Bbox1 (gamma-butyrobetaine hydroxylase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bbox1 (gamma-butyrobetaine hydroxylase 1) Rattus norvegicus
Analyze
Symbol: Bbox1
Name: gamma-butyrobetaine hydroxylase 1
RGD ID: 619756
Description: Enables gamma-butyrobetaine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in cytosol and mitochondrion. Orthologous to human BBOX1 (gamma-butyrobetaine hydroxylase 1); PARTICIPATES IN carnitine biosynthetic pathway; lysine degradation pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bbh; Bbox; butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase); gamma butyrobetaine hydroxylase; gamma-BBH; gamma-butyrobetaine dioxygenase; gamma-butyrobetaine hydroxylase; gamma-butyrobetaine,2-oxoglutarate dioxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83117,277,226 - 117,326,383 (-)NCBIGRCr8
mRatBN7.2396,822,654 - 96,871,786 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,822,655 - 96,871,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,395,476 - 100,434,388 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,994,430 - 109,033,342 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,746,656 - 106,785,585 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,425,684 - 101,474,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,427,055 - 101,474,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03108,023,621 - 108,070,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,747,735 - 95,786,852 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,644,162 - 95,683,280 (-)NCBI
Celera395,835,564 - 95,874,303 (-)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-carnitine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(trimethylammonio)butanoate  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
coumarin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
flutamide  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
isoniazide  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
succimer  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
carnitine biosynthetic process  (IBA,IEA,ISO,ISS,TAS)

Cellular Component
cytosol  (IEA,ISO)
mitochondrion  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of the cDNA encoding the rat liver gamma-butyrobetaine hydroxylase. Galland S, etal., Biochim Biophys Acta 1999 Oct 18;1441(1):85-92.
2. Thyroid hormone controls carnitine status through modifications of gamma-butyrobetaine hydroxylase activity and gene expression. Galland S, etal., Cell Mol Life Sci 2002 Mar;59(3):540-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Carnitine biosynthesis: identification of the cDNA encoding human gamma-butyrobetaine hydroxylase. Vaz FM, etal., Biochem Biophys Res Commun. 1998 Sep 18;250(2):506-10.
Additional References at PubMed
PMID:15795431   PMID:18614015   PMID:19056867   PMID:19150623   PMID:20599753   PMID:22014179   PMID:23127966   PMID:23376485   PMID:25416956  


Genomics

Comparative Map Data
Bbox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83117,277,226 - 117,326,383 (-)NCBIGRCr8
mRatBN7.2396,822,654 - 96,871,786 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,822,655 - 96,871,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,395,476 - 100,434,388 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,994,430 - 109,033,342 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,746,656 - 106,785,585 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,425,684 - 101,474,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,427,055 - 101,474,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03108,023,621 - 108,070,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,747,735 - 95,786,852 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,644,162 - 95,683,280 (-)NCBI
Celera395,835,564 - 95,874,303 (-)NCBICelera
Cytogenetic Map3q34NCBI
BBOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,040,815 - 27,127,809 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,040,725 - 27,127,809 (+)EnsemblGRCh38hg38GRCh38
GRCh371127,062,362 - 27,149,356 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,019,085 - 27,105,930 (+)NCBINCBI36Build 36hg18NCBI36
Build 341127,019,573 - 27,105,930NCBI
Celera1127,207,166 - 27,294,016 (+)NCBICelera
Cytogenetic Map11p14.2NCBI
HuRef1126,759,908 - 26,847,062 (+)NCBIHuRef
CHM1_11127,061,931 - 27,148,767 (+)NCBICHM1_1
T2T-CHM13v2.01127,181,297 - 27,268,300 (+)NCBIT2T-CHM13v2.0
Bbox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392110,094,401 - 110,145,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2110,093,042 - 110,144,905 (-)EnsemblGRCm39 Ensembl
