Ptger2 (prostaglandin E receptor 2) - Rat Genome Database

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Gene: Ptger2 (prostaglandin E receptor 2) Rattus norvegicus
Analyze
Symbol: Ptger2
Name: prostaglandin E receptor 2
RGD ID: 620020
Description: Enables prostaglandin E receptor activity. Involved in positive regulation of gastric mucosal blood circulation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EP2; LOC100360765; PGE receptor EP2 subtype; PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2); prostaglandin E receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype-like; prostaglandin E2 receptor type 2; prostanoid EP2 receptor; Ptger-ep2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81520,694,765 - 20,708,475 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1520,696,013 - 20,708,950 (+)EnsemblGRCr8
mRatBN7.21518,215,013 - 18,228,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,217,285 - 18,228,714 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1521,008,805 - 21,020,249 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01521,965,749 - 21,977,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,222,303 - 20,233,747 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,336,029 - 19,349,759 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,338,175 - 19,350,210 (+)Ensemblrn6Rnor6.0
Rnor_5.01523,301,463 - 23,315,207 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41520,205,443 - 20,216,872 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1518,649,190 - 18,660,619 (+)NCBICelera
RGSC_v3.11520,878,084 - 20,889,615 (+)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
AH23848  (ISO)
all-trans-retinoic acid  (ISO)
alternariol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
Azoxymethane  (ISO)
bellidifolin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cryptotanshinone  (ISO)
D-penicillamine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diosmin  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
ethylbenzene  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
hemin  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (ISO)
ketoconazole  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methylisothiazolinone  (ISO)
mifepristone  (EXP)
misoprostol  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nonylphenol  (EXP)
NS-398  (EXP,ISO)
o-xylene  (ISO)
oxaliplatin  (EXP)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylarsine oxide  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium hydrogensulfite  (EXP)
sodium sulfite  (EXP)
sulfur dioxide  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
terbinafine  (ISO)
terbufos  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinyl carbamate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of arachidonate metabolism enzymes and receptors in nasal polyps of aspirin-hypersensitive asthmatics. Adamusiak AM, etal., Int Arch Allergy Immunol. 2012;157(4):354-62. doi: 10.1159/000329744. Epub 2011 Nov 24.
2. Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. Alaa M, etal., Int J Oncol. 2009 Mar;34(3):805-12. doi: 10.3892/ijo_00000206.
3. The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach. Araki H, etal., Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:116-24.
4. Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients. Baba R, etal., J Allergy Clin Immunol Glob. 2022 Sep 12;1(4):299-304. doi: 10.1016/j.jacig.2022.07.007. eCollection 2022 Nov.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. Hattori R, etal., Ann Otol Rhinol Laryngol. 2009 Jul;118(7):536-41. doi: 10.1177/000348940911800714.
7. Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2. Herrerias A, etal., J Inflamm (Lond). 2009 Oct 30;6:30.
8. Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Jinnai N, etal., Hum Mol Genet. 2004 Dec 15;13(24):3203-17. doi: 10.1093/hmg/ddh332. Epub 2004 Oct 20.
9. Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis. Jones AC, etal., Am J Respir Crit Care Med. 2019 Jun 15;199(12):1537-1549. doi: 10.1164/rccm.201804-0715OC.
10. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Kim SH, etal., Pharmacogenet Genomics. 2007 Apr;17(4):295-304. doi: 10.1097/01.fpc.0000239977.61841.fe.
11. Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling. Machado-Carvalho L, etal., Rhinology. 2016 Sep;54(3):254-65. doi: 10.4193/Rhino15.207.
12. Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort. Mani S, etal., Prostaglandins Leukot Essent Fatty Acids. 2021 Mar;166:102252. doi: 10.1016/j.plefa.2021.102252. Epub 2021 Jan 28.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Expression of prostaglandin E2 prostanoid receptor EP2 and interleukin-1β in laryngeal carcinoma - preliminary study. Mochocki M, etal., Contemp Oncol (Pozn). 2015;19(2):113-9. doi: 10.5114/wo.2015.51417. Epub 2015 May 13.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype. Nemoto K, etal., Prostaglandins 1997 Oct;54(4):713-25.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics. Park BL, etal., BMB Rep. 2010 Jun;43(6):445-9. doi: 10.5483/bmbrep.2010.43.6.445.
19. Prostanoid EPâ‚‚ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells. Patel JA, etal., Int J Mol Sci. 2018 Aug 12;19(8):2372. doi: 10.3390/ijms19082372.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells' activity. Serra-Pages M, etal., Clin Exp Allergy. 2015 Oct;45(10):1590-600. doi: 10.1111/cea.12542.
24. Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors. Sturm EM, etal., J Immunol. 2008 Nov 15;181(10):7273-83. doi: 10.4049/jimmunol.181.10.7273.
25. A systemically administered EP2 receptor agonist stimulates pulmonary angiogenesis in a murine model of emphysema. Tsuji T, etal., Prostaglandins Other Lipid Mediat. 2009 Dec;90(3-4):85-8. doi: 10.1016/j.prostaglandins.2009.09.002. Epub 2009 Sep 16.
26. Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance. Ungvári I, etal., PLoS One. 2012;7(3):e33573. doi: 10.1371/journal.pone.0033573. Epub 2012 Mar 14.
27. Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4. van Geffen C, etal., Front Immunol. 2021 Jul 12;12:695933. doi: 10.3389/fimmu.2021.695933. eCollection 2021.
28. Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor-dependent activation of β-catenin in 5/6 nephrectomy rats. Wang Y, etal., ESC Heart Fail. 2021 Jun;8(3):1979-1989. doi: 10.1002/ehf2.13269. Epub 2021 Apr 6.
Additional References at PubMed
PMID:9537820   PMID:10684792   PMID:11533709   PMID:12939279   PMID:14552899   PMID:14606517   PMID:15834430   PMID:16136483   PMID:16437207   PMID:16546360   PMID:16646980   PMID:17058034  
PMID:17947453   PMID:18403039   PMID:18684231   PMID:19524109   PMID:19555672   PMID:19712723   PMID:20713561   PMID:21716255   PMID:21768374   PMID:21939736   PMID:22061836   PMID:22789984  
PMID:23404506   PMID:24146253   PMID:24253784   PMID:25059824   PMID:25715797   PMID:28717970   PMID:28759126   PMID:32165825   PMID:36889213  


Genomics

Comparative Map Data
Ptger2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81520,694,765 - 20,708,475 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1520,696,013 - 20,708,950 (+)EnsemblGRCr8
mRatBN7.21518,215,013 - 18,228,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,217,285 - 18,228,714 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1521,008,805 - 21,020,249 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01521,965,749 - 21,977,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,222,303 - 20,233,747 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,336,029 - 19,349,759 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,338,175 - 19,350,210 (+)Ensemblrn6Rnor6.0
Rnor_5.01523,301,463 - 23,315,207 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41520,205,443 - 20,216,872 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1518,649,190 - 18,660,619 (+)NCBICelera
RGSC_v3.11520,878,084 - 20,889,615 (+)NCBI
Cytogenetic Map15p14NCBI
PTGER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,314,312 - 52,328,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,314,305 - 52,329,822 (+)Ensemblhg38GRCh38
GRCh371452,781,030 - 52,795,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,850,863 - 51,865,074 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341451,850,862 - 51,865,070NCBI
Celera1432,648,601 - 32,662,908 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1432,941,341 - 32,955,648 (+)NCBIHuRef
CHM1_11452,720,192 - 52,734,499 (+)NCBICHM1_1
T2T-CHM13v2.01446,521,407 - 46,535,692 (+)NCBIT2T-CHM13v2.0
Ptger2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,225,568 - 45,241,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,225,652 - 45,241,277 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381444,988,111 - 45,003,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1444,988,195 - 45,003,820 (+)Ensemblmm10GRCm38
MGSCv371445,607,786 - 45,623,495 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361443,910,468 - 43,925,027 (+)NCBIMGSCv36mm8
Celera1441,179,301 - 41,195,008 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.68NCBI
Ptger2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,757,888 - 10,774,688 (-)Ensembl
ChiLan1.0NW_00495540910,760,801 - 10,775,197 (-)NCBIChiLan1.0ChiLan1.0
PTGER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,441,812 - 53,459,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11452,661,559 - 52,676,942 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01432,910,755 - 32,926,138 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,195,381 - 51,209,686 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,195,381 - 51,209,686 (+)EnsemblpanPan2panpan1.1
