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Gene: A1cf (APOBEC1 complementation factor) Rattus norvegicus

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Symbol:

A1cf

Name:

APOBEC1 complementation factor

RGD ID:

619834

Description:

Enables mRNA binding activity. Involved in cytidine to uridine editing and positive regulation of protein secretion. Located in cytoplasm and heterochromatin. Part of mRNA editing complex. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

A1cft; Acf; Apobec-1; apobec-1 complementation factor; Apobec-1 complementation factor APOBEC-1 stimulating protein; Apobec-1 complementation factor, APOBEC-1 stimulating protein; APOBEC1 complementation factorT; APOBEC1-stimulating protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	A1CF (APOBEC1 complementation factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	A1cf (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	A1cf (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	A1CF (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	A1CF (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	A1cf (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	A1CF (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	A1CF (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	A1cf (APOBEC1 complementation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	A1CF (APOBEC1 complementation factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	A1cf (APOBEC1 complementation factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	a1cf (apobec1 complementation factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	a1cf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	239,149,436 - 239,242,460 (+)	NCBI		GRCr8
mRatBN7.2	1	229,736,037 - 229,823,499 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	229,736,106 - 229,824,354 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	238,102,542 - 238,188,586 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	245,032,243 - 245,118,286 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	237,866,865 - 237,946,606 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	250,426,027 - 250,514,245 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	250,426,158 - 250,514,866 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	257,660,187 - 257,747,893 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	235,865,843 - 235,958,065 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	236,029,865 - 236,122,088 (+)	NCBI
Celera	1	226,856,680 - 226,943,695 (+)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gout (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

7,9-dihydro-1H-purine-2,6,8(3H)-trione (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

arsenous acid (ISO)

benzene (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

endosulfan (EXP)

flavonoids (EXP)

furan (EXP)

GW 4064 (ISO)

hydrogen peroxide (ISO)

nefazodone (EXP)

nitrofen (EXP)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

quercetin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulforaphane (EXP)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytidine to uridine editing (IEA,IMP,ISO,TAS)

embryo implantation (IEA,ISO)

mRNA localization resulting in post-transcriptional regulation of gene expression (IEA,ISO)

mRNA modification (IEA,ISO)

mRNA processing (IEA)

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ISO)

positive regulation of protein secretion (IMP)

protein stabilization (ISO,ISS)

Cellular Component

apolipoprotein B mRNA editing enzyme complex (ISO,ISS)

cytoplasm (IDA,IEA,ISO)

endoplasmic reticulum (IEA)

heterochromatin (IDA)

mRNA editing complex (IDA)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

double-stranded RNA binding (ISO,ISS)

enzyme-substrate adaptor activity (ISO)

mRNA binding (IBA,IDA)

protein binding (IPI,ISO)

RNA binding (IEA)

single-stranded RNA binding (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Reduced expression and increased CpG dinucleotide methylation of the rat APOBEC-1 promoter in transgenic rabbits.	Apostel F, etal., Biochim Biophys Acta 2002 Sep 27;1577(3):384-94.
2.	A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.	Blanc V, etal., J Biol Chem. 2003 Oct 17;278(42):41198-204. Epub 2003 Aug 1.
3.	[Effect of truncal vagotomy on the exocrine function of the pancreas in the dog]	Dabrowski Z, etal., Pol Tyg Lek 1978 Jul 10;33(28):1093-5.
4.	Effects of multiple genetic loci on the pathogenesis from serum urate to gout.	Dong Z, etal., Sci Rep. 2017 Mar 2;7:43614. doi: 10.1038/srep43614.
5.	Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.	Galloway CA, etal., Biochim Biophys Acta. 2010 Nov;1802(11):976-85. doi: 10.1016/j.bbadis.2010.06.003. Epub 2010 Jun 9.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor.	Lehmann DM, etal., Nucleic Acids Res. 2006 Jul 4;34(11):3299-308. Print 2006.
8.	Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.	Lellek H, etal., J Biol Chem. 2000 Jun 30;275(26):19848-56.
9.	Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.	Mehta A, etal., Mol Cell Biol. 2000 Mar;20(5):1846-54.
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).	Petersen-Mahrt SK and Neuberger MS, J Biol Chem 2003 May 30;278(22):19583-6. Epub 2003 Apr 14.
12.	Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.	Rasheed H, etal., Arthritis Res Ther. 2017 Jul 5;19(1):161. doi: 10.1186/s13075-017-1369-y.
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	[Experience in the certification of veterinary specialists].	Romanenko AV, Veterinariia. 1978 Dec;(12):47-8.
16.	The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors.	Sowden MP, etal., J Cell Sci 2002 Mar 1;115(Pt 5):1027-39.

