Gabrg2 (gamma-aminobutyric acid type A receptor subunit gamma 2) - Rat Genome Database

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Gene: Gabrg2 (gamma-aminobutyric acid type A receptor subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Gabrg2
Name: gamma-aminobutyric acid type A receptor subunit gamma 2
RGD ID: 61966
Description: Enables GABA-A receptor activity and chloride channel activity. Contributes to GABA receptor activity. Involved in GABAergic synaptic transmission. Located in dendrite membrane and inhibitory synapse. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; childhood absence epilepsy; developmental and epileptic encephalopathy 74; and familial febrile seizures 8. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2); INTERACTS WITH 1-bromopropane; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor subunit gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma 2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81026,876,926 - 26,965,523 (-)NCBIGRCr8
mRatBN7.21026,374,693 - 26,463,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1031,110,673 - 31,199,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01030,599,199 - 30,687,869 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,085,907 - 26,174,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,090,913 - 27,179,786 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01026,934,991 - 27,024,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41027,037,561 - 27,126,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11027,038,609 - 27,127,123 (-)NCBI
Celera1025,891,936 - 25,979,598 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (ISO)
(R)-camphor  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-(2-methoxyphenyl)piperazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,6-Dimethylphenol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-ethyl-4-methylpiperidine-2,6-dione  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
alpha-hexachlorocyclohexane  (ISO)
Alphaxolone  (EXP)
amphetamine  (ISO)
anthracenes  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzodiazepine  (ISO)
bicuculline  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromoform  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
camphor  (ISO)
carisoprodol  (ISO)
carvone  (ISO)
CGP 52608  (ISO)
cocaine  (EXP,ISO)
cypermethrin  (ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (ISO)
diazepam  (EXP,ISO)
dieldrin  (EXP,ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
Etizolam  (EXP)
etomidate  (EXP,ISO)
famotidine  (EXP)
felbamate  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flumazenil  (ISO)
flunitrazepam  (ISO)
flurotyl  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
hexobarbital  (EXP)
ketamine  (EXP)
lanthanum atom  (ISO)
lead(0)  (ISO)
levonorgestrel  (EXP)
lipopolysaccharide  (ISO)
Lorazepam  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menthone  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
Methylone  (ISO)
midazolam  (ISO)
morphine  (ISO)
muscimol  (ISO)
nicotine  (ISO)
Niflumic acid  (EXP)
o-cresol  (EXP)
p-menthan-3-ol  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
picrotoxin  (EXP,ISO)
picrotoxinin  (ISO)
poly(I:C)  (EXP)
pregnenolone sulfate  (EXP)
propofol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
Testosterone propionate  (ISO)
theophylline  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaleplon  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zolpidem  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons. Bekdash RA and Harrison NL, Brain Behav. 2015 Aug;5(8):e00355. doi: 10.1002/brb3.355. Epub 2015 Jun 2.
2. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. Bianchi MT and Macdonald RL, J Physiol 2002 Oct 1;544(Pt 1):3-18.
3. The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function. Boileau AJ, etal., J Neurosci. 2010 Apr 7;30(14):4895-903. doi: 10.1523/JNEUROSCI.5039-09.2010.
4. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Cagetti E, etal., Mol Pharmacol. 2003 Jan;63(1):53-64. doi: 10.1124/mol.63.1.53.
5. Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. Draguhn A, etal., Neuron 1990 Dec;5(6):781-8.
6. Interaction of GABA receptor/channel rho(1) and gamma(2) subunit. Ekema GM, etal., Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2326-33.
7. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. Enoch MA, etal., PLoS One. 2012;7(1):e29369. doi: 10.1371/journal.pone.0029369. Epub 2012 Jan 13.
8. Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon. Facciolo RM, etal., Exp Brain Res 2002 Feb;142(4):504-11.
9. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Graf ER, etal., Cell. 2004 Dec 29;119(7):1013-26.
13. A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Kananura C, etal., Arch Neurol 2002 Jul;59(7):1137-41.
14. Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. Khan AJ, etal., Mutat Res. 2009 May 12;664(1-2):55-63. doi: 10.1016/j.mrfmmm.2009.02.009. Epub 2009 Feb 28.
15. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Laverty D, etal., Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.
16. Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy. Li XQ, etal., World J Gastroenterol. 2005 Jun 7;11(21):3319-22.
17. Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. Liang J, etal., J Neurosci. 2007 Nov 7;27(45):12367-77. doi: 10.1523/JNEUROSCI.2786-07.2007.
18. Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Lieberman R, etal., Alcohol. 2018 Feb;66:45-53. doi: 10.1016/j.alcohol.2017.08.005. Epub 2017 Aug 12.
19. Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder. Lin SK, etal., Pharmacogenomics J. 2003;3(6):349-55. doi: 10.1038/sj.tpj.6500203.
20. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. Loh EW, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):439-43. doi: 10.1002/ajmg.b.30429.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
24. Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus. Nuñez JL and McCarthy MM, Exp Neurol. 2008 Apr;210(2):699-708. doi: 10.1016/j.expneurol.2008.01.001. Epub 2008 Jan 19.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Petrie J, etal., Alcohol Clin Exp Res. 2001 Jun;25(6):819-28.
27. Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. Radel M, etal., Arch Gen Psychiatry. 2005 Jan;62(1):47-55. doi: 10.1001/archpsyc.62.1.47.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
32. Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Shivers BD, etal., Neuron 1989 Sep;3(3):327-37.
33. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, etal., Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.
34. The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Somogyi P, etal., Neuropharmacology. 1996;35(9-10):1425-44.
35. Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol. Volgin DV, Neurosci Lett. 2008 Jul 11;439(2):182-6. doi: 10.1016/j.neulet.2008.05.011. Epub 2008 May 8.
36. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
37. The gamma-subunit governs the susceptibility of recombinant gamma-aminobutyric acid type A receptors to block by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N). Zarnowska ED, etal., Anesth Analg. 2005 Aug;101(2):401-406. doi: 10.1213/01.ANE.0000155264.67729.E4.
38. Structure of a human synaptic GABAA receptor. Zhu S, etal., Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1966765   PMID:2165521   PMID:9682826   PMID:10900017   PMID:12145412   PMID:12477932   PMID:12574411   PMID:12812758   PMID:15182195  
PMID:15282269   PMID:15659595   PMID:15850489   PMID:16248887   PMID:16740643   PMID:17148443   PMID:17208003   PMID:18094250   PMID:18281286   PMID:18292084   PMID:18305175   PMID:18585436  
PMID:18675324   PMID:19261880   PMID:19358834   PMID:19501070   PMID:19703932   PMID:20823221   PMID:20937799   PMID:21439793   PMID:21924329   PMID:22572883   PMID:22806324   PMID:23909897  
PMID:24141149   PMID:24218551   PMID:24425869   PMID:24573278   PMID:25193658   PMID:25489750   PMID:27129275   PMID:31894752   PMID:32428626   PMID:32579917   PMID:33958479  


Genomics

Comparative Map Data
Gabrg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81026,876,926 - 26,965,523 (-)NCBIGRCr8
mRatBN7.21026,374,693 - 26,463,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1031,110,673 - 31,199,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01030,599,199 - 30,687,869 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,085,907 - 26,174,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,090,913 - 27,179,786 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01026,934,991 - 27,024,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41027,037,561 - 27,126,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11027,038,609 - 27,127,123 (-)NCBI
Celera1025,891,936 - 25,979,598 (-)NCBICelera
Cytogenetic Map10q21NCBI
GABRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385162,067,465 - 162,155,539 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5162,000,057 - 162,162,977 (+)EnsemblGRCh38hg38GRCh38
GRCh375161,494,471 - 161,582,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365161,427,295 - 161,515,106 (+)NCBINCBI36Build 36hg18NCBI36
Build 345161,427,294 - 161,515,106NCBI
Celera5157,525,645 - 157,613,546 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5156,587,110 - 156,675,113 (+)NCBIHuRef
CHM1_15160,927,088 - 161,014,986 (+)NCBICHM1_1
T2T-CHM13v2.05162,596,314 - 162,684,391 (+)NCBIT2T-CHM13v2.0
Gabrg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391141,801,017 - 41,891,684 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1141,801,030 - 41,891,684 (-)EnsemblGRCm39 Ensembl
GRCm381141,910,190 - 42,000,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1141,910,203 - 42,000,857 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,723,697 - 41,814,180 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,753,618 - 41,844,101 (-)NCBIMGSCv36mm8
Celera1145,722,009 - 45,812,211 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1124.8NCBI
Gabrg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540815,765,984 - 15,857,244 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540815,766,161 - 15,857,121 (+)NCBIChiLan1.0ChiLan1.0
GABRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24157,231,806 - 157,325,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15155,371,352 - 155,472,434 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05157,436,113 - 157,529,586 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15164,135,166 - 164,222,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5164,068,122 - 164,222,179 (+)Ensemblpanpan1.1panPan2
GABRG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1448,794,770 - 48,901,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl448,796,852 - 48,901,548 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha448,687,383 - 48,794,507 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0449,225,668 - 49,333,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl449,225,441 - 49,333,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1449,035,654 - 49,142,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0449,167,827 - 49,274,742 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0449,689,277 - 49,797,598 (-)NCBIUU_Cfam_GSD_1.0
Gabrg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213103,160,016 - 103,220,841 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365151,607,722 - 1,671,336 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365151,609,370 - 1,670,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1661,441,632 - 61,543,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11661,441,622 - 61,543,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21666,516,866 - 66,618,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12364,422,519 - 64,512,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2364,422,391 - 64,513,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603413,092,532 - 13,182,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473327,504,660 - 27,594,039 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473327,506,827 - 27,593,750 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrg2
675 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:20
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000004619
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

Markers in Region
D10Uia8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,406,389 - 26,406,593 (+)MAPPERmRatBN7.2
Rnor_6.01027,122,614 - 27,122,817NCBIRnor6.0
Rnor_5.01026,966,653 - 26,966,856UniSTSRnor5.0
RGSC_v3.41027,067,123 - 27,067,326UniSTSRGSC3.4
Celera1025,921,441 - 25,921,644UniSTS
Cytogenetic Map10q21UniSTS
BE120391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,374,724 - 26,374,884 (+)MAPPERmRatBN7.2
Rnor_6.01027,090,945 - 27,091,104NCBIRnor6.0
Rnor_5.01026,935,023 - 26,935,182UniSTSRnor5.0
RGSC_v3.41027,035,481 - 27,035,640UniSTSRGSC3.4
Celera1025,889,856 - 25,890,015UniSTS
RH 3.4 Map10277.0UniSTS
Cytogenetic Map10q21UniSTS
G45867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,452,448 - 26,452,705 (+)MAPPERmRatBN7.2
Rnor_6.01027,168,023 - 27,168,279NCBIRnor6.0
Rnor_5.01027,012,688 - 27,012,944UniSTSRnor5.0
RGSC_v3.41027,114,843 - 27,115,099UniSTSRGSC3.4
Celera1025,968,373 - 25,968,623UniSTS
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68
Low 4 1 1 4 3 1
Below cutoff 2 4 14 6 6 6 6 6 2 1 26 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004619   ⟹   ENSRNOP00000004619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)Ensembl
Rnor_6.0 Ensembl1027,093,025 - 27,179,254 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082445   ⟹   ENSRNOP00000072234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1026,376,200 - 26,464,346 (-)Ensembl
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)Ensembl
RefSeq Acc Id: NM_001393775   ⟹   NP_001380704
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81026,876,926 - 26,965,523 (-)NCBI
mRatBN7.21026,374,693 - 26,463,937 (-)NCBI
RefSeq Acc Id: NM_183327   ⟹   NP_899156
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81026,876,926 - 26,965,523 (-)NCBI
mRatBN7.21026,374,693 - 26,463,937 (-)NCBI
Rnor_6.01027,093,025 - 27,179,254 (-)NCBI
Rnor_5.01026,934,991 - 27,024,440 (-)NCBI
RGSC_v3.41027,037,561 - 27,126,074 (-)RGD
Celera1025,891,936 - 25,979,598 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_899156   ⟸   NM_183327
- Peptide Label: isoform 2 precursor
- UniProtKB: P18508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072234   ⟸   ENSRNOT00000082445
RefSeq Acc Id: ENSRNOP00000004619   ⟸   ENSRNOT00000004619
RefSeq Acc Id: NP_001380704   ⟸   NM_001393775
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6PW52 (UniProtKB/TrEMBL),   A0A0G2K2G4 (UniProtKB/TrEMBL)
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18508-F1-model_v2 AlphaFold P18508 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61966 AgrOrtholog
BioCyc Gene G2FUF-25475 BioCyc
Ensembl Genes ENSRNOG00000003241 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003048 UniProtKB/Swiss-Prot
  ENSRNOG00060019761 UniProtKB/Swiss-Prot
  ENSRNOG00065001340 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004619 ENTREZGENE
  ENSRNOT00000004619.3 UniProtKB/TrEMBL
  ENSRNOT00000082445 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000082445.2 UniProtKB/Swiss-Prot
  ENSRNOT00055004755 UniProtKB/Swiss-Prot
  ENSRNOT00060034154 UniProtKB/Swiss-Prot
  ENSRNOT00065001774 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312477 IMAGE-MGC_LOAD
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAg2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAg_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29709 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109285 IMAGE-MGC_LOAD
NCBI Gene 29709 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GABRG2 RGD
PhenoGen Gabrg2 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARGAMMA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003241 RatGTEx
  ENSRNOG00055003048 RatGTEx
  ENSRNOG00060019761 RatGTEx
  ENSRNOG00065001340 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2G4 ENTREZGENE, UniProtKB/TrEMBL
  GBRG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q562A9_RAT UniProtKB/TrEMBL
  Q6PW52 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrg2  gamma-aminobutyric acid type A receptor subunit gamma 2  Gabrg2  gamma-aminobutyric acid type A receptor gamma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrg2  gamma-aminobutyric acid type A receptor gamma 2 subunit  Gabrg2  gamma-aminobutyric acid (GABA) A receptor, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrg2  gamma-aminobutyric acid (GABA) A receptor, gamma 2  Gabrg2  gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Gabrg2  gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2  Gabrg2  gamma-aminobutyric acid A receptor, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gabrg2  gamma-aminobutyric acid A receptor, gamma 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA is expressed in high amounts in nucleus tractus solitarii and protein expression is seen in many areas of the medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_other gamma subunit confers GABAA receptor insensitivity to inhibition by zinc ions 728419
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528