GRCm382110,264,056 - 110,314,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2110,262,697 - 110,314,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv372110,105,240 - 110,145,882 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362110,065,922 - 110,106,564 (-)NCBIMGSCv36mm8
Celera2111,425,130 - 111,465,702 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.7NCBI
Bbox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,368,842 - 6,433,797 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,368,842 - 6,433,797 (+)NCBIChiLan1.0ChiLan1.0
BBOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,241,406 - 29,330,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,241,841 - 29,330,440 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,995,120 - 27,083,832 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,898,529 - 26,986,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,898,529 - 26,986,705 (+)Ensemblpanpan1.1panPan2
BBOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,707,648 - 47,766,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,706,717 - 47,766,503 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,198,477 - 47,257,514 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02148,848,545 - 48,906,661 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2148,847,346 - 48,906,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12147,834,272 - 47,892,256 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,002,172 - 48,061,307 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,588,367 - 48,647,500 (+)NCBIUU_Cfam_GSD_1.0
Bbox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,893,678 - 36,958,956 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365406,048,472 - 6,153,731 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365406,048,481 - 6,113,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl233,227,974 - 33,296,559 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1233,227,965 - 33,296,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,864,213 - 35,883,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BBOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,970,238 - 38,063,854 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,967,283 - 38,062,244 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038135,283,933 - 135,376,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476616,903,323 - 16,957,584 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476616,903,327 - 16,962,176 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bbox1
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000006197
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)396127817102200699Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH131044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,822,676 - 96,822,880 (+)MAPPERmRatBN7.2
Rnor_6.03101,425,711 - 101,425,914NCBIRnor6.0
Rnor_5.03108,022,280 - 108,022,483UniSTSRnor5.0
RGSC_v3.4395,746,394 - 95,746,597UniSTSRGSC3.4
Celera395,834,223 - 95,834,426UniSTS
RH 3.4 Map3765.3UniSTS
Cytogenetic Map3q33UniSTS
AI170038  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,822,923 - 96,823,080 (+)MAPPERmRatBN7.2
Rnor_6.03101,425,958 - 101,426,114NCBIRnor6.0
Rnor_5.03108,022,527 - 108,022,683UniSTSRnor5.0
RGSC_v3.4395,746,641 - 95,746,797UniSTSRGSC3.4
Celera395,834,470 - 95,834,626UniSTS
Cytogenetic Map3q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 13 85 87 88 59 17 59 6 152 46 67 31 47 29

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF160958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF644503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000080175   ⟹   ENSRNOP00000073497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl396,822,655 - 96,871,458 (-)Ensembl
Rnor_6.0 Ensembl3101,427,055 - 101,465,995 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091869   ⟹   ENSRNOP00000072919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3101,429,362 - 101,474,890 (-)Ensembl
RefSeq Acc Id: NM_001413175   ⟹   NP_001400104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,064 (-)NCBI
mRatBN7.2396,822,654 - 96,871,492 (-)NCBI
RefSeq Acc Id: NM_022629   ⟹   NP_072151
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,317,637 (-)NCBI
mRatBN7.2396,822,654 - 96,863,065 (-)NCBI
Rnor_6.03101,427,052 - 101,465,995 (-)NCBI
Rnor_5.03108,023,621 - 108,070,883 (-)NCBI
RGSC_v3.4395,747,735 - 95,786,852 (-)RGD
Celera395,835,564 - 95,874,303 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105800   ⟹   XP_038961728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,367 (-)NCBI
mRatBN7.2396,822,654 - 96,871,529 (-)NCBI
RefSeq Acc Id: XM_039105801   ⟹   XP_038961729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,383 (-)NCBI
mRatBN7.2396,822,654 - 96,871,785 (-)NCBI
RefSeq Acc Id: XM_039105802   ⟹   XP_038961730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,367 (-)NCBI
mRatBN7.2396,822,654 - 96,871,785 (-)NCBI
RefSeq Acc Id: XM_039105804   ⟹   XP_038961732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,367 (-)NCBI
mRatBN7.2396,822,654 - 96,871,786 (-)NCBI
RefSeq Acc Id: XM_063284523   ⟹   XP_063140593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,277,226 - 117,326,367 (-)NCBI
RefSeq Acc Id: XM_063284524   ⟹   XP_063140594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83117,283,520 - 117,326,382 (-)NCBI
RefSeq Acc Id: NP_072151   ⟸   NM_022629
- UniProtKB: Q9QZU7 (UniProtKB/Swiss-Prot),   A6HP13 (UniProtKB/TrEMBL),   A0A0G2K5N7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073497   ⟸   ENSRNOT00000080175
Ensembl Acc Id: ENSRNOP00000072919   ⟸   ENSRNOT00000091869
RefSeq Acc Id: XP_038961732   ⟸   XM_039105804
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961729   ⟸   XM_039105801
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961730   ⟸   XM_039105802
- Peptide Label: isoform X1
- UniProtKB: Q9QZU7 (UniProtKB/Swiss-Prot),   A6HP13 (UniProtKB/TrEMBL),   A0A0G2K5N7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961728   ⟸   XM_039105800
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001400104   ⟸   NM_001413175
- UniProtKB: Q9QZU7 (UniProtKB/Swiss-Prot),   A6HP13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140593   ⟸   XM_063284523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140594   ⟸   XM_063284524
- Peptide Label: isoform X2
Protein Domains
Gamma-butyrobetaine hydroxylase-like N-terminal   TauD/TfdA-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZU7-F1-model_v2 AlphaFold Q9QZU7 1-387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692283
Promoter ID:EPDNEW_R2807
Type:initiation region
Name:Bbox1_1
Description:gamma-butyrobetaine hydroxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2808  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03101,466,057 - 101,466,117EPDNEW
RGD ID:13692284
Promoter ID:EPDNEW_R2808
Type:multiple initiation site
Name:Bbox1_2
Description:gamma-butyrobetaine hydroxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2807  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03101,474,485 - 101,474,545EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619756 AgrOrtholog
BioCyc Gene G2FUF-48471 BioCyc
BioCyc Pathway PWY-6100 [L-carnitine biosynthesis] BioCyc
BioCyc Pathway Image PWY-6100 BioCyc
Ensembl Genes ENSRNOG00000059519 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023529 UniProtKB/Swiss-Prot
  ENSRNOG00060001824 UniProtKB/Swiss-Prot
  ENSRNOG00065016125 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080175 UniProtKB/TrEMBL
  ENSRNOT00000080175.2 UniProtKB/Swiss-Prot
  ENSRNOT00055040436 UniProtKB/Swiss-Prot
  ENSRNOT00060002808 UniProtKB/Swiss-Prot
  ENSRNOT00065026822 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2020.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AlphaKG_dependent_hydroxylases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBBH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBBH-like_N UniProtKB/TrEMBL
  GBBH-like_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBH-like_N UniProtKB/Swiss-Prot
  TauD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TauD/TfdA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64564 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64564 ENTREZGENE
PANTHER GAMMA-BUTYROBETAINE DIOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF971 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TauD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bbox1 PhenoGen
RatGTEx ENSRNOG00000059519 RatGTEx
  ENSRNOG00055023529 RatGTEx
  ENSRNOG00060001824 RatGTEx
  ENSRNOG00065016125 RatGTEx
Superfamily-SCOP Clavaminate synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5N7 ENTREZGENE, UniProtKB/TrEMBL
  A6HP13 ENTREZGENE, UniProtKB/TrEMBL
  A6YRI8_RAT UniProtKB/TrEMBL
  BODG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Bbox1  gamma-butyrobetaine hydroxylase 1  Bbox1  butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bbox1  butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1  Bbox1  butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Bbox1  butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)  Bbox  gamma-butyrobetaine hydroxylase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Bbox  gamma-butyrobetaine hydroxylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression is first detected after weaning and is increased in the adult 632240