Enables collagen binding activity. Involved in negative regulation of neuron projection development and neuron remodeling. Predicted to be located in nucleoplasm; plasma membrane; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of CSPG4 protein]
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of CSPG4 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of CSPG4 protein
2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of CSPG4 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of CSPG4 protein
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA] and XBP1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]
Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements.
Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar.
Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion.
NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration?
Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis.
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue.
Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice.
extracellular domain contains three subdomains: an N-terminal globular domain (domain 1), a central extended domain that has the sites for glycosaminoglycan (GAG) attachment (domain 2), and a juxtamembrane domain (domain 3)
protein expression increases after 24 hr of injury, peaks at 1 week, and remains elevated for at least an additional 7 weeks after spinal cord injury (SCI)
