,451,563 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,851,318 - 87,855,025 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,337,641 - 96,341,346 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,607,183 - 89,610,890 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,965,370 - 83,969,466 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,965,608 - 83,969,559 (+)Ensemblrn6Rnor6.0
Rnor_5.0185,176,324 - 85,180,404 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,229,581 - 82,233,249 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,861,288 - 76,864,957 (+)NCBICelera
RGSC_v3.1182,307,691 - 82,311,359 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cyp2t1
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000068322
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
BF418972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,451,320 - 82,451,503 (+)MAPPERmRatBN7.2
Rnor_6.0183,969,223 - 83,969,405NCBIRnor6.0
Rnor_5.0185,180,161 - 85,180,343UniSTSRnor5.0
RGSC_v3.4182,233,006 - 82,233,188UniSTSRGSC3.4
Celera176,864,714 - 76,864,896UniSTS
RH 3.4 Map1840.4UniSTS
Cytogenetic Map1q21UniSTS
RH125240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,451,578 - 82,451,695 (+)MAPPERmRatBN7.2
Rnor_6.0183,969,481 - 83,969,597NCBIRnor6.0
Rnor_5.0185,180,419 - 85,180,535UniSTSRnor5.0
RGSC_v3.4182,233,264 - 82,233,380UniSTSRGSC3.4
Celera176,864,972 - 76,865,088UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 78 59 6 342 178 11 137 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000068322   ⟹   ENSRNOP00000061482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,574,572 - 91,579,215 (+)Ensembl
mRatBN7.2 Ensembl182,446,921 - 82,451,563 (+)Ensembl
Rnor_6.0 Ensembl183,965,798 - 83,969,465 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079995   ⟹   ENSRNOP00000072323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,575,220 - 91,579,213 (+)Ensembl
mRatBN7.2 Ensembl182,447,047 - 82,451,563 (+)Ensembl
Rnor_6.0 Ensembl183,965,608 - 83,969,559 (+)Ensembl
RefSeq Acc Id: NM_134369   ⟹   NP_599196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,575,510 - 91,579,215 (+)NCBI
mRatBN7.2182,447,859 - 82,451,564 (+)NCBI
Rnor_6.0183,965,798 - 83,969,466 (+)NCBI
Rnor_5.0185,176,324 - 85,180,404 (+)NCBI
RGSC_v3.4182,229,581 - 82,233,249 (+)RGD
Celera176,861,288 - 76,864,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228558   ⟹   XP_006228620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,573,923 - 91,579,215 (+)NCBI
mRatBN7.2182,447,447 - 82,451,564 (+)NCBI
Rnor_6.0183,965,370 - 83,969,466 (+)NCBI
Rnor_5.0185,176,324 - 85,180,404 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_599196 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK53421 (Get FASTA)   NCBI Sequence Viewer  
  EDM07973 (Get FASTA)   NCBI Sequence Viewer  
  EDM07974 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061482.2
  ENSRNOP00000072323
  ENSRNOP00000072323.1
RefSeq Acc Id: NP_599196   ⟸   NM_134369
- Peptide Label: precursor
- UniProtKB: A0A0G2K2P4 (UniProtKB/TrEMBL),   E9PSZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228620   ⟸   XM_006228558
- Peptide Label: isoform X1
- UniProtKB: E9PSZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072323   ⟸   ENSRNOT00000079995
Ensembl Acc Id: ENSRNOP00000061482   ⟸   ENSRNOT00000068322

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2P4-F1-model_v2 AlphaFold A0A0G2K2P4 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689859
Promoter ID:EPDNEW_R367
Type:multiple initiation site
Name:Cyp2t1_1
Description:cytochrome P450, family 2, subfamily t, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,965,782 - 83,965,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620086 AgrOrtholog
BioCyc Gene G2FUF-60326 BioCyc
Ensembl Genes ENSRNOG00000028891 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068322.3 UniProtKB/TrEMBL
  ENSRNOT00000079995 ENTREZGENE
  ENSRNOT00000079995.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP2_fam UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
KEGG Report rno:171380 UniProtKB/TrEMBL
NCBI Gene 171380 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450, FAMILY 2, SUBFAMILY T, POLYPEPTIDE 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2t1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2F UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028891 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2K2P4 ENTREZGENE, UniProtKB/TrEMBL
  A6J9B0_RAT UniProtKB/TrEMBL
  A6J9B1_RAT UniProtKB/TrEMBL
  E9PSZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q91Y29_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2t1  cytochrome P450, family 2, subfamily t, polypeptide 1  Cyp2t1  cytochrome P450 monooxygenase CYP2T1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Cyp2t1  cytochrome P450 monooxygenase CYP2T1      Symbol and Name status set to provisional 70820 PROVISIONAL