Madd (MAP-kinase activating death domain) - Rat Genome Database

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Gene: Madd (MAP-kinase activating death domain) Rattus norvegicus
Analyze
Symbol: Madd
Name: MAP-kinase activating death domain
RGD ID: 619922
Description: Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain); PARTICIPATES IN ceramide signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAP kinase-activating death domain protein; rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; RabGEF; RabGEP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Maddm1Mcwi  
Genetic Models: FHH-Maddm1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,570,141 - 97,613,688 (-)NCBIGRCr8
mRatBN7.2377,114,330 - 77,157,865 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,114,314 - 77,157,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,593,357 - 80,636,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,192,364 - 89,235,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,043,634 - 87,086,083 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,960,301 - 80,003,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,669,054 - 86,711,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,498,321 - 75,541,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,408,586 - 75,437,445 (-)NCBI
Celera376,323,258 - 76,366,073 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
axon cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO)
membrane  (ISO,ISS)
plasma membrane  (IEA,ISO)
synapse  (IDA,IEP)
synaptic vesicle  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells. Imai A, etal., Arch Biochem Biophys. 2013 Aug 1;536(1):31-7. doi: 10.1016/j.abb.2013.05.002. Epub 2013 May 20.
3. A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis--inhibition of interaction with GTP and reduction of this inhibition by phospholipid. Jin-no Y, etal., Genes Cells. 1997 Apr;2(4):273-88.
4. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter. Kawabe H, etal., Genes Cells 2003 Jun;8(6):537-46.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis. Oishi H, etal., J Biol Chem. 1998 Dec 18;273(51):34580-5.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Purification and properties of Rab3 GEP (DENN/MADD). Sakisaka T and Takai Y, Methods Enzymol. 2005;403:254-61.
14. The onset of apoptosis of neurons induced by ischemia-reperfusion injury is delayed by transient period of hypertension in rats. Smrcka M, etal., Physiol Res. 2003;52(1):117-22.
15. Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins. Wada M, etal., J Biol Chem 1997 Feb 14;272(7):3875-8.
Additional References at PubMed
PMID:8988362   PMID:9115275   PMID:11577081   PMID:14735464   PMID:15007167   PMID:18849981   PMID:20937701   PMID:22871113   PMID:25931508   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Madd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,570,141 - 97,613,688 (-)NCBIGRCr8
mRatBN7.2377,114,330 - 77,157,865 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,114,314 - 77,157,701 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,593,357 - 80,636,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,192,364 - 89,235,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,043,634 - 87,086,083 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,960,301 - 80,003,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,669,054 - 86,711,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,498,321 - 75,541,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,408,586 - 75,437,445 (-)NCBI
Celera376,323,258 - 76,366,073 (-)NCBICelera
Cytogenetic Map3q24NCBI
MADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,269,188 - 47,330,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,269,161 - 47,330,031 (+)EnsemblGRCh38hg38GRCh38
GRCh371147,290,739 - 47,351,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,247,535 - 47,308,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,248,259 - 47,308,157NCBI
Celera1147,430,145 - 47,490,862 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,989,904 - 47,050,670 (+)NCBIHuRef
CHM1_11147,290,116 - 47,350,822 (+)NCBICHM1_1
T2T-CHM13v2.01147,425,958 - 47,486,853 (+)NCBIT2T-CHM13v2.0
Madd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,967,705 - 91,013,404 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,967,705 - 91,014,182 (-)EnsemblGRCm39 Ensembl
GRCm38291,137,360 - 91,184,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,137,360 - 91,183,837 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,977,517 - 91,024,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,938,200 - 90,984,657 (-)NCBIMGSCv36mm8
Celera292,522,135 - 92,568,708 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.46NCBI
Madd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422902,969 - 940,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422902,969 - 940,201 (-)NCBIChiLan1.0ChiLan1.0
MADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,471,009 - 49,531,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,490,871 - 49,550,962 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,216,006 - 47,276,422 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,769,863 - 47,829,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,773,733 - 47,828,360 (+)Ensemblpanpan1.1panPan2
MADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,290,226 - 42,332,237 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,290,754 - 42,328,586 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,019,254 - 41,060,604 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,944,691 - 42,986,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,944,691 - 42,986,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,430,983 - 42,472,278 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,986,221 - 42,027,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,715,501 - 42,756,968 (-)NCBIUU_Cfam_GSD_1.0
Madd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,779,478 - 19,825,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,892,033 - 1,932,418 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,891,120 - 1,936,559 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,270,789 - 15,315,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,270,783 - 15,315,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,477,477 - 16,538,588 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,987,573 - 18,041,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,986,860 - 18,042,266 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,287,755 - 115,344,365 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Madd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,421,603 - 1,459,507 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,421,603 - 1,459,738 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Madd
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:53
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000017360
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

Markers in Region
D3Wox32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,115,056 - 77,115,198 (+)MAPPERmRatBN7.2
Rnor_6.0379,960,382 - 79,960,523NCBIRnor6.0
Rnor_5.0386,669,135 - 86,669,276UniSTSRnor5.0
RGSC_v3.4375,498,402 - 75,498,543UniSTSRGSC3.4
Celera376,323,339 - 76,323,480UniSTS
Cytogenetic Map3q24UniSTS
STS-U22662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,984 - 77,159,214 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,307 - 80,004,536NCBIRnor6.0
Rnor_5.0386,713,060 - 86,713,289UniSTSRnor5.0
RGSC_v3.4375,542,357 - 75,542,586UniSTSRGSC3.4
Celera376,367,357 - 76,367,586UniSTS
Cytogenetic Map3q24UniSTS
AI548269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,931 - 77,159,087 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,254 - 80,004,409NCBIRnor6.0
Rnor_5.0386,713,007 - 86,713,162UniSTSRnor5.0
RGSC_v3.4375,542,304 - 75,542,459UniSTSRGSC3.4
Celera376,367,304 - 76,367,459UniSTS
Cytogenetic Map3q24UniSTS
BE102504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,115,017 - 77,115,192 (+)MAPPERmRatBN7.2
Rnor_6.0379,960,343 - 79,960,517NCBIRnor6.0
Rnor_5.0386,669,096 - 86,669,270UniSTSRnor5.0
RGSC_v3.4375,498,363 - 75,498,537UniSTSRGSC3.4
Celera376,323,300 - 76,323,474UniSTS
Cytogenetic Map3q24UniSTS
RH139546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,157,990 - 77,158,204 (+)MAPPERmRatBN7.2
Rnor_6.0380,003,313 - 80,003,526NCBIRnor6.0
Rnor_5.0386,712,066 - 86,712,279UniSTSRnor5.0
RGSC_v3.4375,541,363 - 75,541,576UniSTSRGSC3.4
Celera376,366,363 - 76,366,576UniSTS
Cytogenetic Map3q24UniSTS
PMC33205P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,159,202 - 77,159,438 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,525 - 80,004,760NCBIRnor6.0
Rnor_5.0386,713,278 - 86,713,513UniSTSRnor5.0
RGSC_v3.4375,542,575 - 75,542,810UniSTSRGSC3.4
Celera376,367,575 - 76,367,810UniSTS
Cytogenetic Map3q24UniSTS


Genetic Models
This gene Madd is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 2 18 2 74 12 20 9
Low 1 43 48 39 1 39 8 11 23 21 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000017360   ⟹   ENSRNOP00000017360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,976 - 77,157,701 (-)Ensembl
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079394   ⟹   ENSRNOP00000075233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,976 - 77,157,701 (-)Ensembl
Rnor_6.0 Ensembl379,960,359 - 80,000,091 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103435   ⟹   ENSRNOP00000084938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,138,063 - 77,157,701 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104046   ⟹   ENSRNOP00000081884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,976 - 77,157,701 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111515   ⟹   ENSRNOP00000087537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,314 - 77,157,701 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111613   ⟹   ENSRNOP00000076460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,314 - 77,157,701 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112841   ⟹   ENSRNOP00000081476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,114,314 - 77,157,701 (-)Ensembl
RefSeq Acc Id: NM_053585   ⟹   NP_446037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,787 - 97,613,509 (-)NCBI
mRatBN7.2377,114,976 - 77,157,701 (-)NCBI
Rnor_6.0379,960,301 - 80,003,023 (-)NCBI
Rnor_5.0386,669,054 - 86,711,776 (-)NCBI
RGSC_v3.4375,498,321 - 75,541,073 (-)RGD
Celera376,323,258 - 76,366,073 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106011   ⟹   XP_038961939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106019   ⟹   XP_038961947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106021   ⟹   XP_038961949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106022   ⟹   XP_038961950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106028   ⟹   XP_038961956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106031   ⟹   XP_038961959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_063284751   ⟹   XP_063140821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,677 (-)NCBI
RefSeq Acc Id: XM_063284752   ⟹   XP_063140822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,140 (-)NCBI
RefSeq Acc Id: XM_063284753   ⟹   XP_063140823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,286 (-)NCBI
RefSeq Acc Id: XM_063284754   ⟹   XP_063140824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,678 (-)NCBI
RefSeq Acc Id: XM_063284755   ⟹   XP_063140825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,677 (-)NCBI
RefSeq Acc Id: XM_063284756   ⟹   XP_063140826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284757   ⟹   XP_063140827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,677 (-)NCBI
RefSeq Acc Id: XM_063284758   ⟹   XP_063140828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284759   ⟹   XP_063140829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,677 (-)NCBI
RefSeq Acc Id: XM_063284760   ⟹   XP_063140830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284761   ⟹   XP_063140831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284762   ⟹   XP_063140832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284763   ⟹   XP_063140833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284764   ⟹   XP_063140834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284765   ⟹   XP_063140835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,677 (-)NCBI
RefSeq Acc Id: XM_063284766   ⟹   XP_063140836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284767   ⟹   XP_063140837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,676 (-)NCBI
RefSeq Acc Id: XM_063284768   ⟹   XP_063140838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284769   ⟹   XP_063140839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,138 (-)NCBI
RefSeq Acc Id: XM_063284770   ⟹   XP_063140840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284771   ⟹   XP_063140841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284772   ⟹   XP_063140842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284773   ⟹   XP_063140843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284774   ⟹   XP_063140844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284775   ⟹   XP_063140845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284776   ⟹   XP_063140846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284777   ⟹   XP_063140847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284778   ⟹   XP_063140848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,688 (-)NCBI
RefSeq Acc Id: XM_063284779   ⟹   XP_063140849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284780   ⟹   XP_063140850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284781   ⟹   XP_063140851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,675 (-)NCBI
RefSeq Acc Id: XM_063284782   ⟹   XP_063140852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284783   ⟹   XP_063140853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284784   ⟹   XP_063140854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284785   ⟹   XP_063140855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284786   ⟹   XP_063140856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284787   ⟹   XP_063140857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,674 (-)NCBI
RefSeq Acc Id: XM_063284788   ⟹   XP_063140858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284789   ⟹   XP_063140859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284790   ⟹   XP_063140860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,673 (-)NCBI
RefSeq Acc Id: XM_063284791   ⟹   XP_063140861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,571,468 - 97,613,672 (-)NCBI
RefSeq Acc Id: XM_063284792   ⟹   XP_063140862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,603,012 (-)NCBI
RefSeq Acc Id: XM_063284793   ⟹   XP_063140863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,570,141 - 97,613,673 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446037 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961939 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961949 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961956 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961959 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140821 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140822 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140823 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140825 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140826 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140828 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140829 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140830 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140831 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140833 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140834 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140835 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140836 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140837 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140838 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140839 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140840 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140841 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140842 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140843 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140844 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140845 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140846 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140847 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140848 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140849 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140850 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140851 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140852 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140853 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140854 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140855 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140856 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140857 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140858 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140859 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140860 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140861 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140862 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53149 (Get FASTA)   NCBI Sequence Viewer  
  EDL79509 (Get FASTA)   NCBI Sequence Viewer  
  EDL79510 (Get FASTA)   NCBI Sequence Viewer  
  EDL79511 (Get FASTA)   NCBI Sequence Viewer  
  EDL79512 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017360.5
  ENSRNOP00000075233.2
  ENSRNOP00000076460.1
  ENSRNOP00000081476.1
  ENSRNOP00000081884.1
  ENSRNOP00000084938.1
  ENSRNOP00000087537.1
GenBank Protein O08873 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446037   ⟸   NM_053585
- UniProtKB: O08873 (UniProtKB/Swiss-Prot),   A6HNA9 (UniProtKB/TrEMBL),   A0A8I5ZTV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075233   ⟸   ENSRNOT00000079394
RefSeq Acc Id: ENSRNOP00000017360   ⟸   ENSRNOT00000017360
RefSeq Acc Id: XP_038961959   ⟸   XM_039106031
