Dlat (dihydrolipoamide S-acetyltransferase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Dlat (dihydrolipoamide S-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Dlat (Ensembl: Dlat-ps1)
Name: dihydrolipoamide S-acetyltransferase (Ensembl:dihydrolipoamide S-acetyltransferase, pseudogene 1)
RGD ID: 619859
Description: Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrial matrix. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH (R)-adrenaline; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding (Ensembl: processed_pseudogene)
RefSeq Status: PROVISIONAL
Previously known as: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; E2; PBC; PDC-E2; PDCE2; pyruvate dehydrogenase complex component E2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dlat-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,875,537 - 59,900,947 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,868,214 - 59,900,818 (-)EnsemblGRCr8
GRCr8 Ensembl135,060,114 - 35,061,577 (+)EnsemblGRCr8
mRatBN7.2850,979,151 - 51,004,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,231,226 - 33,233,129 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,484,986 - 56,510,281 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,763,886 - 54,789,211 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,628,160 - 52,653,457 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)Ensemblrn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,507,581 - 50,552,393 (-)NCBICelera
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
dinophysistoxin 1  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
haloperidol  (EXP)
hydralazine  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts. Christen U, etal., Biochemistry. 1993 Feb 16;32(6):1492-9.
2. Changes in brain gene expression after long-term sleep deprivation. Cirelli C, etal., J Neurochem. 2006 Sep;98(5):1632-45.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. Gershwin ME, etal., J Immunol. 1987 May 15;138(10):3525-31.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases. Matuda S, etal., Biochim Biophys Acta 1992 May 7;1131(1):114-8.
7. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9045657   PMID:9242632   PMID:12477932   PMID:14651853   PMID:15489334   PMID:17634366   PMID:18184587   PMID:18184588   PMID:18614015   PMID:20833797   PMID:25525879   PMID:26316108  
PMID:26945066   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Dlat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,875,537 - 59,900,947 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,868,214 - 59,900,818 (-)EnsemblGRCr8
GRCr8 Ensembl135,060,114 - 35,061,577 (+)EnsemblGRCr8
mRatBN7.2850,979,151 - 51,004,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,231,226 - 33,233,129 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,484,986 - 56,510,281 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,763,886 - 54,789,211 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,628,160 - 52,653,457 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,062,549 - 55,087,832 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)Ensemblrn6Rnor6.0
Rnor_5.0853,659,920 - 53,685,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,989,491 - 54,014,779 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,507,581 - 50,552,393 (-)NCBICelera
RGSC_v3.1854,008,592 - 54,033,135 (-)NCBI
Cytogenetic Map8q23NCBI
DLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,025,408 - 112,064,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,025,033 - 112,064,404 (+)Ensemblhg38GRCh38
GRCh3711111,896,132 - 111,935,128 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,401,381 - 111,439,799 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411111,401,387 - 111,439,798NCBI
Celera11109,048,752 - 109,088,192 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,819,561 - 107,858,905 (+)NCBIHuRef
CHM1_111111,778,793 - 111,818,192 (+)NCBICHM1_1
T2T-CHM13v2.011112,035,650 - 112,074,647 (+)NCBIT2T-CHM13v2.0
Dlat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,545,933 - 50,571,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,545,933 - 50,571,080 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38950,634,633 - 50,659,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,634,633 - 50,659,780 (-)Ensemblmm10GRCm38
MGSCv37950,442,738 - 50,467,885 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36950,386,865 - 50,412,010 (-)NCBIMGSCv36mm8
Celera947,920,941 - 47,946,308 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Dlat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,718,067 - 13,744,239 (+)Ensembl
ChiLan1.0NW_00495541213,718,091 - 13,746,220 (+)NCBIChiLan1.0ChiLan1.0
DLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,770,172 - 112,813,947 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,864,456 - 113,909,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,910,857 - 106,950,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,755,310 - 110,793,876 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,756,001 - 110,792,795 (+)EnsemblpanPan2panpan1.1
DLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,062,833 - 21,094,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,064,026 - 21,094,153 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha520,985,229 - 21,016,566 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0521,086,208 - 21,117,183 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,086,325 - 21,117,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,147,724 - 21,178,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,047,717 - 21,079,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,096,415 - 21,127,748 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dlat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,268,188 - 94,312,532 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,393,071 - 2,437,522 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,395,452 - 2,437,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,738,564 - 39,796,806 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1939,738,639 - 39,763,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,595,812 - 44,605,405 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2944,530,186 - 44,541,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,379,165 - 103,419,585 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,380,426 - 103,420,386 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604322,562,984 - 22,603,121 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,181,671 - 7,214,751 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247847,181,550 - 7,216,779 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dlat
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1845,102,661 - 45,127,471 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dlat
158 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:66
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000032152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
DLAT  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,232,108 - 33,233,092 (+)MAPPERmRatBN7.2
mRatBN7.2133,232,998 - 33,233,092 (+)MAPPERmRatBN7.2
mRatBN7.2850,979,880 - 50,979,975 (-)MAPPERmRatBN7.2
mRatBN7.2133,232,108 - 33,233,702 (+)MAPPERmRatBN7.2
Rnor_6.0135,868,892 - 35,869,875NCBIRnor6.0
Rnor_6.0135,868,892 - 35,870,578NCBIRnor6.0
Rnor_5.0137,266,408 - 37,268,094UniSTSRnor5.0
Rnor_5.0137,266,408 - 37,267,391UniSTSRnor5.0
RGSC_v3.4173,379,962 - 3,380,945UniSTSRGSC3.4
Celera131,843,186 - 31,844,169UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map8q23UniSTS
RH139711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,007,856 - 51,008,020 (+)MAPPERmRatBN7.2
Rnor_6.0855,091,254 - 55,091,417NCBIRnor6.0
Rnor_5.0853,688,660 - 53,688,823UniSTSRnor5.0
RGSC_v3.4854,018,201 - 54,018,364UniSTSRGSC3.4
Celera850,555,815 - 50,555,978UniSTS
RH 3.4 Map8548.2UniSTS
Cytogenetic Map8q23UniSTS
RH127531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,975,229 - 50,975,431 (+)MAPPERmRatBN7.2
Rnor_6.0855,058,628 - 55,058,829NCBIRnor6.0
Rnor_5.0853,655,999 - 53,656,200UniSTSRnor5.0
RGSC_v3.4853,985,570 - 53,985,771UniSTSRGSC3.4
Celera850,523,425 - 50,523,626UniSTS
RH 3.4 Map8549.8UniSTS
Cytogenetic Map8q23UniSTS
RH128680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,009,346 - 51,009,496 (+)MAPPERmRatBN7.2
Rnor_6.0855,092,743 - 55,092,892NCBIRnor6.0
Rnor_5.0853,690,149 - 53,690,298UniSTSRnor5.0
RGSC_v3.4854,019,690 - 54,019,839UniSTSRGSC3.4
Celera850,557,304 - 50,557,453UniSTS
RH 3.4 Map8545.1UniSTS
Cytogenetic Map8q23UniSTS
RH132308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,977,083 - 50,977,265 (+)MAPPERmRatBN7.2
Rnor_6.0855,060,482 - 55,060,663NCBIRnor6.0
Rnor_5.0853,657,853 - 53,658,034UniSTSRnor5.0
RGSC_v3.4853,987,424 - 53,987,605UniSTSRGSC3.4
Celera850,525,279 - 50,525,460UniSTS
RH 3.4 Map8546.9UniSTS
Cytogenetic Map8q23UniSTS
RH132630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,963,394 - 50,963,610 (+)MAPPERmRatBN7.2
Rnor_6.0855,046,794 - 55,047,009NCBIRnor6.0
Rnor_5.0853,644,116 - 53,644,331UniSTSRnor5.0
RGSC_v3.4853,973,737 - 53,973,952UniSTSRGSC3.4
Celera850,511,814 - 50,512,029UniSTS
RH 3.4 Map8548.3UniSTS
Cytogenetic Map8q23UniSTS
RH138741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,978,712 - 50,978,868 (+)MAPPERmRatBN7.2
mRatBN7.2133,234,104 - 33,234,260 (-)MAPPERmRatBN7.2
mRatBN7.2850,978,712 - 50,978,868 (-)MAPPERmRatBN7.2
mRatBN7.2133,234,104 - 33,234,260 (+)MAPPERmRatBN7.2
Rnor_6.0855,062,111 - 55,062,266NCBIRnor6.0
Rnor_6.0135,871,591 - 35,871,746NCBIRnor6.0
Rnor_5.0853,659,482 - 53,659,637UniSTSRnor5.0
Rnor_5.0137,269,107 - 37,269,262UniSTSRnor5.0
RGSC_v3.4853,989,053 - 53,989,208UniSTSRGSC3.4
RGSC_v3.4173,381,958 - 3,382,113UniSTSRGSC3.4
Celera850,526,908 - 50,527,063UniSTS
Celera131,845,182 - 31,845,337UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032152   ⟹   ENSRNOP00000032890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,868,214 - 59,900,818 (-)Ensembl
mRatBN7.2 Ensembl850,978,051 - 51,004,479 (-)Ensembl
Rnor_6.0 Ensembl855,062,551 - 55,087,832 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148798   ⟹   ENSRNOP00000103252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,875,539 - 59,900,818 (-)Ensembl
RefSeq Acc Id: NM_031025   ⟹   NP_112287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,875,537 - 59,900,818 (-)NCBI
mRatBN7.2850,979,151 - 51,004,435 (-)NCBI
Rnor_6.0855,062,549 - 55,087,832 (-)NCBI
Rnor_5.0853,659,920 - 53,685,238 (-)NCBI
RGSC_v3.4853,989,491 - 54,014,779 (-)RGD
Celera850,507,581 - 50,552,393 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266204   ⟹   XP_063122274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,885,292 - 59,900,947 (-)NCBI
RefSeq Acc Id: NP_112287   ⟸   NM_031025
- UniProtKB: Q3B7V7 (UniProtKB/Swiss-Prot),   P08461 (UniProtKB/Swiss-Prot),   A6J4E7 (UniProtKB/TrEMBL),   A0A8I6B5J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032890   ⟸   ENSRNOT00000032152
RefSeq Acc Id: XP_063122274   ⟸   XM_063266204
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103252   ⟸   ENSRNOT00000148798
Protein Domains
Lipoyl-binding   Peripheral subunit-binding (PSBD)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08461-F1-model_v2 AlphaFold P08461 1-632 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695950
Promoter ID:EPDNEW_R6474
Type:initiation region
Name:Dlat_1
Description:dihydrolipoamide S-acetyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,087,882 - 55,087,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619859 AgrOrtholog
BioCyc Gene G2FUF-30556 BioCyc
BioCyc Pathway PYRUVDEHYD-PWY [pyruvate decarboxylation to acetyl CoA I] BioCyc
BioCyc Pathway Image PYRUVDEHYD-PWY BioCyc
Ensembl Genes ENSRNOG00000009994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000017095 Ensembl
Ensembl Transcript ENSRNOT00000032152.5 UniProtKB/Swiss-Prot
  ENSRNOT00000148798 ENTREZGENE
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot
  3.30.559.10 UniProtKB/Swiss-Prot
  4.10.320.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115402 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/Swiss-Prot
  2-oxoacid_DH_actylTfrase UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  CAT-like_dom_sf UniProtKB/Swiss-Prot
  E2/Pdx1 UniProtKB/Swiss-Prot
  E3-bd_dom_sf UniProtKB/Swiss-Prot
  LAT1 UniProtKB/Swiss-Prot
  PSBD UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:81654 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125038 IMAGE-MGC_LOAD
NCBI Gene 81654 ENTREZGENE
PANTHER DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR23151 UniProtKB/Swiss-Prot
Pfam 2-oxoacid_dh UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  E3_binding UniProtKB/Swiss-Prot
PhenoGen Dlat PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  LIPOYL UniProtKB/Swiss-Prot
  PSBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009994 RatGTEx
  ENSRNOG00000017095 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot
  SSF47005 UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot
UniProt A0A8I6B5J2 ENTREZGENE
  A6J4E7 ENTREZGENE, UniProtKB/TrEMBL
  ODP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B7V7 ENTREZGENE
UniProt Secondary Q3B7V7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Dlat  dihydrolipoamide S-acetyltransferase  Dlat  dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dlat  dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)    dihydrolipoamide acetyltransferase  Name updated 1299863 APPROVED
2002-08-07 Dlat  dihydrolipoamide acetyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL