Slc23a1 (solute carrier family 23 member 1) - Rat Genome Database

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Gene: Slc23a1 (solute carrier family 23 member 1) Rattus norvegicus
Analyze
Symbol: Slc23a1
Name: solute carrier family 23 member 1
RGD ID: 619875
Description: Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane; brush border; and cytoplasm. Orthologous to human SLC23A1 (solute carrier family 23 member 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: na(+)/L-ascorbic acid transporter 1; sodium-coupled ascorbic acid transporter 1; sodium-coupled ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; solute carrier family 23 (ascorbic acid transporter), member 1; solute carrier family 23 (nucleobase transporters), member 1; SVCT1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,490,549 - 27,504,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1827,490,374 - 27,504,702 (-)EnsemblGRCr8
mRatBN7.21827,214,940 - 27,230,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,216,281 - 27,230,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1827,343,879 - 27,355,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,106,018 - 28,117,920 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,440,904 - 27,452,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01828,413,910 - 28,428,133 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,414,009 - 28,428,117 (-)Ensemblrn6Rnor6.0
Rnor_5.01828,127,118 - 28,141,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41828,238,953 - 28,250,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1826,950,004 - 26,961,940 (-)NCBICelera
RGSC_v3.11828,265,423 - 28,277,535 (-)NCBI
Cytogenetic Map18p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
epoxiconazole  (ISO)
eugenol  (EXP)
flutamide  (EXP)
inulin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
methapyrilene  (ISO)
N-nitrosodimethylamine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
taurocholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IBA,IEA,ISO,ISS)
basal plasma membrane  (IDA,IEA,ISO)
brush border  (IDA)
cytoplasm  (IDA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney. Lee JH, etal., Histochem Cell Biol. 2006 Oct;126(4):491-4. Epub 2006 May 4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose. Song J, etal., J Biol Chem 2002 May 3;277(18):15252-60.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. A family of mammalian Na+-dependent L-ascorbic acid transporters. Tsukaguchi H, etal., Nature 1999 May 6;399(6731):70-5.
Additional References at PubMed
PMID:10631088   PMID:11895172   PMID:11984597   PMID:12559983   PMID:15333707   PMID:15489334   PMID:15993839   PMID:17575980   PMID:18094143   PMID:18247577   PMID:18417304   PMID:19056867  
PMID:19216494   PMID:21733302   PMID:22348976   PMID:23708151  


