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Gene: Ckmt1 (creatine kinase, mitochondrial 1) Rattus norvegicus

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Symbol:

Ckmt1

Name:

creatine kinase, mitochondrial 1

RGD ID:

61976

Description:

Enables creatine kinase activity and identical protein binding activity. Involved in several processes, including cerebellum development; digestive tract development; and skeletal muscle tissue development. Located in mitochondrial inner-outer membrane contact site and perikaryon. Biomarker of status epilepticus. Orthologous to several human genes including CKMT1B (creatine kinase, mitochondrial 1B); PARTICIPATES IN cardiolipin metabolic pathway; INTERACTS WITH 1-bromopropane; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acidic-type mitochondrial creatine kinase; Ckmt1b; creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1, ubiquitous; creatine kinase, mitochondrial 1B; mia-CK; U-MtCK; ubiquitous mitochondrial creatine kinase

RGD Orthologs

Human

Mouse

Green Monkey

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CKMT1B (creatine kinase, mitochondrial 1B)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ckmt1 (creatine kinase, mitochondrial 1, ubiquitous)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103246095 (creatine kinase U-type, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CKMT1A (creatine kinase, mitochondrial 1A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OrthoDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Ckmt1 (creatine kinase, mitochondrial 1, ubiquitous)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CKMT1B (creatine kinase, mitochondrial 1B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CKMT1A (creatine kinase, mitochondrial 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ckmt2a (creatine kinase, mitochondrial 2a (sarcomeric))	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	ckmt1 (creatine kinase, mitochondrial 1)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5144	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F32B5.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	W10C8.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	argk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Argk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F46H5.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC434.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4546	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ckmt1b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	128,783,408 - 128,789,485 (+)	NCBI		GRCr8
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	108,330,705 - 108,335,758 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,005,834 - 112,010,830 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	120,601,357 - 120,606,353 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	118,261,760 - 118,266,756 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	108,058,145 - 108,064,001 (+)	NCBI
Celera	3	107,232,840 - 107,237,770 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 16 (ISO)

Bloom syndrome (ISO)

Brain Injuries (IEP)

colorectal cancer (ISO)

Deafness-Infertility Syndrome (ISO)

Hearing Loss (ISO)

status epilepticus (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-bromopropane (EXP)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,5-hexanedione (EXP)

2-acetamidofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

amphetamine (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Brodifacoum (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

decabromodiphenyl ether (ISO)

dichlorine (EXP)

diethylstilbestrol (ISO)

dioxygen (ISO)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

isotretinoin (ISO)

maneb (ISO)

methimazole (EXP)

methotrexate (ISO)

mitomycin C (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nicotine (ISO)

ozone (EXP,ISO)

paracetamol (EXP)

paraquat (EXP,ISO)

PCB138 (EXP)

perfluorooctanoic acid (EXP)

senecionine (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

testosterone (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

trichloroethene (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebellum development (IEP)

digestive tract development (IEP)

kidney development (IEP)

negative regulation of apoptotic process (IEA,ISO)

phosphocreatine biosynthetic process (IBA,IEA)

skeletal muscle tissue development (IEP)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrial inner-outer membrane contact site (IDA)

mitochondrion (IBA,ISO)

perikaryon (IDA)

Molecular Function

ATP binding (IEA)

creatine kinase activity (IBA,IDA,IEA)

identical protein binding (IPI)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cardiolipin metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function.	Briones TL, etal., Acta Neuropathol Commun. 2013 Sep 6;1:57. doi: 10.1186/2051-5960-1-57.
2.	Expression of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in the fetal rat brain: evidence for a nuclear energy shuttle.	Chen L, etal., J Comp Neurol. 1995 Dec 18;363(3):389-401.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Mitochondrial creatine kinase functional development in post-natal rat skeletal muscle. A combined polarographic/31P NMR study.	Kernec F, etal., Mol Cell Biochem. 1999 Apr;194(1-2):165-71.
5.	Effects of creatine and beta-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.	Kim DW, etal., BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141.
6.	Location and regulation of octameric mitochondrial creatine kinase in the contact sites.	Kottke M, etal., Biochim Biophys Acta. 1991 Jan 30;1061(2):215-25.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Developmental expression of sarcomeric and ubiquitous mitochondrial creatine kinase is tissue-specific.	Payne RM and Strauss AW, Biochim Biophys Acta. 1994 Sep 13;1219(1):33-8.
10.	Structural characterization and tissue-specific expression of the mRNAs encoding isoenzymes from two rat mitochondrial creatine kinase genes.	Payne RM, etal., Biochim Biophys Acta 1991 Jul 23;1089(3):352-61.
11.	Metabolism and function of mitochondrial cardiolipin.	Ren M, etal., Prog Lipid Res. 2014 Jul;55:1-16. doi: 10.1016/j.plipres.2014.04.001. Epub 2014 Apr 24.
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation.	Shen W, etal., Biochem J 2002 Oct 15;367(Pt 2):369-80.

Additional References at PubMed

PMID:1939264	PMID:12477932	PMID:14651853	PMID:17634366	PMID:18614015	PMID:18629616	PMID:21370995	PMID:22871113	PMID:23376485	PMID:23620342	PMID:29476059	PMID:32357304

Genomics

Comparative Map Data

Ckmt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	128,783,408 - 128,789,485 (+)	NCBI		GRCr8
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	108,330,705 - 108,335,758 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,005,834 - 112,010,830 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	120,601,357 - 120,606,353 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	118,261,760 - 118,266,756 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	108,058,145 - 108,064,001 (+)	NCBI
Celera	3	107,232,840 - 107,237,770 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

CKMT1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	43,592,857 - 43,599,406 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	43,593,054 - 43,604,901 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p14 Ensembl	15	43,692,886 - 43,699,222 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	43,885,055 - 43,891,604 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	41,672,544 - 41,678,896 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	41,673,545 - 41,678,874	NCBI
Celera	15	20,779,315 - 20,779,894 (+)	NCBI		Celera
Cytogenetic Map	15	q15.3	NCBI
HuRef	15	20,807,783 - 20,814,119 (+)	NCBI		HuRef
CHM1_1	15	44,003,241 - 44,009,651 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	41,400,216 - 41,406,765 (+)	NCBI		T2T-CHM13v2.0

Ckmt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	121,188,257 - 121,194,218 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	121,188,195 - 121,194,218 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	121,357,773 - 121,363,737 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	121,357,714 - 121,363,737 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	121,184,377 - 121,189,473 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	121,050,082 - 121,055,178 (+)	NCBI		MGSCv36	mm8
Celera	2	122,509,569 - 122,514,651 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.37	NCBI

LOC103246095
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	39,397,797 - 39,401,046 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666182	30,622 - 36,247 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ckmt1
140 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	42
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000051354
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	84091273	129091273	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

MARC_3102-3103:991936731:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	108,330,997 - 108,331,718 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	113,319,697 - 113,320,417	NCBI	Rnor6.0
Rnor_5.0	3	119,859,244 - 119,859,964	UniSTS	Rnor5.0
RGSC_v3.4	3	108,159,128 - 108,159,848	UniSTS	RGSC3.4
Celera	3	107,233,081 - 107,233,801	UniSTS
Cytogenetic Map	3	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	46	113	67	66	35	21	35	6	185	88	93	45	59	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000051354 ⟹ ENSRNOP00000044253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	108,330,750 - 108,335,758 (+)	Ensembl
Rnor_6.0 Ensembl	3	113,319,456 - 113,324,457 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000089230 ⟹ ENSRNOP00000071371

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	108,330,705 - 108,335,758 (+)	Ensembl
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl

RefSeq Acc Id:

NM_001012738 ⟹ NP_001012756

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	128,784,482 - 128,789,483 (+)	NCBI
mRatBN7.2	3	108,330,757 - 108,335,758 (+)	NCBI
Rnor_6.0	3	113,319,456 - 113,324,457 (+)	NCBI
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	RGD
Celera	3	107,232,840 - 107,237,770 (+)	RGD

Sequence:

show sequence

CTGGCCGCTTGCTTGCTGCGCTTCTCCTGCAGCCTGGTAGGCACTGGCTGCTACTTCAGCTTCA
GCCTTCGTCGCGACCCCTATTTTGGCTCCAGTCTCCGACCCTGCTCCGTCCTCTCTCTACTTGG
TTGCATCCTCCCTCCTAGTTCCAGATTTGCGCCAGATCCTGCTCCAAATCCGGTAGCCGCATCC
CCAAGCCATGGCTGGTCCCTTCTCCCGTCTGCTGTCTGCCCGCCCCGGACTCAAGCTCCTGGCT
TTGGCTGGAGCTGGGTCTCTCGCCGCCGGGATTCTGCTCCGTCCGGAATCTGTACGAGCGGCCA
CCGGTGAACGGAGGAGACTGTATCCCCCGAGCGCTGAGTACCCAGACCTCCGAAAGCACAACAA
CTGCATGGCCAGTCACCTGACCCCAGCAGTCTATGCACGGCTCTGCGACAAGACCACACCCACT
GGCTGGACACTAGATCAGTGCATCCAGACTGGAGTGGACAACCCTGGCCACCCCTTCATCAAGA
CTGTGGGCATGGTGGCTGGAGATGAGGAGACCTATGAGGTATTTGCCGAACTGTTTGACCCTGT
GATCCAAGAGCGGCATAATGGATATGACCCTAGAACAATGAAGCACACCACTGACCTTGATGCC
AGCAAAATCCGTTCTGGCTACTTTGATGAGAGGTACGTATTGTCCTCAAGAGTCAGAACTGGCC
GAAGTATCAGGGGACTCAGTCTCCCTCCAGCCTGCACTCGGGCAGAGCGACGAGAGGTGGAGCG
TGTTGTGGTGGACGCGCTGAGTGGCCTGAAGGGCGACCTGGCTGGACGGTACTACAGGCTCAGT
GAGATGACAGAGGCTGAGCAGCAGCAGCTTATTGACGACCATTTCCTGTTTGATAAACCTGTGT
CCCCATTGCTGACAGCAGCAGGCATGGCTCGAGACTGGCCAGATGCCCGAGGAATCTGGCACAA
CAATGAGAAGAGTTTCTTGATCTGGGTGAATGAGGAGGACCACACACGGGTCATCTCTATGGAG
AAAGGCGGCAACATGAAGAGAGTGTTTGAAAGATTCTGCCGGGGCCTCAAAGAGGTGGAGAAGC
TGATCCAGGAACGAGGCTGGGAGTTCATGTGGAATGAGCGTTTAGGATACATCTTGACCTGTCC
ATCTAACCTGGGCACTGGACTTCGGGCAGGAGTACACGTCAAACTGCCACTGCTAAGCAAAGAT
AGCCGCTTCCCAAAGATCCTGGAGAACCTAAGGCTGCAAAAGCGTGGGACTGGAGGAGTGGACA
CGGCTGCCACAGGCAGTGTCTTTGACATCTCTAATCTGGATCGACTTGGCAAGTCAGAGGTGGA
GCTGGTGCAGCTGGTCATCGATGGGGTGAACTATTTGATTGACTGTGAACGGCGTCTGGAGAAA
GGACAGGATATTCGAATCCCTCCACCTCTTGTCCACGGCAAACATTAACTCCCCGTTCCCAGCA
GATGAATCAAGATTCCCCAGGACTTCTGCATATTTAACAGTGGCCCATTCTACTTGCCAAGGAC
CTGCCTCTCAATCCCTGTCCTAGTAAAGACTCCACGTTCTGTTGAAAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234830 ⟹ XP_006234892

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	128,783,408 - 128,789,485 (+)	NCBI
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI

Sequence:

show sequence

TCCAGTCCAGGAACTGCCAGCTGCAGAGAAGGAAGAGAAGGAAGGAGAAACTCACCATTCCCTG
CCCAACCCCAGCCCCACACCCAGAGCAATCAACAGTTCCAGATTTGCGCCAGATCCTGCTCCAA
ATCCGGTAGCCGCATCCCCAAGCCATGGCTGGTCCCTTCTCCCGTCTGCTGTCTGCCCGCCCCG
GACTCAAGCTCCTGGCTTTGGCTGGAGCTGGGTCTCTCGCCGCCGGGATTCTGCTCCGTCCGGA
ATCTGTACGAGCGGCCACCGGTGAACGGAGGAGACTGTATCCCCCGAGCGCTGAGTACCCAGAC
CTCCGAAAGCACAACAACTGCATGGCCAGTCACCTGACCCCAGCAGTCTATGCACGGCTCTGCG
ACAAGACCACACCCACTGGCTGGACACTAGATCAGTGCATCCAGACTGGAGTGGACAACCCTGG
CCACCCCTTCATCAAGACTGTGGGCATGGTGGCTGGAGATGAGGAGACCTATGAGGTATTTGCC
GAACTGTTTGACCCTGTGATCCAAGAGCGGCATAATGGATATGACCCTAGAACAATGAAGCACA
CCACTGACCTTGATGCCAGCAAAATCCGTTCTGGCTACTTTGATGAGAGGTACGTATTGTCCTC
AAGAGTCAGAACTGGCCGAAGTATCAGGGGACTCAGTCTCCCTCCAGCCTGCACTCGGGCAGAG
CGACGAGAGGTGGAGCGTGTTGTGGTGGACGCGCTGAGTGGCCTGAAGGGCGACCTGGCTGGAC
GGTACTACAGGCTCAGTGAGATGACAGAGGCTGAGCAGCAGCAGCTTATTGACGACCATTTCCT
GTTTGATAAACCTGTGTCCCCATTGCTGACAGCAGCAGGCATGGCTCGAGACTGGCCAGATGCC
CGAGGAATCTGGCACAACAATGAGAAGAGTTTCTTGATCTGGGTGAATGAGGAGGACCACACAC
GGGTCATCTCTATGGAGAAAGGCGGCAACATGAAGAGAGTGTTTGAAAGATTCTGCCGGGGCCT
CAAAGAGGTGGAGAAGCTGATCCAGGAACGAGGCTGGGAGTTCATGTGGAATGAGCGTTTAGGA
TACATCTTGACCTGTCCATCTAACCTGGGCACTGGACTTCGGGCAGGAGTACACGTCAAACTGC
CACTGCTAAGCAAAGATAGCCGCTTCCCAAAGATCCTGGAGAACCTAAGGCTGCAAAAGCGTGG
GACTGGAGGAGTGGACACGGCTGCCACAGGCAGTGTCTTTGACATCTCTAATCTGGATCGACTT
GGCAAGTCAGAGGTGGAGCTGGTGCAGCTGGTCATCGATGGGGTGAACTATTTGATTGACTGTG
AACGGCGTCTGGAGAAAGGACAGGATATTCGAATCCCTCCACCTCTTGTCCACGGCAAACATTA
ACTCCCCGTTCCCAGCAGATGAATCAAGATTCCCCAGGACTTCTGCATATTTAACAGTGGCCCA
TTCTACTTGCCAAGGACCTGCCTCTCAATCCCTGTCCTAGTAAAGACTCCACGTTCTGTTGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012756	(Get FASTA)	NCBI Sequence Viewer
	XP_006234892	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91335	(Get FASTA)	NCBI Sequence Viewer
	EDL79988	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000044253.3
	ENSRNOP00000071371.2
GenBank Protein	P25809	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001012756 ⟸ NM_001012738
- Peptide Label:	precursor
- UniProtKB:	P25809 (UniProtKB/Swiss-Prot), Q5BJT9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGPFSRLLSARPGLKLLALAGAGSLAAGILLRPESVRAATGERRRLYPPSAEYPDLRKHNNCM ASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQ ERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVV VDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNE KSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSN LGTGLRAGVHVKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELV QLVIDGVNYLIDCERRLEKGQDIRIPPPLVHGKH hide sequence

RefSeq Acc Id:	XP_006234892 ⟸ XM_006234830
- Peptide Label:	isoform X1
- UniProtKB:	P25809 (UniProtKB/Swiss-Prot), Q5BJT9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGPFSRLLSARPGLKLLALAGAGSLAAGILLRPESVRAATGERRRLYPPSAEYPDLRKHNNCM ASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQ ERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVV VDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNE KSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSN LGTGLRAGVHVKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELV QLVIDGVNYLIDCERRLEKGQDIRIPPPLVHGKH hide sequence

Ensembl Acc Id:

ENSRNOP00000071371 ⟸ ENSRNOT00000089230

Ensembl Acc Id:

ENSRNOP00000044253 ⟸ ENSRNOT00000051354

Protein Domains

Phosphagen kinase C-terminal Phosphagen kinase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P25809-F1-model_v2	AlphaFold	P25809	1-418	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692360

Promoter ID:

EPDNEW_R2879

Type:

multiple initiation site

Name:

Ckmt1_1

Description:

creatine kinase, mitochondrial 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	113,318,577 - 113,318,637	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61976	AgrOrtholog
BioCyc Gene	G2FUF-48137	BioCyc
BioCyc Pathway	PWY-6158 [creatine phosphate biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6158	BioCyc
Ensembl Genes	ENSRNOG00000014573	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051354.4	UniProtKB/TrEMBL
	ENSRNOT00000089230.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.135.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glutamine synthetase/guanido kinase, catalytic domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7314893	IMAGE-MGC_LOAD
InterPro	ATP-guanido_PTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln_synth/guanido_kin_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29593	UniProtKB/TrEMBL
MGC_CLONE	MGC:109333	IMAGE-MGC_LOAD
NCBI Gene	29593	ENTREZGENE
PANTHER	CREATINE KINASE U-TYPE, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11547	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ATP-gua_Ptrans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-gua_PtransN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ckmt1	PhenoGen
PROSITE	PHOSPHAGEN_KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014573	RatGTEx
Superfamily-SCOP	SSF48034	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55931	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K0A9_RAT	UniProtKB/TrEMBL
	A6HPN7_RAT	UniProtKB/TrEMBL
	KCRU_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5BJT9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-11-18	Ckmt1	creatine kinase, mitochondrial 1	Ckmt1b	creatine kinase, mitochondrial 1B	Name and Symbol changed	629549	APPROVED
2012-01-24	Ckmt1b	creatine kinase, mitochondrial 1B	Ckmt1	creatine kinase, mitochondrial 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-11-05	Ckmt1	creatine kinase, mitochondrial 1	Ckmt1	creatine kinase, mitochondrial 1, ubiquitous	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ckmt1	creatine kinase, mitochondrial 1, ubiquitous			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expression in uterus and placenta is regulated during pregnancy	61552

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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