Cspg4 (chondroitin sulfate proteoglycan 4) - Rat Genome Database

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Gene: Cspg4 (chondroitin sulfate proteoglycan 4) Rattus norvegicus
Analyze
Symbol: Cspg4
Name: chondroitin sulfate proteoglycan 4
RGD ID: 619942
Description: Enables collagen binding activity. Involved in negative regulation of neuron projection development and neuron remodeling. Predicted to be located in plasma membrane and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chondroitin sulfate proteoglycan NG2; HSN tumor-specific antigen; membrane-spanning proteoglycan NG2; Ng2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,160,942 - 66,195,987 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,160,942 - 66,200,806 (+)EnsemblGRCr8
mRatBN7.2857,264,962 - 57,300,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx862,788,359 - 62,823,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,067,205 - 61,102,268 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0858,931,641 - 58,966,706 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,532,465 - 61,567,510 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)Ensemblrn6Rnor6.0
Rnor_5.0860,101,160 - 60,136,205 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4860,610,835 - 60,645,877 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera856,733,067 - 56,768,114 (+)NCBICelera
RGSC_v3.1860,629,888 - 60,664,931 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
hexane  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
potassium chromate  (ISO)
propiconazole  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. Behm FG, etal., Blood 1996 Feb 1;87(3):1134-9.
2. NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury. Buss A, etal., BMC Neurol. 2009 Jul 15;9:32.
3. The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats. Chida Y, etal., Brain Res. 2011 Sep 26;1414:22-31. Epub 2011 Jul 20.
4. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
5. Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. Donnelly EM, etal., J Gene Med. 2010 Nov;12(11):863-72. doi: 10.1002/jgm.1509. Epub 2010 Oct 26.
6. NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia. Gao Q, etal., Neuroscience. 2010 Jan 20;165(2):386-94. Epub .
7. Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Girolamo F, etal., Neurobiol Dis. 2011 Sep;43(3):678-89. Epub 2011 Jun 6.
8. Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord. Kucharova K, etal., J Neuroinflammation. 2011 Nov 13;8:158.
9. Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease. Kumar S, etal., J Neurosci Res. 2009 Nov 15;87(15):3415-27.
10. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, etal., Cell. 2011 Jun 24;145(7):1088-101. doi: 10.1016/j.cell.2011.05.015.
11. The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice. Lowry N, etal., Biomaterials. 2012 Jan 11.
12. Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion. Matsumoto H, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):149-63. Epub 2007 Jun 13.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Expression of NG2-positive cells during optic neuritis. Nakamura K, etal., Jpn J Ophthalmol. 2010 Jan;54(1):100-2. Epub 2010 Feb 12.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination. Niehaus A, etal., Ann Neurol. 2000 Sep;48(3):362-71.
17. The primary structure of NG2, a novel membrane-spanning proteoglycan. Nishiyama A, etal., J Cell Biol 1991 Jul;114(2):359-71.
18. NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration? Oderfeld-Nowak B, etal., Arch Ital Biol. 2009 Dec;147(4):105-15.
19. Chronic lithium treatment decreases NG2 cell proliferation in rat dentate hilus, amygdala and corpus callosum. Orre K, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):503-10. Epub 2009 Feb 6.
20. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. Ott VL, etal., J Immunol 2002 May 1;168(9):4430-9.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. Staub E, etal., FEBS Lett 2002 Sep 11;527(1-3):114-8.
25. Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis. Stephenson DT, etal., Mol Autism. 2011 May 16;2(1):7.
26. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang X, etal., J Neurosci Res 2003 Feb 1;71(3):427-44.
27. The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. Tillet E, etal., J Biol Chem. 1997 Apr 18;272(16):10769-76.
28. Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. Ughrin YM, etal., J Neurosci 2003 Jan 1;23(1):175-86.
29. Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats. Wang P, etal., CNS Neurosci Ther. 2011 Oct;17(5):327-32. doi: 10.1111/j.1755-5949.2011.00265.x.
30. GGF2 (Nrg1-beta3) treatment enhances NG2(+) cell response and improves functional recovery after spinal cord injury. Whittaker MT, etal., Glia. 2012 Feb;60(2):281-94. doi: 10.1002/glia.21262. Epub 2011 Oct 31.
31. Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Zhao JW, etal., Eur J Neurosci. 2009 May;29(9):1853-69. Epub 2009 Apr 28.
Additional References at PubMed
PMID:2269670   PMID:8077056   PMID:8305732   PMID:8590808   PMID:8824254   PMID:9281375   PMID:10036240   PMID:10358027   PMID:10366628   PMID:10587647   PMID:10889192   PMID:10967549  
PMID:11493670   PMID:11668599   PMID:14572468   PMID:14664826   PMID:15023573   PMID:15181153   PMID:15504744   PMID:15817274   PMID:15824037   PMID:15866049   PMID:16093329   PMID:16534776  
PMID:16627368   PMID:16902766   PMID:17503442   PMID:17591920   PMID:17686464   PMID:19581412   PMID:19861972   PMID:20053907   PMID:21423176   PMID:22640018   PMID:23376485   PMID:23447615  
PMID:23533145   PMID:25471575   PMID:26437238   PMID:27068509   PMID:27498042   PMID:27582000   PMID:32967214   PMID:33822814   PMID:34102261  


Genomics

Comparative Map Data
Cspg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,160,942 - 66,195,987 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,160,942 - 66,200,806 (+)EnsemblGRCr8
mRatBN7.2857,264,962 - 57,300,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx862,788,359 - 62,823,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,067,205 - 61,102,268 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0858,931,641 - 58,966,706 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,532,465 - 61,567,510 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)Ensemblrn6Rnor6.0
Rnor_5.0860,101,160 - 60,136,205 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4860,610,835 - 60,645,877 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera856,733,067 - 56,768,114 (+)NCBICelera
RGSC_v3.1860,629,888 - 60,664,931 (+)NCBI
Cytogenetic Map8q24NCBI
CSPG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381575,674,322 - 75,713,466 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1575,674,322 - 75,712,848 (-)Ensemblhg38GRCh38
GRCh371575,966,663 - 76,005,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361573,753,718 - 73,792,244 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341573,754,018 - 73,792,151NCBI
Celera1552,892,353 - 52,930,874 (-)NCBICelera
Cytogenetic Map15q24.2NCBI
HuRef1552,722,948 - 52,761,468 (-)NCBIHuRef
CHM1_11576,086,119 - 76,124,652 (-)NCBICHM1_1
T2T-CHM13v2.01573,545,032 - 73,584,178 (-)NCBIT2T-CHM13v2.0
Cspg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39956,772,388 - 56,807,154 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl956,772,317 - 56,807,154 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38956,865,104 - 56,899,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl956,865,033 - 56,899,870 (+)Ensemblmm10GRCm38
MGSCv37956,712,911 - 56,747,677 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36956,663,297 - 56,697,272 (+)NCBIMGSCv36mm8
Celera954,090,244 - 54,125,014 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map930.32NCBI
Cspg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554502,631,327 - 2,662,269 (+)Ensembl
ChiLan1.0NW_0049554502,631,310 - 2,663,118 (+)NCBIChiLan1.0ChiLan1.0
CSPG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,867,979 - 64,906,630 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11569,030,759 - 69,070,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01554,583,010 - 54,621,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11574,176,684 - 74,214,717 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1574,177,909 - 74,200,498 (-)EnsemblpanPan2panpan1.1
CSPG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13038,465,486 - 38,498,365 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3038,465,241 - 38,497,971 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3038,394,709 - 38,427,802 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03038,670,891 - 38,703,644 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,670,951 - 38,703,634 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,620,966 - 38,654,238 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,663,208 - 38,700,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,897,574 - 38,936,898 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cspg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,590,615 - 116,627,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647134,438,676 - 34,475,052 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647134,438,676 - 34,475,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSPG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl757,949,455 - 57,988,335 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1757,949,182 - 57,988,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2762,640,958 - 62,678,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSPG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1267,735,972 - 7,761,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl267,694,014 - 7,761,342 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048133,933,356 - 133,972,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cspg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894561,683 - 594,878 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624894564,252 - 595,048 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cspg4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1850,771,566 - 50,806,714 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cspg4
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:114
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000023326
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat

Markers in Region
D8Rat151  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8866,174,576 - 66,174,719 (+)Marker Load Pipeline
mRatBN7.2857,278,597 - 57,278,740 (+)MAPPERmRatBN7.2
Rnor_6.0861,546,100 - 61,546,242NCBIRnor6.0
Rnor_5.0860,114,795 - 60,114,937UniSTSRnor5.0
RGSC_v3.4860,624,410 - 60,624,716RGDRGSC3.4
RGSC_v3.4860,624,467 - 60,624,609UniSTSRGSC3.4
Celera856,746,703 - 56,746,845UniSTS
RGSC_v3.1860,643,521 - 60,643,663RGD
RH 3.4 Map8650.5UniSTS
RH 3.4 Map8650.5RGD
RH 2.0 Map8500.7RGD
SHRSP x BN Map841.41RGD
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 87 86 55 38 55 6 298 138 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023326   ⟹   ENSRNOP00000023326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,160,942 - 66,195,987 (+)Ensembl
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)Ensembl
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122593   ⟹   ENSRNOP00000111272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,160,942 - 66,199,287 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158209   ⟹   ENSRNOP00000110526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,160,942 - 66,200,806 (+)Ensembl
RefSeq Acc Id: NM_031022   ⟹   NP_112284
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,160,942 - 66,195,987 (+)NCBI
mRatBN7.2857,264,962 - 57,300,010 (+)NCBI
Rnor_6.0861,532,465 - 61,567,510 (+)NCBI
Rnor_5.0860,101,160 - 60,136,205 (+)NCBI
RGSC_v3.4860,610,835 - 60,645,877 (+)RGD
Celera856,733,067 - 56,768,114 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112284 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA39884 (Get FASTA)   NCBI Sequence Viewer  
  EDL95589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023326
GenBank Protein Q00657 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112284   ⟸   NM_031022
- Peptide Label: precursor
- UniProtKB: Q00657 (UniProtKB/Swiss-Prot),   F1LS79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023326   ⟸   ENSRNOT00000023326
Ensembl Acc Id: ENSRNOP00000110526   ⟸   ENSRNOT00000158209
Ensembl Acc Id: ENSRNOP00000111272   ⟸   ENSRNOT00000122593
Protein Domains
Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00657-F1-model_v2 AlphaFold Q00657 1-2326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696001
Promoter ID:EPDNEW_R6526
Type:initiation region
Name:Cspg4_1
Description:chondroitin sulfate proteoglycan 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0861,532,413 - 61,532,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619942 AgrOrtholog
BioCyc Gene G2FUF-30344 BioCyc
Ensembl Genes ENSRNOG00000017208 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023326 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  CSPG_rpt UniProtKB/Swiss-Prot
  FRAS1_ECM UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
KEGG Report rno:81651 UniProtKB/Swiss-Prot
NCBI Gene 81651 ENTREZGENE
PANTHER CHONDROITIN SULFATE PROTEOGLYCAN 4 UniProtKB/Swiss-Prot
  MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/Swiss-Prot
Pfam Cadherin_3 UniProtKB/Swiss-Prot
  Laminin_G_1 UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Cspg4 PhenoGen
PROSITE CSPG UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017208 RatGTEx
SMART LamG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0ABK0M2M8_RAT UniProtKB/TrEMBL
  A0ABK0M2T4_RAT UniProtKB/TrEMBL
  A6J4R6_RAT UniProtKB/TrEMBL
  CSPG4_RAT UniProtKB/Swiss-Prot
  F1LS79 ENTREZGENE, UniProtKB/TrEMBL
  Q00657 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Cspg4  chondroitin sulfate proteoglycan 4    membrane-spanning proteoglycan NG2  Name updated 1299863 APPROVED
2002-08-07 Cspg4  membrane-spanning proteoglycan NG2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains extracellular domain contains three subdomains: an N-terminal globular domain (domain 1), a central extended domain that has the sites for glycosaminoglycan (GAG) attachment (domain 2), and a juxtamembrane domain (domain 3) 632592
gene_expression expressed in neurons and macrophages 625651
gene_process domains 1 and 3 of NG2 can inhibit neurite growth independently 632592
gene_process may prohibit axonal regeneration after injury 625651
gene_regulation protein expression increases after 24 hr of injury, peaks at 1 week, and remains elevated for at least an additional 7 weeks after spinal cord injury (SCI) 625651