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Gene: Capn8 (calpain 8) Rattus norvegicus

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Symbol:

Capn8

Name:

calpain 8

RGD ID:

620085

Description:

Predicted to enable calcium-dependent cysteine-type endopeptidase activity and identical protein binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within calcium-dependent self proteolysis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human CAPN8 (calpain 8); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

calpain large subunit 4; calpain-8; CL-2'; Cls4; cysteine protease; nCL-2; new calpain 2; novel Calpain Large subunit; stomach-specific M-type calpain; tissue-specific calpain 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CAPN8 (calpain 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Capn8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Capn8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CAPN8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CAPN8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Capn8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CAPN8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CAPN8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Capn8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Capn8 (calpain 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Capn8 (calpain 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CAPN8 (calpain 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	capn8 (calpain 8)	Alliance	DIOPT (OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CalpA	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CalpA	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	clp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	clp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CalpB	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CalpB	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	clp-3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	clp-4	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	clp-4	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	clp-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	capn8.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	capn8.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	capn8.3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	capn8.5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	capn8.6	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	96,783,640 - 96,847,825 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	96,783,667 - 96,847,820 (+)	Ensembl				GRCr8
mRatBN7.2	13	94,252,218 - 94,316,146 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	94,253,054 - 94,316,146 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	96,758,311 - 96,821,407 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	98,158,249 - 98,221,336 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,340,418 - 95,403,520 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	100,980,149 - 101,043,110 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	100,980,574 - 101,043,110 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	105,915,507 - 105,977,240 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	98,577,291 - 98,663,533 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	93,783,986 - 93,846,620 (+)	NCBI		Celera
RGSC_v3.1	13	98,766,226 - 98,852,469 (+)	NCBI
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

celiac disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

endosulfan (ISO)

fenvalerate (EXP)

flavonoids (EXP)

furan (EXP)

gentamycin (EXP)

malathion (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

permethrin (ISO)

phenethyl caffeate (EXP)

rotenone (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

streptozocin (ISO)

tetrachloroethene (ISO)

thiram (ISO)

trametinib (ISO)

trichloroethene (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-dependent self proteolysis (ISO)

proteolysis (IBA,IEA)

Cellular Component

cytoplasm (IBA,IEA)

Golgi apparatus (IEA)

Molecular Function

calcium ion binding (IEA)

calcium-dependent cysteine-type endopeptidase activity (IBA,IEA,ISO)

cysteine-type peptidase activity (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

metal ion binding (IEA)

peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.	Sorimachi H, etal., J Biol Chem 1993 Sep 15;268(26):19476-82.

Additional References at PubMed

PMID:12150941	PMID:16476741	PMID:17646163

Genomics

Comparative Map Data

Capn8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	96,783,640 - 96,847,825 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	96,783,667 - 96,847,820 (+)	Ensembl				GRCr8
mRatBN7.2	13	94,252,218 - 94,316,146 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	94,253,054 - 94,316,146 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	96,758,311 - 96,821,407 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	98,158,249 - 98,221,336 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,340,418 - 95,403,520 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	100,980,149 - 101,043,110 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	100,980,574 - 101,043,110 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	105,915,507 - 105,977,240 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	98,577,291 - 98,663,533 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	93,783,986 - 93,846,620 (+)	NCBI		Celera
RGSC_v3.1	13	98,766,226 - 98,852,469 (+)	NCBI
Cytogenetic Map	13	q26	NCBI

CAPN8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	223,541,616 - 223,665,701 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	223,538,007 - 223,665,723 (-)	Ensembl			hg38	GRCh38
GRCh37	1	223,714,979 - 223,853,403 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	221,866,556 - 221,920,053 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	196,935,481 - 197,009,067 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI
HuRef	1	194,409,228 - 194,466,000 (-)	NCBI		HuRef
HuRef	1	194,391,572 - 194,408,142 (-)	NCBI		HuRef
CHM1_1	1	224,987,931 - 225,125,224 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	222,780,346 - 222,855,423 (-)	NCBI		T2T-CHM13v2.0