Additional References at PubMed

PMID:11871661	PMID:12881431	PMID:14570923	PMID:16055734	PMID:17229474	PMID:20541536	PMID:24916387

Genomics

Comparative Map Data

A1cf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	239,149,436 - 239,242,460 (+)	NCBI		GRCr8
mRatBN7.2	1	229,736,037 - 229,823,499 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	229,736,106 - 229,824,354 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	238,102,542 - 238,188,586 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	245,032,243 - 245,118,286 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	237,866,865 - 237,946,606 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	250,426,027 - 250,514,245 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	250,426,158 - 250,514,866 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	257,660,187 - 257,747,893 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	235,865,843 - 235,958,065 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	236,029,865 - 236,122,088 (+)	NCBI
Celera	1	226,856,680 - 226,943,695 (+)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

A1CF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	50,799,409 - 50,885,627 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	50,799,409 - 50,885,675 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	52,559,169 - 52,645,387 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	52,236,331 - 52,315,441 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	52,236,330 - 52,315,441	NCBI
Celera	10	45,829,119 - 45,908,228 (-)	NCBI		Celera
Cytogenetic Map	10	q11.23	NCBI
HuRef	10	46,537,685 - 46,623,956 (-)	NCBI		HuRef
CHM1_1	10	52,841,000 - 52,927,266 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	51,648,044 - 51,734,261 (-)	NCBI		T2T-CHM13v2.0

A1cf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	31,846,156 - 31,929,765 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	31,846,164 - 31,926,395 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	31,868,756 - 31,952,365 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	31,868,764 - 31,948,995 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	31,943,251 - 32,023,896 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	31,934,758 - 32,015,403 (+)	NCBI		MGSCv36	mm8
Celera	19	32,656,858 - 32,737,433 (+)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI

A1cf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	5,992,538 - 6,077,770 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	5,992,538 - 6,077,769 (-)	NCBI	ChiLan1.0	ChiLan1.0

A1CF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	63,106,674 - 63,197,715 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	63,111,996 - 63,203,037 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	47,451,293 - 47,538,062 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	49,588,168 - 49,675,543 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	49,588,168 - 49,675,543 (-)	Ensembl	panpan1.1		panPan2

A1CF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	37,027,165 - 37,109,842 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	37,027,275 - 37,102,888 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	36,912,827 - 36,995,367 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	38,560,154 - 38,642,825 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	38,560,187 - 38,636,835 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	36,461,590 - 36,550,642 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	36,048,241 - 36,131,022 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	37,288,420 - 37,371,161 (+)	NCBI		UU_Cfam_GSD_1.0

A1cf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	76,615,094 - 76,662,949 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936735	2,130,943 - 2,177,815 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

A1CF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	98,908,630 - 98,987,524 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	98,908,585 - 98,990,362 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	107,777,628 - 107,848,254 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

A1CF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	80,286,872 - 80,367,587 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	80,314,081 - 80,370,348 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	40,941,786 - 41,019,626 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

A1cf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624791	12,757,319 - 12,868,422 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624791	12,757,319 - 12,868,364 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in A1cf
874 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	87
Count of miRNA genes:	71
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000052256, ENSRNOT00000067643
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	234238494	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	214537555	238757011	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228985440	245907899	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210702053	240947965	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	218753689	245907899	Rat
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	213533809	243914901	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	224054293	243747962	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	224054293	243747962	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	223262787	260522016	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	6	9	42	88	85	59	23	59	6	165	50	22	41	43	26