- Peptide Label: isoform X31
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961950   ⟸   XM_039106022
- Peptide Label: isoform X22
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961947   ⟸   XM_039106019
- Peptide Label: isoform X19
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961956   ⟸   XM_039106028
- Peptide Label: isoform X29
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961949   ⟸   XM_039106021
- Peptide Label: isoform X21
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961939   ⟸   XM_039106011
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZTV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084938   ⟸   ENSRNOT00000103435
RefSeq Acc Id: ENSRNOP00000081884   ⟸   ENSRNOT00000104046
RefSeq Acc Id: ENSRNOP00000087537   ⟸   ENSRNOT00000111515
RefSeq Acc Id: ENSRNOP00000081476   ⟸   ENSRNOT00000112841
RefSeq Acc Id: ENSRNOP00000076460   ⟸   ENSRNOT00000111613
RefSeq Acc Id: XP_063140848   ⟸   XM_063284778
- Peptide Label: isoform X32
RefSeq Acc Id: XP_063140824   ⟸   XM_063284754
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140829   ⟸   XM_063284759
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140827   ⟸   XM_063284757
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063140835   ⟸   XM_063284765
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063140825   ⟸   XM_063284755
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140821   ⟸   XM_063284751
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140834   ⟸   XM_063284764
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063140828   ⟸   XM_063284758
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063140832   ⟸   XM_063284762
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063140837   ⟸   XM_063284767
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063140826   ⟸   XM_063284756
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140830   ⟸   XM_063284760
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063140846   ⟸   XM_063284776
- Peptide Label: isoform X28
RefSeq Acc Id: XP_063140842   ⟸   XM_063284772
- Peptide Label: isoform X24
RefSeq Acc Id: XP_063140836   ⟸   XM_063284766
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063140841   ⟸   XM_063284771
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063140833   ⟸   XM_063284763
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063140840   ⟸   XM_063284770
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063140831   ⟸   XM_063284761
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063140847   ⟸   XM_063284777
- Peptide Label: isoform X30
RefSeq Acc Id: XP_063140843   ⟸   XM_063284773
- Peptide Label: isoform X25
RefSeq Acc Id: XP_063140845   ⟸   XM_063284775
- Peptide Label: isoform X27
RefSeq Acc Id: XP_063140863   ⟸   XM_063284793
- Peptide Label: isoform X47
RefSeq Acc Id: XP_063140844   ⟸   XM_063284774
- Peptide Label: isoform X26
RefSeq Acc Id: XP_063140838   ⟸   XM_063284768
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063140823   ⟸   XM_063284753
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140822   ⟸   XM_063284752
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140839   ⟸   XM_063284769
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063140862   ⟸   XM_063284792
- Peptide Label: isoform X46
RefSeq Acc Id: XP_063140851   ⟸   XM_063284781
- Peptide Label: isoform X35
RefSeq Acc Id: XP_063140850   ⟸   XM_063284780
- Peptide Label: isoform X34
RefSeq Acc Id: XP_063140857   ⟸   XM_063284787
- Peptide Label: isoform X41
RefSeq Acc Id: XP_063140855   ⟸   XM_063284785
- Peptide Label: isoform X39
RefSeq Acc Id: XP_063140856   ⟸   XM_063284786
- Peptide Label: isoform X40
RefSeq Acc Id: XP_063140853   ⟸   XM_063284783
- Peptide Label: isoform X37
RefSeq Acc Id: XP_063140849   ⟸   XM_063284779
- Peptide Label: isoform X33
RefSeq Acc Id: XP_063140860   ⟸   XM_063284790
- Peptide Label: isoform X44
RefSeq Acc Id: XP_063140859   ⟸   XM_063284789
- Peptide Label: isoform X43
RefSeq Acc Id: XP_063140858   ⟸   XM_063284788
- Peptide Label: isoform X42
RefSeq Acc Id: XP_063140854   ⟸   XM_063284784
- Peptide Label: isoform X38
RefSeq Acc Id: XP_063140852   ⟸   XM_063284782
- Peptide Label: isoform X36
RefSeq Acc Id: XP_063140861   ⟸   XM_063284791
- Peptide Label: isoform X45
Protein Domains
cDENN   dDENN   Death   uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08873-F1-model_v2 AlphaFold O08873 1-1602 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692208
Promoter ID:EPDNEW_R2733
Type:single initiation site
Name:Madd_1
Description:MAP-kinase activating death domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,003,037 - 80,003,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619922 AgrOrtholog
BioCyc Gene G2FUF-48747 BioCyc
Ensembl Genes ENSRNOG00000012568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017360.7 UniProtKB/TrEMBL
  ENSRNOT00000079394.2 UniProtKB/TrEMBL
  ENSRNOT00000103435.1 UniProtKB/TrEMBL
  ENSRNOT00000104046.1 UniProtKB/TrEMBL
  ENSRNOT00000111515.1 UniProtKB/TrEMBL
  ENSRNOT00000111613.1 UniProtKB/TrEMBL
  ENSRNOT00000112841.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DENN_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 94193 ENTREZGENE
PANTHER MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Madd PhenoGen
PROSITE DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012568 RatGTEx
SMART dDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA27_RAT UniProtKB/TrEMBL
  A0A8I5Y5V9_RAT UniProtKB/TrEMBL
  A0A8I5ZSL5_RAT UniProtKB/TrEMBL
  A0A8I5ZTV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A266_RAT UniProtKB/TrEMBL
  A0A8I6A7E5_RAT UniProtKB/TrEMBL
  A0A8L2Q8M9_RAT UniProtKB/TrEMBL
  A6HNA8_RAT UniProtKB/TrEMBL
  A6HNA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HNB0_RAT UniProtKB/TrEMBL
  A6HNB1_RAT UniProtKB/TrEMBL
  MADD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Madd  MAP-kinase activating death domain      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Madd  MAP-kinase activating death domain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues, enriched in brain 633238
gene_protein 1,602 amino acids; 178 kDa 633238