Tubb4a (tubulin, beta 4A class IVa) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tubb4a (tubulin, beta 4A class IVa) Rattus norvegicus
Analyze
Symbol: Tubb4a
Name: tubulin, beta 4A class IVa
RGD ID: 619730
Description: Predicted to enable GTP binding activity; calcium ion binding activity; and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including flagellated sperm motility; microtubule cytoskeleton organization; and negative regulation of microtubule polymerization. Predicted to be located in several cellular components, including axonemal microtubule; internode region of axon; and neuronal cell body. Predicted to be active in cytoplasm; microtubule; and sperm flagellum. Used to study demyelinating disease. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tubb4; tubulin beta-4A chain; tubulin, beta 4; tubulin, beta 4 class IVa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,004,836 - 2,012,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,004,840 - 2,012,286 (-)EnsemblGRCr8
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,351,879 - 2,359,326 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,701,246 - 7,708,694 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,657,095 - 6,664,543 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)Ensemblrn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methoxy-17beta-estradiol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
carbon nanotube  (ISO)
D-glucose  (ISO)
diallyl disulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
FR900359  (ISO)
glucose  (ISO)
glyphosate  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axoneme  (IEA,ISO)
cell projection  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA)
internode region of axon  (IEA,ISO)
microtubule  (IBA,IEA,ISO)
microtubule cytoskeleton  (IEA,ISO)
myelin sheath  (IEA,ISO)
neuronal cell body  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
demyelination  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential distribution of beta-tubulin isotypes in cerebellum. Burgoyne RD, etal., EMBO J 1988 Aug;7(8):2311-9.
2. A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination. Duncan ID, etal., Ann Neurol. 2017 May;81(5):690-702. doi: 10.1002/ana.24930. Epub 2017 May 9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10211825   PMID:11724907   PMID:12475942   PMID:12477932   PMID:14625387   PMID:15277470   PMID:16421295   PMID:16574095   PMID:17634366   PMID:21525035   PMID:21630459   PMID:23106098  
PMID:23284756   PMID:23533145   PMID:24625528   PMID:25931508  


Genomics

Comparative Map Data
Tubb4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,004,836 - 2,012,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,004,840 - 2,012,286 (-)EnsemblGRCr8
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,351,879 - 2,359,326 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,701,246 - 7,708,694 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,657,095 - 6,664,543 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)Ensemblrn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q11NCBI
TUBB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,494,319 - 6,502,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,494,319 - 6,502,848 (-)Ensemblhg38GRCh38
GRCh37196,494,330 - 6,502,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,445,330 - 6,453,330 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,445,329 - 6,453,330NCBI
Celera196,434,150 - 6,442,152 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,257,064 - 6,265,066 (-)NCBIHuRef
CHM1_1196,493,927 - 6,501,914 (-)NCBICHM1_1
T2T-CHM13v2.0196,483,817 - 6,492,345 (-)NCBIT2T-CHM13v2.0
Tubb4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)Ensemblmm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBIMGSCv36mm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,133,429 - 3,139,552 (+)Ensembl
ChiLan1.0NW_0049554953,134,181 - 3,138,725 (+)NCBIChiLan1.0ChiLan1.0
TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,901,916 - 10,910,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,127,833 - 10,136,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,521,425 - 5,529,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,443,913 - 6,451,785 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,441,323 - 6,451,785 (-)EnsemblpanPan2panpan1.1
TUBB4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,351,274 - 54,356,867 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,008,052 - 214,013,612 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,821,110 - 3,826,940 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,821,171 - 3,826,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,599,140 - 72,605,361 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,599,244 - 72,605,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,063,925 - 73,085,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,104,265 - 6,111,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,094,130 - 6,111,762 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660811,895,229 - 1,903,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tubb4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tubb4a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1488,458,261 - 88,464,805 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tubb4a
