Isl1 (ISL LIM homeobox 1) - Rat Genome Database

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Gene: Isl1 (ISL LIM homeobox 1) Rattus norvegicus
Analyze
Symbol: Isl1
Name: ISL LIM homeobox 1
RGD ID: 61957
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; LIM domain binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: insulin gene enhancer protein ISL-1; Isl-1; isl-1 homeobox; isl-1=homeobox; ISL1 transcription factor LIM/homeodomain; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; ISL1 transcription factor, LIM/homeodomain, (islet-1); islet-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8249,813,618 - 49,823,442 (-)NCBIGRCr8
mRatBN7.2248,079,412 - 48,090,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,080,522 - 48,095,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx255,203,901 - 55,213,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0253,262,535 - 53,272,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0248,114,441 - 48,124,280 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Isl1Ratatrial fibrillation  ISOISL1 (Homo sapiens)243049245DNA:mutation:cds:c.481G>T (human)RGD 
Isl1Ratatrial heart septal defect susceptibilityISOISL1 (Homo sapiens)243049248DNA:SNP: :rs1017(human)RGD 
Isl1Ratcongenital heart disease no_associationISOISL1 (Homo sapiens)243049243DNA:SNPs:3'UTR:(human)RGD 
Isl1Ratcongenital heart disease susceptibilityISOISL1 (Homo sapiens)243049242DNA:SNPs more ...RGD 
Isl1Ratcongenital heart disease  ISOISL1 (Homo sapiens)243048468DNA:mutation:cds: c.409G>T (p.E137X)(human)RGD 
Isl1Ratdilated cardiomyopathy  ISOISL1 (Homo sapiens)243049244DNA:mutation:cds:c.631A>T(human)RGD 
Isl1Ratdouble outlet right ventricle  ISOISL1 (Homo sapiens)243048467DNA:mutation:cds:c.225C>G(human)RGD 
Isl1RatDyslipidemias treatmentIEP 243049251 RGD 
Isl1RatDyslipidemias treatmentISOIsl1 (Mus musculus)243049251 RGD 
Isl1Rathypothyroidism susceptibilityISOIsl1 (Mus musculus)11353031 RGD 
Isl1Ratmyocardial infarction  ISOIsl1 (Mus musculus)243048464 RGD 
Isl1Ratmyocardial infarction amelioratesISOISL1 (Homo sapiens)243048463 RGD 
Isl1Rattype 1 diabetes mellitus  ISOISL1 (Homo sapiens)2311116DNA:SNPs: :multiple (human)RGD 
Isl1Rattype 2 diabetes mellitus  ISOISL1 (Homo sapiens)2311117associated with Obesity and DNA:SNP:promoter:g.-47A>G (human)RGD 
Isl1Rattype 2 diabetes mellitus  IEP 243065124mRNA and protein:decreased expression:pancreas:RGD 
Isl1Ratventricular septal defect susceptibilityISOISL1 (Homo sapiens)243049248DNA:SNP: :rs1017(human)RGD 
Isl1Ratventricular septal defect  ISOISL1 (Homo sapiens)243048461DNA:polymorphisms: :rs3762977 and IVS1+17C(human)RGD 
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Original Reference(s)
Isl1Ratbladder exstrophy-epispadias-cloacal exstrophy complex  ISOISL1 (Homo sapiens)8554872ClinVar more ...ClinVar 
Isl1Ratcongenital heart disease  ISOISL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Heart and malformation ofClinVar 
Isl1RatNeurodevelopmental Disorders  ISOISL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Isl1RatNeoplasm Recurrence, Local  ISOISL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26332997
Isl1Ratneuroblastoma  ISOISL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30127528
Isl1Raturinary bladder cancer  ISOISL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26332997

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Isl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOIsl1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ISL1 mRNACTDPMID:24058054 and PMID:26139165
Isl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOISL1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of ISL1 mRNACTDPMID:21296121
Isl1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOIsl1 (Mus musculus)64804642 more ...CTDPMID:38648751
Isl1Rat2-methylcholine affects expressionISOISL1 (Homo sapiens)6480464beta-methylcholine affects the expression of ISL1 mRNACTDPMID:21179406
Isl1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:23196670
Isl1Rat3-Nitrobenzanthrone affects expressionISOISL1 (Homo sapiens)64804643-nitrobenzanthrone affects the expression of ISL1 mRNACTDPMID:34036453
Isl1Rat4,4'-sulfonyldiphenol increases expressionISOIsl1 (Mus musculus)6480464bisphenol S results in increased expression of ISL1 mRNACTDPMID:30951980
Isl1Rat4-hydroxyphenyl retinamide increases expressionISOIsl1 (Mus musculus)6480464Fenretinide results in increased expression of ISL1 mRNACTDPMID:28973697
Isl1Rat5-fluorouracil decreases expressionISOIsl1 (Mus musculus)6480464Fluorouracil results in decreased expression of ISL1 proteinCTDPMID:21296659
Isl1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ISL1 mRNACTDPMID:30047161
Isl1Ratacetic acid decreases expressionISOIsl1 (Mus musculus)6480464Acetic Acid results in decreased expression of ISL1 proteinCTDPMID:21296659
Isl1Rataflatoxin B1 affects expressionISOISL1 (Homo sapiens)6480464Aflatoxin B1 affects the expression of ISL1 proteinCTDPMID:20106945
Isl1Rataflatoxin B1 decreases methylationISOISL1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of ISL1 geneCTDPMID:27153756
Isl1Ratall-trans-retinoic acid increases expressionISOISL1 (Homo sapiens)6480464Tretinoin results in increased expression of ISL1 mRNACTDPMID:21934132 and PMID:34742744
Isl1Ratall-trans-retinoic acid decreases expressionISOIsl1 (Mus musculus)6480464Tretinoin results in decreased expression of ISL1 mRNACTDPMID:37278767
Isl1Ratall-trans-retinoic acid affects expressionISOISL1 (Homo sapiens)6480464Tretinoin affects the expression of ISL1 mRNACTDPMID:31600526
Isl1Ratall-trans-retinoic acid decreases expressionISOISL1 (Homo sapiens)6480464Tretinoin results in decreased expression of ISL1 mRNACTDPMID:23724009
Isl1Ratall-trans-retinoic acid increases expressionISOIsl1 (Mus musculus)6480464Tretinoin results in increased expression of ISL1 mRNACTDPMID:20865013
Isl1Ratall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of ISL1 mRNACTDPMID:20488242
Isl1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ISL1 mRNACTDPMID:35163327

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Biological Process
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Original Reference(s)
Isl1Ratatrial septum morphogenesis involved_inIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratatrial septum morphogenesis involved_inISOIsl1 (Mus musculus)1624291UniProtKB:Q02248 and PMID:17519333RGDPMID:17519333
Isl1Rataxon regeneration  IEP 2311122 RGD 
Isl1Rataxonogenesis involved_inIBAFB:FBgn0003896 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Isl1Ratcanonical Wnt signaling pathway acts_upstream_ofIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcanonical Wnt signaling pathway acts_upstream_ofISOIsl1 (Mus musculus)1624291MGI:88276 PMID:19620969RGDPMID:19620969
Isl1Ratcardiac cell fate determination involved_inIEAUniProtKB:P61371 and ensembl:ENSP000002306581600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcardiac cell fate determination acts_upstream_of_or_withinISOIsl1 (Mus musculus)1624291 PMID:19620969RGDPMID:19620969
Isl1Ratcardiac cell fate determination acts_upstream_of_or_withinIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcardiac cell fate determination involved_inISOISL1 (Homo sapiens)1624291 PMID:19571884RGDPMID:19571884
Isl1Ratcardiac muscle cell myoblast differentiation acts_upstream_of_or_withinIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcardiac muscle cell myoblast differentiation acts_upstream_of_or_withinISOIsl1 (Mus musculus)1624291 PMID:19620969RGDPMID:19620969
Isl1Ratcardiac right ventricle morphogenesis involved_inIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcardiac right ventricle morphogenesis involved_inISOIsl1 (Mus musculus)1624291UniProtKB:Q02248 and PMID:17519333RGDPMID:17519333
Isl1Ratcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
Isl1Ratcell differentiation involved_inIEAARBA:ARBA000274291600115GO_REF:0000117UniProtGO_REF:0000117
Isl1Ratcell population proliferation acts_upstream_ofISOIsl1 (Mus musculus)1624291 PMID:15659653RGDPMID:15659653
Isl1Ratcell population proliferation acts_upstream_ofIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratcellular response to glucocorticoid stimulus involved_inIEP 8553931PMID:19619559BHF-UCL 
Isl1Ratcellular response to transforming growth factor beta stimulus  IEP 13210526 RGD 
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Cellular Component
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Original Reference(s)
Isl1Ratchromatin located_inIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratchromatin located_inISOIsl1 (Mus musculus)1624291 PMID:18539116RGDPMID:18539116
Isl1Ratcytoplasm  IDA 243065124MMO:0000538RGD 
Isl1Ratnucleus  IDA 8554127MMO:0000662RGD 
Isl1Ratnucleus is_active_inIBAMGI:101791 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Isl1Ratnucleus located_inIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Isl1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Isl1Ratnucleus located_inISOIsl1 (Mus musculus)1624291 PMID:10536059 more ...RGDPMID:10536059 more ...
Isl1Ratnucleus located_inIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Isl1Rattranscription regulator complex part_ofIDA 155230693PMID:18539116UniProt 
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Molecular Function
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Original Reference(s)
Isl1RatbHLH transcription factor binding enablesIEAUniProtKB:P61371 and ensembl:ENSP000002306581600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1RatbHLH transcription factor binding enablesISOISL1 (Homo sapiens)1624291UniProtKB:Q13562 and PMID:16321656RGDPMID:16321656
Isl1Ratchromatin binding enablesIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1Ratchromatin binding enablesISOIsl1 (Mus musculus)1624291 PMID:18434421 more ...RGDPMID:18434421 more ...
Isl1Ratcis-regulatory region sequence-specific DNA binding enablesIBAPANTHER:PTN001197649 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Isl1Ratcore promoter sequence-specific DNA binding  IDA 8554127 RGD 
Isl1RatDNA binding enablesIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Isl1RatDNA binding enablesIEAInterPro:IPR0013561600115GO_REF:0000002InterProGO_REF:0000002
Isl1RatDNA binding enablesISOIsl1 (Mus musculus)1624291 PMID:19620969RGDPMID:19620969
Isl1RatDNA binding enablesIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1RatDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-03711600115GO_REF:0000043UniProtGO_REF:0000043
Isl1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 8553931PMID:19619559NTNU_SB 
Isl1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOIsl1 (Mus musculus)1624291 PMID:15659653RGDPMID:15659653
Isl1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P61372 and ensembl:ENSMUSP000000448791600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOISL1 (Homo sapiens)1624291 PMID:19619559RGDPMID:19619559
Isl1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:101791 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Isl1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR017970 and InterPro:IPR0471691600115GO_REF:0000002InterProGO_REF:0000002
Isl1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P61371 and ensembl:ENSP000002306581600115GO_REF:0000107EnsemblGO_REF:0000107
Isl1RatLIM domain binding  IMP 243065122 RGD 
Isl1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
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#
Reference Title
Reference Citation
1. Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Barat-Houari M, etal., Diabetes. 2002 May;51(5):1640-3.
2. Islet-1 gene delivery improves myocardial performance after experimental infarction. Barzelay A, etal., Atherosclerosis. 2012 Aug;223(2):284-90. doi: 10.1016/j.atherosclerosis.2012.05.025. Epub 2012 May 30.
3. Expression, purification and characterization of the homeodomain of rat ISL-1 protein. Behravan G, etal., Protein Eng. 1997 Nov;10(11):1327-31.
4. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Brønnum H, etal., Exp Cell Res. 2013 Feb 15;319(4):424-35. doi: 10.1016/j.yexcr.2012.12.019. Epub 2012 Dec 24.
5. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Castinetti F, etal., Mol Endocrinol. 2015 Oct;29(10):1510-21. doi: 10.1210/me.2015-1192. Epub 2015 Aug 21.
6. Lack of association of the 3'-UTR polymorphism (rs1017) in the ISL1 gene and risk of congenital heart disease in the white population. Cresci M, etal., Pediatr Cardiol. 2013 Apr;34(4):938-41. doi: 10.1007/s00246-012-0578-z. Epub 2012 Nov 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Gay F, etal., Mol Endocrinol. 2000 Oct;14(10):1627-48.
9. The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter. Granger A, etal., Mol Endocrinol. 2006 Sep;20(9):2093-108. Epub 2006 Apr 13.
10. Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration. Hol EM, etal., Neuroscience. 1999;88(3):917-25.
11. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Holm P, etal., Diabetes. 2004 Jun;53(6):1584-91.
12. Functional analysis of the nuclear LIM domain interactor NLI. Jurata LW and Gill GN, Mol Cell Biol. 1997 Oct;17(10):5688-98.
13. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Karlsson O, etal., Nature 1990 Apr 26;344(6269):879-82.
14. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Kojima H, etal., Diabetes 2002 May;51(5):1398-408.
15. Association between ISL1 variants and susceptibility to ventricular septal defect in a Chinese cohort. Lang J, etal., Mol Diagn Ther. 2013 Apr;17(2):101-6. doi: 10.1007/s40291-013-0033-8.
16. A regulatory network to segregate the identity of neuronal subtypes. Lee S, etal., Dev Cell. 2008 Jun;14(6):877-89. doi: 10.1016/j.devcel.2008.03.021.
17. Statin downregulation of miR-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression. Liang L, etal., Metabolism. 2020 Jun;107:154226. doi: 10.1016/j.metabol.2020.154226. Epub 2020 Apr 8.
18. Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people. Luo ZL, etal., Genet Mol Res. 2014 Feb 28;13(1):1329-38. doi: 10.4238/2014.February.28.5.
19. ISL1 loss-of-function mutation contributes to congenital heart defects. Ma L, etal., Heart Vessels. 2019 Apr;34(4):658-668. doi: 10.1007/s00380-018-1289-z. Epub 2018 Nov 2.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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PMID:8565076   PMID:9000074   PMID:9806931   PMID:10536059   PMID:12900460   PMID:14664703   PMID:14667410   PMID:14702043   PMID:14766174   PMID:15659653   PMID:16321656   PMID:16687132  
PMID:17519333   PMID:17553340   PMID:17928203   PMID:18367596   PMID:18434416   PMID:18434421   PMID:18524626   PMID:18849985   PMID:19571884   PMID:19620969   PMID:19666821   PMID:21734270  
PMID:22343290   PMID:22343712   PMID:23610558   PMID:23805044   PMID:24147056   PMID:24310985   PMID:24643061   PMID:24821700   PMID:25433207   PMID:25775587   PMID:26393440   PMID:38819467  



Isl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8249,813,618 - 49,823,442 (-)NCBIGRCr8
mRatBN7.2248,079,412 - 48,090,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,080,522 - 48,095,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx255,203,901 - 55,213,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0253,262,535 - 53,272,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0248,114,441 - 48,124,280 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
ISL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38551,383,448 - 51,394,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl551,383,448 - 51,394,730 (+)EnsemblGRCh38hg38GRCh38
GRCh37550,679,282 - 50,690,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36550,714,715 - 50,726,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 34550,715,025 - 50,726,310NCBI
Celera547,625,609 - 47,637,216 (+)NCBICelera
Cytogenetic Map5q11.1NCBI
HuRef547,642,569 - 47,654,183 (+)NCBIHuRef
CHM1_1550,681,961 - 50,693,557 (+)NCBICHM1_1
T2T-CHM13v2.0552,202,628 - 52,213,920 (+)NCBIT2T-CHM13v2.0
Isl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913116,434,806 - 116,446,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13116,434,817 - 116,446,225 (-)EnsemblGRCm39 Ensembl
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBIMGSCv36mm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.87NCBI
Isl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544615,824,035 - 15,835,046 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544615,824,956 - 15,835,000 (-)NCBIChiLan1.0ChiLan1.0
ISL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2462,546,522 - 62,564,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1560,700,147 - 60,717,845 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0562,635,095 - 62,650,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1564,253,037 - 64,264,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl564,252,715 - 64,264,674 (-)Ensemblpanpan1.1panPan2
ISL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1463,638,009 - 63,648,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl463,637,443 - 63,648,183 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha463,397,586 - 63,408,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0464,141,344 - 64,152,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl464,141,331 - 64,152,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1463,906,232 - 63,917,266 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0464,028,384 - 64,039,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0464,567,747 - 64,578,778 (-)NCBIUU_Cfam_GSD_1.0
Isl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213206,869,998 - 206,881,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648015,805,247 - 15,817,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648015,805,259 - 15,817,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1630,963,000 - 30,973,907 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11630,962,994 - 30,974,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21632,548,015 - 32,559,227 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1447,665,861 - 47,678,631 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl447,666,536 - 47,677,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660823,504,978 - 3,526,896 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247597,994,242 - 8,006,311 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247597,996,177 - 8,006,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Isl1
61 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir31rno-miR-31a-5pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assayFunctional MTI23270756

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000017305
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat

1 to 10 of 49 rows
PMC186328P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2248,086,133 - 48,086,320 (+)MAPPERmRatBN7.2
Rnor_6.0248,494,429 - 48,494,615NCBIRnor6.0
Rnor_5.0266,877,308 - 66,877,494UniSTSRnor5.0
RGSC_v3.4248,055,642 - 48,055,828UniSTSRGSC3.4
Celera243,813,868 - 43,814,054UniSTS
Cytogenetic Map2q15UniSTS
RH141578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2248,082,313 - 48,082,512 (+)MAPPERmRatBN7.2
Rnor_6.0248,490,609 - 48,490,807NCBIRnor6.0
Rnor_5.0266,873,488 - 66,873,686UniSTSRnor5.0
RGSC_v3.4248,051,822 - 48,052,020UniSTSRGSC3.4
Celera243,810,048 - 43,810,246UniSTS
RH 3.4 Map2327.7UniSTS
Cytogenetic Map2q15UniSTS
D10Bir8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0466,216,096 - 66,216,306NCBIRnor5.0
Rnor_5.010102,852,602 - 102,852,872NCBIRnor5.0
RGSC_v3.410104,539,788 - 104,540,057UniSTSRGSC3.4
RGSC_v3.4466,232,144 - 66,232,353UniSTSRGSC3.4
Celera1098,286,975 - 98,287,244UniSTS
Celera462,414,402 - 62,414,611UniSTS
Cytogenetic Map10q32.2UniSTS
Cytogenetic Map2q15UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 41 112 72 71 40 22 40 6 148 80 92 13 55 31



Ensembl Acc Id: ENSRNOT00000017305   ⟹   ENSRNOP00000017305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl248,080,616 - 48,095,584 (-)Ensembl
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117391   ⟹   ENSRNOP00000076523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl248,080,522 - 48,090,444 (-)Ensembl
RefSeq Acc Id: NM_017339   ⟹   NP_059035
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8249,813,618 - 49,823,442 (-)NCBI
mRatBN7.2248,080,616 - 48,090,444 (-)NCBI
Rnor_6.0248,488,911 - 48,501,217 (-)NCBI
Rnor_5.0266,871,790 - 66,883,936 (-)NCBI
RGSC_v3.4248,050,124 - 48,060,394 (-)RGD
Celera243,808,350 - 43,818,250 (-)RGD
Sequence:
Protein RefSeqs NP_059035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB30128 (Get FASTA)   NCBI Sequence Viewer  
  AAS46773 (Get FASTA)   NCBI Sequence Viewer  
  EDM10395 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076523
GenBank Protein P61374 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059035   ⟸   NM_017339
- UniProtKB: P61374 (UniProtKB/Swiss-Prot),   A6I5T7 (UniProtKB/TrEMBL),   A0A8L2Q8Q3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017305   ⟸   ENSRNOT00000017305
Ensembl Acc Id: ENSRNOP00000076523   ⟸   ENSRNOT00000117391
Homeobox   LIM zinc-binding

Name Modeler Protein Id AA Range Protein Structure
AF-P61374-F1-model_v2 AlphaFold P61374 1-349 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54311 BioCyc
Ensembl Genes ENSRNOG00000012556 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000117391 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  ISL1/2-like UniProtKB/Swiss-Prot
  ISL1/2-like_LIM1 UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:64444 UniProtKB/Swiss-Prot
NCBI Gene 64444 ENTREZGENE
PANTHER INSULIN GENE ENHANCER PROTEIN UniProtKB/Swiss-Prot
  INSULIN GENE ENHANCER PROTEIN ISL-1 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
  LIM UniProtKB/Swiss-Prot
PhenoGen Isl1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012556 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF46689 UniProtKB/Swiss-Prot
UniProt A0A8I5Y041_RAT UniProtKB/TrEMBL
  A0A8L2Q8Q3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T7 ENTREZGENE, UniProtKB/TrEMBL
  ISL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20663 UniProtKB/Swiss-Prot
  P47894 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Isl1  ISL LIM homeobox 1  Isl1  ISL1 transcription factor, LIM/homeodomain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Isl1  ISL1 transcription factor, LIM/homeodomain 1      Symbol and Name updated 629477 APPROVED
2003-03-12 Isl1  ISL1 transcription factor, LIM/homeodomain 1  Isl-1  isl-1=homeobox  Data merged from RGD:621772 628472 PROVISIONAL
2002-08-07 Isl-1  isl-1=homeobox      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Isl1  ISL1 transcription factor, LIM/homeodomain      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in central and peripheral nervous system and the islet cells of the pancreas 729019