Fhl2 (four and a half LIM domains 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fhl2 (four and a half LIM domains 2) Rattus norvegicus
Analyze
Symbol: Fhl2
Name: four and a half LIM domains 2
RGD ID: 61963
Description: Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FHL-2; four and a half LIM domains protein 2; LIM domain protein DRAL; skeletal muscle LIM-protein 3; SLIM 3; SLIM-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,881,091 - 52,954,540 (-)NCBIGRCr8
mRatBN7.2945,388,979 - 45,462,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,388,981 - 45,431,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx953,883,965 - 53,913,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,006,764 - 59,035,926 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,287,269 - 57,316,406 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,920,611 - 49,994,906 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,591,185 - 49,664,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,319,997 - 42,349,055 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,321,410 - 42,350,469 (-)NCBI
Celera943,107,290 - 43,136,314 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glycitein  (ISO)
glycitin  (ISO)
hexestrol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
maneb  (ISO)
menadione  (ISO)
mestranol  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
M band  (IDA)
nucleus  (IBA,IEA,ISO)
Z disc  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. FHL2 binds calcineurin and represses pathological cardiac growth. Hojayev B, etal., Mol Cell Biol. 2012 Oct;32(19):4025-34. doi: 10.1128/MCB.05948-11. Epub 2012 Jul 30.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. Scholl FA, etal., J Cell Biol. 2000 Oct 30;151(3):495-506.
9. FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Sun J, etal., Circ Res. 2006 Sep 1;99(5):468-76. Epub 2006 Aug 3.
10. Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. Tanahashi H and Tabira T, Hum Mol Genet 2000 Sep 22;9(15):2281-9.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10906324   PMID:11813260   PMID:12151099   PMID:12432079   PMID:15509787   PMID:15692560   PMID:16311053   PMID:17975004   PMID:18255255   PMID:18586895   PMID:21423176   PMID:22159597  
PMID:25103794   PMID:26316108   PMID:29771425   PMID:34342639   PMID:35176204   PMID:35352799  


Genomics

Comparative Map Data
Fhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8952,881,091 - 52,954,540 (-)NCBIGRCr8
mRatBN7.2945,388,979 - 45,462,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,388,981 - 45,431,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx953,883,965 - 53,913,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,006,764 - 59,035,926 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,287,269 - 57,316,406 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0949,920,611 - 49,994,906 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,591,185 - 49,664,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,319,997 - 42,349,055 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,321,410 - 42,350,469 (-)NCBI
Celera943,107,290 - 43,136,314 (-)NCBICelera
Cytogenetic Map9q22NCBI
FHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382105,357,712 - 105,438,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2105,357,712 - 105,438,513 (-)EnsemblGRCh38hg38GRCh38
GRCh372105,974,169 - 106,054,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,343,715 - 105,421,392 (-)NCBINCBI36Build 36hg18NCBI36
Build 342105,435,802 - 105,513,478NCBI
Celera2100,177,732 - 100,255,816 (-)NCBICelera
Cytogenetic Map2q12.2NCBI
HuRef299,745,771 - 99,823,720 (-)NCBIHuRef
CHM1_12105,981,590 - 106,059,537 (-)NCBICHM1_1
T2T-CHM13v2.02105,818,881 - 105,899,699 (-)NCBIT2T-CHM13v2.0
Fhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,162,233 - 43,237,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,162,234 - 43,236,144 (-)EnsemblGRCm39 Ensembl
GRCm38143,123,071 - 43,198,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,123,074 - 43,196,984 (-)EnsemblGRCm38mm10GRCm38
MGSCv37143,179,919 - 43,220,806 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36143,067,623 - 43,108,396 (-)NCBIMGSCv36mm8
Celera143,461,506 - 43,502,542 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map122.33NCBI
Fhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,240,117 - 10,286,289 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547010,240,117 - 10,286,117 (-)NCBIChiLan1.0ChiLan1.0
FHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,318,702 - 22,357,262 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A22,321,474 - 22,360,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A96,391,513 - 96,469,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A106,446,368 - 106,524,555 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,446,368 - 106,484,895 (-)Ensemblpanpan1.1panPan2
FHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11037,997,912 - 38,065,633 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1037,997,942 - 38,065,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1037,924,199 - 37,991,867 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01038,854,939 - 38,922,615 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1038,854,978 - 38,923,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,579,623 - 38,647,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01038,859,021 - 38,926,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01039,050,777 - 39,118,466 (+)NCBIUU_Cfam_GSD_1.0
Fhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629287,195,507 - 87,233,273 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936764613,193 - 656,224 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936764613,863 - 656,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,363,555 - 49,467,527 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1349,389,900 - 49,448,459 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,610,541 - 51,729,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1148,992,881 - 9,069,432 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl148,990,861 - 9,069,227 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041176,712,666 - 176,789,126 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247499,453,088 - 9,483,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247499,453,081 - 9,507,050 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fhl2
777 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:45
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000023014
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat

Markers in Region
BE114833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2945,390,407 - 45,390,582 (+)MAPPERmRatBN7.2
Rnor_6.0949,922,041 - 49,922,215NCBIRnor6.0
Rnor_5.0949,592,615 - 49,592,789UniSTSRnor5.0
RGSC_v3.4942,320,985 - 42,321,159UniSTSRGSC3.4
Celera943,108,278 - 43,108,452UniSTS
RH 3.4 Map9399.9UniSTS
Cytogenetic Map9q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 9
Medium 3 34 21 6 16 6 3 3 50 35 36 10 3
Low 36 35 3 35 5 8 24 5 1 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023014   ⟹   ENSRNOP00000023014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl945,389,172 - 45,431,171 (-)Ensembl
Rnor_6.0 Ensembl949,920,854 - 49,950,093 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101412   ⟹   ENSRNOP00000088694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl945,389,239 - 45,431,192 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114387   ⟹   ENSRNOP00000084804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl945,388,981 - 45,419,109 (-)Ensembl
RefSeq Acc Id: NM_001412599   ⟹   NP_001399528
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,923,326 (-)NCBI
mRatBN7.2945,388,979 - 45,431,212 (-)NCBI
RefSeq Acc Id: NM_031677   ⟹   NP_113865
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,954,540 (-)NCBI
mRatBN7.2945,388,979 - 45,462,421 (-)NCBI
Rnor_6.0949,921,053 - 49,950,071 (-)NCBI
Rnor_5.0949,591,185 - 49,664,022 (-)NCBI
RGSC_v3.4942,319,997 - 42,349,055 (-)RGD
Celera943,107,290 - 43,136,314 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084158   ⟹   XP_038940086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8952,881,091 - 52,911,057 (-)NCBI
mRatBN7.2945,388,979 - 45,418,825 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113865   ⟸   NM_031677
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023014   ⟸   ENSRNOT00000023014
RefSeq Acc Id: XP_038940086   ⟸   XM_039084158
- Peptide Label: isoform X1
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084804   ⟸   ENSRNOT00000114387
RefSeq Acc Id: ENSRNOP00000088694   ⟸   ENSRNOT00000101412
RefSeq Acc Id: NP_001399528   ⟸   NM_001412599
- UniProtKB: O35115 (UniProtKB/Swiss-Prot),   A6INR3 (UniProtKB/TrEMBL),   A0A8I6A8C5 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35115-F1-model_v2 AlphaFold O35115 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61963 AgrOrtholog
BioCyc Gene G2FUF-27672 BioCyc
Ensembl Genes ENSRNOG00000016866 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065029634 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023014 ENTREZGENE
  ENSRNOT00000023014.4 UniProtKB/Swiss-Prot
  ENSRNOT00000101412.1 UniProtKB/TrEMBL
  ENSRNOT00000114387.1 UniProtKB/TrEMBL
  ENSRNOT00065051169 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63839 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 63839 ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fhl2 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016866 RatGTEx
  ENSRNOG00065029634 RatGTEx
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229306
UniProt A0A8I6A8C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GC70_RAT UniProtKB/TrEMBL
  A6INR3 ENTREZGENE, UniProtKB/TrEMBL
  FHL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fhl2  four and a half LIM domains 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains four LIM domains and an N-terminal half LIM domain 61586
gene_function is an adaptor protein that links PS2 to an intracellular signaling 61586