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF290984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF442133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF442134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF442135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY028945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067643 ⟹ ENSRNOP00000062802

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	229,736,106 - 229,824,354 (+)	Ensembl
Rnor_6.0 Ensembl	1	250,426,158 - 250,514,866 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106085 ⟹ ENSRNOP00000095037

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	229,736,106 - 229,806,404 (+)	Ensembl

RefSeq Acc Id:

NM_133400 ⟹ NP_596891

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	239,149,493 - 239,235,442 (+)	NCBI
mRatBN7.2	1	229,736,106 - 229,822,097 (+)	NCBI
Rnor_6.0	1	250,426,192 - 250,512,413 (+)	NCBI
Rnor_5.0	1	257,660,187 - 257,747,893 (+)	NCBI
RGSC_v3.4	1	235,865,843 - 235,958,065 (+)	RGD
Celera	1	226,856,680 - 226,943,695 (+)	RGD

Sequence:

show sequence

GAATTCACCATAATCAAGAAACCTTTTCCGGGTGGGGGAACCTCAGAAATTACTCAGTGAGCAA
CCCTAATTAACCTGATTTTTTGCTGATAATCACTCTCAATGGAATCAAATCACAAATCCGGGGA
TGGATTGAGCGGCACCCAGAAGGAAGCAGCACTCCGCGCACTGGTCCAGCGCACAGGATATAGC
TTGGTCCAGGAAAATGGACAAAGAAAATATGGTGGTCCTCCACCAGGCTGGGATACTACACCCC
CAGAAAGGGGCTGCGAGATTTTCATTGGGAAACTTCCCCGGGACCTTTTTGAGGATGAACTCAT
ACCATTGTGTGAAAAAATTGGTAAAATTTATGAAATGAGAATGATGATGGATTTCAATGGGAAC
AACAGAGGCTATGCATTTGTAACCTTCTCAAATAAGCAGGAAGCCAAGAATGCAATCAAGCAAC
TTAATAATTATGAAATTCGGAATGGCCGTCTCCTGGGCGTCTGTGCCAGTGTGGACAACTGCCG
GTTGTTTGTGGGGGGAATCCCCAAAACCAAAAAGAGAGAAGAAATCTTGTCAGAGATGAAAAAG
GTCACTGAAGGAGTTGTTGATGTCATTGTCTACCCAAGCGCTGCCGATAAAACCAAAAACCGGG
GGTTTGCCTTTGTGGAATATGAGAGTCACCGCGCAGCCGCCATGGCTAGGCGGAGGCTGCTGCC
AGGAAGAATTCAGTTGTGGGGACATCCTATCGCAGTAGACTGGGCAGAGCCAGAAGTCGAAGTT
GACGAAGACACAATGTCTTCCGTGAAAATCCTGTACGTAAGGAACCTTATGCTGTCTACCTCGG
AAGAGATGATTGAGAAGGAATTCAACAGTATTAAACCAGGTGCTGTGGAACGGGTGAAGAAGAT
CCGAGACTATGCTTTTGTGCATTTCAGTAACCGAGAAGATGCAGTTGAAGCCATGAAGGCTTTG
AATGGCAAGGTGCTGGATGGTTCCCCAATAGAAGTGACCTTGGCCAAGCCAGTGGACAAGGACA
GTTACGTTAGGTACACCCGGGGCACCGGGGGCAGGAACACCATGCTGCAAGAATACACCTACCC
TCTGAGCCATGTTTATGACCCTACCACAACCTACCTTGGAGCTCCTGTCTTCTATACTCCCCAA
GCCTACGCAGCCATTCCAAGTCTTCATTTCCCAGCTACCAAAGGACATCTCAGCAACAGAGCTC
TCATCCGGACCCCTTCTGTCAGAGGGGCTGCGGGCGTGAGAGGACTGGGCGGCCGTGGGTATTT
GGCATATACAGGCCTGGGTCGAGGATACCAGGTCAAAGGAGACAAGAGACAAGACAAACTCTAT
GACCTTCTGCCTGGGATGGAGCTCACCCCGATGAATACTATCTCTTTAAAACCACAAGGAGTTA
AACTTGCTCCTCAGATATTAGAAGAAATCTGTCAGAAAAATAACTGGGGACAGCCAGTGTACCA
GCTGCACTCTGCCATTGGACAAGACCAAAGACAGTTATTCCTATACAAAGTAACTATCCCAGCG
CTGGCCAGCCAGAATCCTGCGATCCACCCTTTCACACCCCCAAAGCTAAGCGCCTACGTGGATG
AAGCAAAGAGGTACGCCGCAGAGCACACCCTACAGACACTAGGCATCCCCACAGAAGGAGGGGA
CGCTGGGACTACAGCACCCACTGCCACATCCGCCACTGTGTTTCCAGGATACGCTGTCCCCAGT
GCCACCGCTCCTGTGTCTACAGCCCAGCTCAAGCAAGCAGTGACACTTGGACAAGACTTAGCAG
CATATACAACCTATGAGGTCTACCCTACTTTTGCAGTGACCACCCGAGGTGATGGATATGGCAC
CTTCTGA

hide sequence

RefSeq Acc Id:

XM_006231272 ⟹ XP_006231334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	239,149,436 - 239,242,460 (+)	NCBI
mRatBN7.2	1	229,736,115 - 229,823,499 (+)	NCBI
Rnor_6.0	1	250,426,027 - 250,514,245 (+)	NCBI
Rnor_5.0	1	257,660,187 - 257,747,893 (+)	NCBI

Sequence:

show sequence

GCTTCTGTTCAGGCCATAGTGACCCAATTACCTGGTCAAAGGGCTGAGTGAATGCAAGAGGAGG
GTGAGTTAAAGTTTAACTCCCAGGAATTGTAAACCAAACCTACAGCCACTGAACCTTTGGAGTT
TGATACGATGATTAGAATATAACTAACGTGGTGTGCAGAATTCACCATAATCAAGAAACCTTTT
CCGGGTGGGGGAACCTCAGAAATTACTCAGTGAGCAACCCTAATTAACCTGATTTTTTGCTGAT
AATCACTCTCAATGGAATCAAATCACAAATCCGGGGATGGATTGAGCGGCACCCAGAAGGAAGC
AGCACTCCGCGCACTGGTCCAGCGCACAGGATATAGCTTGGTCCAGGAAAATGGACAAAGAAAA
TATGGTGGTCCTCCACCAGGATGGGATACTACACCCCCAGAAAGGGGCTGCGAGATTTTCATTG
GGAAACTTCCCCGGGACCTTTTTGAGGATGAACTCATACCATTGTGTGAAAAAATTGGTAAAAT
TTATGAAATGAGAATGATGATGGATTTCAATGGGAACAACAGAGGCTATGCATTTGTAACCTTC
TCAAATAAGCAGGAAGCCAAGAATGCAATCAAGCAACTTAATAATTATGAAATTCGGAATGGCC
GTCTCCTGGGCGTCTGTGCCAGTGTGGACAACTGCCGGTTGTTTGTGGGGGGAATCCCCAAAAC
CAAAAAGAGAGAAGAAATCTTGTCAGAGATGAAAAAGGTCACTGAAGGAGTTGTTGATGTCATT
GTCTACCCAAGCGCTGCCGATAAAACCAAAAACCGGGGGTTTGCCTTTGTGGAATATGAGAGTC
ACCGCGCAGCCGCCATGGCTAGGCGGAGGCTGCTGCCAGGAAGAATTCAGTTGTGGGGACATCC
TATCGCAGTAGACTGGGCAGAGCCAGAAGTCGAAGTTGACGAAGACACAATGTCTTCCGTGAAA
ATCCTGTACGTAAGGAACCTTATGCTGTCTACCTCGGAAGAGATGATTGAGAAGGAATTCAACA
GTATTAAACCAGGTGCTGTGGAACGGGTGAAGAAGATCCGAGACTATGCTTTTGTGCATTTCAG
TAACCGAGAAGATGCAGTTGAAGCCATGAAGGCTTTGAATGGCAAGGTGCTGGATGGTTCCCCA
ATAGAAGTGACCTTGGCCAAGCCAGTGGACAAGGACAGTTACGTTAGGTACACCCGGGGCACCG
GGGGCAGGAACACCATGCTGCAAGAATACACCTACCCTCTGAGCCATGTTTATGACCCTACCAC
AACCTACCTTGGAGCTCCTGTCTTCTATACTCCCCAAGCCTACGCAGCCATTCCAAGTCTTCAT
TTCCCAGCTACCAAAGGACATCTCAGCAACAGAGCTCTCATCCGGACCCCTTCTGTCAGAGAAA
TTTACATGAATGTCCCTGTAGGGGCTGCGGGCGTGAGAGGACTGGGCGGCCGTGGGTATTTGGC
ATATACAGGCCTGGGTCGAGGATACCAGGTCAAAGGAGACAAGAGACAAGACAAACTCTATGAC
CTTCTGCCTGGGATGGAGCTCACCCCGATGAATACTATCTCTTTAAAACCACAAGGAGTTAAAC
TTGCTCCTCAGATATTAGAAGAAATCTGTCAGAAAAATAACTGGGGACAGCCAGTGTACCAGCT
GCACTCTGCCATTGGACAAGACCAAAGACAGTTATTCCTATACAAAGTAACTATCCCAGCGCTG
GCCAGCCAGAATCCTGCGATCCACCCTTTCACACCCCCAAAGCTAAGCGCCTACGTGGATGAAG
CAAAGAGGTACGCCGCAGAGCACACCCTACAGACACTAGGCATCCCCACAGAAGGAGGGGACGC
TGGGACTACAGCACCCACTGCCACATCCGCCACTGTGTTTCCAGGATACGCTGTCCCCAGTGCC
ACCGCTCCTGTGTCTACAGCCCAGCTCAAGCAAGCAGTGACACTTGGACAAGACTTAGCAGCAT
ATACAACCTATGAGGTCTACCCTACTTTTGCAGTGACCACCCGAGGTGATGCATATGGCGCCTT
CTGAAGATCCCTTTCCTCTAAGAATAAGCCTTTACAGGAGGCTCTGTAGAAGACACAAACCTCT
AACCAGATCCCTCATGATCATAAGTCTGCCTTCCCCAAAGCAATGCCTTCCCTGAGACCACATG
ACTTATTTATCGTATTTCTCACAAAATGTGAATTTTACTCTTCAACAAAATCAAAGGTGAAGGA
GCCTTTTACTTAACAGAAACCTGAAGACCCGCGGACAGCAAAAGTTCTTCCAAGAAGCCTGGAT
GTCTCAGGAAGAGGATAACACCCTGACAAGTTGGTGTATGCTGTTGGACCGAGAGCTGGGCAGT
CAGTAGCAAGGCACAGTCAGTAAAATCCCCATCTCAGTCGCCGGCTCACAGCTGCTTCATCATT
CACAGAATGTAGACACCAGAGGAAACCAGGAAGCTTTGTAAGAGGCCTTCAGCATTGTGTGTGG
GGTATGACCAGGCTGAGTTCAGCAAAACTGTCTGAAACGTTATAGATCCCTTGTTACTTTTGGT
CTGAAAGTTCCATACCTTTTATCTATCATAGGTCGGCACCTTCCTGTCCCTGCAACCTCTGGGG
ACTTTCTAAGTAATCAATACCATGTGTTTCAGATATGCTTGAGGCAAATCCAAGCCATGTATTT
ATTCAACCCCTTAAGGCACTGTTTTCCTTTAGAATTCTTACCCTGCTCAAGGACTGCCAAATCA
CAGACACCATGCCAGGACCAAGCTCTAGAGTGAAAGATGACTCGTTTGTCTGGAAAGTCCGGCT
TGTCCATATTAATTTGCTTTCATCTCAGACTCATTCTTCGGCTGATTTCAAACACTACAAAGTG
AATCAGATCTACATACAAATCACATGATATTTTCATAATCAAAGTTGACCAAAAAGTCATCTCA
AAGAGAAAAGTGAACTTGGTTGACTTTTGTCTCACTGTGTAGCCCAGGCTGGCCTCCATCTTGT
GATCTCCCTGCCTCTATCCCCACCCCATGCTGGTGTTGTTGCTACACCACCATACTCACCTCCA
AGCAGTCATGTTAAAATTGAGGTTACCTTTGAATTCTCTGCCCAGTTCATGTTAGTCTAGCAAG
AGGCATTGTCTTTCCCATTTTTTTTTAATTCTCTTTCAATGTGTGCAGCTGGCTCTACCATGGC
TGAGTCCCTGAAACTATTTCAGGAAAGCCTTACACCCATCATGGTTGCTTAGAGACCATCCCGT
CATTGTTCAGTAAAAGTGTTCCTGAGTATTTGGACCATCTGGTAGTGACCAGGGGAGGGAAGCT
GCATACAGGTAAAAAGGGTGGAATGTTCTGAAACAAATTAGATATAACTCCAGCCTTATTAGTG
ATTTTTTTAGGAGATAAGCTGCTTGAATCTCCATTAAAAAAAAAAAAAAAGCTTTTGGCTCCTG
TGAAAGTCTGGAGAATTCAAGAGAAAACAAAGACAATGGTACAGAAAATATTGTCAACTCCTTC
TTGGAATTCTGGAATCTAAAATCAGGTCAAATTTCATCCAGTCAAATGCTAACCAGAGATGATT
ACCTCATAACCTTTGGGTTCAGCTGAACACCCTAAACAGAGAACCTCCAGCGGAAGCTGAAAGG
CTCTGGATTTTCTGGACATGCCTTCCTTCTCAGATTCTTGTCCTAAGCACAGGAACTCCCAAAC
TTGGCAACACATCCAAAACACCTGAAGAGCTTCCAATACGTTAAGGCCAAGCTCATGTGTTAGA
AATCGTGTTAGAGAGTCTTGGCGTGAGGGCCTGATGTCAGTGTTTTGAGAAGATTCCTGGGTGA
TTCGAATGTGTAGCTTGGTGTGGGACTGTAAAGAGTCTTGTAGA

hide sequence

RefSeq Acc Id:

XM_039085015 ⟹ XP_038940943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	239,149,436 - 239,242,460 (+)	NCBI
mRatBN7.2	1	229,736,037 - 229,823,499 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_596891	(Get FASTA)	NCBI Sequence Viewer
	XP_006231334	(Get FASTA)	NCBI Sequence Viewer
	XP_038940943	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK50145	(Get FASTA)	NCBI Sequence Viewer
	AAK83095	(Get FASTA)	NCBI Sequence Viewer
	AAO15465	(Get FASTA)	NCBI Sequence Viewer
	AAO15466	(Get FASTA)	NCBI Sequence Viewer
	AAO15467	(Get FASTA)	NCBI Sequence Viewer
	AAO15468	(Get FASTA)	NCBI Sequence Viewer
	AAO15469	(Get FASTA)	NCBI Sequence Viewer
	EDM13127	(Get FASTA)	NCBI Sequence Viewer
	EDM13128	(Get FASTA)	NCBI Sequence Viewer
	EDM13129	(Get FASTA)	NCBI Sequence Viewer
	EDM13130	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062802.4
	ENSRNOP00000095037.1
GenBank Protein	Q923K9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_596891 ⟸ NM_133400

- UniProtKB:

Q924K3 (UniProtKB/Swiss-Prot), Q8CH58 (UniProtKB/Swiss-Prot), Q8CH57 (UniProtKB/Swiss-Prot), Q8CH56 (UniProtKB/Swiss-Prot), Q8CH55 (UniProtKB/Swiss-Prot), Q923K9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDTTPPERGCEIFIGKLP
RDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLG
VCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAA
AMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKP
GAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRN
TMLQEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVRGAAGV
RGLGGRGYLAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQK
NNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEHTLQT
LGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFAV
TTRGDGYGTF

hide sequence

RefSeq Acc Id:	XP_006231334 ⟸ XM_006231272
- Peptide Label:	isoform X1
- UniProtKB:	Q924K3 (UniProtKB/Swiss-Prot), Q923K9 (UniProtKB/Swiss-Prot), Q8CH58 (UniProtKB/Swiss-Prot), Q8CH57 (UniProtKB/Swiss-Prot), Q8CH56 (UniProtKB/Swiss-Prot), Q8CH55 (UniProtKB/Swiss-Prot), F1LNL0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDTTPPERGCEIFIGKLP RDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLG VCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAA AMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKP GAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRN TMLQEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMN VPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQ ILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRY AAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTY EVYPTFAVTTRGDAYGAF hide sequence

Ensembl Acc Id:

ENSRNOP00000062802 ⟸ ENSRNOT00000067643

RefSeq Acc Id:	XP_038940943 ⟸ XM_039085015
- Peptide Label:	isoform X2
- UniProtKB:	A6I0Z6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095037 ⟸ ENSRNOT00000106085

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q923K9-F1-model_v2	AlphaFold	Q923K9	1-594	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690855

Promoter ID:

EPDNEW_R1380

Type:

initiation region

Name:

A1cf_1

Description:

APOBEC1 complementation factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	250,426,201 - 250,426,261	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619834	AgrOrtholog
BioCyc Gene	G2FUF-55926	BioCyc
Ensembl Genes	ENSRNOG00000033195	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067643.5	UniProtKB/TrEMBL
	ENSRNOT00000106085.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.160.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.70.330	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	A1CF_DSRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ACF_RRM1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HnRNP_R/Q_splicing_fac	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RRM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:170912	UniProtKB/Swiss-Prot
NCBI Gene	170912	ENTREZGENE
PANTHER	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR21245:SF8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DND1_DSRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RRM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	A1cf	PhenoGen
PROSITE	RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033195	RatGTEx
SMART	RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	dsRNA-binding domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54928	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AIW3_RAT	UniProtKB/TrEMBL
	A1CF_RAT	UniProtKB/Swiss-Prot
	A6I0Z6	ENTREZGENE, UniProtKB/TrEMBL
	F1LNL0	ENTREZGENE, UniProtKB/TrEMBL
	Q8CH55	ENTREZGENE
	Q8CH56	ENTREZGENE
	Q8CH57	ENTREZGENE
	Q8CH58	ENTREZGENE
	Q923K9	ENTREZGENE
	Q924K3	ENTREZGENE
UniProt Secondary	Q8CH55	UniProtKB/Swiss-Prot
	Q8CH56	UniProtKB/Swiss-Prot
	Q8CH57	UniProtKB/Swiss-Prot
	Q8CH58	UniProtKB/Swiss-Prot
	Q924K3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-23	A1cfT	APOBEC1 complementation factorT	A1cf	APOBEC1 complementation factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-23	A1cf	APOBEC1 complementation factor	A1cfT	APOBEC1 complementation factorT	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-11	A1cft	APOBEC1 complementation factort	A1cf	APOBEC1 complementation factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-11	A1cf	APOBEC1 complementation factor	A1cft	APOBEC1 complementation factort	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-08	A1cf	APOBEC1 complementation factor	Acf	apobec-1 complementation factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Acf	apobec-1 complementation factor		Apobec-1 complementation factor, APOBEC-1 stimulating protein	Name updated	1299863	APPROVED
2002-08-07	Acf	Apobec-1 complementation factor, APOBEC-1 stimulating protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_protein	66 kDa protein	631910

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar