Grb2 (growth factor receptor bound protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grb2 (growth factor receptor bound protein 2) Rattus norvegicus
Analyze
Symbol: Grb2
Name: growth factor receptor bound protein 2
RGD ID: 619758
Description: Enables several functions, including epidermal growth factor receptor binding activity; guanyl-nucleotide exchange factor adaptor activity; and insulin receptor substrate binding activity. Involved in insulin-like growth factor receptor signaling pathway. Part of protein-containing complex. Is active in presynapse. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter protein GRB2; Ash-psi; growth factor receptor-bound protein 2; growth factor receptor-bound protein 2-like; LOC103690155; MGC108668; protein Ash; SH2/SH3 adapter GRB2; uncharacterized LOC103690155
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,380,354 - 101,448,138 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,380,356 - 101,448,138 (-)EnsemblGRCr8
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,941,694 - 106,010,414 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,404,767 - 105,473,487 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,802,375 - 100,870,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)Ensemblrn6Rnor6.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,455,840 - 99,524,352 (-)NCBICelera
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysin  (ISO)
citalopram  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
enzyme inhibitor  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
furfural  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
letrozole  (ISO)
maneb  (ISO)
melatonin  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
Nonidet P-40  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylarsine oxide  (EXP)
phosphane  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sorafenib  (ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA,ISO)
cell-cell junction  (IEA,ISO)
COP9 signalosome  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO,TAS)
endosome  (IEA,ISO,ISS)
Golgi apparatus  (IEA)
Grb2-EGFR complex  (IEA,ISO)
membrane  (IEA,ISO)
nucleoplasm  (IBA)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO)
presynapse  (IDA,IEP)
protein-containing complex  (IDA)
vesicle membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
B cell receptor signaling pathway  (IEA)
brain-derived neurotrophic factor signaling pathway  (ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
endometrial cancer pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway   (IEA)
insulin signaling pathway  (IDA,IEA,ISO)
insulin-like growth factor signaling pathway  (IMP,ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway   (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway  (IEA)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway   (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
transforming growth factor-beta Smad dependent signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Ahmed Z, etal., Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. Chadwick W, etal., J Signal Transuct. 2011;2011. pii: 636951.
5. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cheng AM, etal., Cell 1998 Dec 11;95(6):793-803.
6. SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling. Chu J, etal., Blood. 1998 Sep 1;92(5):1697-706.
7. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
8. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Dadke S and Chernoff J, Biochem J. 2002 Jun 1;364(Pt 2):377-83.
9. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Dankort DL, etal., Mol Cell Biol. 1997 Sep;17(9):5410-25.
10. Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Fernandes ML, etal., Endocrine. 2001 Dec;16(3):227-34.
11. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. Fukazawa T, etal., J Biol Chem. 1996 Jun 14;271(24):14554-9.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
14. Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel. Gril B, etal., Int J Cancer. 2007 Jul 15;121(2):407-15. doi: 10.1002/ijc.22674.
15. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
16. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
17. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart F, etal., Mol Vis. 2005 Dec 9;11:1061-70.
18. Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Hunter S, etal., Mol Endocrinol. 1997 Aug;11(9):1213-22.
19. Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors. Ishihara H, etal., J Biol Chem. 1997 Apr 4;272(14):9581-6.
20. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. Jackman JK, etal., J Biol Chem. 1995 Mar 31;270(13):7029-32.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
23. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. Kimura T, etal., J Biol Chem. 1996 Nov 1;271(44):27962-8.
24. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Kong M, etal., J Biol Chem. 2000 Nov 17;275(46):36035-42.
25. Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. Lin X, etal., Neoplasia. 2017 Nov;19(11):857-867. doi: 10.1016/j.neo.2017.06.006. Epub 2017 Sep 18.
26. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). Liu F, etal., J Biol Chem. 1996 Dec 6;271(49):31290-5.
27. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
28. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. MacDonald JI, etal., J Biol Chem. 2000 Jun 16;275(24):18225-33.
29. Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Matuoka K, etal., Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9015-9.
30. Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. McPherson PS, etal., Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6486-90. doi: 10.1073/pnas.91.14.6486.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. Panchamoorthy G, etal., J Biol Chem. 1996 Feb 9;271(6):3187-94.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. Poy MN, etal., J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. Russo C, etal., J Biol Chem 2002 Sep 20;277(38):35282-8.
41. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Salcini AE, etal., Oncogene. 1994 Oct;9(10):2827-36.
42. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Sasaoka T, etal., Endocrinology. 1996 Oct;137(10):4427-34. doi: 10.1210/endo.137.10.8828504.
43. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. Sasaoka T, etal., J Biol Chem. 1994 Dec 23;269(51):32621-5.
44. mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation. Satoh S and Tominaga T, J Biol Chem. 2001 Oct 19;276(42):39290-4. Epub 2001 Aug 16.
45. Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Saxton TM, etal., Curr Biol 2001 May 1;11(9):662-70.
46. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
47. Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. Wang Y, etal., Cancer Lett. 2012 Sep 28;322(2):223-31. doi: 10.1016/j.canlet.2012.03.026. Epub 2012 Mar 27.
48. Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms. Watanabe K, etal., J Biol Chem 1995 Jun 9;270(23):13733-9.
49. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. Zucconi A, etal., J Mol Biol. 2001 Apr 13;307(5):1329-39.
Additional References at PubMed
PMID:7689150   PMID:7953556   PMID:8183574   PMID:8316835   PMID:8388384   PMID:8438166   PMID:8663064   PMID:8889548   PMID:9259551   PMID:9722539   PMID:9918770   PMID:10196222  
PMID:11498538   PMID:11585837   PMID:11877424   PMID:12147689   PMID:12167719   PMID:12218049   PMID:12477932   PMID:12577067   PMID:12837289   PMID:12837295   PMID:12925710   PMID:12960006  
PMID:13679576   PMID:14985334   PMID:15469895   PMID:15488758   PMID:15489334   PMID:15569713   PMID:15736129   PMID:15983387   PMID:16038803   PMID:16908534   PMID:17923684   PMID:18258597  
PMID:19056867   PMID:19509291   PMID:20086093   PMID:20160708   PMID:20398064   PMID:20458337   PMID:20624904   PMID:21179510   PMID:21180072   PMID:22536782   PMID:22561606   PMID:22658674  
PMID:22726438   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23793062   PMID:25650006   PMID:26782545   PMID:28065675   PMID:28235806   PMID:28618656   PMID:32652777  


Genomics

Comparative Map Data
Grb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,380,354 - 101,448,138 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,380,356 - 101,448,138 (-)EnsemblGRCr8
mRatBN7.210100,881,404 - 100,949,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,869,718 - 100,949,309 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,941,694 - 106,010,414 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,404,767 - 105,473,487 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,802,375 - 100,870,155 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,193,953 - 104,263,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)Ensemblrn6Rnor6.0
Rnor_5.010104,735,560 - 104,738,091 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.010104,019,823 - 104,087,251 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,722,014 - 105,818,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,455,840 - 99,524,352 (-)NCBICelera
RGSC_v3.110105,737,088 - 105,833,269 (-)NCBI
Cytogenetic Map10q32.1NCBI
GRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,318,076 - 75,405,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,318,076 - 75,405,709 (-)Ensemblhg38GRCh38
GRCh371773,314,157 - 73,401,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,825,752 - 70,913,385 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341770,825,752 - 70,913,329NCBI
Celera1769,906,645 - 69,994,307 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,724,752 - 68,824,731 (-)NCBIHuRef
CHM1_11773,378,804 - 73,466,430 (-)NCBICHM1_1
T2T-CHM13v2.01776,210,297 - 76,297,898 (-)NCBIT2T-CHM13v2.0
Grb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,534,871 - 115,599,423 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,534,871 - 115,599,423 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,644,045 - 115,708,597 (-)Ensemblmm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBIMGSCv36mm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Grb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,186,590 - 2,259,456 (-)Ensembl
ChiLan1.0NW_0049555532,186,590 - 2,258,964 (-)NCBIChiLan1.0ChiLan1.0
GRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,357,798 - 91,445,600 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,180,874 - 96,268,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,265,307 - 69,352,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,817,471 - 74,904,022 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,817,471 - 74,903,796 (-)EnsemblpanPan2panpan1.1
GRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,108,128 - 5,182,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,117,164 - 5,180,296 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha95,787,497 - 5,861,309 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.095,778,347 - 5,852,258 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,778,263 - 5,852,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,817,381 - 5,891,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,927,508 - 6,001,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,988,590 - 6,061,075 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,750,590 - 5,819,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594592,740 - 661,369 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936594592,760 - 661,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,940,647 - 6,010,835 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1125,940,723 - 6,009,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,860,464 - 5,928,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,264,818 - 46,346,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,264,825 - 46,347,156 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607717,032,097 - 17,115,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,143,141 - 5,219,244 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248015,143,239 - 5,219,136 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1968,393,553 - 68,459,670 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grb2
228 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:146
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000005347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat

Markers in Region
RH133824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,882,910 - 100,883,103 (+)MAPPERmRatBN7.2
Rnor_6.010105,068,742 - 105,068,932NCBIRnor6.0
Rnor_6.010104,195,460 - 104,195,652NCBIRnor6.0
Rnor_5.010104,085,552 - 104,085,744UniSTSRnor5.0
Rnor_5.010104,737,067 - 104,737,257UniSTSRnor5.0
RGSC_v3.410105,723,521 - 105,723,713UniSTSRGSC3.4
Celera1099,457,347 - 99,457,539UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
20 12 76 211 91 90 59 147 59 6 449 263 18 191 99 116 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000005347   ⟹   ENSRNOP00000005347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,380,356 - 101,448,138 (-)Ensembl
mRatBN7.2 Ensembl10100,881,416 - 100,939,377 (-)Ensembl
Rnor_6.0 Ensembl10104,193,955 - 104,263,071 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095127   ⟹   ENSRNOP00000080275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,380,356 - 101,448,138 (-)Ensembl
mRatBN7.2 Ensembl10100,881,962 - 100,949,309 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111297   ⟹   ENSRNOP00000083430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,869,718 - 100,949,269 (-)Ensembl
RefSeq Acc Id: NM_030846   ⟹   NP_110473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,380,354 - 101,448,138 (-)NCBI
mRatBN7.210100,881,404 - 100,949,193 (-)NCBI
Rnor_6.010104,193,953 - 104,263,071 (-)NCBI
Rnor_5.010104,735,560 - 104,738,091 (-)NCBI
RGSC_v3.410105,722,014 - 105,818,649 (-)RGD
Celera1099,455,840 - 99,524,352 (-)RGD
Sequence:
RefSeq Acc Id: NP_110473   ⟸   NM_030846
- UniProtKB: Q5BKA7 (UniProtKB/Swiss-Prot),   P62994 (UniProtKB/Swiss-Prot),   A6HKQ4 (UniProtKB/TrEMBL),   A0A8L2Q1H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005347   ⟸   ENSRNOT00000005347
Ensembl Acc Id: ENSRNOP00000083430   ⟸   ENSRNOT00000111297
Ensembl Acc Id: ENSRNOP00000080275   ⟸   ENSRNOT00000095127
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62994-F1-model_v2 AlphaFold P62994 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697894
Promoter ID:EPDNEW_R8418
Type:initiation region
Name:Grb2_1
Description:growth factor receptor bound protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,263,169 - 104,263,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619758 AgrOrtholog
BIND 129613
  129614
  129615
  129616
  134462
BioCyc Gene G2FUF-22660 BioCyc
Ensembl Genes ENSRNOG00000003990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005347 ENTREZGENE
  ENSRNOT00000095127.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7382476 IMAGE-MGC_LOAD
InterPro Grb2-like UniProtKB/Swiss-Prot
  GRB2_C_SH3 UniProtKB/Swiss-Prot
  GRB2_N_SH3 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:81504 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108668 IMAGE-MGC_LOAD
NCBI Gene 81504 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Grb2 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003990 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8L2Q1H5 ENTREZGENE, UniProtKB/TrEMBL
  A6HKQ0_RAT UniProtKB/TrEMBL
  A6HKQ2_RAT UniProtKB/TrEMBL
  A6HKQ4 ENTREZGENE, UniProtKB/TrEMBL
  A6HKQ6_RAT UniProtKB/TrEMBL
  GRB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA7 ENTREZGENE
UniProt Secondary P29354 UniProtKB/Swiss-Prot
  Q14450 UniProtKB/Swiss-Prot
  Q5BKA7 UniProtKB/Swiss-Prot
  Q63057 UniProtKB/Swiss-Prot
  Q63059 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Grb2  growth factor receptor bound protein 2  LOC103690155  uncharacterized LOC103690155  Data merged from RGD:9320652 737654 PROVISIONAL
2014-08-25 LOC103690155  uncharacterized LOC103690155      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Grb2  growth factor receptor bound protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology mammalian homolog of C. elegans Sem-5 728541