Trpm7 (transient receptor potential cation channel, subfamily M, member 7) - Rat Genome Database

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Gene: Trpm7 (transient receptor potential cation channel, subfamily M, member 7) Rattus norvegicus
Analyze
Symbol: Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
RGD ID: 620053
Description: Enables calcium channel activity and protein kinase activity. Involved in several processes, including calcium ion transport; intracellular magnesium ion homeostasis; and memory. Located in neuronal cell body; synaptic vesicle membrane; and varicosity. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Chak; LOC679906; long transient receptor potential channel 7; LTrpC-7; Ltrpc7; similar to Transient receptor potential cation channel subfamily M member 7 (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C-interacting kinase) (TRP-PLIK); transient receptor potential cation channel subfamily M member 7; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; Trp-plik
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,499,617 - 134,588,113 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3134,499,617 - 134,588,113 (-)EnsemblGRCr8
mRatBN7.23114,046,258 - 114,134,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,046,258 - 114,135,190 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3117,929,825 - 118,020,772 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,525,352 - 126,616,298 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,185,735 - 124,276,677 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,258,189 - 119,347,084 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,259,467 - 119,330,345 (-)Ensemblrn6Rnor6.0
Rnor_5.03125,783,080 - 125,871,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,320,799 - 114,410,498 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3112,886,549 - 112,974,913 (-)NCBICelera
RGSC_v3.13114,227,081 - 114,234,961 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
alloxan  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlordecone  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
loperamide  (ISO)
magnesium atom  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
naltriben  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
SB 431542  (EXP)
sodium atom  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. Hara K, etal., Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):310-3.
3. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Hermosura MC, etal., Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11510-5. Epub 2005 Jul 28.
4. TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation. Jiang H, etal., Brain Res Bull. 2008 May 15;76(1-2):124-30. Epub 2008 Feb 12.
5. Regulation of a TRPM7-like current in rat brain microglia. Jiang X, etal., J Biol Chem 2003 Oct 31;278(44):42867-76. Epub 2003 Aug 6.
6. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Krapivinsky G, etal., Neuron. 2006 Nov 9;52(3):485-96.
7. Distribution profiles of transient receptor potential melastatin- and vanilloid-related channels in rat spermatogenic cells and sperm. Li S, etal., Mol Biol Rep. 2010 Mar;37(3):1287-93. Epub 2009 Mar 26.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Runnels LW, etal., Nat Cell Biol 2002 May;4(5):329-36.
14. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Runnels LW, etal., Science 2001 Feb 9;291(5506):1043-7.
15. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Sun HS, etal., Nat Neurosci. 2009 Oct;12(10):1300-7. Epub 2009 Sep 6.
16. Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro. Zhang J, etal., J Biol Chem. 2011 Jun 10;286(23):20194-207. Epub 2011 Apr 12.
17. Effect of electroacupuncture on TRPM7 mRNA expression after cerebral ischemia/reperfusion in rats via TrkA pathway. Zhao L, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(3):247-50.
Additional References at PubMed
PMID:15591230   PMID:16109804   PMID:16407977   PMID:17482355   PMID:17712480   PMID:18539771   PMID:18782578   PMID:18799634   PMID:19145781   PMID:19661151   PMID:21539414   PMID:21926172  
PMID:22231470   PMID:22406504   PMID:22429021   PMID:22663985   PMID:23047499   PMID:23958495   PMID:24026041   PMID:24316671   PMID:24679001   PMID:24733250   PMID:24817288   PMID:24871786  
PMID:24939696   PMID:25148577   PMID:25150141   PMID:26900082   PMID:27010689   PMID:27108806   PMID:28123180   PMID:28545665   PMID:28736242   PMID:29079194   PMID:29511803   PMID:29775892  
PMID:29842890   PMID:29924992   PMID:31002158   PMID:31288723   PMID:31444399   PMID:32146159   PMID:32706027   PMID:33028185   PMID:33494094   PMID:33891828   PMID:33924361   PMID:34766907  
PMID:34789674   PMID:35099165   PMID:36122679   PMID:36705408   PMID:36794562   PMID:36869357   PMID:37653221   PMID:38180616   PMID:38581988  


Genomics

Comparative Map Data
Trpm7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,499,617 - 134,588,113 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3134,499,617 - 134,588,113 (-)EnsemblGRCr8
mRatBN7.23114,046,258 - 114,134,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,046,258 - 114,135,190 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3117,929,825 - 118,020,772 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,525,352 - 126,616,298 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,185,735 - 124,276,677 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,258,189 - 119,347,084 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,259,467 - 119,330,345 (-)Ensemblrn6Rnor6.0
Rnor_5.03125,783,080 - 125,871,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,320,799 - 114,410,498 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3112,886,549 - 112,974,913 (-)NCBICelera
RGSC_v3.13114,227,081 - 114,234,961 (-)NCBI
Cytogenetic Map3q36NCBI
TRPM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,557,158 - 50,686,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,552,473 - 50,686,797 (-)Ensemblhg38GRCh38
GRCh371550,849,355 - 50,978,994 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,639,782 - 48,766,286 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341548,639,782 - 48,766,260NCBI
Celera1527,741,918 - 27,871,940 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,680,107 - 27,809,975 (-)NCBIHuRef
CHM1_11550,967,308 - 51,096,974 (-)NCBICHM1_1
T2T-CHM13v2.01548,365,238 - 48,493,853 (-)NCBIT2T-CHM13v2.0
Trpm7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,633,478 - 126,718,181 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,633,485 - 126,718,150 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382126,791,558 - 126,876,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,791,565 - 126,876,230 (-)Ensemblmm10GRCm38
MGSCv372126,617,294 - 126,701,997 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362126,483,006 - 126,567,652 (-)NCBIMGSCv36mm8
Celera2128,031,446 - 128,117,211 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Trpm7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,691,039 - 3,785,908 (+)Ensembl
ChiLan1.0NW_0049554093,690,722 - 3,787,139 (+)NCBIChiLan1.0ChiLan1.0
TRPM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,808,442 - 39,937,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,988,947 - 44,115,197 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,513,220 - 29,639,506 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,852,859 - 47,977,451 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,853,187 - 47,977,451 (-)EnsemblpanPan2panpan1.1
TRPM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,465,546 - 16,579,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,466,234 - 16,579,594 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3016,391,627 - 16,505,679 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03016,609,528 - 16,723,877 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,609,860 - 16,723,804 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,531,991 - 16,646,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,650,052 - 16,764,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,756,456 - 16,870,962 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,716,326 - 94,818,173 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,565,054 - 12,665,962 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,564,617 - 12,666,229 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,146,117 - 121,250,224 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11121,146,093 - 121,250,227 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21134,584,969 - 134,689,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,644,637 - 32,772,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,669,187 - 32,771,378 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048108,383,877 - 108,505,678 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpm7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,491,157 - 9,588,346 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247319,490,885 - 9,588,255 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Trpm7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15105,629,085 - 105,714,011 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trpm7
289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:141
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000033341
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Got232  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.43114,373,862 - 114,374,158UniSTSRGSC3.4
Cytogenetic Map3q36UniSTS
RH128920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,046,386 - 114,046,604 (+)MAPPERmRatBN7.2
Rnor_6.03119,258,318 - 119,258,535NCBIRnor6.0
Rnor_5.03125,783,209 - 125,783,426UniSTSRnor5.0
RGSC_v3.43114,320,927 - 114,321,144UniSTSRGSC3.4
Celera3112,886,678 - 112,886,895UniSTS
Cytogenetic Map3q36UniSTS
RH133336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,063,906 - 114,064,120 (+)MAPPERmRatBN7.2
Rnor_6.03119,275,975 - 119,276,188NCBIRnor6.0
Rnor_5.03125,800,866 - 125,801,079UniSTSRnor5.0
RGSC_v3.43114,338,888 - 114,339,101UniSTSRGSC3.4
Celera3112,904,193 - 112,904,406UniSTS
RH 3.4 Map3988.5UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077398   ⟹   ENSRNOP00000070727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,571,358 (-)Ensembl
mRatBN7.2 Ensembl3114,046,258 - 114,118,088 (-)Ensembl
Rnor_6.0 Ensembl3119,259,467 - 119,330,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079191   ⟹   ENSRNOP00000075669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,571,358 (-)Ensembl
mRatBN7.2 Ensembl3114,046,258 - 114,118,088 (-)Ensembl
Rnor_6.0 Ensembl3119,259,467 - 119,330,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111052   ⟹   ENSRNOP00000092648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,587,990 (-)Ensembl
mRatBN7.2 Ensembl3114,046,258 - 114,135,190 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112004   ⟹   ENSRNOP00000084991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,571,430 (-)Ensembl
mRatBN7.2 Ensembl3114,046,258 - 114,118,082 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140555   ⟹   ENSRNOP00000104909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,588,113 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154637   ⟹   ENSRNOP00000105389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,505,218 - 134,587,787 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166801   ⟹   ENSRNOP00000105095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,499,617 - 134,588,113 (-)Ensembl
RefSeq Acc Id: NM_053705   ⟹   NP_446157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,499,617 - 134,588,113 (-)NCBI
mRatBN7.23114,046,258 - 114,134,765 (-)NCBI
Rnor_6.03119,258,189 - 119,347,084 (-)NCBI
Rnor_5.03125,783,080 - 125,871,514 (-)NCBI
Celera3112,886,549 - 112,974,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105837   ⟹   XP_038961765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,499,621 - 134,587,996 (-)NCBI
mRatBN7.23114,046,258 - 114,134,799 (-)NCBI
RefSeq Acc Id: XR_010064692
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,505,956 - 134,587,996 (-)NCBI
RefSeq Acc Id: NP_446157   ⟸   NM_053705
- UniProtKB: A0A8I6AVX9 (UniProtKB/Swiss-Prot),   Q925B3 (UniProtKB/Swiss-Prot),   A7L642 (UniProtKB/Swiss-Prot),   A6HPZ2 (UniProtKB/TrEMBL),   A0A8I6A0V0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075669   ⟸   ENSRNOT00000079191
Ensembl Acc Id: ENSRNOP00000070727   ⟸   ENSRNOT00000077398
RefSeq Acc Id: XP_038961765   ⟸   XM_039105837
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0V0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092648   ⟸   ENSRNOT00000111052
Ensembl Acc Id: ENSRNOP00000084991   ⟸   ENSRNOT00000112004
Ensembl Acc Id: ENSRNOP00000104909   ⟸   ENSRNOT00000140555
Ensembl Acc Id: ENSRNOP00000105389   ⟸   ENSRNOT00000154637
Ensembl Acc Id: ENSRNOP00000105095   ⟸   ENSRNOT00000166801
Protein Domains
Alpha-type protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620053 AgrOrtholog
BioCyc Gene G2FUF-48016 BioCyc
Ensembl Genes ENSRNOG00000057806 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055005258 UniProtKB/Swiss-Prot
  ENSRNOG00060014340 UniProtKB/Swiss-Prot
  ENSRNOG00065012816 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000111052 ENTREZGENE
  ENSRNOT00000111052.1 UniProtKB/Swiss-Prot
  ENSRNOT00000166801 ENTREZGENE
  ENSRNOT00055008471 UniProtKB/Swiss-Prot
  ENSRNOT00060024764 UniProtKB/Swiss-Prot
  ENSRNOT00065020985 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.1010 UniProtKB/Swiss-Prot
  MHCK/EF2 kinase UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MHCK_EF2_kinase UniProtKB/Swiss-Prot
  TRPM UniProtKB/Swiss-Prot
  TRPM7 UniProtKB/Swiss-Prot
  TRPM_SLOG UniProtKB/Swiss-Prot
  TRPM_tetra UniProtKB/Swiss-Prot
  TRPM_tetra_sf UniProtKB/Swiss-Prot
KEGG Report rno:679906 UniProtKB/Swiss-Prot
NCBI Gene Trpm7 ENTREZGENE
PANTHER PTHR13800:SF8 UniProtKB/Swiss-Prot
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/Swiss-Prot
Pfam Alpha_kinase UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  LSDAT_euk UniProtKB/Swiss-Prot
  TRPM2 UniProtKB/Swiss-Prot
  TRPM_tetra UniProtKB/Swiss-Prot
PhenoGen Trpm7 PhenoGen
PROSITE ALPHA_KINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057806 RatGTEx
  ENSRNOG00055005258 RatGTEx
  ENSRNOG00060014340 RatGTEx
  ENSRNOG00065012816 RatGTEx
SMART Alpha_kinase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JYN5_RAT UniProtKB/TrEMBL
  A0A0G2KB64_RAT UniProtKB/TrEMBL
  A0A8I6A0V0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVX9 ENTREZGENE
  A0ABK0LJY3_RAT UniProtKB/TrEMBL
  A0ABK0LTV9_RAT UniProtKB/TrEMBL
  A0ABK0LX34_RAT UniProtKB/TrEMBL
  A6HPZ2 ENTREZGENE
  A7L642 ENTREZGENE
  Q925B3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A8I6AVX9 UniProtKB/Swiss-Prot
  A6HPZ2 UniProtKB/Swiss-Prot
  A7L642 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Trpm7  transient receptor potential cation channel, subfamily M, member 7  Trpm7  transient receptor potential-related protein, ChaK  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-22 Trpm7  transient receptor potential-related protein, ChaK  LOC679906  similar to Transient receptor potential cation channel subfamily M member 7 (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C-interacting kinase) (TRP-PLIK)  Data merged from RGD:1598164 737654 APPROVED
2006-11-20 LOC679906  similar to Transient receptor potential cation channel subfamily M member 7 (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C-interacting kinase) (TRP-PLIK)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Trpm7  transient receptor potential-related protein, ChaK  Chak    Symbol and Name updated 1299863 APPROVED
2002-08-07 Chak  transient receptor potential-related protein, ChaK      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction kinase domain directly interacts with the C2 domain of phospholipase C 632430
gene_regulation receptor-mediated activation of PLC leads to its own inactivation 632430
gene_regulation Trpm7 current is inhibited by tyrosine kinase inhibitors 1299260