PTGER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1828,523,318 - 28,536,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl828,522,681 - 28,536,922 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha828,274,789 - 28,288,408 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0828,698,142 - 28,712,635 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl828,699,025 - 28,712,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,369,315 - 28,383,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,428,898 - 28,442,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0828,777,540 - 28,791,160 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptger2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,666,763 - 76,679,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366972,440,901 - 2,453,975 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366972,440,943 - 2,453,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1181,994,560 - 182,009,953 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11181,993,961 - 182,009,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,268,089 - 202,282,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,395,799 - 29,410,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2429,396,464 - 29,409,575 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605317,664,018 - 17,678,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,726,975 - 16,741,557 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473116,729,846 - 16,741,529 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptger2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11277,997,895 - 78,009,801 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptger2
259 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000075209
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat

Markers in Region
RH134047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,228,901 - 18,229,081 (+)MAPPERmRatBN7.2
Rnor_6.01519,349,947 - 19,350,126NCBIRnor6.0
Rnor_5.01523,315,395 - 23,315,574UniSTSRnor5.0
RGSC_v3.41520,889,803 - 20,889,982UniSTSRGSC3.4
RGSC_v3.41520,217,060 - 20,217,239UniSTSRGSC3.4
Celera1518,660,807 - 18,660,986UniSTS
RH 3.4 Map15149.7UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 59 164 90 89 58 92 58 6 341 182 11 142 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075209   ⟹   ENSRNOP00000064907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1520,696,013 - 20,708,950 (+)Ensembl
mRatBN7.2 Ensembl1518,217,285 - 18,228,714 (+)Ensembl
Rnor_6.0 Ensembl1519,338,175 - 19,350,210 (+)Ensembl
RefSeq Acc Id: NM_031088   ⟹   NP_112350
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81520,697,046 - 20,708,475 (+)NCBI
mRatBN7.21518,217,285 - 18,228,714 (+)NCBI
Rnor_6.01519,338,330 - 19,349,759 (+)NCBI
Rnor_5.01523,301,463 - 23,315,207 (+)NCBI
RGSC_v3.41520,205,443 - 20,216,872 (+)RGD
Celera1518,649,190 - 18,660,619 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093687   ⟹   XP_038949615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81520,694,771 - 20,701,592 (+)NCBI
mRatBN7.21518,215,015 - 18,222,120 (+)NCBI
RefSeq Acc Id: XR_001841264
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81520,694,765 - 20,708,145 (+)NCBI
mRatBN7.21518,215,013 - 18,228,384 (+)NCBI
Rnor_6.01519,336,029 - 19,349,361 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_112350 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949615 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA97889 (Get FASTA)   NCBI Sequence Viewer  
  AAB53325 (Get FASTA)   NCBI Sequence Viewer  
  AAM73855 (Get FASTA)   NCBI Sequence Viewer  
  EDL88294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064907
  ENSRNOP00000064907.1
GenBank Protein Q62928 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112350   ⟸   NM_031088
- UniProtKB: Q547S0 (UniProtKB/Swiss-Prot),   Q62928 (UniProtKB/Swiss-Prot),   A6KDY9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064907   ⟸   ENSRNOT00000075209
RefSeq Acc Id: XP_038949615   ⟸   XM_039093687
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62928-F1-model_v2 AlphaFold Q62928 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620020 AgrOrtholog
BioCyc Gene G2FUF-14230 BioCyc
Ensembl Genes ENSRNOG00000050968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075209 ENTREZGENE
  ENSRNOT00000075209.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
  Prostglndn_EP2_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:81752 UniProtKB/Swiss-Prot
NCBI Gene 81752 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
  PTHR11866:SF8 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ptger2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDEP2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050968 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6KDY9 ENTREZGENE, UniProtKB/TrEMBL
  PE2R2_RAT UniProtKB/Swiss-Prot
  Q547S0 ENTREZGENE
  Q62928 ENTREZGENE
UniProt Secondary Q547S0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Ptger2  prostaglandin E receptor 2  Ptger2  prostaglandin E receptor 2 (subtype EP2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Ptger2  prostaglandin E receptor 2 (subtype EP2)  LOC100360765  prostaglandin E2 receptor EP2 subtype-like  Data merged from RGD:2321493 737654 PROVISIONAL
2010-05-06 LOC100360765  prostaglandin E2 receptor EP2 subtype-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-24 Ptger2  prostaglandin E receptor 2 (subtype EP2)  Ptger2  prostaglandin E receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Ptger2  prostaglandin E receptor 2, subtype EP2    prostaglandin E receptor EP2 subtype  Name updated 1299863 APPROVED
2002-08-07 Ptger2  prostaglandin E receptor EP2 subtype      Symbol and Name status set to provisional 70820 PROVISIONAL