Gene:	Grb2 ( Rattus norvegicus ) growth factor receptor bound protein 2
Description:	acts as a link between tyrosine kinase receptors and Ras signaling
Synonyms:	MGC108668;  (details...)
ArrayIDs:	5907758; 1370617_at; 1368385_a_at; 6003656; 6285080; rc_AI170776_s_at; A_43_P15304; 6674437; rc_AA801130_at; A_44_P112697; GE1196334; 6533432; A_43_P14930; 6533420; 6348946; 1368386_at; 6112512; 5810699; 6176821; D49847_at; 6252514; 6477716;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: GRB2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Grb2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Grb2 genome assembly 3.1 10 105737088 - 105833269     Rat Celera Assembly 10 99455840 - 99524352     RGSC genome assembly v3.4 10 105722014 - 105818649     Cytogenetic 10 q32.3 Mus musculus Grb2 Mouse genome assembly build 36.1 11 115505444 - 115569911     Cytogenetic 11 11 E2 Homo sapiens GRB2 human genome assembly 17 70825752 - 70913329     Human genome assembly build 36.2 17 70825752 - 70913384     Cytogenetic 17 q24-q25   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology SH3/SH2 adaptor activity,  protein binding,  epidermal growth factor receptor binding ...  (details...)
Biological Process	Gene Ontology regulation of MAPKKK cascade,  cell differentiation,  branching involved in embryonic placenta morphogenesis ...  (details...)
Cellular Component	Gene Ontology protein complex,  cytoplasm,  membrane ...  (details...)
Phenotype	Ontology perinatal lethality,  cleft palate,  increased tumor incidence (details...)
Pathway	Ontology scatter factor/hepatocyte growth factor signaling pathway,  Huntington disease pathway,  mitogen activated protein kinase signaling pathway ...  (details...)
Homology	Note Reference mammalian homolog of C. elegans Sem-5 728541
External Links
Databases	DATABASE ID SOURCE SMART: SH3 IPI SMART: SH2 IPI PROSITE: SH3 IPI PROSITE: SH2 IPI UNIPARC: UPI000002AABE IPI UNIPARC: UPI0001B7A54B IPI UNIPARC: UPI00000E6727 IPI UNIPARC: UPI000004EF93 IPI UNIPARC: UPI000002AABF IPI KEGG Report: rno:81504 ENTREZGENE HomoloGene Group ID: 1576 ENTREZGENE Germonline: 619758 Pfam: SH2 IPI Pfam: SH3_1 IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04320 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE InterPro: SH3_region. IPI InterPro: SH3_domain. IPI InterPro: Neu_cyt_fact_2. IPI InterPro: SH2. IPI Ensembl Protein: ENSRNOP00000043863 IPI Ensembl Protein: ENSRNOP00000005347 IPI IPI: IPI00231574 IPI IPI: IPI00567134 IPI IPI: IPI00204921 IPI IPI: IPI00382077 IPI IPI: IPI00203630 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Grb2 ENTREZGENE IMAGE_CLONE: IMAGE:7382476 IMAGE-MGC_LOAD MGC_CLONE: MGC:108668 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000003990 IPI UniProt: GRB2_RAT IPI UniProt: GRB2_RAT IPI UniProt: GRB2_RAT IPI UniProt: Q63058_RAT IPI Superfamily-SCOP: SH3 IPI BIND: 134462 BIND: 129614 BIND: 129613 BIND: 129615 BIND: 129616 PRINTS: SH3DOMAIN. IPI PRINTS: SH2DOMAIN. IPI PRINTS: P67PHOX. IPI
Sequences	Nucleotide: AA926364 Get FASTA Search GEO Profiles Nucleotide: BC091144 Get FASTA Search GEO Profiles Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: D49846 Get FASTA Search GEO Profiles Nucleotide: NM_030846 Get FASTA Search GEO Profiles Nucleotide: D49847 Get FASTA Search GEO Profiles Nucleotide: D49848 Get FASTA Search GEO Profiles Nucleotide: X62853 Get FASTA Search GEO Profiles (View all 8 Nucleotide Accessions) Protein: EDM06605 Get FASTA Protein: P62994 Get FASTA Protein: CAA44665 Get FASTA Protein: BAA08647 Get FASTA Protein: BAA08646 Get FASTA Protein: BAA08645 Get FASTA Protein: NP_110473 Get FASTA Protein: AAH91144 Get FASTA Protein: EDM06604 Get FASTA Protein: Q63058 Get FASTA (View all 10 Protein Accessions)
Clusters	UniGene: 3360
References
Curated References	16 references in RGD related to Grb2
Other References	22 other references at PubMed related to Grb2
Database Information
RGD ID	619758
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 20-JAN-05: Grb2 growth factor receptor bound protein 2 APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Grb2 growth factor receptor bound protein 2 PROVISIONAL Symbol and Name status set to provisional 70820