Capn8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	182,392,314 - 182,462,021 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	182,392,572 - 182,459,917 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	182,564,749 - 182,634,456 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	182,565,007 - 182,632,352 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	184,495,138 - 184,562,483 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	184,401,687 - 184,469,027 (+)	NCBI		MGSCv36	mm8
Celera	1	189,607,684 - 189,674,095 (+)	NCBI		Celera
Cytogenetic Map	1	H5	NCBI
cM Map	1	85.37	NCBI

Capn8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955520	1,340,038 - 1,379,765 (+)	NCBI	ChiLan1.0	ChiLan1.0

CAPN8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	25,702,861 - 25,776,332 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	25,658,741 - 25,732,320 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	199,214,906 - 199,288,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	204,226,467 - 204,299,951 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	204,227,881 - 204,299,869 (-)	Ensembl			panPan2	panpan1.1

CAPN8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	40,408,408 - 40,451,843 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	40,408,141 - 40,452,068 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	39,889,884 - 39,933,647 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	40,240,089 - 40,283,649 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	40,240,066 - 40,283,649 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	40,082,775 - 40,125,819 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	40,090,714 - 40,134,119 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	40,359,429 - 40,402,976 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Capn8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	53,906,255 - 53,984,289 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	763,291 - 841,042 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	763,085 - 841,060 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAPN8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	19,665,855 - 19,732,139 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	19,622,274 - 19,732,106 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	22,098,806 - 22,131,151 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAPN8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	5,936,582 - 6,030,929 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	6,117,601 - 6,246,167 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Capn8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624835	5,665,473 - 5,697,975 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Capn8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	60,861,998 - 60,927,322 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Capn8
202 total Variants

miRNA Target Status (No longer updated)

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mir101a	rno-miR-101a-3p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830
Mir101-2	rno-miR-101b-3p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830
Mir301a	rno-miR-301a-3p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830

Predicted Target Of

	Summary Value
Count of predictions:	99
Count of miRNA genes:	78
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000004649, ENSRNOT00000067005
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	53	127	62	61	31	65	31	6	254	148	11	99	54	90	30	6	6

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF514419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D14478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D14479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D14480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004649 ⟹ ENSRNOP00000004649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	96,784,751 - 96,825,357 (+)	Ensembl
mRatBN7.2 Ensembl	13	94,253,068 - 94,293,682 (+)	Ensembl
Rnor_6.0 Ensembl	13	100,980,588 - 101,020,665 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000067005 ⟹ ENSRNOP00000062898

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	96,784,438 - 96,847,820 (+)	Ensembl
mRatBN7.2 Ensembl	13	94,253,054 - 94,316,146 (+)	Ensembl
Rnor_6.0 Ensembl	13	100,980,574 - 101,043,110 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096500 ⟹ ENSRNOP00000097093

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	96,783,667 - 96,847,820 (+)	Ensembl
mRatBN7.2 Ensembl	13	94,253,054 - 94,313,885 (+)	Ensembl

RefSeq Acc Id:

NM_133309 ⟹ NP_579843

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,784,737 - 96,847,820 (+)	NCBI
mRatBN7.2	13	94,253,054 - 94,316,146 (+)	NCBI
Rnor_6.0	13	100,980,574 - 101,043,110 (+)	NCBI
Rnor_5.0	13	105,915,507 - 105,977,240 (+)	NCBI
RGSC_v3.4	13	98,577,291 - 98,663,533 (+)	RGD
Celera	13	93,783,986 - 93,846,620 (+)	RGD

