Bmal1 (basic helix-loop-helix ARNT like 1) - Rat Genome Database

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Gene: Bmal1 (basic helix-loop-helix ARNT like 1) Rattus norvegicus
Analyze
Symbol: Bmal1
Name: basic helix-loop-helix ARNT like 1
RGD ID: 62003
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in circadian rhythm and positive regulation of DNA-templated transcription. Located in nucleus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in alcohol dependence and bipolar disorder. Orthologous to human BMAL1 (basic helix-loop-helix ARNT like 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Arntl; aryl hydrocarbon receptor nuclear translocator-like; aryl hydrocarbon receptor nuclear translocator-like protein 1; basic helix-loop-helix ARNT-like protein 1; brain and muscle ARNT-like 1; tic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Bmal1em1Mcwi
Genetic Models: SD-Bmal1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,766,222 - 176,864,741 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,829,305 - 176,864,739 (+)EnsemblGRCr8
mRatBN7.21167,331,756 - 167,430,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,331,633 - 167,430,231 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1175,666,810 - 175,765,622 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,852,900 - 182,951,712 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,548,108 - 175,646,871 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,039,002 - 178,137,469 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,039,063 - 178,137,465 (+)Ensemblrn6Rnor6.0
Rnor_5.01185,007,527 - 185,105,413 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41171,062,181 - 171,162,426 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1165,202,275 - 165,299,946 (+)NCBICelera
RGSC_v3.11171,251,951 - 171,282,040 (+)NCBI
Cytogenetic Map1q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amino acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
carnosine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chloroprene  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
cocaine hydrochloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
creatinine  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
furan  (ISO)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lysophosphatidylcholine  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (EXP,ISO)
methylarsonic acid  (ISO)
milrinone  (EXP)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nitrates  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
styrene  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
tioguanine  (EXP)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (ISO)
circadian regulation of gene expression  (IEA,ISO,ISS)
circadian rhythm  (IBA,IEA,IEP,ISO)
DNA-templated transcription  (IEA)
energy homeostasis  (ISO)
gene expression  (ISO)
maternal process involved in parturition  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of fat cell differentiation  (ISO,ISS)
negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (ISO,ISS)
negative regulation of TOR signaling  (ISO,ISS)
oxidative stress-induced premature senescence  (ISO,ISS)
positive regulation of canonical Wnt signaling pathway  (ISO,ISS)
positive regulation of circadian rhythm  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO,ISS)
positive regulation of protein acetylation  (ISO,ISS)
positive regulation of skeletal muscle cell differentiation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,ISS)
protein import into nucleus  (ISO)
regulation of cell cycle  (ISO,ISS)
regulation of cellular senescence  (ISO,ISS)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of hair cycle  (IEA,ISO,ISS)
regulation of insulin secretion  (ISO,ISS)
regulation of neurogenesis  (ISO,ISS)
regulation of protein catabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of type B pancreatic cell development  (ISO,ISS)
response to redox state  (IEA,ISO,ISS)
rhythmic process  (IEA)
spermatogenesis  (ISO,ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse. Banach E, etal., J Affect Disord. 2018 Dec 1;241:142-146. doi: 10.1016/j.jad.2018.07.080. Epub 2018 Jul 31.
2. Mop3 is an essential component of the master circadian pacemaker in mammals. Bunger MK, etal., Cell 2000 Dec 22;103(7):1009-17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus. Honma S, etal., Biochem Biophys Res Commun 1998 Sep 8;250(1):83-7.
6. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
7. Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion. Johnston JG, etal., Hypertension. 2020 Jun;75(6):1624-1634. doi: 10.1161/HYPERTENSIONAHA.119.13908. Epub 2020 Apr 20.
8. Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Kondratov RV, etal., Genes Dev. 2006 Jul 15;20(14):1868-73.
9. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
10. [Changes of biological clock protein in neonatal rats with hypoxic-ischemic brain damage]. Li YF, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jan;15(1):62-6.
11. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. Matagne V, etal., J Neuroendocrinol. 2012 Jun;24(6):916-29. doi: 10.1111/j.1365-2826.2012.02302.x.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. The adipocyte clock controls brown adipogenesis through the TGF-beta and BMP signaling pathways. Nam D, etal., J Cell Sci. 2015 May 1;128(9):1835-47. doi: 10.1242/jcs.167643. Epub 2015 Mar 6.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats. Oishi K, etal., Biochem Biophys Res Commun. 1998 Dec 18;253(2):199-203.
16. Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. Peschke E, etal., J Pineal Res. 2008 Jul 1.
17. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors. Renzi A, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G634-43. doi: 10.1152/ajpgi.00206.2011. Epub 2011 Jul 14.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
21. Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family. Wolting CD and McGlade CJ, Mamm Genome 1998 Jun;9(6):463-8.
Additional References at PubMed
PMID:9079689   PMID:9576906   PMID:9704006   PMID:11441146   PMID:12024206   PMID:12150932   PMID:12397359   PMID:12477932   PMID:12738229   PMID:12843397   PMID:12897057   PMID:14645221  
PMID:14672706   PMID:15147242   PMID:15193144   PMID:15560782   PMID:16606840   PMID:17264215   PMID:17728404   PMID:17823250   PMID:18208549   PMID:18316400   PMID:18644859   PMID:19141540  
PMID:19217292   PMID:19299583   PMID:19387896   PMID:19605937   PMID:19740747   PMID:20093779   PMID:20106950   PMID:20430893   PMID:20562852   PMID:20861012   PMID:21113167   PMID:21613214  
PMID:21628546   PMID:21680841   PMID:21768648   PMID:21952132   PMID:22101268   PMID:22208286   PMID:22611086   PMID:22653727   PMID:22697126   PMID:22894897   PMID:22900038   PMID:22940729  
PMID:22960268   PMID:23056261   PMID:23263459   PMID:23395176   PMID:23525013   PMID:23596172   PMID:23738784   PMID:23785138   PMID:23831463   PMID:24005054   PMID:24043798   PMID:24048828  
PMID:24051492   PMID:24089055   PMID:24239982   PMID:24268780   PMID:24378737   PMID:24385426   PMID:24481314   PMID:24549704   PMID:24619734   PMID:24736997   PMID:25068868   PMID:25669688  
PMID:25936801   PMID:26051626   PMID:26271538   PMID:26776516   PMID:26901093   PMID:27365111   PMID:27717746   PMID:27771283   PMID:28423013   PMID:28985504   PMID:29085284   PMID:29165002  
PMID:29266826   PMID:29849897   PMID:30096135   PMID:31958455   PMID:32334629   PMID:33351992   PMID:33620678   PMID:34157911   PMID:35174626   PMID:35870088   PMID:36062789   PMID:36266079  
PMID:36613816   PMID:37086572   PMID:37093431   PMID:37356134   PMID:37381033   PMID:38035406   PMID:38597076   PMID:38678672  


Genomics

Comparative Map Data
Bmal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,766,222 - 176,864,741 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,829,305 - 176,864,739 (+)EnsemblGRCr8
mRatBN7.21167,331,756 - 167,430,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,331,633 - 167,430,231 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1175,666,810 - 175,765,622 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,852,900 - 182,951,712 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,548,108 - 175,646,871 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,039,002 - 178,137,469 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,039,063 - 178,137,465 (+)Ensemblrn6Rnor6.0
Rnor_5.01185,007,527 - 185,105,413 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41171,062,181 - 171,162,426 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1165,202,275 - 165,299,946 (+)NCBICelera
RGSC_v3.11171,251,951 - 171,282,040 (+)NCBI
Cytogenetic Map1q33NCBI
BMAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,276,652 - 13,387,266 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,276,647 - 13,388,048 (+)Ensemblhg38GRCh38
GRCh371113,298,199 - 13,408,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,255,901 - 13,365,389 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341113,255,925 - 13,365,386NCBI
Celera1113,425,472 - 13,534,997 (+)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1112,979,421 - 13,089,003 (+)NCBIHuRef
CHM1_11113,298,302 - 13,407,784 (+)NCBICHM1_1
T2T-CHM13v2.01113,369,378 - 13,480,010 (+)NCBIT2T-CHM13v2.0
Bmal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,777,820 - 112,913,333 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7112,806,672 - 112,913,333 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387113,178,471 - 113,314,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,207,465 - 113,314,126 (+)Ensemblmm10GRCm38
MGSCv377120,350,979 - 120,457,636 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367112,998,646 - 113,105,303 (+)NCBIMGSCv36mm8
Celera7113,186,397 - 113,287,835 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.17NCBI
Bmal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541428,684,226 - 28,748,360 (+)Ensembl
ChiLan1.0NW_00495541428,652,663 - 28,748,360 (+)NCBIChiLan1.0ChiLan1.0
BMAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2915,716,032 - 15,825,471 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,678,367 - 15,788,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,436,580 - 13,547,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,163,028 - 13,240,376 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,163,028 - 13,240,376 (+)EnsemblpanPan2panpan1.1
ARNTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,254,235 - 36,323,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,290,070 - 36,323,622 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2135,726,263 - 35,827,668 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02137,105,577 - 37,207,038 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2137,105,604 - 37,207,069 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12136,364,101 - 36,465,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02136,540,532 - 36,641,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02136,829,310 - 36,930,753 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bmal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494749,133,675 - 49,231,340 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365285,164,481 - 5,239,128 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365285,167,611 - 5,239,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARNTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl245,895,289 - 45,988,570 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1245,895,637 - 46,025,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,303,279 - 49,335,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,430,670 - 51,540,344 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,431,180 - 51,462,674 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038149,016,016 - 149,124,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247665,317,635 - 5,391,645 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247665,295,120 - 5,391,645 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bmal1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1288,215,187 - 88,280,082 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bmal1
938 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1148
Count of miRNA genes:326
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000019645, ENSRNOT00000046313
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
BM387564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,382,554 - 167,382,704 (+)MAPPERmRatBN7.2
Rnor_6.01178,089,797 - 178,089,946NCBIRnor6.0
Rnor_5.01185,057,937 - 185,058,086UniSTSRnor5.0
RGSC_v3.41171,114,736 - 171,114,885UniSTSRGSC3.4
Celera1165,253,308 - 165,253,457UniSTS
RH 3.4 Map11318.5UniSTS
Cytogenetic Map1q34UniSTS
UniSTS:224416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,367,349 - 167,367,440 (+)MAPPERmRatBN7.2
Rnor_6.01178,074,593 - 178,074,683NCBIRnor6.0
Rnor_5.01185,042,851 - 185,042,941UniSTSRnor5.0
RGSC_v3.41171,097,580 - 171,097,670UniSTSRGSC3.4
Celera1165,238,080 - 165,238,170UniSTS
Cytogenetic Map1q34UniSTS


Genetic Models
This gene Bmal1 is modified in the following models/strains:
SD-Bmal1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF317669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  PP731905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046313   ⟹   ENSRNOP00000042830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,829,305 - 176,864,739 (+)Ensembl
mRatBN7.2 Ensembl1167,331,820 - 167,430,231 (+)Ensembl
Rnor_6.0 Ensembl1178,039,063 - 178,137,465 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095012   ⟹   ENSRNOP00000082167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,829,305 - 176,864,739 (+)Ensembl
mRatBN7.2 Ensembl1167,331,633 - 167,430,231 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097013   ⟹   ENSRNOP00000087129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,834,351 - 176,864,739 (+)Ensembl
mRatBN7.2 Ensembl1167,331,633 - 167,430,231 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114442   ⟹   ENSRNOP00000086597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,834,364 - 176,864,739 (+)Ensembl
mRatBN7.2 Ensembl1167,399,854 - 167,430,231 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139118   ⟹   ENSRNOP00000103053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,834,373 - 176,864,737 (+)Ensembl
RefSeq Acc Id: NM_024362   ⟹   NP_077338
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,328 - 176,864,741 (+)NCBI
mRatBN7.21167,331,820 - 167,430,235 (+)NCBI
Rnor_6.01178,039,063 - 178,137,469 (+)NCBI
Rnor_5.01185,007,527 - 185,105,413 (+)NCBI
RGSC_v3.41171,062,181 - 171,162,426 (+)RGD
Celera1165,202,275 - 165,299,946 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230029   ⟹   XP_006230091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,222 - 176,864,741 (+)NCBI
mRatBN7.21167,331,759 - 167,430,235 (+)NCBI
Rnor_6.01178,039,004 - 178,137,469 (+)NCBI
Rnor_5.01185,007,527 - 185,105,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230030   ⟹   XP_006230092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,245 - 176,864,741 (+)NCBI
mRatBN7.21167,331,757 - 167,430,235 (+)NCBI
Rnor_6.01178,039,003 - 178,137,469 (+)NCBI
Rnor_5.01185,007,527 - 185,105,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589065   ⟹   XP_017444554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,240 - 176,864,741 (+)NCBI
mRatBN7.21167,331,757 - 167,430,235 (+)NCBI
Rnor_6.01178,039,003 - 178,137,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589067   ⟹   XP_017444556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,260 - 176,864,741 (+)NCBI
mRatBN7.21167,331,757 - 167,430,235 (+)NCBI
Rnor_6.01178,039,003 - 178,137,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589068   ⟹   XP_017444557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,245 - 176,864,741 (+)NCBI
mRatBN7.21167,331,756 - 167,430,235 (+)NCBI
Rnor_6.01178,039,002 - 178,137,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589070   ⟹   XP_017444559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,834,364 - 176,864,741 (+)NCBI
mRatBN7.21167,399,868 - 167,430,235 (+)NCBI
Rnor_6.01178,107,150 - 178,137,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109748   ⟹   XP_038965676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,260 - 176,864,741 (+)NCBI
mRatBN7.21167,331,757 - 167,430,235 (+)NCBI
RefSeq Acc Id: XM_039109755   ⟹   XP_038965683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,260 - 176,864,741 (+)NCBI
mRatBN7.21167,331,757 - 167,430,235 (+)NCBI
RefSeq Acc Id: XM_039109778   ⟹   XP_038965706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,835,122 - 176,864,741 (+)NCBI
mRatBN7.21167,400,612 - 167,430,235 (+)NCBI
RefSeq Acc Id: XM_039109788   ⟹   XP_038965716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,834,364 - 176,864,741 (+)NCBI
mRatBN7.21167,399,866 - 167,430,235 (+)NCBI
RefSeq Acc Id: XM_063287791   ⟹   XP_063143861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,828,522 - 176,864,741 (+)NCBI
RefSeq Acc Id: XM_063287804   ⟹   XP_063143874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,260 - 176,864,741 (+)NCBI
RefSeq Acc Id: XM_063287814   ⟹   XP_063143884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,766,260 - 176,864,741 (+)NCBI
Protein Sequences
Protein RefSeqs NP_077338 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230091 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230092 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444554 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444556 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444557 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444559 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965676 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965683 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965706 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965716 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143861 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143874 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143884 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC21449 (Get FASTA)   NCBI Sequence Viewer  
  AAG34180 (Get FASTA)   NCBI Sequence Viewer  
  AAH99833 (Get FASTA)   NCBI Sequence Viewer  
  BAA33450 (Get FASTA)   NCBI Sequence Viewer  
  EDM17800 (Get FASTA)   NCBI Sequence Viewer  
  EDM17801 (Get FASTA)   NCBI Sequence Viewer  
  EDM17802 (Get FASTA)   NCBI Sequence Viewer  
  EDM17803 (Get FASTA)   NCBI Sequence Viewer  
  EDM17804 (Get FASTA)   NCBI Sequence Viewer  
  EDM17805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042830
  ENSRNOP00000082167
  ENSRNOP00000087129
GenBank Protein Q9EPW1 (Get FASTA)   NCBI Sequence Viewer  
  XAF83723 (Get FASTA)   NCBI Sequence Viewer  
  XAF83724 (Get FASTA)   NCBI Sequence Viewer  
  XAF83725 (Get FASTA)   NCBI Sequence Viewer  
  XAF83726 (Get FASTA)   NCBI Sequence Viewer  
  XAF83727 (Get FASTA)   NCBI Sequence Viewer  
  XAF83728 (Get FASTA)   NCBI Sequence Viewer  
  XAF83729 (Get FASTA)   NCBI Sequence Viewer  
  XAF83730 (Get FASTA)   NCBI Sequence Viewer  
  XAF83731 (Get FASTA)   NCBI Sequence Viewer  
  XAF83732 (Get FASTA)   NCBI Sequence Viewer  
  XAF83733 (Get FASTA)   NCBI Sequence Viewer  
  XAF83734 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077338   ⟸   NM_024362
- UniProtKB: Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   Q9EPW1 (UniProtKB/Swiss-Prot),   D3ZT62 (UniProtKB/TrEMBL),   A6I877 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230091   ⟸   XM_006230029
- Peptide Label: isoform X3
- UniProtKB: Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   Q9EPW1 (UniProtKB/Swiss-Prot),   D3ZT62 (UniProtKB/TrEMBL),   A6I877 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230092   ⟸   XM_006230030
- Peptide Label: isoform X4
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444557   ⟸   XM_017589068
- Peptide Label: isoform X2
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444556   ⟸   XM_017589067
- Peptide Label: isoform X1
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I5ZXD2 (UniProtKB/TrEMBL),   A6I875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444554   ⟸   XM_017589065
- Peptide Label: isoform X1
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I5ZXD2 (UniProtKB/TrEMBL),   A6I875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444559   ⟸   XM_017589070
- Peptide Label: isoform X6
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I6A2N7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042830   ⟸   ENSRNOT00000046313
RefSeq Acc Id: XP_038965676   ⟸   XM_039109748
- Peptide Label: isoform X1
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I5ZXD2 (UniProtKB/TrEMBL),   A6I875 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965683   ⟸   XM_039109755
- Peptide Label: isoform X1
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I5ZXD2 (UniProtKB/TrEMBL),   A6I875 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965716   ⟸   XM_039109788
- Peptide Label: isoform X7
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965706   ⟸   XM_039109778
- Peptide Label: isoform X5
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000082167   ⟸   ENSRNOT00000095012
Ensembl Acc Id: ENSRNOP00000086597   ⟸   ENSRNOT00000114442
Ensembl Acc Id: ENSRNOP00000087129   ⟸   ENSRNOT00000097013
RefSeq Acc Id: XP_063143884   ⟸   XM_063287814
- Peptide Label: isoform X3
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A6I877 (UniProtKB/TrEMBL),   D3ZT62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143874   ⟸   XM_063287804
- Peptide Label: isoform X3
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A6I877 (UniProtKB/TrEMBL),   D3ZT62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143861   ⟸   XM_063287791
- Peptide Label: isoform X1
- UniProtKB: Q9EPW1 (UniProtKB/Swiss-Prot),   Q499M8 (UniProtKB/Swiss-Prot),   O88810 (UniProtKB/Swiss-Prot),   O88337 (UniProtKB/Swiss-Prot),   A0A8I5ZXD2 (UniProtKB/TrEMBL),   A6I875 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103053   ⟸   ENSRNOT00000139118
Protein Domains
bHLH   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPW1-F1-model_v2 AlphaFold Q9EPW1 1-626 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690323
Promoter ID:EPDNEW_R848
Type:initiation region
Name:Arntl_1
Description:aryl hydrocarbon receptor nuclear translocator-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01178,039,017 - 178,039,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62003 AgrOrtholog
BioCyc Gene G2FUF-57769 BioCyc
Ensembl Genes ENSRNOG00000014448 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000046313 ENTREZGENE
  ENSRNOT00000095012 ENTREZGENE
  ENSRNOT00000097013 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7936079 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot
  Circadian_TF UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Nuc_translocat UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold UniProtKB/Swiss-Prot
KEGG Report rno:29657 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124556 IMAGE-MGC_LOAD
NCBI Gene 29657 ENTREZGENE
PANTHER CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS_11 UniProtKB/Swiss-Prot
PhenoGen Bmal1 PhenoGen
PRINTS NCTRNSLOCATR UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014448 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
UniProt A0A8I5ZXD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2H7_RAT UniProtKB/TrEMBL
  A0A8I6A2N7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LC48_RAT UniProtKB/TrEMBL
  A6I875 ENTREZGENE, UniProtKB/TrEMBL
  A6I877 ENTREZGENE, UniProtKB/TrEMBL
  BMAL1_RAT UniProtKB/Swiss-Prot
  D3ZT62 ENTREZGENE, UniProtKB/TrEMBL
  O88337 ENTREZGENE
  O88810 ENTREZGENE
  Q499M8 ENTREZGENE
  Q9EPW1 ENTREZGENE
UniProt Secondary O88337 UniProtKB/Swiss-Prot
  O88810 UniProtKB/Swiss-Prot
  Q499M8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-29 Bmal1  basic helix-loop-helix ARNT like 1  Arntl  aryl hydrocarbon receptor nuclear translocator-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arntl  aryl hydrocarbon receptor nuclear translocator-like       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression circadian rhythm of expression displayed in the suprachiasmatic nucleus (SCN), the site of the circadian clock, with the highest level at the subjective night 67927
gene_expression expressed in the olfactory bulb, hippocampus, and cerebellum 67927
gene_product member of the basic loop-helix-loop/PAS transcription factor family 61539
gene_product member of the basic loop-helix-loop/PAS transcription factor family 67927
gene_protein 626 amino acid 61539
gene_protein 626 amino acid 67927