Genomics

Comparative Map Data
Slc23a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,490,549 - 27,504,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1827,490,374 - 27,504,702 (-)EnsemblGRCr8
mRatBN7.21827,214,940 - 27,230,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,216,281 - 27,230,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1827,343,879 - 27,355,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,106,018 - 28,117,920 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,440,904 - 27,452,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01828,413,910 - 28,428,133 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,414,009 - 28,428,117 (-)Ensemblrn6Rnor6.0
Rnor_5.01828,127,118 - 28,141,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41828,238,953 - 28,250,889 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1826,950,004 - 26,961,940 (-)NCBICelera
RGSC_v3.11828,265,423 - 28,277,535 (-)NCBI
Cytogenetic Map18p11NCBI
SLC23A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385139,367,196 - 139,385,676 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5139,367,196 - 139,385,495 (-)Ensemblhg38GRCh38
GRCh375138,702,885 - 138,718,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,730,787 - 138,746,900 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345138,730,787 - 138,746,900NCBI
Celera5134,824,593 - 134,840,618 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,892,618 - 133,908,788 (-)NCBIHuRef
CHM1_15138,135,498 - 138,151,676 (-)NCBICHM1_1
T2T-CHM13v2.05139,893,271 - 139,911,881 (-)NCBIT2T-CHM13v2.0
Slc23a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,747,657 - 35,762,900 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,747,657 - 35,760,297 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381835,604,224 - 35,629,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,614,604 - 35,627,244 (-)Ensemblmm10GRCm38
MGSCv371835,774,258 - 35,786,881 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361835,740,578 - 35,753,192 (-)NCBIMGSCv36mm8
MGSCv361835,794,115 - 35,806,597 (-)NCBIMGSCv36mm8
Celera1836,070,745 - 36,083,392 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.17NCBI
Slc23a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,176,000 - 1,186,940 (+)Ensembl
ChiLan1.0NW_0049554181,176,390 - 1,192,270 (+)NCBIChiLan1.0ChiLan1.0
SLC23A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24134,638,723 - 134,649,462 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15132,775,959 - 132,789,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05134,737,344 - 134,756,153 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,859,975 - 140,877,214 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,859,984 - 140,877,214 (-)EnsemblpanPan2panpan1.1
SLC23A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1234,694,064 - 34,708,498 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl234,698,838 - 34,708,412 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha231,801,133 - 31,809,319 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0235,148,002 - 35,162,589 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl235,152,908 - 35,162,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,205,366 - 32,213,552 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,071,664 - 33,079,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,823,283 - 33,831,469 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc23a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,138,372 - 153,159,132 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365318,457,957 - 8,471,258 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365318,457,779 - 8,471,244 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC23A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2141,258,323 - 141,276,442 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12141,258,318 - 141,277,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22147,081,831 - 147,107,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC23A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,040,163 - 42,056,593 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,044,590 - 42,055,831 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603435,832,046 - 35,861,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc23a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474332,174,922 - 32,186,697 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474332,169,051 - 32,186,618 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc23a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1158,742,773 - 8,754,154 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc23a1
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:54
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000027048
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
RH129257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21827,218,120 - 27,218,272 (+)MAPPERmRatBN7.2
mRatBN7.21179,078,689 - 179,078,953 (-)MAPPERmRatBN7.2
Rnor_6.01193,699,300 - 193,699,584NCBIRnor6.0
Rnor_6.01828,415,673 - 28,415,824NCBIRnor6.0
Rnor_5.01828,128,783 - 28,128,934UniSTSRnor5.0
Rnor_5.01200,756,118 - 200,756,402UniSTSRnor5.0
RGSC_v3.41183,456,241 - 183,457,302UniSTSRGSC3.4
RGSC_v3.41828,240,618 - 28,240,769UniSTSRGSC3.4
Celera1826,951,669 - 26,951,820UniSTS
Celera1176,757,650 - 176,757,801UniSTS
Cytogenetic Map18p11UniSTS
RH137333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21827,216,660 - 27,216,844 (+)MAPPERmRatBN7.2
Rnor_6.01828,414,213 - 28,414,396NCBIRnor6.0
Rnor_5.01828,127,323 - 28,127,506UniSTSRnor5.0
RGSC_v3.41828,239,158 - 28,239,341UniSTSRGSC3.4
Celera1826,950,209 - 26,950,392UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 34 110 91 90 59 91 59 6 321 157 10 89 81 88 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078202   ⟹   ENSRNOP00000073343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1828,418,191 - 28,428,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084372   ⟹   ENSRNOP00000072205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1827,490,374 - 27,504,702 (-)Ensembl
mRatBN7.2 Ensembl1827,216,281 - 27,230,697 (-)Ensembl
Rnor_6.0 Ensembl1828,414,009 - 28,425,944 (-)Ensembl
RefSeq Acc Id: NM_017315   ⟹   NP_059011
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,490,549 - 27,502,485 (-)NCBI
mRatBN7.21827,216,456 - 27,228,397 (-)NCBI
Rnor_6.01828,414,008 - 28,425,944 (-)NCBI
Rnor_5.01828,127,118 - 28,141,110 (-)NCBI
RGSC_v3.41828,238,953 - 28,250,889 (-)RGD
Celera1826,950,004 - 26,961,940 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254602   ⟹   XP_006254664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81827,490,549 - 27,504,563 (-)NCBI
mRatBN7.21827,214,940 - 27,230,564 (-)NCBI
Rnor_6.01828,413,910 - 28,428,133 (-)NCBI
Rnor_5.01828,127,118 - 28,141,110 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059011 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254664 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD30367 (Get FASTA)   NCBI Sequence Viewer  
  AAH78851 (Get FASTA)   NCBI Sequence Viewer  
  EDL76269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072205
GenBank Protein Q9WTW7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059011   ⟸   NM_017315
- UniProtKB: Q9WTW7 (UniProtKB/Swiss-Prot),   A6J2Y7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254664   ⟸   XM_006254602
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R5A1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073343   ⟸   ENSRNOT00000078202
Ensembl Acc Id: ENSRNOP00000072205   ⟸   ENSRNOT00000084372

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTW7-F1-model_v2 AlphaFold Q9WTW7 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700710
Promoter ID:EPDNEW_R11232
Type:initiation region
Name:Slc23a1_1
Description:solute carrier family 23 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01828,425,981 - 28,426,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619875 AgrOrtholog
BioCyc Gene G2FUF-7901 BioCyc
Ensembl Genes ENSRNOG00000061695 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084372 ENTREZGENE
IMAGE_CLONE IMAGE:7127602 IMAGE-MGC_LOAD
InterPro Xant/urac/vitC UniProtKB/Swiss-Prot
KEGG Report rno:50621 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93503 IMAGE-MGC_LOAD
NCBI Gene 50621 ENTREZGENE
PANTHER XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam Xan_ur_permease UniProtKB/Swiss-Prot
PhenoGen Slc23a1 PhenoGen
RatGTEx ENSRNOG00000061695 RatGTEx
UniProt A0A8L2R5A1 ENTREZGENE, UniProtKB/TrEMBL
  A6J2Y7 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTW7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc23a1  solute carrier family 23 member 1  Slc23a1  solute carrier family 23 (ascorbic acid transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc23a1  solute carrier family 23 (ascorbic acid transporter), member 1  Slc23a1  solute carrier family 23 (nucleobase transporters), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Slc23a1  solute carrier family 23 (nucleobase transporters), member 1  SVCT1  sodium-coupled ascorbic acid transporter 1  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 SVCT1  sodium-coupled ascorbic acid transporter 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is confined to intestine, kidney, and liver 634186
gene_process regulates the supply and metabolism of vitamin C 634186