Sequence:

show sequence

GCCCTGGAAGCCCTGCTTTCCTGACACCCTACAGGACTCACAGGCAGGCCATGGCAGCTCTGGC
AGCGGGAGTATCCAAGCAACGTGCAGTTGCTGAGGGGCTTGGCTCTAACCAGAATGCTGTGAAG
TATCTGGGCCAGGACTTCGAGACCCTGAGGAAGCAGTGCTTGAACTCGGGGGTCCTATTTAAGG
ACCCAGAATTTCCAGCATGTCCATCAGCTTTGGGCTACAAGGATCTAGGACCAGGCTCCCCAGA
CACTCAAGGCATCGTATGGAAGCGACCCACGGAATTGTGTCCCAACCCTCAGTTTATTGTTGGT
GGAGCCACACGCACAGACATCCGCCAAGGGGGTCTTGGAGACTGCTGGCTTCTAGCAGCCATTG
CCTCCCTCACCTTGAATGAAAAGCTGCTTTACCGGGTGCTTCCCAGGGACCAGAGCTTCCAGAA
GGACTACGCGGGCATATTTCATTTCCAGTTCTGGCAGTATGGAGAGTGGGTGGAGGTGGTCATT
GATGACCGGCTCCCCACCAAGAACGGGCAGCTGCTTTTTCTACACTCCGAAGAAGGCAATGAGT
TTTGGAGCGCTCTGCTGGAGAAAGCCTATGCCAAGCTAAATGGTTCATATGAGGCTCTTGTTGG
AGGCTCCACAATCGAGGGGTTTGAGGATTTCACAGGTGGCATCTCTGAGTTTTATGACTTGAAG
AAGCCTCCGGAAAATCTGTACTACATCATCCAGAAGGCCCTCCGCAAAGGCTCTCTGCTGGGCT
GCTCCATTGATGTCTCAACTGCAGCTGAAGCAGAAGCCACCACCAGGCAAAAGCTGGTTAAGGG
TCATGCATACTCTGTTACTGGAGTCGAAGAGGTGAATTTCCATGGCCGTCCAGAGAAGCTGATC
AGGTTGAGGAACCCGTGGGGTGAAGTGGAGTGGTCGGGAGCCTGGAGTGATAATGCACCTGAGT
GGAATTACATAGATCCAAGGAGGAAGGAGGAGCTGGACAAGAAAGCAGAAGATGGCGAGTTCTG
GATGTCCTTTTCGGATTTCTTGAAGCAGTACTCCCGACTGGAGATCTGCAACCTGTCCCCAGAC
TCTCTGAGCAGTGAAGAGATACACAAATGGAACCTAGTACTCTTCAACGGCCGCTGGACACGGG
GTTCTACAGCCGGGGGCTGCCTGAACTACCCAGGCACGTACTGGACCAACCCCCAGTTTAAAAT
CCATTTGGATGAGGTGGATGAGGACCAGGAGGAGGGCACCAGTGAACCCTGCTGTACCGTGCTG
CTGGGTCTGATGCAGAAGAATCGAAGACGTCAAAAGAGGATCGGCCAGGGCATGCTCAGCATAG
GCTACGCTGTCTACCAGATTCCCAAGGAGTTGGAGAGTCACACGGATGCACACCTTGGCCGGGA
CTTCTTCCTGGGACGCCAGCCCTCTACCTGCTCCAGCACTTACATGAACCTTCGGGAGGTGTCC
AGCAGGGTCCGACTCCCCCCGGGACAGTACCTGGTGGTGCCATCCACCTTCGAGCCCTTCAAGG
ATGGTGACTTCTGCTTGAGGGTGTTCTCAGAGAAGAAGGCCAAGGCTCTGGAAATTGGGGATAC
TGTATCTGGACACCCTCATGAGCCACATCCCCGTGACATGGATGAAGAAGATGAACATGTCCGG
AGCCTGTTTGAGGAGTTTGTGGGCAAGGATTCTGAGATCAGTGCTAATCAGCTCAAGAGGGTCC
TGAATGAAGTACTTTCTAAACGAACAGACATGAAATTTGATGGATTCAACATCAACACTTGCAG
AGAAATGATCAGCCTGCTGGATAGTGATGGGACAGGAAGCCTGGGACCTATGGAGTTCAAGACT
CTCTGGCTGAAGATCCGCACATATCTGGAGATCTTCCAAGAAATGGACCATAACCATGTAGGGA
CCATTGAAGCCCATGAGATGAGGACAGCTCTCAAGAAAGCAGGTTTCACCCTCAACAACCAGGT
GCAGCAGACCATTGCCATGAGGTATGCGTGCAGTAAGCTTGGTGTTGACTTCAACGGTTTTGTG
GCGTGTATGATCCGCCTGGAGACCCTGTTCAAACTGTTCAGGCTTTTGGATAAGGACCAGAATG
GCATTGTCCAGCTCTCCCTGGCTGAGTGGCTGTGCTGTGTGCTGGTCTGACCCGCTGTTTGGAC
ATCAACAACTTCCCTGTCTCCCACTTGTCCCTTTCAGTCTTATGAACATGTGACCTCAGGTGGC
ATTTACTGACTGTTGTATTGTTCCAGCCAACTGTTGTTCCTGAGACACTGCCTTTCCCAACAGA
GCAGTCTAGGGAGCCCCAGATCTCTCAGCAGCACCGAGCTATGAGCTAACTGGGCAGATCCCAG
GGTTCAGCAGAAGGAAAAGAATCAATTAAAGTTGTGGGCCAGG

hide sequence

RefSeq Acc Id:

XM_006250363 ⟹ XP_006250425

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,783,640 - 96,825,354 (+)	NCBI
mRatBN7.2	13	94,252,218 - 94,293,683 (+)	NCBI
Rnor_6.0	13	100,980,149 - 101,020,666 (+)	NCBI
Rnor_5.0	13	105,915,507 - 105,977,240 (+)	NCBI

Sequence:

show sequence

TGGCACCTTCTTCTGGCCTCCAAGGACATATCAGTTATTTAATGCATGGGTATACACGCAGGCA
AAGCACCATGCACATTAAAGATAAAAGTGCAGAGGGTTATTCTCTGTCTGTTCTGGAGACCCAC
AGATCTAAGTTACTTCTACTGGACTAAAACCAAGGTGTGGGCAGGGCAACTCCTTGTTGAAGTC
CTCCCTGCCCTATCCAGCTTCTGGAGACGTCTGATAGCCTCCGCTGTGGCATCTGAATAGTTTG
TGAACAGCAGGAGAAGGTGGGGCAGAGTCACCTGCACCTTGGGTACATATTTGACCCTGTTTAT
GACTCATGTCCCTTTGGAACAGAGCCTCCCTCAGGTGGAAAGTCTACATGCCCCACCTCCCTGT
GAGCTGCCTTATAGGGCAGCATCCCCACAGGGCTCTGAGAGGCCCTGGAAGCCCTGCTTTCCTG
ACACCCTACAGGACTCACAGGCAGGCCATGGCAGCTCTGGCAGCGGGAGTATCCAAGCAACGTG
CAGTTGCTGAGGGGCTTGGCTCTAACCAGAATGCTGTGAAGTATCTGGGCCAGGACTTCGAGAC
CCTGAGGAAGCAGTGCTTGAACTCGGGGGTCCTATTTAAGGACCCAGAATTTCCAGCATGTCCA
TCAGCTTTGGGCTACAAGGATCTAGGACCAGGCTCCCCAGACACTCAAGGCATCGTATGGAAGC
GACCCACGGAATTGTGTCCCAACCCTCAGTTTATTGTTGGTGGAGCCACACGCACAGACATCCG
CCAAGGGGGTCTTGGAGACTGCTGGCTTCTAGCAGCCATTGCCTCCCTCACCTTGAATGAAAAG
CTGCTTTACCGGGTGCTTCCCAGGGACCAGAGCTTCCAGAAGGACTACGCGGGCATATTTCATT
TCCAGTTCTGGCAGTATGGAGAATGGGTGGAGGTGGTCATTGATGACCGGCTCCCCACCAAGAA
CGGGCAGCTGCTTTTTCTACACTCCGAAGAAGGCAATGAGTTTTGGAGCGCTCTGCTGGAGAAA
GCCTATGCCAAGCTAAATGGTTCGTATGAGGCTCTTGTTGGAGGCTCCACAATCGAGGGGTTTG
AGGATTTCACAGGTGGCATCTCTGAGTTTTATGACTTGAAGAAGCCTCCGGAAAATCTGTACTA
CATCATCCAGAAGGCCCTCCGCAAAGGCTCTCTGCTGGGCTGCTCCATTGATGTCTCAACTGCA
GCTGAAGCAGAAGCCACCACCAGGCAAAAGCTGGTTAAGGGTCATGCATACTCTGTTACTGGAG
TCGAAGAGGTGAATTTCCATGGCCGTCCAGAGAAGCTGATCAGGTTGAGGAACCCATGGGGTGA
AGTGGAGTGGTCGGGAGCCTGGAGTGATAATGCACCTGAGTGGAATTACATAGATCCAAGGAGG
AAGGAGGAGCTGGACAAGAAAGCAGAAGATGGCGAGTTCTGGATGTCCTTTTCGGATTTCTTGA
AGCAGTACTCCCGACTGGAGATCTGCAACCTGTCCCCAGACTCTCTGAGCAGTGAAGAGATACA
CAAATGGAACCTAGTACTCTTCAACGGCCGCTGGACACGGGGTTCTACAGCCGGGGGCTGCCTG
AACTACCCAGGCTCCTCCTAGGTCGAGCCCACTGAGGCAGCAGCTGAAGAAACAACTGAGAAAC
GACCCTGCAGCTCCCTGGAGAGACACAGGAAAGAAAAACATGCACCCCGCTTGCTAGTGCCCTC
CTTCACACTTCTTTGGTTTGCTGTTGCTCTGCTGATTTGTGTTGATTGACTTGCTATCTCTGGG
CAGGGTGGAAGAGCAGCCATTTCTTCCCAACCAGAGCACTGCGTGCTGTAGAAAAGGCAGCATT
GTAAAACCCCATGTGGGTACAGACAGAGCACAAGGTCCTCCCTCCACTCCCATCCATCTCCATC
TGGCTGCAAAGACCAGCTGTTGTCAGGCCTGAAGGGGGAGCTGATGGCCTGCCCCCATCAGTCA
GCTTAACGCTTGTGAGACCTGAGGGGCACTCCTTTCCTGGAGCTTCCGTTTCTCAGCCCTCACA
ATGGTTCATAATTCCTACCTTCCAACTCGCTGGGGCCCAGTGAGCATTGTAACACAGAGTGCAC
GGGGAAGCGCTTTGTAAACTGAGCAGCGTTATACAAATGGGATGTGTTATTTTTATGGCCCATT
CTCTTCCTATAGTACTGTTAAGGAGTAAACAAAAAATGTGGGGATTGCCGTAATGCTACATTCG
GGAGAAATTAAAATATGCTCACCATTAGTGAGCTCTTAGGAAAGACGTAGGAAATTCGCGTGGA
TCATTCTGGAAGCTCAGAACCATAGGGGGTTCCCAAGGTATCTGCACGCACCAAATCATAATCC
CATCTGTGCTGCCAGCTAGCTGTCAGAGAGAAATGGATTGTTCTTGCCTCGTGGTAATGAAGTA
AGTGCAGAAGATTACTGAATTTTCTGTCTCCCCTGGAATCCACAGACACCTGATCTTAAAATCT
ATATACACCTGAGCCCTGAGGGGGGGGAAAATATCTAGAAATGGAGGTTCTGAGGAGAGGCTGA
ATAAGTACTCTTACTGTTAGGGGAAAAATAAAGACTGTGCCTCGGCCGTA

hide sequence

RefSeq Acc Id:

XM_063271979 ⟹ XP_063128049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,783,640 - 96,833,303 (+)	NCBI

RefSeq Acc Id:

XM_063271980 ⟹ XP_063128050

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,813,289 - 96,833,303 (+)	NCBI

RefSeq Acc Id:

XM_063271981 ⟹ XP_063128051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,783,640 - 96,833,303 (+)	NCBI

RefSeq Acc Id:

XM_063271982 ⟹ XP_063128052

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,783,640 - 96,833,303 (+)	NCBI

RefSeq Acc Id:

XM_063271983 ⟹ XP_063128053

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	96,783,640 - 96,847,825 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_579843	(Get FASTA)	NCBI Sequence Viewer
	XP_006250425	(Get FASTA)	NCBI Sequence Viewer
	XP_063128049	(Get FASTA)	NCBI Sequence Viewer
	XP_063128050	(Get FASTA)	NCBI Sequence Viewer
	XP_063128051	(Get FASTA)	NCBI Sequence Viewer
	XP_063128052	(Get FASTA)	NCBI Sequence Viewer
	XP_063128053	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAM94284	(Get FASTA)	NCBI Sequence Viewer
	BAA03369	(Get FASTA)	NCBI Sequence Viewer
	BAA03370	(Get FASTA)	NCBI Sequence Viewer
	BAA03371	(Get FASTA)	NCBI Sequence Viewer
	EDL94877	(Get FASTA)	NCBI Sequence Viewer
	EDL94878	(Get FASTA)	NCBI Sequence Viewer
	EDL94879	(Get FASTA)	NCBI Sequence Viewer
	EDL94880	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004649
	ENSRNOP00000004649.6
	ENSRNOP00000062898
	ENSRNOP00000062898.3
GenBank Protein	Q78EJ9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_579843 ⟸ NM_133309

- UniProtKB:

Q78EJ8 (UniProtKB/Swiss-Prot), Q64698 (UniProtKB/Swiss-Prot), Q8K407 (UniProtKB/Swiss-Prot), Q78EJ9 (UniProtKB/Swiss-Prot), A6JGM1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAALAAGVSKQRAVAEGLGSNQNAVKYLGQDFETLRKQCLNSGVLFKDPEFPACPSALGYKDLG
PGSPDTQGIVWKRPTELCPNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVLPRD
QSFQKDYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSY
EALVGGSTIEGFEDFTGGISEFYDLKKPPENLYYIIQKALRKGSLLGCSIDVSTAAEAEATTRQ
KLVKGHAYSVTGVEEVNFHGRPEKLIRLRNPWGEVEWSGAWSDNAPEWNYIDPRRKEELDKKAE
DGEFWMSFSDFLKQYSRLEICNLSPDSLSSEEIHKWNLVLFNGRWTRGSTAGGCLNYPGTYWTN
PQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQKRIGQGMLSIGYAVYQIPKELESHTDA
HLGRDFFLGRQPSTCSSTYMNLREVSSRVRLPPGQYLVVPSTFEPFKDGDFCLRVFSEKKAKAL
EIGDTVSGHPHEPHPRDMDEEDEHVRSLFEEFVGKDSEISANQLKRVLNEVLSKRTDMKFDGFN
INTCREMISLLDSDGTGSLGPMEFKTLWLKIRTYLEIFQEMDHNHVGTIEAHEMRTALKKAGFT
LNNQVQQTIAMRYACSKLGVDFNGFVACMIRLETLFKLFRLLDKDQNGIVQLSLAEWLCCVLV

hide sequence

RefSeq Acc Id:	XP_006250425 ⟸ XM_006250363
- Peptide Label:	isoform X5
- UniProtKB:	A6JGM3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLWNRASLRWKVYMPHLPVSCLIGQHPHRALRGPGSPAFLTPYRTHRQAMAALAAGVSKQRAV AEGLGSNQNAVKYLGQDFETLRKQCLNSGVLFKDPEFPACPSALGYKDLGPGSPDTQGIVWKRP TELCPNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVLPRDQSFQKDYAGIFHFQ FWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALVGGSTIEGFED FTGGISEFYDLKKPPENLYYIIQKALRKGSLLGCSIDVSTAAEAEATTRQKLVKGHAYSVTGVE EVNFHGRPEKLIRLRNPWGEVEWSGAWSDNAPEWNYIDPRRKEELDKKAEDGEFWMSFSDFLKQ YSRLEICNLSPDSLSSEEIHKWNLVLFNGRWTRGSTAGGCLNYPGSS hide sequence

Ensembl Acc Id:

ENSRNOP00000062898 ⟸ ENSRNOT00000067005

Ensembl Acc Id:

ENSRNOP00000004649 ⟸ ENSRNOT00000004649

Ensembl Acc Id:

ENSRNOP00000097093 ⟸ ENSRNOT00000096500

RefSeq Acc Id:	XP_063128053 ⟸ XM_063271983
- Peptide Label:	isoform X6
- UniProtKB:	A6JGM1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128049 ⟸ XM_063271979
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063128052 ⟸ XM_063271982
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063128051 ⟸ XM_063271981
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063128050 ⟸ XM_063271980
- Peptide Label:	isoform X2

Protein Domains

Calpain catalytic EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q78EJ9-F1-model_v2	AlphaFold	Q78EJ9	1-703	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699079

Promoter ID:

EPDNEW_R9604

Type:

single initiation site

Name:

Capn8_1

Description:

calpain 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	100,980,571 - 100,980,631	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620085	AgrOrtholog
BioCyc Gene	G2FUF-17062	BioCyc
Ensembl Genes	ENSRNOG00000003468	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004649	ENTREZGENE
	ENSRNOT00000004649.7	UniProtKB/Swiss-Prot
	ENSRNOT00000067005	ENTREZGENE
	ENSRNOT00000067005.5	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.380	UniProtKB/Swiss-Prot
	Cysteine proteinases	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
InterPro	C2_III	UniProtKB/Swiss-Prot
	Calpain_cysteine_protease	UniProtKB/Swiss-Prot
	Calpain_domain_III	UniProtKB/Swiss-Prot
	Calpain_III	UniProtKB/Swiss-Prot
	Calpain_III_sf	UniProtKB/Swiss-Prot
	EF-hand-dom_pair	UniProtKB/Swiss-Prot
	EF_hand_dom	UniProtKB/Swiss-Prot
	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot
	Pept_cys_AS	UniProtKB/Swiss-Prot
	Peptidase_C2_calpain_cat	UniProtKB/Swiss-Prot
KEGG Report	rno:170808	UniProtKB/Swiss-Prot
NCBI Gene	170808	ENTREZGENE
PANTHER	CALPAIN	UniProtKB/Swiss-Prot
	PTHR10183:SF374	UniProtKB/Swiss-Prot
Pfam	Calpain_III	UniProtKB/Swiss-Prot
	Peptidase_C2	UniProtKB/Swiss-Prot
PhenoGen	Capn8	PhenoGen
PRINTS	CALPAIN	UniProtKB/Swiss-Prot
PROSITE	CALPAIN_CAT	UniProtKB/Swiss-Prot
	EF_HAND_1	UniProtKB/Swiss-Prot
	EF_HAND_2	UniProtKB/Swiss-Prot
	THIOL_PROTEASE_CYS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003468	RatGTEx
SMART	calpain_III	UniProtKB/Swiss-Prot
	CysPc	UniProtKB/Swiss-Prot
	EFh	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot
	SSF49758	UniProtKB/Swiss-Prot
	SSF54001	UniProtKB/Swiss-Prot
UniProt	A0A8I6ASA4_RAT	UniProtKB/TrEMBL
	A6JGM1	ENTREZGENE, UniProtKB/TrEMBL
	A6JGM2_RAT	UniProtKB/TrEMBL
	A6JGM3	ENTREZGENE, UniProtKB/TrEMBL
	A6JGM4_RAT	UniProtKB/TrEMBL
	CAN8_RAT	UniProtKB/Swiss-Prot
	Q64698	ENTREZGENE
	Q78EJ8	ENTREZGENE
	Q78EJ9	ENTREZGENE
	Q8K407	ENTREZGENE
UniProt Secondary	Q64698	UniProtKB/Swiss-Prot
	Q78EJ8	UniProtKB/Swiss-Prot
	Q8K407	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Capn8	calpain 8			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Capn8	calpain 8			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_transcript	alternative splice variants nCL-2 and nCL-2' both contain cysteine protease domains, however, variant nCL-2' does not contain the calcium binding domain	632482

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD