Gzmb (granzyme B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gzmb (granzyme B) Rattus norvegicus
Analyze
Symbol: Gzmb (Ensembl: Gzmbl3)
Name: granzyme B (Ensembl:Granzyme B-like 3)
RGD ID: 620018
Description: Enables serine-type endopeptidase activity. Involved in neuron apoptotic process and positive regulation of necroptotic process. Located in early endosome. Biomarker of brain infarction. Orthologous to human GZMB (granzyme B); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fragmentin; GLP I; GLP III; GLP-1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-like protein 1; granzyme-like protein I; MGC156565; natural killer cell protease 1; RNKP-1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,459,007 - 34,462,469 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,459,007 - 34,462,469 (-)EnsemblGRCr8
mRatBN7.21530,343,352 - 30,346,814 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,173,603 - 30,346,814 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1532,334,740 - 32,338,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,485,381 - 33,488,843 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,743,468 - 31,746,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,413,793 - 35,417,316 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,891,059 - 29,893,786 (-)NCBICelera
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-azacytidine  (ISO)
acetamide  (EXP)
adenosine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
coformycin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dichlorvos  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
folpet  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
Fusarenone X  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
heparin  (EXP)
imiquimod  (ISO)
ionomycin  (ISO)
irinotecan  (EXP)
L-ascorbic acid  (ISO)
lipopolysaccharide  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methoxychlor  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nonanoic acid  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
tamoxifen  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP,ISO)
valproic acid  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum. Amerik AYu, etal., FEBS Lett 1993 Jun 14;324(2):226-30.
2. Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice. Bem RA, etal., J Immunol. 2010 Jan 15;184(2):931-8. Epub 2009 Dec 16.
3. Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat. Chaitanya GV and Babu PP, Brain Res. 2008 Dec 30;1246:178-90. Epub 2008 Oct 9.
4. Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Chaitanya GV and Babu PP, Cell Mol Neurobiol. 2009 Jun;29(4):563-73. Epub 2009 Feb 19.
5. Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model. Chaitanya GV, etal., Neuroscience. 2010 Feb 17;165(4):1203-16. Epub 2009 Nov 4.
6. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Cloning of cDNA for granzyme-like protein III, a novel serine proteinase from rat duodenum. Grigorenko VG, etal., FEBS Lett 1994 Apr 11;342(3):278-80.
9. Definition and redesign of the extended substrate specificity of granzyme B. Harris JL, etal., J Biol Chem. 1998 Oct 16;273(42):27364-73. doi: 10.1074/jbc.273.42.27364.
10. Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens. Hodge S, etal., Clin Exp Immunol. 2009 Nov;158(2):230-6. Epub 2009 Aug 3.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. Ruggles SW, etal., J Biol Chem. 2004 Jul 16;279(29):30751-9. Epub 2004 May 3.
17. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Thiery J, etal., Blood. 2010 Feb 25;115(8):1582-93. Epub 2009 Dec 28.
18. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients. Urbanowicz RA, etal., Respir Res. 2010 Jun 11;11:76.
19. Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. Vermijlen D, etal., J Leukoc Biol 2002 Oct;72(4):668-76.
20. RNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes. Zunino SJ, etal., J Immunol 1990 Mar 1;144(5):2001-9.
Additional References at PubMed
PMID:1727874   PMID:1732416   PMID:11331782   PMID:12477932   PMID:14978081   PMID:15454490   PMID:15944262   PMID:16618603   PMID:18292522   PMID:19170890   PMID:19915045   PMID:19946888  
PMID:20450731   PMID:21426642   PMID:21795594   PMID:26432892   PMID:29107333   PMID:29445095   PMID:37531918  


Genomics

Comparative Map Data
Gzmb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,459,007 - 34,462,469 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,459,007 - 34,462,469 (-)EnsemblGRCr8
mRatBN7.21530,343,352 - 30,346,814 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,173,603 - 30,346,814 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1532,334,740 - 32,338,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,485,381 - 33,488,843 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,743,468 - 31,746,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,413,862 - 35,417,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,413,793 - 35,417,316 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,296,950 - 39,300,381 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41535,195,075 - 35,198,506 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,891,059 - 29,893,786 (-)NCBICelera
RGSC_v3.11535,211,149 - 35,214,166 (-)NCBI
Cytogenetic Map15p12NCBI
GZMB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,630,954 - 24,634,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,630,954 - 24,634,267 (-)Ensemblhg38GRCh38
GRCh371425,100,160 - 25,103,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,170,000 - 24,173,272 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341424,170,003 - 24,173,272NCBI
Celera144,964,951 - 4,968,224 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,214,872 - 5,218,144 (-)NCBIHuRef
CHM1_11425,099,053 - 25,102,325 (-)NCBICHM1_1
T2T-CHM13v2.01418,829,837 - 18,833,074 (-)NCBIT2T-CHM13v2.0
Gzmb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,496,293 - 56,499,791 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,496,295 - 56,499,717 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381456,258,836 - 56,262,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,258,838 - 56,262,260 (-)Ensemblmm10GRCm38
MGSCv371456,877,693 - 56,881,097 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361455,212,927 - 55,216,331 (-)NCBIMGSCv36mm8
Celera1454,055,471 - 54,058,875 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
GZMB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,978,516 - 25,981,806 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11425,195,008 - 25,198,304 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,399,888 - 5,403,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,523,619 - 23,526,931 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,523,619 - 23,526,931 (-)EnsemblpanPan2panpan1.1
GZMB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,508,718 - 4,511,824 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,470,577 - 4,512,628 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,430,126 - 4,433,251 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,620,020 - 4,623,146 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,601,184 - 4,623,149 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,309,346 - 4,312,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,371,938 - 4,375,062 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,634,356 - 4,637,481 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GZMB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,705,409 - 74,708,790 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1774,705,499 - 74,708,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2779,831,207 - 79,834,515 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GZMB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,574,452 - 1,577,861 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,574,453 - 1,577,798 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603613,270,472 - 13,273,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gzmb
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:52
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000041430
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH141566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21530,343,613 - 30,343,803 (+)MAPPERmRatBN7.2
Rnor_6.01535,414,115 - 35,414,304NCBIRnor6.0
Rnor_5.01539,297,203 - 39,297,392UniSTSRnor5.0
RGSC_v3.41535,061,296 - 35,061,485UniSTSRGSC3.4
RGSC_v3.41535,195,328 - 35,195,517UniSTSRGSC3.4
Celera1530,064,847 - 30,065,036UniSTS
Celera1529,935,088 - 29,935,277UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 4 23 41 28 34 14 88 14 199 127 11 31 46 45 20 2 2

Sequence


RefSeq Acc Id: NM_138517   ⟹   NP_612526
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,459,007 - 34,462,469 (-)NCBI
mRatBN7.21530,343,352 - 30,346,814 (-)NCBI
Rnor_6.01535,413,862 - 35,417,293 (-)NCBI
Rnor_5.01539,296,950 - 39,300,381 (-)NCBI
RGSC_v3.41535,195,075 - 35,198,506 (-)RGD
Celera1530,064,594 - 30,068,025 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_612526 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27476 (Get FASTA)   NCBI Sequence Viewer  
  EDM14323 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040429.3
  ENSRNOP00000075556
GenBank Protein P18291 (Get FASTA)   NCBI Sequence Viewer  
  Q06605 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_612526   ⟸   NM_138517
- Peptide Label: precursor
- UniProtKB: P18291 (UniProtKB/Swiss-Prot),   A6KH94 (UniProtKB/TrEMBL),   A0A8L2QRC7 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18291-F1-model_v2 AlphaFold P18291 1-248 view protein structure
AF-Q06605-F1-model_v2 AlphaFold Q06605 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699707
Promoter ID:EPDNEW_R10230
Type:single initiation site
Name:Gzmb_1
Description:granzyme B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01535,417,315 - 35,417,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620018 AgrOrtholog
BioCyc Gene G2FUF-13635 BioCyc
Ensembl Genes ENSRNOG00000049976 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041430.6 UniProtKB/Swiss-Prot
  ENSRNOT00000083961 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124652 IMAGE-MGC_LOAD
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:171528 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156565 IMAGE-MGC_LOAD
NCBI Gene 171528 ENTREZGENE
PANTHER GRANZYME B UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Gzmb PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049976 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A8L2QRC7 ENTREZGENE
  A1L119_RAT UniProtKB/TrEMBL
  A6KH94 ENTREZGENE, UniProtKB/TrEMBL
  GRAB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q06605 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Gzmb  granzyme B  Gzmb  granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-22 Gzmb  granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)  Gzmb  granzyme B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gzmb  granzyme B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gzmb  granzyme B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 88.2% identity to GLP I and 50.6% identity to GLP II 632830
gene_protein 248 amino acid residues 632830