Lrp4 (LDL receptor related protein 4) - Rat Genome Database

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Gene: Lrp4 (LDL receptor related protein 4) Rattus norvegicus
Analyze
Symbol: Lrp4
Name: LDL receptor related protein 4
RGD ID: 619731
Description: Enables apolipoprotein binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in dendrite morphogenesis and synapse organization. Located in several cellular components, including plasma membrane raft; postsynaptic density; and synaptic membrane. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP-4; Megf7; multiple epidermal growth factor-like domains 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,885,400 - 97,939,370 (+)EnsemblGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,634,746 - 76,688,537 (+)NCBICelera
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
maneb  (ISO)
metacetamol  (ISO)
methidathion  (ISO)
methylmercury chloride  (EXP)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyridaben  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A role for LRP4 in neuronal cell viability is related to apoE-binding. Lu Y, etal., Brain Res. 2007 Oct 26;1177:19-28. Epub 2007 Aug 25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II. Tian QB, etal., Eur J Neurosci. 2006 Jun;23(11):2864-76.
11. A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. Tomita Y, etal., J Biochem (Tokyo) 1998 Oct;124(4):784-9.
12. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
13. LRP4 serves as a coreceptor of agrin. Zhang B, etal., Neuron. 2008 Oct 23;60(2):285-97. doi: 10.1016/j.neuron.2008.10.006.
14. Structural basis of agrin-LRP4-MuSK signaling. Zong Y, etal., Genes Dev. 2012 Feb 1;26(3):247-58. doi: 10.1101/gad.180885.111.
Additional References at PubMed
PMID:9693030   PMID:15057822   PMID:16207730   PMID:16263759   PMID:16517118   PMID:17119023   PMID:18289866   PMID:18508042   PMID:18848351   PMID:20093106   PMID:20381006   PMID:20383322  
PMID:21471202   PMID:21969364   PMID:22038977   PMID:22854782   PMID:24140340   PMID:30699436  


Genomics

Comparative Map Data
Lrp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,885,400 - 97,939,370 (+)EnsemblGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,634,746 - 76,688,537 (+)NCBICelera
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Cytogenetic Map3q24NCBI
LRP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,856,717 - 46,918,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,856,717 - 46,918,642 (-)Ensemblhg38GRCh38
GRCh371146,878,268 - 46,940,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,834,994 - 46,896,652 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341146,834,994 - 46,874,397NCBI
Celera1147,024,050 - 47,085,802 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,584,196 - 46,645,441 (-)NCBIHuRef
CHM1_11146,876,690 - 46,938,585 (-)NCBICHM1_1
T2T-CHM13v2.01147,013,618 - 47,075,418 (-)NCBIT2T-CHM13v2.0
Lrp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,287,794 - 91,344,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,287,856 - 91,344,124 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,457,456 - 91,513,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)Ensemblmm10GRCm38
MGSCv37291,297,688 - 91,354,058 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36291,258,540 - 91,314,618 (+)NCBIMGSCv36mm8
Celera292,845,990 - 92,902,350 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Lrp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,191,338 - 1,238,227 (+)Ensembl
ChiLan1.0NW_0049554221,191,338 - 1,238,227 (+)NCBIChiLan1.0ChiLan1.0
LRP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,062,785 - 49,123,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,082,564 - 49,143,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,808,090 - 46,868,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,364,195 - 47,409,143 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,366,321 - 47,411,105 (-)EnsemblpanPan2panpan1.1
LRP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,616,683 - 42,667,297 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,616,426 - 42,665,794 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,344,660 - 41,396,887 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01843,271,285 - 43,323,513 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,271,155 - 43,323,246 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,756,909 - 42,808,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,312,112 - 42,364,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,041,646 - 43,093,851 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,100,527 - 20,153,707 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,211,514 - 2,263,937 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,211,519 - 2,262,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,979,254 - 17,017,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,393,489 - 18,474,514 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,413,513 - 18,471,444 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038115,697,194 - 115,757,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,708,866 - 1,757,629 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp4
630 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:319
Count of miRNA genes:197
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000021353
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 84 59 6 348 184 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021353   ⟹   ENSRNOP00000021353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,885,400 - 97,939,370 (+)Ensembl
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)Ensembl
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086242   ⟹   ENSRNOP00000072367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,897,763 - 97,939,370 (+)Ensembl
mRatBN7.2 Ensembl377,441,988 - 77,483,593 (+)Ensembl
Rnor_6.0 Ensembl380,362,865 - 80,412,815 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124954   ⟹   ENSRNOP00000103967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,885,400 - 97,935,505 (+)Ensembl
RefSeq Acc Id: NM_031322   ⟹   NP_112612
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,571 - 97,939,366 (+)NCBI
mRatBN7.2377,429,798 - 77,483,593 (+)NCBI
Rnor_6.0380,362,858 - 80,416,679 (+)NCBI
Rnor_5.0387,062,818 - 87,116,798 (+)NCBI
RGSC_v3.4375,821,638 - 75,875,100 (+)RGD
Celera376,634,746 - 76,688,537 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284643   ⟹   XP_063140713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,373 - 97,919,536 (+)NCBI
RefSeq Acc Id: XR_001837050
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,373 - 97,928,289 (+)NCBI
mRatBN7.2377,429,600 - 77,472,516 (+)NCBI
Rnor_6.0380,362,643 - 80,405,543 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_112612 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140713 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA88688 (Get FASTA)   NCBI Sequence Viewer  
  BAD18061 (Get FASTA)   NCBI Sequence Viewer  
  EDL79527 (Get FASTA)   NCBI Sequence Viewer  
  EDL79528 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021353
  ENSRNOP00000021353.3
GenBank Protein Q9QYP1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112612   ⟸   NM_031322
- Peptide Label: precursor
- UniProtKB: Q9QYP1 (UniProtKB/Swiss-Prot),   Q76LU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021353   ⟸   ENSRNOT00000021353
Ensembl Acc Id: ENSRNOP00000072367   ⟸   ENSRNOT00000086242
RefSeq Acc Id: XP_063140713   ⟸   XM_063284643
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103967   ⟸   ENSRNOT00000124954
Protein Domains
EGF-like   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYP1-F1-model_v2 AlphaFold Q9QYP1 1-1905 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619731 AgrOrtholog
BioCyc Gene G2FUF-48734 BioCyc
Ensembl Genes ENSRNOG00000015285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021353 ENTREZGENE
  ENSRNOT00000021353.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR-related UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
NCBI Gene 83469 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/Swiss-Prot
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PhenoGen Lrp4 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015285 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
UniProt A0A0G2K2T4_RAT UniProtKB/TrEMBL
  A0ABK0L3P7_RAT UniProtKB/TrEMBL
  A6HNC6_RAT UniProtKB/TrEMBL
  A6HNC7_RAT UniProtKB/TrEMBL
  LRP4_RAT UniProtKB/Swiss-Prot
  Q76LU2 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYP1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp4  LDL receptor related protein 4  Lrp4  low density lipoprotein receptor-related protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lrp4  low density lipoprotein receptor-related protein 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lrp4  low density lipoprotein receptor-related protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL