Isl1 (ISL LIM homeobox 1) - Rat Genome Database

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Gene: Isl1 (ISL LIM homeobox 1) Rattus norvegicus
Analyze
Symbol: Isl1
Name: ISL LIM homeobox 1
RGD ID: 61957
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; LIM domain binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ISL1 transcription factor, LIM/homeodomain, (islet-1) ; insulin gene enhancer protein ISL-1; Isl-1; isl-1 homeobox; isl-1=homeobox; ISL1 transcription factor LIM/homeodomain; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; islet-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8249,813,618 - 49,823,442 (-)NCBIGRCr8
mRatBN7.2248,079,412 - 48,090,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,080,522 - 48,095,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx255,203,901 - 55,213,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0253,262,535 - 53,272,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0248,114,441 - 48,124,280 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
CHIR 99021  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
glyphosate  (ISO)
homocysteine  (ISO)
inositol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
panobinostat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
ribavirin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial septum morphogenesis  (IEA,ISO)
axon regeneration  (IEP)
axonogenesis  (IBA)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac cell fate determination  (IEA,ISO)
cardiac muscle cell myoblast differentiation  (IEA,ISO)
cardiac right ventricle morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
endocardial cushion morphogenesis  (IEA,ISO)
heart development  (ISO,ISS)
heart morphogenesis  (ISO)
innervation  (IEA,ISO)
mesenchymal cell differentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (IDA)
negative regulation of mesenchymal cell proliferation  (IMP)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of protein-containing complex assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural crest cell migration  (IEA,ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuron fate specification  (IBA,IEA,ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO)
pancreas development  (IEA,ISO)
peripheral nervous system neuron axonogenesis  (IEA,ISO)
peripheral nervous system neuron development  (ISO)
pharyngeal system development  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of cell differentiation  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of granulocyte colony-stimulating factor production  (IEA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA,ISO)
positive regulation of insulin secretion  (IEA,IMP,ISO)
positive regulation of interleukin-1 alpha production  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage colony-stimulating factor production  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of smoothened signaling pathway  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IGI,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type B pancreatic cell apoptotic process  (IMP)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of DNA-templated transcription  (IDA)
regulation of gene expression  (ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
secondary heart field specification  (IEA,ISO)
sensory system development  (IEA,ISO)
sinoatrial node cell development  (IEA,ISO)
spinal cord motor neuron cell fate specification  (IEA,ISO)
spinal cord motor neuron differentiation  (ISO)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (IEA,ISO)
trigeminal nerve development  (IEA,ISO)
ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
visceral motor neuron differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IDA)
nucleus  (IBA,IDA,IEA,ISO)
transcription regulator complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Barat-Houari M, etal., Diabetes. 2002 May;51(5):1640-3.
2. Islet-1 gene delivery improves myocardial performance after experimental infarction. Barzelay A, etal., Atherosclerosis. 2012 Aug;223(2):284-90. doi: 10.1016/j.atherosclerosis.2012.05.025. Epub 2012 May 30.
3. Expression, purification and characterization of the homeodomain of rat ISL-1 protein. Behravan G, etal., Protein Eng. 1997 Nov;10(11):1327-31.
4. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Brønnum H, etal., Exp Cell Res. 2013 Feb 15;319(4):424-35. doi: 10.1016/j.yexcr.2012.12.019. Epub 2012 Dec 24.
5. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Castinetti F, etal., Mol Endocrinol. 2015 Oct;29(10):1510-21. doi: 10.1210/me.2015-1192. Epub 2015 Aug 21.
6. Lack of association of the 3'-UTR polymorphism (rs1017) in the ISL1 gene and risk of congenital heart disease in the white population. Cresci M, etal., Pediatr Cardiol. 2013 Apr;34(4):938-41. doi: 10.1007/s00246-012-0578-z. Epub 2012 Nov 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Gay F, etal., Mol Endocrinol. 2000 Oct;14(10):1627-48.
9. The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter. Granger A, etal., Mol Endocrinol. 2006 Sep;20(9):2093-108. Epub 2006 Apr 13.
10. Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration. Hol EM, etal., Neuroscience. 1999;88(3):917-25.
11. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Holm P, etal., Diabetes. 2004 Jun;53(6):1584-91.
12. Functional analysis of the nuclear LIM domain interactor NLI. Jurata LW and Gill GN, Mol Cell Biol. 1997 Oct;17(10):5688-98.
13. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Karlsson O, etal., Nature 1990 Apr 26;344(6269):879-82.
14. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Kojima H, etal., Diabetes 2002 May;51(5):1398-408.
15. Association between ISL1 variants and susceptibility to ventricular septal defect in a Chinese cohort. Lang J, etal., Mol Diagn Ther. 2013 Apr;17(2):101-6. doi: 10.1007/s40291-013-0033-8.
16. A regulatory network to segregate the identity of neuronal subtypes. Lee S, etal., Dev Cell. 2008 Jun;14(6):877-89. doi: 10.1016/j.devcel.2008.03.021.
17. Statin downregulation of miR-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression. Liang L, etal., Metabolism. 2020 Jun;107:154226. doi: 10.1016/j.metabol.2020.154226. Epub 2020 Apr 8.
18. Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people. Luo ZL, etal., Genet Mol Res. 2014 Feb 28;13(1):1329-38. doi: 10.4238/2014.February.28.5.
19. ISL1 loss-of-function mutation contributes to congenital heart defects. Ma L, etal., Heart Vessels. 2019 Apr;34(4):658-668. doi: 10.1007/s00380-018-1289-z. Epub 2018 Nov 2.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex. Seo SY, etal., Mol Cell Biol. 2015 Oct;35(20):3579-89. doi: 10.1128/MCB.00335-15. Epub 2015 Aug 10.
24. The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells. Shao W, etal., J Mol Endocrinol. 2018 Jul;61(1):1-12. doi: 10.1530/JME-17-0181. Epub 2018 Apr 20.
25. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. Stevens KN, etal.
26. microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway. Sun Q, etal., Aging (Albany NY). 2020 Jun 16;12(12):11446-11465. doi: 10.18632/aging.103230. Epub 2020 Jun 16.
27. The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage. Wang M and Drucker DJ, Endocrinology 1994 Mar;134(3):1416-22.
28. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. Wang M and Drucker DJ, J Biol Chem. 1995 May 26;270(21):12646-52.
29. MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats. Wang XY, etal., J Cell Physiol. 2019 Apr;234(4):4997-5010. doi: 10.1002/jcp.27300. Epub 2018 Oct 20.
30. A New ISL1 Loss-of-Function Mutation Predisposes to Congenital Double Outlet Right Ventricle. Wang Z, etal., Int Heart J. 2019 Sep 27;60(5):1113-1122. doi: 10.1536/ihj.18-685. Epub 2019 Sep 4.
31. ISL1 loss-of-function variation causes familial atrial fibrillation. Wu SH, etal., Eur J Med Genet. 2020 Nov;63(11):104029. doi: 10.1016/j.ejmg.2020.104029. Epub 2020 Aug 6.
32. ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model. Xiang Q, etal., Stem Cell Res Ther. 2018 Feb 26;9(1):51. doi: 10.1186/s13287-018-0803-7.
33. Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy. Xu YJ, etal., J Cardiovasc Transl Res. 2019 Jun;12(3):257-267. doi: 10.1007/s12265-018-9851-8. Epub 2018 Dec 10.
34. The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2. Zhang H, etal., J Mol Biol. 2009 Sep 25;392(3):566-77. doi: 10.1016/j.jmb.2009.07.036. Epub 2009 Jul 17.
Additional References at PubMed
PMID:8565076   PMID:9000074   PMID:9806931   PMID:10536059   PMID:12900460   PMID:14664703   PMID:14667410   PMID:14702043   PMID:14766174   PMID:15659653   PMID:16321656   PMID:16687132  
PMID:17519333   PMID:17553340   PMID:17928203   PMID:18367596   PMID:18434416   PMID:18434421   PMID:18524626   PMID:18849985   PMID:19571884   PMID:19620969   PMID:19666821   PMID:21734270  
PMID:22343290   PMID:22343712   PMID:23610558   PMID:23805044   PMID:24147056   PMID:24310985   PMID:24643061   PMID:24821700   PMID:25433207   PMID:25775587   PMID:26393440   PMID:38819467  


Genomics

Comparative Map Data
Isl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8249,813,618 - 49,823,442 (-)NCBIGRCr8
mRatBN7.2248,079,412 - 48,090,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl248,080,522 - 48,095,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx255,203,901 - 55,213,771 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0253,262,535 - 53,272,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0248,114,441 - 48,124,280 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0248,488,911 - 48,501,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0266,871,790 - 66,883,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4248,050,124 - 48,060,394 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,978,356 - 47,988,627 (-)NCBI
Celera243,808,350 - 43,818,250 (-)NCBICelera
Cytogenetic Map2q14NCBI
ISL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38551,383,448 - 51,394,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl551,383,448 - 51,394,730 (+)EnsemblGRCh38hg38GRCh38
GRCh37550,679,282 - 50,690,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36550,714,715 - 50,726,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 34550,715,025 - 50,726,310NCBI
Celera547,625,609 - 47,637,216 (+)NCBICelera
Cytogenetic Map5q11.1NCBI
HuRef547,642,569 - 47,654,183 (+)NCBIHuRef
CHM1_1550,681,961 - 50,693,557 (+)NCBICHM1_1
T2T-CHM13v2.0552,202,628 - 52,213,920 (+)NCBIT2T-CHM13v2.0
Isl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913116,434,806 - 116,446,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13116,434,817 - 116,446,225 (-)EnsemblGRCm39 Ensembl
GRCm3813116,298,270 - 116,309,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13116,298,281 - 116,309,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713117,088,478 - 117,099,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613117,418,963 - 117,430,370 (-)NCBIMGSCv36mm8
Celera13120,696,034 - 120,707,388 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.87NCBI
Isl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544615,824,035 - 15,835,046 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544615,824,956 - 15,835,000 (-)NCBIChiLan1.0ChiLan1.0
ISL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2462,546,522 - 62,564,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1560,700,147 - 60,717,845 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0562,635,095 - 62,650,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1564,253,037 - 64,264,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl564,252,715 - 64,264,674 (-)Ensemblpanpan1.1panPan2
ISL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1463,638,009 - 63,648,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl463,637,443 - 63,648,183 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha463,397,586 - 63,408,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0464,141,344 - 64,152,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl464,141,331 - 64,152,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1463,906,232 - 63,917,266 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0464,028,384 - 64,039,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0464,567,747 - 64,578,778 (-)NCBIUU_Cfam_GSD_1.0
Isl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213206,869,998 - 206,881,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648015,805,247 - 15,817,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648015,805,259 - 15,817,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1630,963,000 - 30,973,907 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11630,962,994 - 30,974,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21632,548,015 - 32,559,227 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1447,665,861 - 47,678,631 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl447,666,536 - 47,677,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660823,504,978 - 3,526,896 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247597,994,242 - 8,006,311 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247597,996,177 - 8,006,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Isl1
61 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir31rno-miR-31a-5pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assayFunctional MTI23270756

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000017305
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)23922393748793699Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
PMC186328P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2248,086,133 - 48,086,320 (+)MAPPERmRatBN7.2
Rnor_6.0248,494,429 - 48,494,615NCBIRnor6.0
Rnor_5.0266,877,308 - 66,877,494UniSTSRnor5.0
RGSC_v3.4248,055,642 - 48,055,828UniSTSRGSC3.4
Celera243,813,868 - 43,814,054UniSTS
Cytogenetic Map2q15UniSTS
RH141578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2248,082,313 - 48,082,512 (+)MAPPERmRatBN7.2
Rnor_6.0248,490,609 - 48,490,807NCBIRnor6.0
Rnor_5.0266,873,488 - 66,873,686UniSTSRnor5.0
RGSC_v3.4248,051,822 - 48,052,020UniSTSRGSC3.4
Celera243,810,048 - 43,810,246UniSTS
RH 3.4 Map2327.7UniSTS
Cytogenetic Map2q15UniSTS
D10Bir8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0466,216,096 - 66,216,306NCBIRnor5.0
Rnor_5.010102,852,602 - 102,852,872NCBIRnor5.0
RGSC_v3.410104,539,788 - 104,540,057UniSTSRGSC3.4
RGSC_v3.4466,232,144 - 66,232,353UniSTSRGSC3.4
Celera1098,286,975 - 98,287,244UniSTS
Celera462,414,402 - 62,414,611UniSTS
Cytogenetic Map10q32.2UniSTS
Cytogenetic Map2q15UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 41 112 72 71 40 22 40 6 148 80 92 13 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000017305   ⟹   ENSRNOP00000017305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl248,080,616 - 48,095,584 (-)Ensembl
Rnor_6.0 Ensembl248,487,736 - 48,501,436 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117391   ⟹   ENSRNOP00000076523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl248,080,522 - 48,090,444 (-)Ensembl
RefSeq Acc Id: NM_017339   ⟹   NP_059035
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8249,813,618 - 49,823,442 (-)NCBI
mRatBN7.2248,080,616 - 48,090,444 (-)NCBI
Rnor_6.0248,488,911 - 48,501,217 (-)NCBI
Rnor_5.0266,871,790 - 66,883,936 (-)NCBI
RGSC_v3.4248,050,124 - 48,060,394 (-)RGD
Celera243,808,350 - 43,818,250 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB30128 (Get FASTA)   NCBI Sequence Viewer  
  AAS46773 (Get FASTA)   NCBI Sequence Viewer  
  EDM10395 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017305.4
  ENSRNOP00000076523.1
GenBank Protein P61374 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059035   ⟸   NM_017339
- UniProtKB: P61374 (UniProtKB/Swiss-Prot),   A6I5T7 (UniProtKB/TrEMBL),   A0A8L2Q8Q3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017305   ⟸   ENSRNOT00000017305
Ensembl Acc Id: ENSRNOP00000076523   ⟸   ENSRNOT00000117391
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61374-F1-model_v2 AlphaFold P61374 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61957 AgrOrtholog
BioCyc Gene G2FUF-54311 BioCyc
Ensembl Genes ENSRNOG00000012556 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017305.6 UniProtKB/TrEMBL
  ENSRNOT00000117391.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISL1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISL1/2-like_LIM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64444 ENTREZGENE
PANTHER INSULIN GENE ENHANCER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULIN GENE ENHANCER PROTEIN ISL-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isl1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012556 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y041_RAT UniProtKB/TrEMBL
  A0A8L2Q8Q3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T7 ENTREZGENE, UniProtKB/TrEMBL
  ISL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20663 UniProtKB/Swiss-Prot
  P47894 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Isl1  ISL LIM homeobox 1  Isl1  ISL1 transcription factor, LIM/homeodomain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Isl1  ISL1 transcription factor, LIM/homeodomain 1      Symbol and Name updated 629477 APPROVED
2003-03-12 Isl1  ISL1 transcription factor, LIM/homeodomain 1  Isl-1  isl-1=homeobox  Data merged from RGD:621772 628472 PROVISIONAL
2002-08-07 Isl-1  isl-1=homeobox      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Isl1  ISL1 transcription factor, LIM/homeodomain      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in central and peripheral nervous system and the islet cells of the pancreas 729019