Mtpn (myotrophin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mtpn (myotrophin) Rattus norvegicus
Analyze
Symbol: Mtpn
Name: myotrophin
RGD ID: 619806
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cerebellar granule cell differentiation; and regulation of macromolecule metabolic process. Located in axon; cytosol; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human MTPN (myotrophin); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gcdp; granule cell differentiation protein; growth factor; MGC108675; protein V-1; stimulates myocyte growth; V-1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8465,126,390 - 65,153,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl465,115,980 - 65,153,924 (-)EnsemblGRCr8
mRatBN7.2464,159,273 - 64,186,686 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl464,157,641 - 64,186,724 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx469,116,325 - 69,143,737 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0465,026,060 - 65,053,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0463,434,435 - 63,461,845 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0463,012,009 - 63,039,422 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl463,012,011 - 63,039,422 (-)Ensemblrn6Rnor6.0
Rnor_5.0462,732,736 - 62,760,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4462,896,762 - 62,924,175 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera459,206,334 - 59,233,762 (-)NCBICelera
RGSC_v3.1463,171,383 - 63,200,312 (-)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
Methylazoxymethanol acetate  (EXP)
methylmercury(1+)  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
poly(I:C)  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
T-2 toxin  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization and functional significance of myotrophin: a gene with multiple transcripts. Adhikary G, etal., Gene. 2005 Jun 20;353(1):31-40.
2. cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy. Anderson KM, etal., J Mol Cell Cardiol. 1999 Apr;31(4):705-19.
3. Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops. Das B, etal., J Biol Chem. 2008 Oct 10;283(41):27947-56. doi: 10.1074/jbc.M801210200. Epub 2008 Aug 7.
4. Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy. Furukawa Y, etal., Neuromuscul Disord 2003 Jan;13(1):32-41.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy. Gupta S and Sen S, Biochim Biophys Acta. 2002 May 8;1589(3):247-60.
7. Glucocorticoid inhibits expression of V-1, a catecholamine biosynthesis regulatory protein, in cultured adrenal medullary cells. Hiwatashi Y, etal., FEBS Lett 2002 Sep 25;528(1-3):166-70.
8. Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells. Kitazawa M, etal., Biochem Biophys Res Commun. 2005 May 27;331(1):181-6.
9. Myotrophin/V-1 does not act as an extracellular signal to induce myocyte hypertrophy. Knuefermann P, etal., Tex Heart Inst J. 2006;33(3):281-9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Myotrophin in human cardiomyopathic heart. Sil P, etal., Circ Res. 1993 Jul;73(1):98-108.
15. Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. Sivasubramanian N, etal., J Biol Chem 1996 Feb 2;271(5):2812-6.
16. Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. Suzuki T, etal., Biochem Biophys Res Commun 2002 May 10;293(3):962-8.
17. A rat cerebellar protein containing the cdc10/SWI6 motif. Taoka M, etal., Eur J Biochem 1992 Jul 15;207(2):615-20.
18. Murine cerebellar neurons express a novel gene encoding a protein related to cell cycle control and cell fate determination proteins. Taoka M, etal., J Biol Chem 1994 Apr 1;269(13):9946-51.
19. Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats. Yamakuni T, etal., Biochem Biophys Res Commun 2002 Nov 15;298(5):793-7.
20. V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells. Yamakuni T, etal., FEBS Lett 2002 Oct 23;530(1-3):94-8.
Additional References at PubMed
PMID:9194197   PMID:9634699   PMID:12079376   PMID:12477932   PMID:12488317   PMID:15489334   PMID:15532712   PMID:16895918   PMID:17113103   PMID:23376485   PMID:28131823  


Genomics

Comparative Map Data
Mtpn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8465,126,390 - 65,153,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl465,115,980 - 65,153,924 (-)EnsemblGRCr8
mRatBN7.2464,159,273 - 64,186,686 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl464,157,641 - 64,186,724 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx469,116,325 - 69,143,737 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0465,026,060 - 65,053,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0463,434,435 - 63,461,845 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0463,012,009 - 63,039,422 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl463,012,011 - 63,039,422 (-)Ensemblrn6Rnor6.0
Rnor_5.0462,732,736 - 62,760,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4462,896,762 - 62,924,175 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera459,206,334 - 59,233,762 (-)NCBICelera
RGSC_v3.1463,171,383 - 63,200,312 (-)NCBI
Cytogenetic Map4q22NCBI
MTPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387135,926,760 - 135,977,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7135,926,760 - 135,977,375 (-)Ensemblhg38GRCh38
GRCh377135,611,508 - 135,662,107 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367135,262,049 - 135,312,604 (-)NCBIBuild 36Build 36hg18NCBI36
Celera7130,348,855 - 130,399,560 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7129,914,553 - 129,965,190 (-)NCBIHuRef
CHM1_17135,545,252 - 135,596,008 (-)NCBICHM1_1
T2T-CHM13v2.07137,233,963 - 137,284,569 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27134,955,940 - 135,006,645 (-)NCBI
Mtpn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39635,485,759 - 35,516,823 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl635,485,841 - 35,516,823 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38635,508,824 - 35,539,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl635,508,906 - 35,539,888 (-)Ensemblmm10GRCm38
MGSCv37635,458,824 - 35,489,888 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36635,439,058 - 35,469,939 (-)NCBIMGSCv36mm8
Celera635,501,209 - 35,532,303 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map615.27NCBI
Mtpn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554946,805,262 - 6,845,394 (+)Ensembl
ChiLan1.0NW_0049554946,805,518 - 6,844,454 (+)NCBIChiLan1.0ChiLan1.0
MTPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26172,750,521 - 172,801,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1724,760,776 - 24,811,817 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07127,896,148 - 127,947,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17140,392,620 - 140,443,591 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7140,392,620 - 140,443,591 (-)EnsemblpanPan2panpan1.1
MTPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11612,316,487 - 12,369,148 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1612,316,336 - 12,369,387 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1613,329,142 - 13,381,817 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01612,291,590 - 12,344,263 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1612,291,377 - 12,347,409 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11612,738,681 - 12,791,312 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01611,837,732 - 11,890,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01611,977,207 - 12,029,889 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mtpn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511818,540,208 - 18,575,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936592644,430 - 679,800 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936592644,618 - 679,615 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1813,330,029 - 13,395,460 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11813,330,049 - 13,395,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21814,099,754 - 14,137,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121104,605,924 - 104,657,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21104,605,592 - 104,657,866 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660721,494,997 - 1,544,426 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtpn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476516,181,809 - 16,218,720 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476516,182,691 - 16,218,634 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mtpn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16104,154,733 - 104,184,842 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mtpn
310 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:838
Count of miRNA genes:321
Interacting mature miRNAs:405
Transcripts:ENSRNOT00000015808
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat

Markers in Region
RH134386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2464,159,517 - 64,159,714 (+)MAPPERmRatBN7.2
Rnor_6.0463,012,254 - 63,012,450NCBIRnor6.0
Rnor_5.0462,732,981 - 62,733,177UniSTSRnor5.0
RGSC_v3.4462,897,007 - 62,897,203UniSTSRGSC3.4
Celera459,206,579 - 59,206,775UniSTS
RH 3.4 Map4398.1UniSTS
Cytogenetic Map4q22UniSTS
RH142541  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2464,166,104 - 64,166,213 (+)MAPPERmRatBN7.2
Rnor_6.0463,018,841 - 63,018,949NCBIRnor6.0
Rnor_5.0462,739,568 - 62,739,676UniSTSRnor5.0
RGSC_v3.4462,903,594 - 62,903,702UniSTSRGSC3.4
Celera459,213,182 - 59,213,290UniSTS
RH 3.4 Map4400.9UniSTS
Cytogenetic Map4q22UniSTS
RH135242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2464,157,781 - 64,157,989 (+)MAPPERmRatBN7.2
Rnor_6.0463,010,518 - 63,010,725NCBIRnor6.0
Rnor_5.0462,731,245 - 62,731,452UniSTSRnor5.0
RGSC_v3.4462,895,271 - 62,895,478UniSTSRGSC3.4
Celera459,204,843 - 59,205,050UniSTS
RH 3.4 Map4402.5UniSTS
RH 3.4 Map4394.9UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015808   ⟹   ENSRNOP00000015808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl465,124,888 - 65,153,924 (-)Ensembl
mRatBN7.2 Ensembl464,157,641 - 64,186,724 (-)Ensembl
Rnor_6.0 Ensembl463,012,011 - 63,039,422 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103488   ⟹   ENSRNOP00000082083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl464,157,643 - 64,186,664 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142742   ⟹   ENSRNOP00000105924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl465,115,980 - 65,153,924 (-)Ensembl
RefSeq Acc Id: NM_024374   ⟹   NP_077350
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8465,126,390 - 65,153,803 (-)NCBI
mRatBN7.2464,159,273 - 64,186,686 (-)NCBI
Rnor_6.0463,012,009 - 63,039,422 (-)NCBI
Rnor_5.0462,732,736 - 62,760,149 (-)NCBI
RGSC_v3.4462,896,762 - 62,924,175 (-)RGD
Celera459,206,334 - 59,233,762 (-)RGD
Sequence:
RefSeq Acc Id: NP_077350   ⟸   NM_024374
- UniProtKB: Q58HB3 (UniProtKB/Swiss-Prot),   P62775 (UniProtKB/Swiss-Prot),   A6IEP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015808   ⟸   ENSRNOT00000015808
Ensembl Acc Id: ENSRNOP00000082083   ⟸   ENSRNOT00000103488
Ensembl Acc Id: ENSRNOP00000105924   ⟸   ENSRNOT00000142742

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62775-F1-model_v2 AlphaFold P62775 1-118 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692963
Promoter ID:EPDNEW_R3487
Type:initiation region
Name:Mtpn_1
Description:myotrophin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0463,039,502 - 63,039,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619806 AgrOrtholog
BioCyc Gene G2FUF-45241 BioCyc
Ensembl Genes ENSRNOG00000011857 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015808 ENTREZGENE
  ENSRNOT00000103488.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7377576 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
KEGG Report rno:79215 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108675 IMAGE-MGC_LOAD
NCBI Gene 79215 ENTREZGENE
PANTHER ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED UniProtKB/Swiss-Prot
  BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
PhenoGen Mtpn PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011857 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A8L2Q8F1_RAT UniProtKB/TrEMBL
  A0ABK0L750_RAT UniProtKB/TrEMBL
  A6IEP4 ENTREZGENE, UniProtKB/TrEMBL
  MTPN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q58HB3 ENTREZGENE
UniProt Secondary P80144 UniProtKB/Swiss-Prot
  Q58HB3 UniProtKB/Swiss-Prot
  Q9DCN8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Mtpn  myotrophin      Symbol and Name status set to approved 625702 APPROVED
2003-11-13 Mtpn  myotrophin  Gcdp  V-1 protein  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 PROVISIONAL
2002-08-07 Gcdp  V-1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in chromaffin cells, cerebellum 625450
gene_expression transient increase in expression is seen during early postnatal development 625450
gene_other a good marker for early stage of muscle regeneration 632798
gene_process may regulate expression of catecholamine-synthesizing enzymes 625450
gene_product member of the ankyrin repeat-containing protein family 632798
gene_protein 117 amino acids 625450
gene_transcript contains a cdc10/SW16 motif 625450