Nsfl1c (NSFL1 cofactor) - Rat Genome Database

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Gene: Nsfl1c (NSFL1 cofactor) Rattus norvegicus
Analyze
Symbol: Nsfl1c
Name: NSFL1 cofactor
RGD ID: 619952
Description: Enables ATPase binding activity and ubiquitin binding activity. Contributes to phospholipid binding activity. Involved in Golgi organization and membrane fusion. Located in cytosol and spindle pole centrosome. Part of VCP-NSFL1C complex. Orthologous to human NSFL1C (NSFL1 cofactor); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p47; p97 cofactor p47; XY body-associated protein XY40; XY40
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,438,708 - 160,463,261 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3160,438,708 - 160,463,228 (+)EnsemblGRCr8
mRatBN7.23139,978,306 - 140,002,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,978,301 - 140,002,870 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,882,849 - 143,907,438 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,466,609 - 152,491,210 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,207,072 - 150,231,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,980,923 - 147,005,478 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,980,923 - 147,005,439 (+)Ensemblrn6Rnor6.0
Rnor_5.03153,337,781 - 153,361,989 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,799,286 - 141,823,762 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,737,682 - 138,762,227 (+)NCBICelera
RGSC_v3.13141,704,858 - 141,729,335 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chrysene  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
dibutyl phthalate  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
hydralazine  (ISO)
ivermectin  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
T-2 toxin  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
chromosome  (IEA)
cytoplasm  (NAS)
cytosol  (IBA,IDA)
Golgi apparatus  (IEA)
Golgi stack  (IEA)
nucleus  (IBA,IEA)
spindle pole centrosome  (IDA)
VCP-NSFL1C complex  (IEA,IPI,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Alexandru G, etal., Cell. 2008 Sep 5;134(5):804-16. doi: 10.1016/j.cell.2008.06.048.
2. Molecular characterization and expression pattern of XY body-associated protein XY40 of the rat. Alsheimer M, etal., Chromosoma 1997 Oct;106(5):308-14.
3. Conformational changes in the AAA ATPase p97-p47 adaptor complex. Beuron F, etal., EMBO J. 2006 May 3;25(9):1967-76. Epub 2006 Apr 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Isolation of a point-mutated p47 lacking binding affinity to p97ATPase. Kaneko Y, etal., FEBS Lett. 2010 Sep 24;584(18):3873-7. doi: 10.1016/j.febslet.2010.07.061. Epub 2010 Aug 6.
6. p47 is a cofactor for p97-mediated membrane fusion. Kondo H, etal., Nature 1997 Jul 3;388(6637):75-8.
7. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. Kress E, etal., J Cell Biol. 2013 May 13;201(4):559-75. doi: 10.1083/jcb.201209107. Epub 2013 May 6.
8. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer HH, etal., EMBO J 2000 May 15;19(10):2181-92.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Phospholipid species act as modulators in p97/p47-mediated fusion of Golgi membranes. Pecheur EI, etal., Biochemistry 2002 Aug 6;41(31):9813-23.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. Ye Y, etal., J Cell Biol. 2003 Jul 7;162(1):71-84.
Additional References at PubMed
PMID:1495983   PMID:9506515   PMID:9824302   PMID:10930451   PMID:11478859   PMID:12411482   PMID:12473691   PMID:12810701   PMID:15489334   PMID:16396499   PMID:16641100   PMID:17601490  
PMID:19182904   PMID:23295407   PMID:23429921  


Genomics

Comparative Map Data
Nsfl1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,438,708 - 160,463,261 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3160,438,708 - 160,463,228 (+)EnsemblGRCr8
mRatBN7.23139,978,306 - 140,002,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,978,301 - 140,002,870 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,882,849 - 143,907,438 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,466,609 - 152,491,210 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,207,072 - 150,231,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,980,923 - 147,005,478 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,980,923 - 147,005,439 (+)Ensemblrn6Rnor6.0
Rnor_5.03153,337,781 - 153,361,989 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,799,286 - 141,823,762 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,737,682 - 138,762,227 (+)NCBICelera
RGSC_v3.13141,704,858 - 141,729,335 (+)NCBI
Cytogenetic Map3q41NCBI
NSFL1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,442,166 - 1,466,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl201,442,162 - 1,473,842 (-)Ensemblhg38GRCh38
GRCh37201,422,811 - 1,447,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,370,811 - 1,396,417 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34201,370,810 - 1,396,417NCBI
Celera201,519,162 - 1,544,783 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,373,688 - 1,399,218 (-)NCBIHuRef
CHM1_1201,421,141 - 1,446,667 (-)NCBICHM1_1
T2T-CHM13v2.0201,491,358 - 1,516,046 (-)NCBIT2T-CHM13v2.0
Nsfl1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,336,102 - 151,353,230 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,336,102 - 151,353,334 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382151,494,182 - 151,511,310 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2151,494,182 - 151,511,414 (+)Ensemblmm10GRCm38
MGSCv372151,320,044 - 151,337,041 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362151,185,749 - 151,202,746 (+)NCBIMGSCv36mm8
Celera2157,311,678 - 157,328,675 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Nsfl1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955596648,978 - 673,585 (-)Ensembl
ChiLan1.0NW_004955596648,978 - 673,586 (-)NCBIChiLan1.0ChiLan1.0
NSFL1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,479,116 - 2,503,537 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1202,475,944 - 2,500,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0201,597,171 - 1,622,708 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1201,364,008 - 1,389,548 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,364,008 - 1,389,548 (-)EnsemblpanPan2panpan1.1
NSFL1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,575,543 - 19,599,002 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2419,575,580 - 19,597,653 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2419,294,327 - 19,317,815 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02420,267,728 - 20,291,217 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,267,773 - 20,291,220 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,544,333 - 19,567,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,649,280 - 19,672,767 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,080,100 - 20,103,589 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nsfl1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,786,098 - 168,806,889 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648517,217,462 - 17,238,628 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648517,217,462 - 17,238,253 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSFL1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1733,869,527 - 33,892,064 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11733,869,487 - 33,890,873 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21738,513,369 - 38,535,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSFL1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,102,384 - 55,127,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl255,103,266 - 55,126,341 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660871,507,616 - 1,533,114 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsfl1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247412,748,796 - 2,774,119 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247412,746,853 - 2,774,038 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nsfl1c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15130,849,304 - 130,875,700 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nsfl1c
308 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000011654
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
WI-20603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23140,002,573 - 140,002,821 (+)MAPPERmRatBN7.2
Rnor_6.03147,005,176 - 147,005,423NCBIRnor6.0
Rnor_5.03153,361,687 - 153,361,934UniSTSRnor5.0
RGSC_v3.43141,823,468 - 141,823,715UniSTSRGSC3.4
Celera3138,761,933 - 138,762,180UniSTS
Cytogenetic Map3q41UniSTS
RH142919  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83160,444,919 - 160,445,159 (+)Marker Load Pipeline
mRatBN7.23139,984,527 - 139,984,767 (+)MAPPERmRatBN7.2
Rnor_6.03146,987,135 - 146,987,374NCBIRnor6.0
Rnor_5.03153,343,993 - 153,344,232UniSTSRnor5.0
RGSC_v3.43141,805,498 - 141,805,737UniSTSRGSC3.4
Celera3138,743,894 - 138,744,133UniSTS
RH 3.4 Map31196.29UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011654   ⟹   ENSRNOP00000011654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,438,708 - 160,463,228 (+)Ensembl
mRatBN7.2 Ensembl3139,978,301 - 140,002,844 (+)Ensembl
Rnor_6.0 Ensembl3146,980,923 - 147,005,439 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090211   ⟹   ENSRNOP00000074814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,438,796 - 160,463,228 (+)Ensembl
mRatBN7.2 Ensembl3139,978,415 - 140,002,868 (+)Ensembl
Rnor_6.0 Ensembl3146,981,984 - 147,005,439 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112578   ⟹   ENSRNOP00000085721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,439,115 - 160,463,228 (+)Ensembl
mRatBN7.2 Ensembl3139,978,974 - 140,002,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119681   ⟹   ENSRNOP00000084299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,438,789 - 160,463,228 (+)Ensembl
mRatBN7.2 Ensembl3139,978,403 - 140,002,870 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125922   ⟹   ENSRNOP00000107246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3160,438,801 - 160,463,228 (+)Ensembl
RefSeq Acc Id: NM_031981   ⟹   NP_114187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83160,438,708 - 160,463,259 (+)NCBI
mRatBN7.23139,978,316 - 140,002,868 (+)NCBI
Rnor_6.03146,980,923 - 147,005,470 (+)NCBI
Rnor_5.03153,337,781 - 153,361,989 (+)NCBI
RGSC_v3.43141,799,286 - 141,823,762 (+)RGD
Celera3138,737,682 - 138,762,227 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284677   ⟹   XP_063140747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83160,447,969 - 160,463,261 (+)NCBI
RefSeq Acc Id: NP_114187   ⟸   NM_031981
- UniProtKB: O35987 (UniProtKB/Swiss-Prot),   A6KHI1 (UniProtKB/TrEMBL),   A0A0G2K911 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074814   ⟸   ENSRNOT00000090211
Ensembl Acc Id: ENSRNOP00000011654   ⟸   ENSRNOT00000011654
Ensembl Acc Id: ENSRNOP00000085721   ⟸   ENSRNOT00000112578
Ensembl Acc Id: ENSRNOP00000084299   ⟸   ENSRNOT00000119681
RefSeq Acc Id: XP_063140747   ⟸   XM_063284677
- Peptide Label: isoform X1
- UniProtKB: A6KHI3 (UniProtKB/TrEMBL),   A0A8I6A2Y8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107246   ⟸   ENSRNOT00000125922
Protein Domains
SEP   UBX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35987-F1-model_v2 AlphaFold O35987 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692522
Promoter ID:EPDNEW_R3047
Type:multiple initiation site
Name:Nsfl1c_1
Description:NSFL1 cofactor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03146,981,018 - 146,981,078EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619952 AgrOrtholog
BIND 130679
  130680
  130681
  130683
BioCyc Gene G2FUF-47314 BioCyc
Ensembl Genes ENSRNOG00000008604 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090211 ENTREZGENE
Gene3D-CATH 3.30.420.210 UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096463 IMAGE-MGC_LOAD
InterPro NSFL1C_SEP_dom_sf UniProtKB/Swiss-Prot
  SEP_domain UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  UBX_dom UniProtKB/Swiss-Prot
KEGG Report rno:83809 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91611 IMAGE-MGC_LOAD
NCBI Gene 83809 ENTREZGENE
PANTHER NSFL1 COFACTOR P47 UniProtKB/Swiss-Prot
  UBX DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam SEP UniProtKB/Swiss-Prot
  UBA_4 UniProtKB/Swiss-Prot
  UBX UniProtKB/Swiss-Prot
PhenoGen Nsfl1c PhenoGen
PROSITE SEP UniProtKB/Swiss-Prot
  UBX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008604 RatGTEx
SMART SEP UniProtKB/Swiss-Prot
  UBX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF102848 UniProtKB/Swiss-Prot
  SSF46934 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0G2K911 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2Y8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GA62_RAT UniProtKB/TrEMBL
  A0A8L2Q670_RAT UniProtKB/TrEMBL
  A0ABK0LNI0_RAT UniProtKB/TrEMBL
  A6KHI1 ENTREZGENE, UniProtKB/TrEMBL
  A6KHI2_RAT UniProtKB/TrEMBL
  A6KHI3 ENTREZGENE, UniProtKB/TrEMBL
  A6KHI4_RAT UniProtKB/TrEMBL
  NSF1C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nsfl1c  NSFL1 cofactor  Nsfl1c  NSFL1 (p97) cofactor (p47)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nsfl1c  NSFL1 (p97) cofactor (p47)  p47  p47 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 p47  p47 protein      Symbol and Name status set to provisional 70820 PROVISIONAL