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:60
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000075767
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
SGC32809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,918,642 - 1,918,775 (-)MAPPERmRatBN7.2
Rnor_6.099,967,486 - 9,967,618NCBIRnor6.0
Rnor_5.098,967,238 - 8,967,370UniSTSRnor5.0
Celera96,598,948 - 6,599,080UniSTS
RH137126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,917,838 - 1,918,041 (-)MAPPERmRatBN7.2
Rnor_6.099,968,220 - 9,968,422NCBIRnor6.0
Rnor_5.098,967,972 - 8,968,174UniSTSRnor5.0
Celera96,599,682 - 6,599,884UniSTS
MARC_24021-24022:1029778648:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,188 - 51,465,794 (+)MAPPERmRatBN7.2
mRatBN7.291,918,543 - 1,919,149 (-)MAPPERmRatBN7.2
Rnor_6.099,967,112 - 9,967,717NCBIRnor6.0
Rnor_6.01956,228,759 - 56,229,364NCBIRnor6.0
Rnor_5.098,966,864 - 8,967,469UniSTSRnor5.0
Rnor_5.01966,939,876 - 66,940,481UniSTSRnor5.0
RGSC_v3.41953,750,652 - 53,751,257UniSTSRGSC3.4
Celera1950,697,659 - 50,698,264UniSTS
Celera96,598,574 - 6,599,179UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 65 164 90 89 58 83 58 6 341 179 10 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075767   ⟹   ENSRNOP00000065633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl92,004,840 - 2,012,286 (-)Ensembl
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)Ensembl
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)Ensembl
RefSeq Acc Id: NM_080882   ⟹   NP_543158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,004,836 - 2,012,281 (-)NCBI
mRatBN7.291,917,841 - 1,925,286 (-)NCBI
Rnor_6.099,961,020 - 9,968,420 (+)NCBI
Rnor_5.098,960,772 - 8,968,172 (+)NCBI
Celera96,592,438 - 6,599,882 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_543158 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68216 (Get FASTA)   NCBI Sequence Viewer  
  BAB72260 (Get FASTA)   NCBI Sequence Viewer  
  EDL83577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065633
  ENSRNOP00000065633.1
RefSeq Acc Id: NP_543158   ⟸   NM_080882
- UniProtKB: Q6P9T8 (UniProtKB/Swiss-Prot),   B4F7C2 (UniProtKB/TrEMBL),   A6KQR9 (UniProtKB/TrEMBL),   M0R843 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065633   ⟸   ENSRNOT00000075767
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4F7C2-F1-model_v2 AlphaFold B4F7C2 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696438
Promoter ID:EPDNEW_R6963
Type:multiple initiation site
Name:Tubb4a_1
Description:tubulin, beta 4A class IVa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,961,046 - 9,961,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619730 AgrOrtholog
BioCyc Gene G2FUF-28490 BioCyc
Ensembl Genes ENSRNOG00000047505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075767 ENTREZGENE
  ENSRNOT00000075767.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.600 UniProtKB/TrEMBL
  3.30.1330.20 UniProtKB/TrEMBL
  3.40.50.1440 UniProtKB/TrEMBL
InterPro Beta-tubulin_BS UniProtKB/TrEMBL
  Beta_tubulin UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/TrEMBL
  Tubulin UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/TrEMBL
  Tubulin/FtsZ_C_sf UniProtKB/TrEMBL
  Tubulin/FtsZ_GTPase_sf UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/TrEMBL
KEGG Report rno:29213 UniProtKB/TrEMBL
NCBI Gene 29213 ENTREZGENE
PANTHER Tubulin UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
PhenoGen Tubb4a PhenoGen
PRINTS BETATUBULIN UniProtKB/TrEMBL
  TUBULIN UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/TrEMBL
  TUBULIN_B_AUTOREG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047505 RatGTEx
SMART Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
Superfamily-SCOP Tub_FtsZ_C UniProtKB/TrEMBL
  Tubulin_FtsZ UniProtKB/TrEMBL
UniProt A6KQR9 ENTREZGENE, UniProtKB/TrEMBL
  B4F7C2 ENTREZGENE
  M0R843 ENTREZGENE, UniProtKB/TrEMBL
  Q6P9T8 ENTREZGENE
UniProt Secondary B4F7C2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-19 Tubb4a  tubulin, beta 4A class IVa  Tubb4  tubulin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb4  tubulin, beta 4  Tubb4a  tubulin, beta 4A class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-11 Tubb4a  tubulin, beta 4A class IVa  Tubb4  tubulin, beta 4A class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-11 Tubb4  tubulin, beta 4A class IVa  Tubb4a  tubulin, beta 4 class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb4a  tubulin, beta 4 class IVa  Tubb4  tubulin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tubb4  tubulin, beta 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tubb4  tubulin, beta 4      Symbol and Name status set to provisional 70820 PROVISIONAL